HRP20201721T1 - Antiandrogeni za liječenje nemetastatskog raka prostate koji je otporan na kastraciju - Google Patents
Antiandrogeni za liječenje nemetastatskog raka prostate koji je otporan na kastraciju Download PDFInfo
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- HRP20201721T1 HRP20201721T1 HRP20201721TT HRP20201721T HRP20201721T1 HR P20201721 T1 HRP20201721 T1 HR P20201721T1 HR P20201721T T HRP20201721T T HR P20201721TT HR P20201721 T HRP20201721 T HR P20201721T HR P20201721 T1 HRP20201721 T1 HR P20201721T1
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- antiandrogen
- therapeutically effective
- effective amount
- months
- male
- Prior art date
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- 230000002280 anti-androgenic effect Effects 0.000 title claims 23
- 239000000051 antiandrogen Substances 0.000 title claims 23
- 230000000683 nonmetastatic effect Effects 0.000 title claims 6
- 206010060862 Prostate cancer Diseases 0.000 title claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 title claims 4
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 title 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 9
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 9
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 9
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 claims 9
- 239000000556 agonist Substances 0.000 claims 8
- HJBWBFZLDZWPHF-UHFFFAOYSA-N apalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S HJBWBFZLDZWPHF-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 3
- 108010037003 Buserelin Proteins 0.000 claims 2
- GJKXGJCSJWBJEZ-XRSSZCMZSA-N Deslorelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CNC2=CC=CC=C12 GJKXGJCSJWBJEZ-XRSSZCMZSA-N 0.000 claims 2
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims 2
- 108010069236 Goserelin Proteins 0.000 claims 2
- 108010000817 Leuprolide Proteins 0.000 claims 2
- 108010021717 Nafarelin Proteins 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 229960002719 buserelin Drugs 0.000 claims 2
- CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 claims 2
- 229960005408 deslorelin Drugs 0.000 claims 2
- 108700025485 deslorelin Proteins 0.000 claims 2
- 229960002913 goserelin Drugs 0.000 claims 2
- HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 claims 2
- 108700020746 histrelin Proteins 0.000 claims 2
- 229960002193 histrelin Drugs 0.000 claims 2
- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical group CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 claims 2
- 229960004338 leuprorelin Drugs 0.000 claims 2
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 2
- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 claims 2
- 229960002333 nafarelin Drugs 0.000 claims 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 238000011474 orchiectomy Methods 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
Claims (20)
1. Terapeutski učinkovita količina antiandrogena za upotrebu u postupku liječenja nemetastatskog raka prostate otpornog na kastraciju kod muškarca, pri čemu spomenuti postupak obuhvaća davanje spomenutog antiandrogena muškarcu sa nemetastatskim rakom prostate otpornim na kastraciju, pri čemu je antiandrogen 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid, a gdje spomenuti postupak dalje obuhvaća održavanje kastracijskih razina testosterona zajedničkim davanjem agonista ili antagonista hormona koji oslobađa gonadotropin (GnRH) ili orkiektomijom, i gdje liječenje osigurava PSA90 u 3 mjeseca, PSA50 u 6 mjeseci, i/ili PSA90 u 6 mjeseci.
2. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 1, pri čemu liječenje osigurava PSA90 u 3 mjeseca.
3. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 1 ili 2, pri čemu liječenje osigurava PSA50 u 6 mjeseci.
4. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, pri čemu liječenje osigurava PSA90 u 6 mjeseci.
5. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem prethodnom zahtjevu, pri čemu je PSA90 u 3 mjeseca, PSA50 u 6 mjeseci, i/ili PSA90 u 6 mjeseci u usporedbi s placebom.
6. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, gdje je nemetastatski rak prostate otporan na kastraciju visoko rizični nemetastatski rak prostate koji je otporan na kastraciju.
7. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 6, gdje muškarac sa visoko rizičnim nemetastatskim rakom prostate otpornim na kastraciju ima vrijeme udvostručavanja antigena specifičnog za prostatu (PSADT) koje je manje od ili jednako 10 mjeseci.
8. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, pri čemu je 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid davan svakodnevno muškarcu.
9. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, pri čemu je 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid davan oralno muškarcu.
10. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, pri čemu je 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid davan oralno muškarcu u dozi od
(a) 30 mg dnevno do 480 mg dnevno; ili
(b) 180 mg dnevno do 480 mg dnevno.
11. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, što je 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid (ARN-509) davan oralno muškarcu u dozi od
(a) 30 mg dnevno;
(b) 90 mg dnevno;
(c) 120 mg dnevno;
(d) 180 mg dnevno;
(e) 240 mg dnevno;
(f) 300 mg dnevno;
(g) 390 mg dnevno; ili
(h) 480 mg dnevno.
12. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, pri čemu je 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid davan oralno muškarcu u dozi od 240 mg dnevno.
13. Terapeutski učinkovita doza antiandrogena za upotrebu kako je zahtijevano u bilo kojem od prethodnih zahtjeva, pri čemu je 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid davan oralno muškarcu prema rasporedu kontinuiranog dnevnog doziranja.
14. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtjevano u bilo kojem od prethodnih zahtjeva, pri čemu je GnRH agonist leuprolid, buserelin, nafarelin, histrelin, goserelin, ili deslorelin.
15. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 14, pri čemu je GnRH agonist leuprolid.
16. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 14, pri čemu je GnRH agonist buserelin.
17. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 14, pri čemu je GnRH agonist nafarelin.
18. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 14, pri čemu je GnRH agonist histrelin.
19. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 14, pri čemu je GnRH agonist goserelin.
20. Terapeutski učinkovita količina antiandrogena za upotrebu kako je zahtijevano u zahtjevu 14, pri čemu je GnRH agonist deslorelin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261705900P | 2012-09-26 | 2012-09-26 | |
EP17187458.9A EP3305285B1 (en) | 2012-09-26 | 2013-09-23 | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201721T1 true HRP20201721T1 (hr) | 2021-02-19 |
Family
ID=49293921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201721TT HRP20201721T1 (hr) | 2012-09-26 | 2020-10-26 | Antiandrogeni za liječenje nemetastatskog raka prostate koji je otporan na kastraciju |
Country Status (35)
Country | Link |
---|---|
US (7) | US9884054B2 (hr) |
EP (3) | EP3305285B1 (hr) |
JP (4) | JP6351597B2 (hr) |
KR (3) | KR20210013342A (hr) |
CN (4) | CN104661658A (hr) |
AU (3) | AU2013323861C1 (hr) |
BR (1) | BR112015006705A8 (hr) |
CA (1) | CA2885415C (hr) |
CL (1) | CL2015000715A1 (hr) |
CR (1) | CR20150140A (hr) |
CY (1) | CY1123716T1 (hr) |
DK (1) | DK3305285T3 (hr) |
EA (3) | EA037806B1 (hr) |
EC (1) | ECSP15011764A (hr) |
ES (1) | ES2836424T3 (hr) |
GT (1) | GT201500071A (hr) |
HK (2) | HK1252867A1 (hr) |
HR (1) | HRP20201721T1 (hr) |
HU (1) | HUE051211T2 (hr) |
IL (3) | IL312316A (hr) |
IN (1) | IN2015DN02387A (hr) |
LT (1) | LT3305285T (hr) |
MX (2) | MX371020B (hr) |
MY (1) | MY180834A (hr) |
NI (1) | NI201500042A (hr) |
NZ (3) | NZ705815A (hr) |
PE (1) | PE20150765A1 (hr) |
PH (3) | PH12015500615A1 (hr) |
PT (1) | PT3305285T (hr) |
RS (1) | RS60976B1 (hr) |
SG (3) | SG10201902568YA (hr) |
SI (1) | SI3305285T1 (hr) |
UA (2) | UA117663C2 (hr) |
WO (1) | WO2014052237A1 (hr) |
ZA (1) | ZA201808499B (hr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3124481B1 (en) | 2010-02-16 | 2018-03-28 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and uses thereof |
MX2014007198A (es) | 2011-12-16 | 2014-10-13 | Olema Pharmaceuticals Inc | Compuestos novedosos de benzopirano, composiciones y usos de los mismos. |
CA2885415C (en) | 2012-09-26 | 2021-06-29 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (ar) * | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
ES2883187T3 (es) | 2014-12-05 | 2021-12-07 | Aragon Pharmaceuticals Inc | Composiciones anticancerosas |
JP6767368B2 (ja) * | 2014-12-05 | 2020-10-14 | アラゴン ファーマシューティカルズ,インコーポレイテッド | 抗癌性組成物 |
MA41107A (fr) * | 2014-12-05 | 2017-10-10 | Aragon Pharmaceuticals Inc | Compositions anti-cancéreuses |
KR101718226B1 (ko) | 2015-08-05 | 2017-03-20 | 울산대학교 산학협력단 | 사쿠라소사포닌 화합물을 유효성분으로 포함하는 안드로겐 수용체 관련 질환의 예방 또는 치료용 조성물 |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
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