DE69310178D1 - K-252a DERIVATE - Google Patents

K-252a DERIVATE

Info

Publication number
DE69310178D1
DE69310178D1 DE69310178T DE69310178T DE69310178D1 DE 69310178 D1 DE69310178 D1 DE 69310178D1 DE 69310178 T DE69310178 T DE 69310178T DE 69310178 T DE69310178 T DE 69310178T DE 69310178 D1 DE69310178 D1 DE 69310178D1
Authority
DE
Germany
Prior art keywords
derivatives
disease
useful
treating parkinson
parkinson
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69310178T
Other languages
English (en)
Other versions
DE69310178T2 (de
Inventor
Michael Lewis
Nicola Neff
Jill Roberts-Lewis
Chikara Murakata
Hiromitsu Saito
Yuzuru Matsuda
James Kauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Cephalon LLC
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Cephalon LLC filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of DE69310178D1 publication Critical patent/DE69310178D1/de
Application granted granted Critical
Publication of DE69310178T2 publication Critical patent/DE69310178T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
DE69310178T 1992-07-24 1993-07-26 K-252a DERIVATE Expired - Lifetime DE69310178T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92010292A 1992-07-24 1992-07-24
PCT/US1993/006974 WO1994002488A1 (en) 1992-07-24 1993-07-26 BIS-STAUROSPORINE AND K-252a DERIVATIVES

Publications (2)

Publication Number Publication Date
DE69310178D1 true DE69310178D1 (de) 1997-05-28
DE69310178T2 DE69310178T2 (de) 1997-09-25

Family

ID=25443161

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69310178T Expired - Lifetime DE69310178T2 (de) 1992-07-24 1993-07-26 K-252a DERIVATE
DE69333874T Expired - Lifetime DE69333874T2 (de) 1992-07-24 1993-07-26 Verwendung von vier K-252a Derivaten
DE69329397T Expired - Lifetime DE69329397T2 (de) 1992-07-24 1993-07-26 Vervendung von K-252a Derivaten zur Förderung der Funktion eines stritialen Neurons

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69333874T Expired - Lifetime DE69333874T2 (de) 1992-07-24 1993-07-26 Verwendung von vier K-252a Derivaten
DE69329397T Expired - Lifetime DE69329397T2 (de) 1992-07-24 1993-07-26 Vervendung von K-252a Derivaten zur Förderung der Funktion eines stritialen Neurons

Country Status (18)

Country Link
US (1) US5461146A (de)
EP (4) EP0768312B1 (de)
JP (3) JP3762427B2 (de)
KR (1) KR100276008B1 (de)
AT (3) ATE152111T1 (de)
AU (1) AU675236B2 (de)
BR (1) BR9306789A (de)
CA (1) CA2140924A1 (de)
DE (3) DE69310178T2 (de)
DK (3) DK0651754T3 (de)
ES (3) ES2151629T3 (de)
GR (2) GR3023817T3 (de)
HK (1) HK1028206A1 (de)
HU (5) HU0301425D0 (de)
NO (2) NO305481B1 (de)
NZ (2) NZ286198A (de)
PT (1) PT768312E (de)
WO (1) WO1994002488A1 (de)

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JPH07505124A (ja) * 1991-11-08 1995-06-08 ザ ユニバーシティ オブ サザン カリフォルニア ニューロトロフィン活性増強のためのｋ−２５２化合物を含む組成物
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

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NO950242L (no) 1995-03-07
EP0768312A2 (de) 1997-04-16
HU9500192D0 (en) 1995-03-28
JP2003113184A (ja) 2003-04-18
DE69329397D1 (de) 2000-10-12
NZ254662A (en) 1996-11-26
HU0301425D0 (en) 2003-07-28
US5461146A (en) 1995-10-24
JP3723533B2 (ja) 2005-12-07
HU225341B1 (en) 2006-10-28
HU225297B1 (en) 2006-09-28
KR100276008B1 (ko) 2000-12-15
ATE196142T1 (de) 2000-09-15
NO305481B1 (no) 1999-06-07
DK0768312T3 (da) 2000-12-11
HUT71239A (en) 1995-11-28
JPH08501080A (ja) 1996-02-06
AU4688193A (en) 1994-02-14
EP1002534B1 (de) 2005-09-21
GR3034917T3 (en) 2001-02-28
ATE152111T1 (de) 1997-05-15
ES2101331T3 (es) 1997-07-01
EP1002534A1 (de) 2000-05-24
ES2248950T3 (es) 2006-03-16
NO990542L (no) 1999-02-05
PT768312E (pt) 2001-03-30
KR950702564A (ko) 1995-07-29
DE69333874D1 (de) 2006-02-02
GR3023817T3 (en) 1997-09-30
DE69329397T2 (de) 2001-03-15
WO1994002488A1 (en) 1994-02-03
EP0768312A3 (de) 1997-06-04
HK1028206A1 (en) 2001-02-09
EP0768312B1 (de) 2000-09-06
NO950242D0 (no) 1995-01-23
EP0651754A1 (de) 1995-05-10
DK1002534T3 (da) 2006-01-23
EP0651754B1 (de) 1997-04-23
EP1512688A1 (de) 2005-03-09
NO307446B1 (no) 2000-04-10
ATE304848T1 (de) 2005-10-15
DE69310178T2 (de) 1997-09-25
CA2140924A1 (en) 1994-01-25
JP2005170955A (ja) 2005-06-30
BR9306789A (pt) 1998-12-08
DK0651754T3 (da) 1997-10-27
HU225342B1 (en) 2006-10-28
JP3762427B2 (ja) 2006-04-05
EP0651754A4 (de) 1995-08-09
NZ286198A (en) 2001-06-29
AU675236B2 (en) 1997-01-30
NO990542D0 (no) 1999-02-05
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DE69333874T2 (de) 2006-05-04
HU0301601D0 (en) 2003-08-28

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