ATE304848T1 - Verwendung von vier k-252a derivaten - Google Patents

Verwendung von vier k-252a derivaten

Info

Publication number
ATE304848T1
ATE304848T1 AT99120008T AT99120008T ATE304848T1 AT E304848 T1 ATE304848 T1 AT E304848T1 AT 99120008 T AT99120008 T AT 99120008T AT 99120008 T AT99120008 T AT 99120008T AT E304848 T1 ATE304848 T1 AT E304848T1
Authority
AT
Austria
Prior art keywords
derivatives
disease
useful
treating parkinson
parkinson
Prior art date
Application number
AT99120008T
Other languages
English (en)
Inventor
Michael E Lewis
Nicola Neff
Jill Roberts-Lewis
Chikara Murakata
Hiromitsu Saito
Yuzuru Matsuda
James C Kauer
Marcie A Glicksman
Original Assignee
Cephalon Inc
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE304848T1 publication Critical patent/ATE304848T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
AT99120008T 1992-07-24 1993-07-26 Verwendung von vier k-252a derivaten ATE304848T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92010292A 1992-07-24 1992-07-24

Publications (1)

Publication Number Publication Date
ATE304848T1 true ATE304848T1 (de) 2005-10-15

Family

ID=25443161

Family Applications (3)

Application Number Title Priority Date Filing Date
AT93917337T ATE152111T1 (de) 1992-07-24 1993-07-26 K-252a derivate
AT96116661T ATE196142T1 (de) 1992-07-24 1993-07-26 Vervendung von k-252a derivaten zur förderung der funktion eines stritialen neurons
AT99120008T ATE304848T1 (de) 1992-07-24 1993-07-26 Verwendung von vier k-252a derivaten

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT93917337T ATE152111T1 (de) 1992-07-24 1993-07-26 K-252a derivate
AT96116661T ATE196142T1 (de) 1992-07-24 1993-07-26 Vervendung von k-252a derivaten zur förderung der funktion eines stritialen neurons

Country Status (18)

Country Link
US (1) US5461146A (de)
EP (4) EP0651754B1 (de)
JP (3) JP3762427B2 (de)
KR (1) KR100276008B1 (de)
AT (3) ATE152111T1 (de)
AU (1) AU675236B2 (de)
BR (1) BR9306789A (de)
CA (1) CA2140924A1 (de)
DE (3) DE69333874T2 (de)
DK (3) DK1002534T3 (de)
ES (3) ES2248950T3 (de)
GR (2) GR3023817T3 (de)
HK (1) HK1028206A1 (de)
HU (5) HU225341B1 (de)
NO (2) NO305481B1 (de)
NZ (2) NZ254662A (de)
PT (1) PT768312E (de)
WO (1) WO1994002488A1 (de)

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Also Published As

Publication number Publication date
ATE152111T1 (de) 1997-05-15
EP0768312A3 (de) 1997-06-04
EP1512688A1 (de) 2005-03-09
JP2005170955A (ja) 2005-06-30
ES2101331T3 (es) 1997-07-01
CA2140924A1 (en) 1994-01-25
EP1002534A1 (de) 2000-05-24
HU225342B1 (en) 2006-10-28
DK0768312T3 (da) 2000-12-11
ES2151629T3 (es) 2001-01-01
NO305481B1 (no) 1999-06-07
GR3034917T3 (en) 2001-02-28
EP0651754A4 (de) 1995-08-09
DE69310178T2 (de) 1997-09-25
HK1028206A1 (en) 2001-02-09
DE69310178D1 (de) 1997-05-28
HU225341B1 (en) 2006-10-28
JP3723533B2 (ja) 2005-12-07
DE69333874T2 (de) 2006-05-04
HUT71239A (en) 1995-11-28
JP3762427B2 (ja) 2006-04-05
NO307446B1 (no) 2000-04-10
EP0768312B1 (de) 2000-09-06
EP0651754B1 (de) 1997-04-23
DE69329397T2 (de) 2001-03-15
NZ254662A (en) 1996-11-26
KR100276008B1 (ko) 2000-12-15
US5461146A (en) 1995-10-24
AU675236B2 (en) 1997-01-30
GR3023817T3 (en) 1997-09-30
NZ286198A (en) 2001-06-29
BR9306789A (pt) 1998-12-08
EP0768312A2 (de) 1997-04-16
DE69329397D1 (de) 2000-10-12
WO1994002488A1 (en) 1994-02-03
ATE196142T1 (de) 2000-09-15
JP2003113184A (ja) 2003-04-18
EP1002534B1 (de) 2005-09-21
EP0651754A1 (de) 1995-05-10
DK0651754T3 (da) 1997-10-27
NO990542D0 (no) 1999-02-05
NO950242L (no) 1995-03-07
JPH08501080A (ja) 1996-02-06
HU0301425D0 (en) 2003-07-28
NO990542L (no) 1999-02-05
KR950702564A (ko) 1995-07-29
DE69333874D1 (de) 2006-02-02
ES2248950T3 (es) 2006-03-16
NO950242D0 (no) 1995-01-23
AU4688193A (en) 1994-02-14
PT768312E (pt) 2001-03-30
DK1002534T3 (da) 2006-01-23
HU0301601D0 (en) 2003-08-28
HU9500192D0 (en) 1995-03-28
HU225297B1 (en) 2006-09-28

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