ATE152111T1 - K-252a derivate - Google Patents

K-252a derivate

Info

Publication number
ATE152111T1
ATE152111T1 AT93917337T AT93917337T ATE152111T1 AT E152111 T1 ATE152111 T1 AT E152111T1 AT 93917337 T AT93917337 T AT 93917337T AT 93917337 T AT93917337 T AT 93917337T AT E152111 T1 ATE152111 T1 AT E152111T1
Authority
AT
Austria
Prior art keywords
derivatives
disease
useful
treating parkinson
parkinson
Prior art date
Application number
AT93917337T
Other languages
English (en)
Inventor
Michael E Lewis
Nicola Neff
Jill Roberts-Lewis
Chikara Murakata
Hiromitsu Saito
Yuzuru Matsuda
James C Kauer
Original Assignee
Cephalon Inc
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE152111T1 publication Critical patent/ATE152111T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT93917337T 1992-07-24 1993-07-26 K-252a derivate ATE152111T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92010292A 1992-07-24 1992-07-24

Publications (1)

Publication Number Publication Date
ATE152111T1 true ATE152111T1 (de) 1997-05-15

Family

ID=25443161

Family Applications (3)

Application Number Title Priority Date Filing Date
AT93917337T ATE152111T1 (de) 1992-07-24 1993-07-26 K-252a derivate
AT96116661T ATE196142T1 (de) 1992-07-24 1993-07-26 Vervendung von k-252a derivaten zur förderung der funktion eines stritialen neurons
AT99120008T ATE304848T1 (de) 1992-07-24 1993-07-26 Verwendung von vier k-252a derivaten

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT96116661T ATE196142T1 (de) 1992-07-24 1993-07-26 Vervendung von k-252a derivaten zur förderung der funktion eines stritialen neurons
AT99120008T ATE304848T1 (de) 1992-07-24 1993-07-26 Verwendung von vier k-252a derivaten

Country Status (17)

Country Link
US (1) US5461146A (de)
EP (4) EP1512688A1 (de)
JP (3) JP3762427B2 (de)
KR (1) KR100276008B1 (de)
AT (3) ATE152111T1 (de)
AU (1) AU675236B2 (de)
BR (1) BR9306789A (de)
CA (1) CA2140924A1 (de)
DE (3) DE69310178T2 (de)
DK (3) DK0651754T3 (de)
ES (3) ES2101331T3 (de)
GR (2) GR3023817T3 (de)
HU (5) HU225297B1 (de)
NO (2) NO305481B1 (de)
NZ (2) NZ254662A (de)
PT (1) PT768312E (de)
WO (1) WO1994002488A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
KR100201343B1 (ko) * 1993-05-28 1999-06-15 바바라 에스 쉴버그 인돌로카르바졸 유도체들의 전립선의 병적상태치료에의 용도
US5468872A (en) * 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
SG63570A1 (en) * 1993-12-07 1999-03-30 Lilly Co Eli Protein kinase c inhibitors
HUT69164A (en) * 1993-12-07 1995-08-28 Lilly Co Eli Improved process for producing bis-indolyl-maleimide derivatives
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
EP1449529B1 (de) * 1993-12-23 2010-01-27 Eli Lilly And Company Proteinkinase C Inhibitoren
AU1911095A (en) * 1994-02-18 1995-09-04 Cephalon, Inc. Aqueous indolocarbazole solutions
KR100464907B1 (ko) * 1994-10-26 2005-07-04 세파론, 인코포레이티드 신경계질환치료용단백질키나아제억제제
US5650407A (en) * 1995-04-05 1997-07-22 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
US5686444A (en) 1995-04-05 1997-11-11 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
US5808060A (en) * 1995-12-11 1998-09-15 Cephalon, Inc. Fused isoindolones
US6232299B1 (en) 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
EP1019043A4 (de) * 1996-05-07 2003-07-30 Univ Pennsylvania Inhibitoren der glykogensynthese-kinase 3 und verfahren zu ihrer identifizierung und verwendung
UA67725C2 (en) 1996-06-03 2004-07-15 Cephalon Inc K-252a derivatives and a method for improvement of functioning and cell survival enhancement
US6875865B1 (en) * 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
ES2184106T3 (es) 1996-06-25 2003-04-01 Cephalon Inc Utilizacion del derivado de k-252a en el tratamiento de trastornos del sistema nervioso periferico o central, y de la hiperproduccion de citoquinas.
US7144997B2 (en) * 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
US5985877A (en) † 1997-08-15 1999-11-16 Cephalon, Inc. Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer
JP4405667B2 (ja) * 1997-12-31 2010-01-27 セフアロン・インコーポレーテツド Ｋ−２５２ａの３’−エピマー誘導体
US6811992B1 (en) 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6013646A (en) * 1998-07-02 2000-01-11 Bayer Corporation Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
US7795246B2 (en) * 1998-08-06 2010-09-14 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) 1998-08-06 2001-03-13 Cephalon, Inc. Particle-forming compositions containing fused pyrrolocarbazoles
HK1040053B (en) 1998-09-25 2007-09-21 Cephalon, Inc. Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons
WO2000021531A1 (en) * 1998-10-13 2000-04-20 Kyowa Hakko Kogyo Co., Ltd. Remedies for ocular diseases
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6841567B1 (en) * 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
US6323215B1 (en) 1999-07-09 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods
CA2379149A1 (en) 1999-07-09 2001-01-18 Ortho-Mcneil Pharmaceutical, Inc. Neurotrophic pyrrolidines and piperidines, and related compositions and methods
AU2576501A (en) * 1999-12-08 2001-06-18 Advanced Medicine, Inc. Protein kinase inhibitors
US20020002169A1 (en) 1999-12-08 2002-01-03 Griffin John H. Protein kinase inhibitors
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
EP1315971A2 (de) * 2000-07-31 2003-06-04 The Regents of The University of California Modell für alzheimer und neurodegenerative krankheiten
DE10113513A1 (de) * 2001-03-20 2002-10-02 Medinnova Ges Med Innovationen Kombinationspräparat zur Prophylaxe und/oder Therapie von Nervenzell- und/oder Gliazellschäden durch ein neues Behandlungsverfahren
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
PL211461B1 (pl) 2001-10-30 2012-05-31 Dana Farber Cancer Inst Inc Zastosowanie pochodnych staurosporyny do wytwarzania kompozycji farmaceutycznej do leczenia lub zapobiegania białaczkom i zespołom mielodysplastycznym, preparat farmaceutyczny do leczenia białaczek i zestaw farmaceutyczny
US6664266B2 (en) * 2002-03-14 2003-12-16 Children's Medical Center Corporation Axon regeneration with PKC inhibitiors
US20050130877A1 (en) * 2003-03-14 2005-06-16 Children's Medical Center Corporation Axon regeneration with PKC inhibitors
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
DE10255343B4 (de) * 2002-11-27 2006-09-07 Nad Ag N,N-Verbrückte, Stickstoff-Substituierte Carbacyclische Indolocarbazole als Proteinkinase-Inhibitoren
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
MXPA06001524A (es) 2003-08-08 2006-05-15 Novartis Ag Combinaciones que comprenden estaurosporinas.
US8592368B2 (en) 2003-12-19 2013-11-26 University Of South Florida JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
BRPI0507995A (pt) 2004-02-27 2007-07-31 Lundbeck & Co As H composto cristalino, forma cristalina do composto, composto sólido, métodos para preparar o composto cristalino, para a fabricação do composto e para a fabricação de uma composição farmacêutica do composto, composição farmacêutica, uso do composto cristalino, e, métodos de tratar uma doença neurodegenerativa e de tratar mal de parkinson
WO2006020145A2 (en) * 2004-07-19 2006-02-23 The Johns Hopkins University Flt3 inhibitors for immune suppression
CN100513850C (zh) * 2005-08-23 2009-07-15 浙江华夏阀门有限公司 三角截面密封套
BRPI0615277A2 (pt) * 2005-08-25 2009-08-04 Creabilis Therapeutics Spa conjugado de polìmeros de k-252a, composição farmacêutica compreendendo o referido conjugado, bem como uso do mesmo
PE20070435A1 (es) 2005-09-16 2007-06-13 Schering Corp Formulacion farmaceutica que comprende temozolomida y un inhibidor de la proteina quinasa
CA2625291A1 (en) 2005-10-11 2007-04-19 Merck Patent Gesellschaft Mit Beschraenkter Haftung Egfr dependent modulation of chemokine expression and influence on therapy and diagnosis of tumors and side effects thereof
EP2147013A4 (de) * 2007-04-16 2012-03-07 Modgene Llc Verfahren und zusammensetzungen zur diagnose und behandlung von depressionen und angst
WO2009067221A2 (en) * 2007-11-20 2009-05-28 Cephalon, Inc. Microemulsion containing indolocarbazole compound and dosage forms containing the same
KR102228358B1 (ko) 2012-12-21 2021-03-16 쉬케후세트 솔란데트 에이치에프 신경 장애 및 통증의 ｅｇｆｒ 표적 치료
WO2019090205A1 (en) * 2017-11-06 2019-05-09 Snap Bio, Inc. Pim kinase inhibitor compositions, methods, and uses thereof
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
WO2024018245A1 (en) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en) 2023-01-20 2024-07-25 Institut National de la Santé et de la Recherche Médicale Autophagy activators for the treatment of rhabdomyolysis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554402A (en) * 1983-12-23 1985-11-19 Aluminum Company Of America Vibration damper for overhead conductor
JPS62102388A (ja) * 1985-10-29 1987-05-12 Toppan Printing Co Ltd Ｉｃカ−ド
JPS62155285A (ja) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
JPS62155284A (ja) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１
US4816450A (en) * 1986-09-15 1989-03-28 Duke University Inhibition of protein kinase C by long-chain bases
JPH0826037B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
US4735939A (en) * 1987-02-27 1988-04-05 The Dow Chemical Company Insecticidal activity of staurosporine
DE3752123T2 (de) * 1987-03-09 1998-05-14 Kyowa Hakko Kogyo Kk Derivate des physiologisch aktiven mittels k-252
IL86632A0 (en) * 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
JPH0725786A (ja) * 1990-05-16 1995-01-27 Univ Rockefeller アルツハイマー病を伴うアミロイドーシスの治療
EP0593663A4 (en) * 1991-07-03 1996-10-30 Regeneron Pharma Method and assay system for neurotrophin activity
DE4133605C2 (de) * 1991-10-10 1994-05-11 Siemens Ag Flexibler Roboterarm
AU3064992A (en) * 1991-11-08 1993-06-07 University Of Southern California Compositions containing k-252 compounds for potentiation of neurotrophin activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
ATE196142T1 (de) 2000-09-15
DE69310178T2 (de) 1997-09-25
EP0651754A1 (de) 1995-05-10
NO990542D0 (no) 1999-02-05
GR3023817T3 (en) 1997-09-30
DE69329397D1 (de) 2000-10-12
KR100276008B1 (ko) 2000-12-15
EP0651754A4 (de) 1995-08-09
EP1002534B1 (de) 2005-09-21
EP0768312A2 (de) 1997-04-16
JP3723533B2 (ja) 2005-12-07
NO950242D0 (no) 1995-01-23
JP3762427B2 (ja) 2006-04-05
ES2101331T3 (es) 1997-07-01
NO307446B1 (no) 2000-04-10
HU9500192D0 (en) 1995-03-28
HU225297B1 (en) 2006-09-28
EP0768312A3 (de) 1997-06-04
EP0651754B1 (de) 1997-04-23
DE69333874T2 (de) 2006-05-04
HU0301425D0 (en) 2003-07-28
NO950242L (no) 1995-03-07
ATE304848T1 (de) 2005-10-15
HU225342B1 (en) 2006-10-28
DK0768312T3 (da) 2000-12-11
BR9306789A (pt) 1998-12-08
NZ286198A (en) 2001-06-29
CA2140924A1 (en) 1994-01-25
WO1994002488A1 (en) 1994-02-03
AU675236B2 (en) 1997-01-30
EP1002534A1 (de) 2000-05-24
KR950702564A (ko) 1995-07-29
JP2003113184A (ja) 2003-04-18
NO990542L (no) 1999-02-05
EP0768312B1 (de) 2000-09-06
HK1028206A1 (en) 2001-02-09
DE69329397T2 (de) 2001-03-15
US5461146A (en) 1995-10-24
HUT71239A (en) 1995-11-28
NZ254662A (en) 1996-11-26
HU0301601D0 (en) 2003-08-28
EP1512688A1 (de) 2005-03-09
DK0651754T3 (da) 1997-10-27
JPH08501080A (ja) 1996-02-06
AU4688193A (en) 1994-02-14
JP2005170955A (ja) 2005-06-30
NO305481B1 (no) 1999-06-07
HU225341B1 (en) 2006-10-28
ES2248950T3 (es) 2006-03-16
DE69310178D1 (de) 1997-05-28
ES2151629T3 (es) 2001-01-01
DE69333874D1 (de) 2006-02-02
DK1002534T3 (da) 2006-01-23
PT768312E (pt) 2001-03-30
GR3034917T3 (en) 2001-02-28

Similar Documents

Publication Publication Date Title
ATE152111T1 (de) K-252a derivate
ES2177665T3 (es) Inhibidores de proteina quinasa para el tratamiento de trastornos neurologicos.
DE69319976D1 (de) 7-Substituierte-9-substituierte Glycylamido-6-Demethyl-6-Deoxytetracycline
IN172468B (de)
FI915920A0 (fi) Serotoninantagonister.
NO932873D0 (no) 9-((substituerte glycyl)amido)-6-dementyl-6-deoksotetrasykliner
EP0363415A4 (en) Compounds for the treatment of alzheimer's disease
KR900009625A (ko) 피리미딘류 및 그의 약리학적으로 허용되는 염류 및 그 용도
ATE123024T1 (de) 4-aminopyridinderivate.
NO944339D0 (no) Melatoninderivater for anvendelse ved behandling av sövnforstyrrelser
NO307364B1 (no) Anvendelse av melatoninderivater
PT889044E (pt) Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central
MX9306395A (es) Intermediarios novedosos para la preparacion de derivados 5,6-dihidropirrolo /2,3-d/-pirimidina y procesamiento para su obtencion.
OA09208A (fr) "Procédé de préparation de dérivés de la thiéno-triazolo-diazépine".

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee