ATE221067T1 - Pyrido(2,3-b)(1,4)benzodiazepinone als m2- rezeptorligand zur behandlung neurologischer störungen - Google Patents
Pyrido(2,3-b)(1,4)benzodiazepinone als m2- rezeptorligand zur behandlung neurologischer störungenInfo
- Publication number
- ATE221067T1 ATE221067T1 AT94914039T AT94914039T ATE221067T1 AT E221067 T1 ATE221067 T1 AT E221067T1 AT 94914039 T AT94914039 T AT 94914039T AT 94914039 T AT94914039 T AT 94914039T AT E221067 T1 ATE221067 T1 AT E221067T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- neurological disorders
- benzodiazepinone
- pyrido
- receptor ligand
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- LDZJARBEIDPEEY-UHFFFAOYSA-N pyrido[2,3-b][1,4]benzodiazepin-2-one Chemical compound C1=C2C=CC=CC2=NC2=NC(=O)C=CC2=N1 LDZJARBEIDPEEY-UHFFFAOYSA-N 0.000 title 1
- 102000007205 Muscarinic M2 Receptor Human genes 0.000 abstract 1
- 108010008407 Muscarinic M2 Receptor Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4287293A | 1993-04-05 | 1993-04-05 | |
| PCT/US1994/003720 WO1994022861A1 (en) | 1993-04-05 | 1994-04-05 | PYRIDO[2,3-b][1,4]BENZODIAZEPINONES AS M2 RECEPTOR LIGAND FOR THE TREATMENT OF NEUROLOGICAL DISORDERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE221067T1 true ATE221067T1 (de) | 2002-08-15 |
Family
ID=21924192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94914039T ATE221067T1 (de) | 1993-04-05 | 1994-04-05 | Pyrido(2,3-b)(1,4)benzodiazepinone als m2- rezeptorligand zur behandlung neurologischer störungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5712269A (de) |
| EP (2) | EP1120416A1 (de) |
| JP (1) | JP3638950B2 (de) |
| AT (1) | ATE221067T1 (de) |
| AU (1) | AU688318B2 (de) |
| CA (1) | CA2159815A1 (de) |
| DE (1) | DE69431050T2 (de) |
| DK (1) | DK0693070T3 (de) |
| ES (1) | ES2180575T3 (de) |
| PT (1) | PT693070E (de) |
| WO (1) | WO1994022861A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| ITMI991452A1 (it) * | 1999-07-01 | 2001-01-01 | Mediolanum Farmaceutici Srl | Antagonisti selettivi per i recettori m2 con struttura 5h-dibenzo b,fazepinica |
| AR025884A1 (es) | 1999-10-01 | 2002-12-18 | Takeda Pharmaceutical | Compuestos de amina ciclica, su produccion y su uso |
| EP1498138A1 (de) * | 2002-04-19 | 2005-01-19 | Takeda Pharmaceutical Company Limited | Mittel zur prävention von hiv-infektion |
| KR20070033032A (ko) | 2004-07-16 | 2007-03-23 | 프로테오시스 악티엔게젤샤프트 | 세포보호제로서 ｐａｒｐ 및 ｓｉｒ 조절 활성을 갖는무스카린 길항제 |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| RU2630577C2 (ru) | 2008-12-04 | 2017-09-11 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
| US20110294791A1 (en) | 2009-01-13 | 2011-12-01 | Proteosys Ag | Pirenzepine as an agent in cancer treatment |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH438343A (de) * | 1962-11-08 | 1967-06-30 | Thomae Gmbh Dr K | Verfahren zur Herstellung von 5,6-Dihydro-6-oxo-11H-pyrido (2,3-b) (1,4)-benzodiazepinen |
| DE3735895A1 (de) * | 1987-10-23 | 1989-05-03 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3818299A1 (de) * | 1988-05-30 | 1989-12-07 | Thomae Gmbh Dr K | Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB9000302D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Muscarinic receptor antagonists |
| DE4112014A1 (de) * | 1991-04-12 | 1992-10-15 | Thomae Gmbh Dr K | Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung |
-
1994
- 1994-04-05 ES ES94914039T patent/ES2180575T3/es not_active Expired - Lifetime
- 1994-04-05 AT AT94914039T patent/ATE221067T1/de not_active IP Right Cessation
- 1994-04-05 DK DK94914039T patent/DK0693070T3/da active
- 1994-04-05 CA CA002159815A patent/CA2159815A1/en not_active Abandoned
- 1994-04-05 WO PCT/US1994/003720 patent/WO1994022861A1/en not_active Ceased
- 1994-04-05 EP EP01200454A patent/EP1120416A1/de not_active Withdrawn
- 1994-04-05 EP EP94914039A patent/EP0693070B1/de not_active Expired - Lifetime
- 1994-04-05 AU AU66261/94A patent/AU688318B2/en not_active Ceased
- 1994-04-05 PT PT94914039T patent/PT693070E/pt unknown
- 1994-04-05 DE DE69431050T patent/DE69431050T2/de not_active Expired - Fee Related
- 1994-04-05 JP JP52246994A patent/JP3638950B2/ja not_active Expired - Fee Related
-
1995
- 1995-01-24 US US08/377,667 patent/US5712269A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69431050T2 (de) | 2003-03-13 |
| ES2180575T3 (es) | 2003-02-16 |
| EP0693070B1 (de) | 2002-07-24 |
| EP1120416A1 (de) | 2001-08-01 |
| WO1994022861A1 (en) | 1994-10-13 |
| EP0693070A1 (de) | 1996-01-24 |
| PT693070E (pt) | 2002-12-31 |
| AU688318B2 (en) | 1998-03-12 |
| DK0693070T3 (da) | 2002-11-11 |
| JPH08510999A (ja) | 1996-11-19 |
| AU6626194A (en) | 1994-10-24 |
| JP3638950B2 (ja) | 2005-04-13 |
| CA2159815A1 (en) | 1994-10-13 |
| US5712269A (en) | 1998-01-27 |
| DE69431050D1 (de) | 2002-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0693070 Country of ref document: EP |
|
| EEFA | Change of the company name | ||
| REN | Ceased due to non-payment of the annual fee |