HRP20201252T1 - Okvir transplantata za popravak hrskavice i postupak njegove izrade - Google Patents

Okvir transplantata za popravak hrskavice i postupak njegove izrade Download PDF

Info

Publication number
HRP20201252T1
HRP20201252T1 HRP20201252TT HRP20201252T HRP20201252T1 HR P20201252 T1 HRP20201252 T1 HR P20201252T1 HR P20201252T T HRP20201252T T HR P20201252TT HR P20201252 T HRP20201252 T HR P20201252T HR P20201252 T1 HRP20201252 T1 HR P20201252T1
Authority
HR
Croatia
Prior art keywords
printing
cells
gelling polysaccharide
mixture
mammalian cells
Prior art date
Application number
HRP20201252TT
Other languages
English (en)
Inventor
Matti KESTI
Marcy Zenobi-Wong
Michael Müller
Original Assignee
ETH Zürich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ETH Zürich filed Critical ETH Zürich
Publication of HRP20201252T1 publication Critical patent/HRP20201252T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612—Cartilage, synovial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3852—Cartilage, e.g. meniscus
    • A61L27/3856—Intervertebral discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y50/00—Data acquisition or data processing for additive manufacturing
    • B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B33Y70/10—Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B19/00—Programme-control systems
    • G05B19/02—Programme-control systems electric
    • G05B19/18—Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form
    • G05B19/4097—Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM
    • G05B19/4099—Surface or curve machining, making 3D objects, e.g. desktop manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/35—Nc in input of data, input till input file format
    • G05B2219/35134—3-D cad-cam
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B2219/00—Program-control systems
    • G05B2219/30—Nc systems
    • G05B2219/49—Nc machine tool, till multiple
    • G05B2219/49007—Making, forming 3-D object, model, surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Composite Materials (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Structural Engineering (AREA)
  • Civil Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Automation & Control Theory (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Human Computer Interaction (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)

Claims (15)

1. Postupak pripreme okvira transplantata za popravak hrskavice, a osobito kod ljudskog pacijenta, koji sadrži korake: - pripremu vodene otopine gelirajućeg polisaharida; - pripremu najmanje jednog od: ○ čestica i/ili vlakana i ○ stanice sisavaca; - miješanje navedene vodene otopine gelirajućeg polisaharida, navedenih čestica i/ili vlakana i/ili navedenih stanica sisavaca da bi se dobila smjesa za printanje; - deponiranje smjese za printanje u trodimenzionalnom obliku, pri čemu je navedeni gelirajući polisaharid gelanska guma, acilirana i/ili sulfatirana gelanska guma, i pri čemu navedena smjese za printanje sadrži 3% ili 3.5% (w/v) navedenog gelirajućeg polisaharida, i pri čemu navedena otopina gelirajućeg polisaharida dalje sadrži alginat.
2. Postupak sukladno zahtjevu 1, pri čemu navedena vodena otopina gelirajućeg polisaharida nadalje sadrži između 10 i 150 mmol/l divalentnih kationa.
3. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu se pripremaju i stanice sisavaca, i najmanje jedno od čestica i vlakana radi dobivanja navedene smjese za printanje.
4. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu navedena vodena otopina gelirajućeg polisaharida sadrži monosaharidni šećer ili disaharidni šećer, na fiziološkoj osmolarnosti.
5. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu je faktor rasta i/ili mitogeni faktor pripremljen u okviru smjese za printanje.
6. Postupak sukladno zahtjevu 5, pri čemu je faktor rasta i/ili mitogeni faktor odabran od BMP-2, BMP-7, TGF-β1, TGF-β2, TGF-β3, FGF-2, i/ili IGF-1.
7. Postupak sukladno zahtjevu 5 ili 6, pri čemu je koncentracija faktora rasta 0.1-5 ng/ml, 5-50 ng/ml ili 50-500 ng/ml.
8. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu su navedene stanice sisavaca stanice hrskavice, matične stanice hrskavice ili prekursorske stanice hrskavice.
9. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu su navedene stanice sisavaca prisutne u koncentracijama od 3x106 stanica/ml - 50x106 stanica/ml.
10. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu navedena smjesa za printanje sadrži 10 ng/ml TGF beta 3.
11. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu se deponiranje navedene smjese za printanje u trodimenzionalnom obliku vrši deponiranje linija navedene smjese za printanje , pri čemu svaka linija ima širinu od 700 do 1100 μm, i navedene linije se preklapaju za 20% do 60%.
12. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu se navedeni trodimenzionalni oblik dobiva postupcima 3-D printanja.
13. Postupak sukladno bilo kojem od prethodnih zahtjeva, pri čemu se navedeni trodimenzionalni oblik dobiva postupcima aditivne proizvodnje.
14. Postupak sukladno zahtjevu 13, kod kojeg je postupak aditivne proizvodnje printanje mlaznicom, bioprinting, ekstruzijski print ili postupak sloj-po-sloj.
15. Okvir transplantata koji se može dobiti ili je dobiven postupkom sukladno bilo kojem zahtjevu od 1 do 14.
HRP20201252TT 2014-12-11 2020-08-10 Okvir transplantata za popravak hrskavice i postupak njegove izrade HRP20201252T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14197449 2014-12-11
EP15158224 2015-03-09
EP15817126.4A EP3230044B1 (en) 2014-12-11 2015-12-11 Graft scaffold for cartilage repair and process for making same
PCT/EP2015/079502 WO2016092106A1 (en) 2014-12-11 2015-12-11 Graft scaffold for cartilage repair and process for making same

Publications (1)

Publication Number Publication Date
HRP20201252T1 true HRP20201252T1 (hr) 2020-11-27

Family

ID=55027702

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20201252TT HRP20201252T1 (hr) 2014-12-11 2020-08-10 Okvir transplantata za popravak hrskavice i postupak njegove izrade

Country Status (18)

Country Link
US (3) US10532126B2 (hr)
EP (2) EP3689609B1 (hr)
JP (1) JP6762936B2 (hr)
CN (1) CN106999635B (hr)
AU (1) AU2015359286B2 (hr)
CA (1) CA2967162C (hr)
CY (1) CY1123170T1 (hr)
DK (2) DK3230044T3 (hr)
ES (1) ES2809457T3 (hr)
HR (1) HRP20201252T1 (hr)
HU (1) HUE050420T2 (hr)
IL (1) IL252771B (hr)
LT (1) LT3230044T (hr)
PL (1) PL3230044T3 (hr)
PT (1) PT3230044T (hr)
RS (1) RS60700B1 (hr)
SI (1) SI3230044T1 (hr)
WO (1) WO2016092106A1 (hr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3912652B1 (en) 2014-12-18 2023-11-15 CELLINK Bioprinting AB Bacterial cellulose nanofibrillar bioink for 3d bioprinting for cell culturing, tissue engineering and regenerative medicine applications
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
JP2019520822A (ja) 2016-06-16 2019-07-25 アスペクト バイオシステムズ リミティド バイオ印刷された半月板移植片及びその使用方法
EP3526007A4 (en) * 2016-10-12 2020-05-27 Advanced Biomatrix, Inc. THREE-DIMENSIONAL (3D) PRINT INKS FROM NATURAL EXTRACELLULAR MATRIX MOLECULES
CN106620873A (zh) * 2016-11-17 2017-05-10 太原理工大学 一种复合水凝胶软骨修复材料及其制备方法
CN106727706A (zh) * 2016-12-26 2017-05-31 湖南新起源医疗技术有限公司 一种用于皮肤损伤修复的细胞制剂的制备方法
CN106943632A (zh) * 2017-03-23 2017-07-14 江南大学 一种胶原/硫酸软骨素复合人工眼角膜及其制备方法
CN108686272B (zh) * 2017-03-29 2021-04-09 复旦大学附属华山医院 静电混纺肝素-瑞舒伐他汀钙壳芯结构纳米纤维动脉瘤覆膜支架及制备方法
JP2020516311A (ja) * 2017-04-10 2020-06-11 ザウェル バイオサイエンスＴｈｅｗｅｌｌ Ｂｉｏｓｃｉｅｎｃｅ 細胞培養および生物医学的応用のためのヒドロゲル
KR102626745B1 (ko) 2017-05-26 2024-01-17 인피니트 머티리얼 솔루션즈, 엘엘씨 수용성 중합체 조성물
EP3427949A1 (en) * 2017-07-12 2019-01-16 Albert-Ludwigs-Universität Freiburg Mechanically tunable bioinks for bioprinting
JP7057076B2 (ja) 2017-08-07 2022-04-19 株式会社クボタ 植物体の生産方法
CN107501612B (zh) * 2017-08-07 2020-04-28 华南理工大学 3d打印氧化石墨烯/纤维素复合材料及其制备方法与应用
CN111278357B (zh) * 2017-08-28 2023-10-31 帝斯曼知识产权资产管理有限公司 包含聚氨酯和聚恶唑啉的合成膜组合物
US11246994B2 (en) 2017-10-19 2022-02-15 Lifecell Corporation Methods for introduction of flowable acellular tissue matrix products into a hand
EP3697462B1 (en) 2017-10-19 2023-07-12 LifeCell Corporation Flowable acellular tissue matrix products and methods of production
US11485072B2 (en) 2017-10-27 2022-11-01 DePuy Synthes Products, Inc. Selective laser sintering of asymmetric particles
CN107823711B (zh) * 2017-11-09 2020-10-30 华中科技大学同济医学院附属协和医院 核壳结构复合材料的制备及利用其构建组织工程微组织的方法
EP3485918A1 (en) * 2017-11-21 2019-05-22 ETH Zürich Gel composition for 3d printing of cell suspensions
US20200298487A1 (en) * 2017-11-29 2020-09-24 Auregen Biotherapeutics Sa Sterile additive manufacturing system
WO2019126600A1 (en) * 2017-12-20 2019-06-27 Aspect Biosystems Ltd. Bioprinted meniscus implant and methods of using same
WO2019122351A1 (en) * 2017-12-22 2019-06-27 Cellink Ab Tissue-specific human bioinks for the physiological 3d-bioprinting of human tissues for in vitro culture and transplantation
CN108159500A (zh) * 2017-12-27 2018-06-15 天津宝坻紫荆科技有限公司 一种3d打印人工骨修复材料及其制备方法
WO2019145795A2 (en) 2018-01-26 2019-08-01 Cellink Ab Systems and methods for optical assessments of bioink printability
CN108355175A (zh) * 2018-02-12 2018-08-03 华中科技大学鄂州工业技术研究院 一种复合纳米纤维支架的制备方法
CN108187137A (zh) * 2018-02-27 2018-06-22 崔友军 一种可生物降解神经修复支架的制备方法
CN110240799A (zh) * 2018-03-09 2019-09-17 中国石油化工股份有限公司 3d打印组合物及其制备方法和应用
CN108578617B (zh) * 2018-04-09 2021-03-30 深圳市莱利赛生物科技有限公司 促进膝关节软骨再生用脐血间质干细胞药物的制备方法
CN108379659A (zh) * 2018-05-06 2018-08-10 西北工业大学 一种细胞密度多梯度人工软骨制备方法
CN108355168A (zh) * 2018-05-14 2018-08-03 上海交通大学医学院附属第九人民医院 一种结合三维打印技术制备髓核回植体的方法
CN108690205A (zh) * 2018-05-28 2018-10-23 深圳市第二人民医院 一种ⅱ型胶原和聚丙烯酰胺复合水凝胶及其制备和应用
CN108853582A (zh) * 2018-06-15 2018-11-23 南京冬尚生物科技有限公司 3D打印PCL-Cu骨组织工程支架及其制备方法
US20200040296A1 (en) * 2018-08-06 2020-02-06 University Of South Carolina Decellularized Tissue as a Microcarrier for Cell Culture and Expansion
US11426818B2 (en) 2018-08-10 2022-08-30 The Research Foundation for the State University Additive manufacturing processes and additively manufactured products
WO2020077118A1 (en) 2018-10-10 2020-04-16 Cellink Ab Double network bioinks
KR20220077156A (ko) 2018-10-25 2022-06-08 셀링크 에이비 시험관내 배양 및 이식을 위한 조직 구축물의 생리학적 3d 바이오프린팅을 위한 바이오검 및 식물성 검 히드로겔 바이오잉크
CN109432501A (zh) * 2018-10-30 2019-03-08 上海交通大学医学院附属第九人民医院 复合纤维支架在制备鼻整形的复合材料中的用途
CN109513037B (zh) * 2018-11-14 2021-09-17 华中科技大学同济医学院附属协和医院 一种负载介孔生物玻璃的小肠粘膜下层创面敷料
CN109248009B (zh) * 2018-11-23 2020-01-14 吉林大学 一种利用3d打印技术制作人工胸骨的方法
KR102302770B1 (ko) * 2018-11-30 2021-09-16 주식회사 엘앤씨바이오 인체 유래 성분을 함유하고 조직 특이적 세포 분화 효과를 갖는 3d 프린팅 바이오 잉크 조성물 및 그 제조방법
KR102098134B1 (ko) * 2019-02-13 2020-04-08 성균관대학교산학협력단 나노 섬유질 콜라겐 3차원 구조체 제조방법
KR20220060501A (ko) * 2019-03-29 2022-05-11 티디비티 아이피 인코포레이티드 조직 및 장기 대체물 그리고 이들의 제조 방법
KR20210146376A (ko) * 2019-03-29 2021-12-03 이노베이티브 올쏘피딕스, 엘엘씨 연골 대체 조성물 및 방법
CN110331124B (zh) * 2019-06-14 2022-03-22 浙江大学 一种导电聚吡咯/细胞外基质复合薄膜及其制备方法
CN110464879A (zh) * 2019-07-15 2019-11-19 暨南大学 一种骨组织工程支架的3d打印方法
CN110302428B (zh) * 2019-07-30 2021-07-13 中国人民解放军陆军军医大学第一附属医院 基于活细胞3d打印的软骨-骨-骨髓复合组织结构及方法
CN110538006B (zh) * 2019-08-13 2022-06-17 上海亚朋生物技术有限公司 纤维增强的三维打印软骨脱细胞基质支架的制作方法
CN110433331B (zh) * 2019-08-26 2021-08-24 四川大学 一种生物活性支架及其制备方法
CN110450401A (zh) * 2019-09-05 2019-11-15 上海交通大学医学院附属第九人民医院 一种液体支撑介质内生物三维打印人工关节的方法
US11826951B2 (en) 2019-09-06 2023-11-28 Cellink Ab Temperature-controlled multi-material overprinting
CN110478529A (zh) * 2019-09-24 2019-11-22 广西医科大学 一种3d打印魔芋胶水凝胶支架及制备方法和应用
CN110575568A (zh) * 2019-10-22 2019-12-17 上海交通大学医学院附属第九人民医院 一种用于3d打印的水凝胶材料、制备方法及用途
CN110680954A (zh) * 2019-11-06 2020-01-14 广西医科大学 一种3d打印黄原胶水凝胶支架及其制备方法
CN110755685A (zh) * 2019-11-06 2020-02-07 广西医科大学 一种3d打印瓜尔胶水凝胶支架及其制备方法
KR102228619B1 (ko) * 2019-11-25 2021-03-17 경희대학교 산학협력단 히알루론산 및 폴리에틸렌글리콜을 포함하여 제조된 세포 시트 및 이의 제조방법
CN111320767B (zh) * 2020-03-04 2023-01-10 西南交通大学 一种用于3d生物打印的可触变性水凝胶的制备方法
WO2021177503A1 (ko) * 2020-03-06 2021-09-10 주식회사 엘앤씨바이오 연골 성분 기반 바이오 잉크를 이용한 소이증 치료 목적 구조체 제작용 조성물 및 그 제조방법
CN113456897A (zh) * 2020-03-31 2021-10-01 威斯顿股份有限公司 生物材料及其用于促进组织再生的用途
BR112022021958A2 (pt) 2020-06-17 2022-12-13 Auregen Biotherapeutics Sa Composições impressas tridimensionais maturadas e seus usos
CN112354017B (zh) * 2020-11-19 2022-07-26 中国医学科学院生物医学工程研究所 一种3d打印的力学仿生耳廓软骨组织工程支架及其制造方法
CN113069596A (zh) * 2021-04-07 2021-07-06 山东建筑大学 一种基于3d打印半月板的复合生物陶瓷修复材料
CN113244455B (zh) * 2021-05-17 2022-08-05 广西医科大学 一种3d打印亚麻籽水凝胶支架及制备方法和应用
CA3222229A1 (en) 2021-06-16 2022-12-22 Auregen Biotherapeutics Sa Gellan gum compositions and method for their preparation
US11944726B2 (en) 2021-06-18 2024-04-02 Dimension Inx Corp Method for fabrication of additively manufactured, self-gelling structures and their use
WO2023247801A1 (en) * 2022-06-24 2023-12-28 Katholieke Universiteit Leuven Printing of cell aggregates
WO2024004696A1 (ja) * 2022-06-30 2024-01-04 国立大学法人大阪大学 三次元造形物の製造方法および三次元造形物作製用インクセット
WO2024043039A1 (ja) * 2022-08-26 2024-02-29 国立大学法人大阪大学 三次元造形物の製造方法および三次元造形物作製用インクセット
CN115519788B (zh) * 2022-09-06 2024-03-15 深圳先进技术研究院 组织工程支架的打印方法、打印系统、终端及存储介质
WO2024081898A1 (en) * 2022-10-13 2024-04-18 North Carolina State University Implantable scaffolds and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6126690A (en) * 1996-07-03 2000-10-03 The Trustees Of Columbia University In The City Of New York Anatomically correct prosthesis and method and apparatus for manufacturing prosthesis
US7531503B2 (en) * 2005-03-11 2009-05-12 Wake Forest University Health Sciences Cell scaffold matrices with incorporated therapeutic agents
CA2602050C (en) * 2005-03-11 2013-12-03 Wake Forest University Health Sciences Production of tissue engineered heart valves
AU2008311957A1 (en) * 2007-10-15 2009-04-23 Wake Forest University Methods and compositions for printing biologically compatible nanotube composites of autologous tissue
EP2552406B1 (en) * 2010-03-26 2018-01-24 Stemmatters, Biotecnologia e Medicina Regenerativa, S.A. Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
US20120089238A1 (en) * 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
WO2014032748A1 (en) * 2012-08-31 2014-03-06 Eth Zurich Process of cartilage repair
AU2013204780A1 (en) * 2013-04-12 2014-10-30 University Of Wollongong Formulation and Method

Also Published As

Publication number Publication date
EP3689609A1 (en) 2020-08-05
US20170348458A1 (en) 2017-12-07
AU2015359286A1 (en) 2017-07-27
JP2018501845A (ja) 2018-01-25
CA2967162A1 (en) 2016-06-16
LT3230044T (lt) 2020-08-25
IL252771B (en) 2022-06-01
US10532126B2 (en) 2020-01-14
ES2809457T3 (es) 2021-03-04
IL252771A0 (en) 2017-08-31
JP6762936B2 (ja) 2020-09-30
PL3230044T3 (pl) 2021-02-08
SI3230044T1 (sl) 2020-10-30
CY1123170T1 (el) 2021-10-29
WO2016092106A1 (en) 2016-06-16
DK3689609T3 (da) 2022-07-04
CN106999635B (zh) 2021-06-11
CN106999635A (zh) 2017-08-01
EP3230044A1 (en) 2017-10-18
PT3230044T (pt) 2020-08-03
EP3230044B1 (en) 2020-07-01
CA2967162C (en) 2019-07-02
US20200139007A1 (en) 2020-05-07
US20230321320A1 (en) 2023-10-12
AU2015359286B2 (en) 2019-05-02
DK3230044T3 (da) 2020-08-17
US11633518B2 (en) 2023-04-25
EP3689609B1 (en) 2022-04-20
RS60700B1 (sr) 2020-09-30
HUE050420T2 (hu) 2020-12-28

Similar Documents

Publication Publication Date Title
HRP20201252T1 (hr) Okvir transplantata za popravak hrskavice i postupak njegove izrade
JP2018501845A5 (hr)
HRP20191538T1 (hr) Proizvod za žvakanje i proces za pravljenje istog
Ma et al. Three‐dimensional printing biotechnology for the regeneration of the tooth and tooth‐supporting tissues
CN104607569B (zh) 一种线型多顶杆同步顶出装置
CN205309582U (zh) 基于视觉定位的大幅面裁剪激光切割机及多轨装置和结构
EP3871858A1 (de) Vorrichtung zur generativen herstellung eines dreidimensionalen objekts
CN207137071U (zh) 一种养殖牛的牛舍消毒器
US20220184274A1 (en) Gelatin and uses thereof
CN108739270A (zh) 一种机械式农业浇水设备
CN114348269A (zh) 一种植保无人机及喷施方法
CN207641728U (zh) 一种水泥轨枕脱膜剂自动喷涂机
CN103055347B (zh) 一种洋葱结构纤维素凝胶材料的制备方法
HRP20221249T1 (hr) Postupak akvakulture za proizvodnju jaja lososa
CN212953205U (zh) 一种自动化出鸭系统
CN205179713U (zh) 一种错列链条及连杆轨道式移栽机构
CA2956359C (en) Cartilage compositions and methods for modifying proteoglycan content
CN205150942U (zh) 一种精密涡轮蜡模存放机构
CN103518922A (zh) 智能音乐糖画机
CN208590412U (zh) 一种自动清粪的芦花鸡笼养装置
CN208101935U (zh) 一种车窗玻璃自助清洗喷淋机构
CN202818985U (zh) 一种甘蔗收割机及其多行扶蔗器
CN107744008B (zh) 一种撸皮装置
CN206147293U (zh) 展示物动态悬吊装置大规模阵列的控制装置
CN101869143A (zh) 坚果奶稳定剂