HRP940464A2 - The primary and secondary neuroprotective effect of flupirtine in neurodegenerative diseases - Google Patents

The primary and secondary neuroprotective effect of flupirtine in neurodegenerative diseases Download PDF

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Publication number
HRP940464A2
HRP940464A2 HRP4327516.8A HRP940464A HRP940464A2 HR P940464 A2 HRP940464 A2 HR P940464A2 HR P940464 A HRP940464 A HR P940464A HR P940464 A2 HRP940464 A2 HR P940464A2
Authority
HR
Croatia
Prior art keywords
flupirtine
fact
production
active substance
treats
Prior art date
Application number
HRP4327516.8A
Other languages
English (en)
Croatian (hr)
Inventor
Michael Schwarz
Gabriela Pergande
Jurgen Engel
Bernd Nickel
Heinz Ulrich
Stefan Szelenyi
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HRP940464A2 publication Critical patent/HRP940464A2/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
HRP4327516.8A 1993-08-17 1994-08-16 The primary and secondary neuroprotective effect of flupirtine in neurodegenerative diseases HRP940464A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4327516A DE4327516A1 (de) 1993-08-17 1993-08-17 Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin

Publications (1)

Publication Number Publication Date
HRP940464A2 true HRP940464A2 (en) 1997-06-30

Family

ID=6495312

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP4327516.8A HRP940464A2 (en) 1993-08-17 1994-08-16 The primary and secondary neuroprotective effect of flupirtine in neurodegenerative diseases

Country Status (27)

Country Link
US (1) US5721258A (de)
EP (1) EP0716602B1 (de)
JP (1) JPH09501664A (de)
KR (1) KR100341952B1 (de)
CN (1) CN1086291C (de)
AT (1) ATE210442T1 (de)
AU (1) AU694447B2 (de)
BG (1) BG62430B1 (de)
BR (1) BR9407293A (de)
CA (1) CA2169718C (de)
CZ (1) CZ289040B6 (de)
DE (2) DE4327516A1 (de)
DK (1) DK0716602T3 (de)
EE (1) EE03204B1 (de)
ES (1) ES2168309T3 (de)
HR (1) HRP940464A2 (de)
HU (1) HU227765B1 (de)
IL (1) IL110681A (de)
NO (1) NO309842B1 (de)
NZ (1) NZ273292A (de)
PT (1) PT716602E (de)
RU (1) RU2166318C2 (de)
SK (1) SK283330B6 (de)
UA (1) UA43351C2 (de)
WO (1) WO1995005175A1 (de)
YU (1) YU49215B (de)
ZA (1) ZA946176B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539861A1 (de) * 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
DE19541405A1 (de) * 1995-11-07 1997-05-15 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen, die mit einer Beeinträchtigung des hämatopoetischen Zellsystems einhergehen
DE19625582A1 (de) * 1996-06-27 1998-01-02 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen
ATE284684T1 (de) 1997-10-27 2005-01-15 Sumitomo Pharma Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
WO2001034172A2 (en) * 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
WO2001039760A2 (en) * 1999-12-01 2001-06-07 Duke University Method of treating batten disease
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
DE10327674A1 (de) 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
DE10328260A1 (de) * 2003-06-23 2005-01-27 Schmidt, K.-G., Dr. med. Flupirtine-Präparat
CA2550023C (en) * 2003-12-16 2011-04-12 Cnsbio Pty Ltd Treatment of neuropathic pain
WO2006065204A1 (en) * 2004-12-14 2006-06-22 Astrazeneca Ab Substituted aminopyridines and uses thereof
EP1688141A1 (de) 2005-01-31 2006-08-09 elbion AG Verwendung von Flupirtine zur Behandlung der hyperaktiven Blase und damit zusammenhängender Erkrankungen und zur Behandlung des Reizdarmsyndroms
US20060258708A1 (en) * 2005-05-16 2006-11-16 Andrulis Peter J Jr Method for treating Parkinson's disease and other neurological diseases
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
DE102011006425A1 (de) 2010-03-31 2011-10-06 Awd.Pharma Gmbh & Co. Kg Pharmazeutische Zubereitung und deren Verwendung
DE102010030053A1 (de) 2010-06-14 2011-12-15 Awd.Pharma Gmbh & Co.Kg Injizierbare Darreichungsform von Flupirtin
MX2016001177A (es) * 2013-07-31 2016-04-29 Teva Pharma Tratamiento de esclerosis multiple con la combinacion de laquinimod y flupirtina.
WO2019014547A1 (en) * 2017-07-14 2019-01-17 Texas Tech University System FUNCTIONALIZED PYRIDINE CARBAMATES HAVING ENHANCED NEUROPROTECTOR ACTIVITY
DE102017007385A1 (de) 2017-08-02 2019-02-07 Christoph Hoock Maleatfreie feste Arzneimittelformen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4481205A (en) * 1980-09-13 1984-11-06 Degussa Aktiengesellschaft 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate
ATE25078T1 (de) * 1982-10-27 1987-02-15 Degussa 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung.
DE3337593A1 (de) * 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
IN172468B (de) * 1990-07-14 1993-08-14 Asta Medica Ag

Also Published As

Publication number Publication date
ZA946176B (en) 1995-03-20
ATE210442T1 (de) 2001-12-15
CN1086291C (zh) 2002-06-19
NO309842B1 (no) 2001-04-09
EP0716602A1 (de) 1996-06-19
SK21496A3 (en) 1997-01-08
ES2168309T3 (es) 2002-06-16
CZ46596A3 (en) 1996-05-15
JPH09501664A (ja) 1997-02-18
NO960607L (no) 1996-02-15
HU9600355D0 (en) 1996-04-29
KR960703591A (ko) 1996-08-31
EP0716602B1 (de) 2001-12-12
DE69429435D1 (de) 2002-01-24
YU51294A (sh) 1998-05-15
HU227765B1 (en) 2012-02-28
DE4327516A1 (de) 1995-02-23
HUT75650A (en) 1997-05-28
NO960607D0 (no) 1996-02-15
BR9407293A (pt) 1996-10-01
CN1129399A (zh) 1996-08-21
PT716602E (pt) 2002-05-31
US5721258A (en) 1998-02-24
YU49215B (sh) 2004-11-25
CZ289040B6 (cs) 2001-10-17
CA2169718C (en) 2002-11-12
IL110681A (en) 1999-08-17
BG100356A (bg) 1996-07-31
RU2166318C2 (ru) 2001-05-10
SK283330B6 (sk) 2003-06-03
IL110681A0 (en) 1994-11-11
AU7652894A (en) 1995-03-14
AU694447B2 (en) 1998-07-23
BG62430B1 (bg) 1999-11-30
CA2169718A1 (en) 1995-02-23
EE03204B1 (et) 1999-08-16
KR100341952B1 (ko) 2003-04-11
DK0716602T3 (da) 2002-03-25
NZ273292A (en) 1999-09-29
UA43351C2 (uk) 2001-12-17
WO1995005175A1 (en) 1995-02-23
DE69429435T2 (de) 2002-06-13

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20020816

Year of fee payment: 9

PNAN Change of the applicant name, address/residence

Owner name: VIATRIS GMBH & CO.KG, DE

PPPP Transfer of rights

Owner name: ASTA MEDICA HEALTH PRODUCTS GMBH & CO. KG, DE

ODBI Application refused