IL110681A - Pharmaceutical compositions containing flupirtine for the treatment of neurodegenerative diseases - Google Patents
Pharmaceutical compositions containing flupirtine for the treatment of neurodegenerative diseasesInfo
- Publication number
- IL110681A IL110681A IL11068194A IL11068194A IL110681A IL 110681 A IL110681 A IL 110681A IL 11068194 A IL11068194 A IL 11068194A IL 11068194 A IL11068194 A IL 11068194A IL 110681 A IL110681 A IL 110681A
- Authority
- IL
- Israel
- Prior art keywords
- pct
- treatment
- pharmaceutical compositions
- compositions containing
- neurodegenerative diseases
- Prior art date
Links
- JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003667 flupirtine Drugs 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 230000004770 neurodegeneration Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 231100001018 bone marrow damage Toxicity 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 231100000874 brain damage Toxicity 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13438500A IL134385A0 (en) | 1991-01-17 | 2000-02-04 | Polynucleotide molecules containing a sequence encoding a trans-splicing proribozyme and methods for cell ablation utilizing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4327516A DE4327516A1 (de) | 1993-08-17 | 1993-08-17 | Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL110681A0 IL110681A0 (en) | 1994-11-11 |
| IL110681A true IL110681A (en) | 1999-08-17 |
Family
ID=6495312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11068194A IL110681A (en) | 1991-01-17 | 1994-08-16 | Pharmaceutical compositions containing flupirtine for the treatment of neurodegenerative diseases |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5721258A (de) |
| EP (1) | EP0716602B1 (de) |
| JP (1) | JPH09501664A (de) |
| KR (1) | KR100341952B1 (de) |
| CN (1) | CN1086291C (de) |
| AT (1) | ATE210442T1 (de) |
| AU (1) | AU694447B2 (de) |
| BG (1) | BG62430B1 (de) |
| BR (1) | BR9407293A (de) |
| CA (1) | CA2169718C (de) |
| CZ (1) | CZ289040B6 (de) |
| DE (2) | DE4327516A1 (de) |
| DK (1) | DK0716602T3 (de) |
| EE (1) | EE03204B1 (de) |
| ES (1) | ES2168309T3 (de) |
| HR (1) | HRP940464A2 (de) |
| HU (1) | HU227765B1 (de) |
| IL (1) | IL110681A (de) |
| NO (1) | NO309842B1 (de) |
| NZ (1) | NZ273292A (de) |
| PT (1) | PT716602E (de) |
| RU (1) | RU2166318C2 (de) |
| SK (1) | SK283330B6 (de) |
| UA (1) | UA43351C2 (de) |
| WO (1) | WO1995005175A1 (de) |
| YU (1) | YU49215B (de) |
| ZA (1) | ZA946176B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19539861A1 (de) * | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
| DE19541405A1 (de) * | 1995-11-07 | 1997-05-15 | Asta Medica Ag | Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen, die mit einer Beeinträchtigung des hämatopoetischen Zellsystems einhergehen |
| DE19625582A1 (de) * | 1996-06-27 | 1998-01-02 | Asta Medica Ag | Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen |
| CN1278167A (zh) | 1997-10-27 | 2000-12-27 | 住友制药株式会社 | 酰胺衍生物 |
| WO2001034172A2 (en) * | 1999-11-05 | 2001-05-17 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
| US6821995B1 (en) | 1999-12-01 | 2004-11-23 | Duke University | Method of treating batten disease |
| WO2001039760A2 (en) * | 1999-12-01 | 2001-06-07 | Duke University | Method of treating batten disease |
| DE10327674A1 (de) * | 2003-06-20 | 2005-01-05 | Awd.Pharma Gmbh & Co. Kg | Injizierbare Darreichungsform von Flupirtin |
| DE10328260A1 (de) * | 2003-06-23 | 2005-01-27 | Schmidt, K.-G., Dr. med. | Flupirtine-Präparat |
| JP4800219B2 (ja) * | 2003-12-16 | 2011-10-26 | レレバーレ エーユーエスティー． ピーティーワイ リミテッド | 方法および組成物 |
| JP2008523139A (ja) * | 2004-12-14 | 2008-07-03 | アストラゼネカ・アクチエボラーグ | 置換アミノピリジン類及びその使用 |
| EP1688141A1 (de) | 2005-01-31 | 2006-08-09 | elbion AG | Verwendung von Flupirtine zur Behandlung der hyperaktiven Blase und damit zusammenhängender Erkrankungen und zur Behandlung des Reizdarmsyndroms |
| US20060258708A1 (en) * | 2005-05-16 | 2006-11-16 | Andrulis Peter J Jr | Method for treating Parkinson's disease and other neurological diseases |
| US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
| DE102011006425A1 (de) | 2010-03-31 | 2011-10-06 | Awd.Pharma Gmbh & Co. Kg | Pharmazeutische Zubereitung und deren Verwendung |
| DE102010030053A1 (de) | 2010-06-14 | 2011-12-15 | Awd.Pharma Gmbh & Co.Kg | Injizierbare Darreichungsform von Flupirtin |
| US20150037318A1 (en) * | 2013-07-31 | 2015-02-05 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and flupirtine |
| US11369593B2 (en) * | 2017-07-14 | 2022-06-28 | Texas Tech University System | Functionalized pyridine carbamates with enhanced neuroprotective activity |
| DE102017007385A1 (de) | 2017-08-02 | 2019-02-07 | Christoph Hoock | Maleatfreie feste Arzneimittelformen |
| CN120346203B (zh) * | 2025-06-23 | 2026-01-09 | 西安交通大学 | GluK1受体激动剂在制备治疗慢性疼痛的药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481205A (en) * | 1980-09-13 | 1984-11-06 | Degussa Aktiengesellschaft | 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate |
| ATE25078T1 (de) * | 1982-10-27 | 1987-02-15 | Degussa | 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung. |
| DE3337593A1 (de) * | 1982-10-27 | 1984-05-03 | Degussa Ag, 6000 Frankfurt | 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung |
| NO860825L (no) * | 1985-03-23 | 1986-09-24 | Degussa | Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin. |
| DE69133065T2 (de) * | 1990-03-02 | 2003-02-27 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon Health Sciences University, Portland | Tri- und tetra-substituierte guanidine und deren verwendung als antagonisten von exzitatorischen aminosäuren |
| IN172468B (de) * | 1990-07-14 | 1993-08-14 | Asta Medica Ag | |
| IL111240A (en) * | 1993-10-18 | 2001-10-31 | Teva Pharma | Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them |
-
1993
- 1993-08-17 DE DE4327516A patent/DE4327516A1/de not_active Ceased
-
1994
- 1994-08-10 AT AT94926828T patent/ATE210442T1/de active
- 1994-08-10 NZ NZ273292A patent/NZ273292A/en not_active IP Right Cessation
- 1994-08-10 DE DE69429435T patent/DE69429435T2/de not_active Expired - Lifetime
- 1994-08-10 EP EP94926828A patent/EP0716602B1/de not_active Expired - Lifetime
- 1994-08-10 AU AU76528/94A patent/AU694447B2/en not_active Expired
- 1994-08-10 CZ CZ1996465A patent/CZ289040B6/cs not_active IP Right Cessation
- 1994-08-10 SK SK214-96A patent/SK283330B6/sk not_active IP Right Cessation
- 1994-08-10 US US08/602,742 patent/US5721258A/en not_active Expired - Lifetime
- 1994-08-10 JP JP7506731A patent/JPH09501664A/ja active Pending
- 1994-08-10 CN CN94193106A patent/CN1086291C/zh not_active Expired - Lifetime
- 1994-08-10 CA CA002169718A patent/CA2169718C/en not_active Expired - Lifetime
- 1994-08-10 PT PT94926828T patent/PT716602E/pt unknown
- 1994-08-10 WO PCT/EP1994/002649 patent/WO1995005175A1/en not_active Ceased
- 1994-08-10 BR BR9407293A patent/BR9407293A/pt not_active Application Discontinuation
- 1994-08-10 RU RU96105707/14A patent/RU2166318C2/ru active
- 1994-08-10 DK DK94926828T patent/DK0716602T3/da active
- 1994-08-10 KR KR1019960700753A patent/KR100341952B1/ko not_active Expired - Lifetime
- 1994-08-10 ES ES94926828T patent/ES2168309T3/es not_active Expired - Lifetime
- 1994-08-10 HU HU9600355A patent/HU227765B1/hu unknown
- 1994-08-15 YU YU51294A patent/YU49215B/sh unknown
- 1994-08-16 HR HRP4327516.8A patent/HRP940464A2/hr not_active Application Discontinuation
- 1994-08-16 IL IL11068194A patent/IL110681A/xx not_active IP Right Cessation
- 1994-08-16 ZA ZA946176A patent/ZA946176B/xx unknown
- 1994-10-08 UA UA96030972A patent/UA43351C2/uk unknown
- 1994-10-25 EE EE9400160A patent/EE03204B1/xx unknown
-
1996
- 1996-02-14 BG BG100356A patent/BG62430B1/bg unknown
- 1996-02-15 NO NO960607A patent/NO309842B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |