HRP20220377T1 - Biljni ekstrakti obogaćeni derivatima ipolamida kao imunosupresivi za liječenje imunoloških poremećaja - Google Patents
Biljni ekstrakti obogaćeni derivatima ipolamida kao imunosupresivi za liječenje imunoloških poremećaja Download PDFInfo
- Publication number
- HRP20220377T1 HRP20220377T1 HRP20220377TT HRP20220377T HRP20220377T1 HR P20220377 T1 HRP20220377 T1 HR P20220377T1 HR P20220377T T HRP20220377T T HR P20220377TT HR P20220377 T HRP20220377 T HR P20220377T HR P20220377 T1 HRP20220377 T1 HR P20220377T1
- Authority
- HR
- Croatia
- Prior art keywords
- ipolamide
- formula
- extract
- plant biomass
- derivatives
- Prior art date
Links
- 208000026278 immune system disease Diseases 0.000 title claims 3
- 229960003444 immunosuppressant agent Drugs 0.000 title claims 3
- 239000003018 immunosuppressive agent Substances 0.000 title claims 3
- RWMXKBUPLSNIJL-BHBNKKJBSA-N Ipolamiide Chemical class O([C@@H]1OC=C([C@]2(CC[C@](C)(O)[C@H]21)O)C(=O)OC)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RWMXKBUPLSNIJL-BHBNKKJBSA-N 0.000 title 1
- 239000000419 plant extract Substances 0.000 title 1
- 241000196324 Embryophyta Species 0.000 claims 17
- 239000000284 extract Substances 0.000 claims 14
- 239000002028 Biomass Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 241001530100 Stachytarpheta Species 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 238000010438 heat treatment Methods 0.000 claims 4
- 238000000605 extraction Methods 0.000 claims 2
- -1 COOCH3 Chemical group 0.000 claims 1
- 240000003186 Stachytarpheta cayennensis Species 0.000 claims 1
- 235000009233 Stachytarpheta cayennensis Nutrition 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 238000002803 maceration Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/92—Unsaturated compounds containing keto groups containing —CHO groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (18)
1. Spojevi opće formule C, koji su derivati ipolamiida
[image]
pri čemu R odgovara H, OH, OGlyc (glikozid); R1, R1’, R1" odgovaraju H, OH; R2 odgovara H, COOH, COOCH3, CH3, CHO; R3 odgovara H, OH, CH3; R4, R4' odgovaraju H, OH, CH2OH, CH3.
2. Spojevi formule C prema zahtjevu 1, odabrani između:
[image]
3. Spojevi formule C kako su definirani u zahtjevima 1 ili 2, za uporabu kao lijek.
4. Spojevi formule C prema zahtjevima 1 ili 2, za uporabu kao imunosupresivi u liječenju imunoloških poremećaja.
5. Spojevi formule C kako su definirani u zahtjevima 1 ili 2, za uporabu u liječenju vitiliga.
6. Farmaceutski pripravak sadrži derivate ipolamiida formule C kako je definirano u zahtjevima 1 ili 2, i farmaceutski prihvatljiv vehikul, koji izborno dodatno sadrži ipolamiid.
7. Postupak za proizvodnju ekstrakta obogaćenog derivatima ipolamiida formule C kako je definirano u zahtjevima 1 ili 2, koji sadrži korake:
a) odabir ulazne biljne biomase s udjelom ipolamiida između 2.5% i 3.5% dobivene iz biljaka roda Stachytarpheta;
b) podnošenje odabrane biomase iz a) sušenju u pećnici na temperaturi između 40 do 80°C, do postizanja stabilizacije vlažnosti između 10 do 12%;
c) mljevenje biljne biomase;
d) izvođenje ekstrakcije biljne biomase kroz korake:
i. zagrijavanje biljne biomase na temperaturi od 70 do 100°C, uz stalno miješanje;
ii. maceracija biljne biomase na sobnoj temperaturi;
iii. zagrijavanje biljne biomase s temperaturom od 70 do 100°C.
8. Postupak za proizvodnju ekstrakta prema zahtjevu 7, dalje sadrži korake:
iv. filtriranje i koncentriranje ekstrakta;
v. sušenje u raspršivaču, tijekom 1 do 60 sekundi, s ulaznom temperaturom između 155 i 165°C i izlaznom temperaturom između 85 do 95°C, spojeno na odvlaživač zraka.
9. Postupak za proizvodnju ekstrakta, prema zahtjevu 7, u kojem se zagrijavanje biljne biomase d) točke iii) odvija 5 do 30 minuta.
10. Postupak za proizvodnju ekstrakta, prema zahtjevu 7, u kojem se zagrijavanje biljne biomase d) točke i) odvija 5 do 15 sati.
11. Postupak za proizvodnju ekstrakta prema zahtjevu 7, u kojem ulazna biljna biomasa obuhvaća nadzemne dijelove biljaka roda Stachytarpheta.
12. Postupak za proizvodnju ekstrakta prema zahtjevu 7, u kojem je biljka Stachytarpheta cayennensis.
13. Postupak za proizvodnju ekstrakta prema zahtjevu 7, u kojem postupak uključuje vodenu ekstrakciju.
14. Postupak za proizvodnju ekstrakta, prema bilo kojem od zahtjeva 7 do 13, koji sadrži korak predviđanja teoretskog sadržaja ipolamiida i njegovih derivata formule C u ekstraktu iz stvarnog sadržaja ipolamiida u ulaznoj biljnoj biomasi pomoću jednadžbe I:
[image]
15. Ekstrakti iz biljaka roda Stachytarpheta obogaćeni derivatima ipolamiida formule C kako je definirano u zahtjevima 1 ili 2.
16. Ekstrakti biljaka iz roda Stachytarpheta obogaćeni derivatima ipolamiida formule C, dobiveni postupkom kako je definirano u bilo kojem od zahtjeva 7 do 14.
17. Ekstrakti biljaka iz roda Stachytarpheta prema zahtjevu 15 ili 16, koji sadrže od 1% do 20% ipolamiida ili derivata ipolamiida formule C.
18. Ekstrakti iz biljaka roda Stachytarpheta prema bilo kojem od zahtjeva 15 do 17, za uporabu kao imunosupresivi u liječenju imunoloških poremećaja.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR102017003318A BR102017003318A2 (pt) | 2017-02-17 | 2017-02-17 | compostos, processo de produção de compostos, extrato enriquecido, frações ativas de extrato enriquecido, processo de produção de extrato enriquecido, método de seleção de biomassa vegetal para produção de extrato enriquecido, composição e uso para tratamento de desordens imunológicas |
| PCT/BR2018/050037 WO2018148816A2 (en) | 2017-02-17 | 2018-02-19 | Compounds, process of production of compounds, enriched extract, enriched extract active fractions, enriched extract process of production, method for selecting vegetal biomass for enriched extract production, composition and use for treatment of immunological disorders |
| EP18707229.3A EP3583103B1 (en) | 2017-02-17 | 2018-02-19 | Plant extracts enriched with ipolamiide derivatives as immunosuppressants for treating immunological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220377T1 true HRP20220377T1 (hr) | 2022-07-08 |
Family
ID=61282932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220377TT HRP20220377T1 (hr) | 2017-02-17 | 2018-02-19 | Biljni ekstrakti obogaćeni derivatima ipolamida kao imunosupresivi za liječenje imunoloških poremećaja |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20200231561A1 (hr) |
| EP (2) | EP4001270A1 (hr) |
| JP (2) | JP7349362B2 (hr) |
| KR (1) | KR20190121790A (hr) |
| CN (1) | CN110475768B (hr) |
| AU (1) | AU2018221956B2 (hr) |
| BR (2) | BR102017003318A2 (hr) |
| CA (1) | CA3052713A1 (hr) |
| CL (1) | CL2019002309A1 (hr) |
| CO (1) | CO2019008891A2 (hr) |
| CY (1) | CY1125187T1 (hr) |
| DK (1) | DK3583103T3 (hr) |
| EC (1) | ECSP19058322A (hr) |
| ES (1) | ES2909387T3 (hr) |
| HR (1) | HRP20220377T1 (hr) |
| IL (1) | IL268732A (hr) |
| LT (1) | LT3583103T (hr) |
| MX (2) | MX2019009655A (hr) |
| PE (1) | PE20200449A1 (hr) |
| PL (1) | PL3583103T3 (hr) |
| PT (1) | PT3583103T (hr) |
| RS (1) | RS63162B1 (hr) |
| SA (1) | SA519402443B1 (hr) |
| SG (1) | SG11201907375VA (hr) |
| SI (1) | SI3583103T1 (hr) |
| WO (1) | WO2018148816A2 (hr) |
| ZA (1) | ZA201906106B (hr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115304652A (zh) * | 2022-07-25 | 2022-11-08 | 福建华闽晟业生物科技有限公司 | 一种利用巨菌草制备野芝麻新甙的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3703543A (en) * | 1969-11-05 | 1972-11-21 | American Home Prod | Hydroxamic acids of alicyclic amino acids |
| DE3030477C2 (de) * | 1980-08-12 | 1986-10-16 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Iridoid-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung |
| JPH0366682A (ja) * | 1989-08-04 | 1991-03-22 | Tsumura & Co | 新規イリドイド誘導体 |
| AU651849B2 (en) * | 1990-10-09 | 1994-08-04 | Tsumura & Co. | Iridoid derivatives and their use as medicines |
| DE19644422C2 (de) * | 1996-10-25 | 2000-06-15 | Stefan Schulz | Verwendung von Terpenen zur Behandlung von Autoimmunkrankheiten und bei Transplantat-Abstoßungsreaktionen |
| EP1145709A1 (de) * | 2000-04-14 | 2001-10-17 | Laboratoires Serobiologiques | Verwendung von Naturstoffen zur Herstellung von kosmetischen Zubereitungen |
| AU2003224361B2 (en) * | 2002-05-10 | 2008-01-31 | Council Of Scientific And Industrial Research | Hepatoprotective activity of 2'-p-Hydroxybenzoylmussaenosidic acid |
| EP1371372A1 (de) * | 2002-06-08 | 2003-12-17 | Cognis Iberia, S.L. | Verwendung von Wirkstoffgemischen enthaltend Tocopherole und Extrakte des Harpagophytum procumbens zur Herstellung eines Medikamentes gegen rheumatische Arthritis |
| JP2008024670A (ja) | 2006-07-24 | 2008-02-07 | Daiwa Kagaku Kogyo Kk | 害虫駆除剤 |
| BRPI0700767B8 (pt) * | 2007-02-15 | 2021-05-25 | Ache Laboratorios Farmaceuticos Sa | composição farmacêutica, produto farmaceutico, processo para obtenção de compostos farmaceuticos e uso de tais compostos para o tratamento do vitiligo |
| CN103120699B (zh) * | 2011-11-18 | 2017-04-19 | 天津市国际生物医药联合研究院 | 环烯醚萜类化合物在制备抗sars的药物中的应用 |
| CN103690551A (zh) * | 2013-07-18 | 2014-04-02 | 江苏大学 | 猪殃殃中环烯醚萜苷提取物及其提取方法和医药用途 |
| DE102015102020A1 (de) * | 2015-02-12 | 2016-08-18 | Renate Wilmanowicz | Immunologisch aktives Phyto-Gemisch und seine Anwendung bei der Prävention und in einem Verfahren zur Behandlung von Effloreszenzen |
-
2017
- 2017-02-17 BR BR102017003318A patent/BR102017003318A2/pt active Search and Examination
-
2018
- 2018-02-19 EP EP21215133.6A patent/EP4001270A1/en active Pending
- 2018-02-19 CA CA3052713A patent/CA3052713A1/en active Pending
- 2018-02-19 ES ES18707229T patent/ES2909387T3/es active Active
- 2018-02-19 MX MX2019009655A patent/MX2019009655A/es unknown
- 2018-02-19 EP EP18707229.3A patent/EP3583103B1/en active Active
- 2018-02-19 LT LTEPPCT/BR2018/050037T patent/LT3583103T/lt unknown
- 2018-02-19 RS RS20220241A patent/RS63162B1/sr unknown
- 2018-02-19 KR KR1020197026718A patent/KR20190121790A/ko not_active Application Discontinuation
- 2018-02-19 DK DK18707229.3T patent/DK3583103T3/da active
- 2018-02-19 JP JP2019544005A patent/JP7349362B2/ja active Active
- 2018-02-19 SI SI201830594T patent/SI3583103T1/sl unknown
- 2018-02-19 SG SG11201907375VA patent/SG11201907375VA/en unknown
- 2018-02-19 WO PCT/BR2018/050037 patent/WO2018148816A2/en active Application Filing
- 2018-02-19 US US16/486,683 patent/US20200231561A1/en active Pending
- 2018-02-19 AU AU2018221956A patent/AU2018221956B2/en active Active
- 2018-02-19 PL PL18707229.3T patent/PL3583103T3/pl unknown
- 2018-02-19 HR HRP20220377TT patent/HRP20220377T1/hr unknown
- 2018-02-19 PT PT187072293T patent/PT3583103T/pt unknown
- 2018-02-19 CN CN201880018995.0A patent/CN110475768B/zh active Active
- 2018-02-19 BR BR112019017128A patent/BR112019017128A2/pt unknown
- 2018-02-19 PE PE2019001711A patent/PE20200449A1/es unknown
-
2019
- 2019-08-13 MX MX2022012282A patent/MX2022012282A/es unknown
- 2019-08-14 CL CL2019002309A patent/CL2019002309A1/es unknown
- 2019-08-14 EC ECSENADI201958322A patent/ECSP19058322A/es unknown
- 2019-08-15 IL IL26873219A patent/IL268732A/en unknown
- 2019-08-15 CO CONC2019/0008891A patent/CO2019008891A2/es unknown
- 2019-08-15 SA SA519402443A patent/SA519402443B1/ar unknown
- 2019-09-16 ZA ZA2019/06106A patent/ZA201906106B/en unknown
-
2022
- 2022-03-21 CY CY20221100223T patent/CY1125187T1/el unknown
-
2023
- 2023-01-25 JP JP2023009384A patent/JP2023061959A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006512330A (ja) | 竹からの抽出のトリテルペノイドサポゲニン化合物の製法と用途 | |
| CN103804443A (zh) | 黄酮苷类化合物及其制备方法 | |
| CN102961439A (zh) | 一种神香草总黄酮提取物及其制备方法和用途 | |
| CN103316096A (zh) | 一种黑种草子总黄酮提取物及其制备方法和用途 | |
| CN104666474A (zh) | 一种酸枣仁提取物及含有酸枣仁提取物的健脑助眠口服液 | |
| HRP20220377T1 (hr) | Biljni ekstrakti obogaćeni derivatima ipolamida kao imunosupresivi za liječenje imunoloških poremećaja | |
| CN104193758B (zh) | 一种从墨旱莲中提取蟛蜞菊内酯类单体化合物的制备方法 | |
| Selvan et al. | Phytochemical screening of acalypha Indica l. leaf extracts. | |
| CN104761445A (zh) | 一种从蒙药达乌里芯芭根部提取分离化学成分的方法 | |
| Nie et al. | Immune-enhancing effects of polysaccharides MLN-1 from by-product of Mai-luo-ning in vivo and in vitro | |
| Das et al. | Qualitative screnning of bioactive secondary metabolites present in Withania somnifera and Rauwolfia serpentina root and stem extract with pharmacological importance | |
| Parikh et al. | Extraction and Phytochemical Evaluation of LitseaGlutinosa Bark Methanolic Extract | |
| CA3187750A1 (en) | A standardized bioflavonoid composition for regulation of homeostasis of host defense mechanism | |
| MX2013008754A (es) | Proceso para la preparacion de un extracto herbal. | |
| Birudu et al. | Secondary metabolites of ethanolic leaf extract of Grewia hirsuta | |
| Trang et al. | Phytocomponents and antioxidant activity in the methanol extract of seed lotus (Nelumbo Nucifera Gaernt.) from Viet Nam | |
| CN101912148B (zh) | 射干浸膏提取方法及射干浸膏在卷烟中的应用 | |
| JP2020507607A5 (hr) | ||
| CN105878072A (zh) | 一种降香香水 | |
| CN103948653A (zh) | 从苦丁茶中提取苦丁茶多酚的工艺 | |
| CN104784231B (zh) | 一种从人参茎叶中获取黄酮苷元的方法 | |
| CN109589347A (zh) | 一种红景天的提取方法 | |
| Tiwari et al. | Phytochemical investigation of Caltropis procera flower extract | |
| CN105213756A (zh) | 用超声波从贝母花中提取贝母总生物碱的方法 | |
| RU2018107502A (ru) | Способ получения лекарственного средства, обладающего тиреотропной и антиоксидантной активностью |