HRP20180989T1 - Cjepivo protiv virusa varicela-zoster - Google Patents
Cjepivo protiv virusa varicela-zoster Download PDFInfo
- Publication number
- HRP20180989T1 HRP20180989T1 HRP20180989TT HRP20180989T HRP20180989T1 HR P20180989 T1 HRP20180989 T1 HR P20180989T1 HR P20180989T T HRP20180989T T HR P20180989TT HR P20180989 T HRP20180989 T HR P20180989T HR P20180989 T1 HRP20180989 T1 HR P20180989T1
- Authority
- HR
- Croatia
- Prior art keywords
- use according
- vzv
- population
- persons
- adjuvant
- Prior art date
Links
- 229940124863 Varicella-zoster virus vaccine Drugs 0.000 title 1
- 101900123149 Varicella-zoster virus Envelope glycoprotein E Proteins 0.000 claims 5
- 206010061598 Immunodeficiency Diseases 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 3
- 201000006082 Chickenpox Diseases 0.000 claims 2
- 208000007514 Herpes zoster Diseases 0.000 claims 2
- 206010046980 Varicella Diseases 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000007420 reactivation Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 229940021648 varicella vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
- A61K39/25—Varicella-zoster virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (13)
1. Upotreba imunogenog pripravka koji sadrži VZV gE, gdje je gE C-terminalno skraćen kako bi se uklonilo karboksiterminalno sidrišno područje, te što gE nije u obliku fuzijskog proteina, i adjuvans TH-1, koji sadrži QS21 i 3D-MPL, naznačena time što je VZV gE namijenjen pripravi medikamenta namijenjenog sprječavanju ili ublažavanju zone i/ili postherpetične neuralgije u populaciji osoba starijih od 50 i imunosno oslabljenih osoba.
2. Upotreba u skladu s patentnim zahtjevom 1, naznačena time što populaciju čine osobe starije od 60.
3. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što populaciju čine osobe starije od 70 godina.
4. Upotreba u skladu s patentnim zahtjevom 1, naznačena time što populaciju čine imunosno oslabljene osobe.
5. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što su osobe imale vodene kozice ili su primile živo cjepivo protiv vodenih kozica.
6. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što kod osoba nije došlo do reaktiviranja virusa vodene kozice-zoster.
7. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što adjuvans sadrži liposome koji sadrže kolesterol.
8. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što se 3D-MPL nalazi u liposomu.
9. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što gE ima amonokiselinski slijed SEQ ID NO:1.
10. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što pripravak sadrži 25 do 100 µg gE.
11. Upotreba u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što je u dvodoznom režimu unosa.
12. Komplet, koji kao odvojene komponente sadrži adjuvans TH-1 i antigen VZV gE u skladu s bilo kojim od prethodnih patentnih zahtjeva, pogodan za improviziranu pripravu cjepivnog pripravka, naznačen time što je namijenjen upotrebi u sprječavanju ili ublažavanju zone i/ili postherpetične neuralgije u populaciji osoba starijih od 50 i imunosno oslabljenih osoba.
13. VZV gE, C-terminalno skraćen kako bi se uklonilo karboksiterminalno sidrišno područje, te koji nije u obliku fuzijskog proteina, naznačen time što je namijenjen upotrebi u sprječavanju ili ublažavanju zone i/ili postherpetične neuralgije u populaciji osoba starijih od 50 i imunosno oslabljenih osoba, gdje se VZV gE primijenjuje u kombinaciji s adjuvansom TH-1, koji sadrži QS21 i 3D-MPL.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0504436.7A GB0504436D0 (en) | 2005-03-03 | 2005-03-03 | Vaccine |
| EP10188215.7A EP2301955B1 (en) | 2005-03-03 | 2006-03-01 | Varicella Zoster virus vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180989T1 true HRP20180989T1 (hr) | 2018-08-10 |
Family
ID=34430592
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150142TT HRP20150142T1 (hr) | 2005-03-03 | 2015-02-04 | Cjepivo protiv virusa varicella zoster |
| HRP20170081TT HRP20170081T1 (hr) | 2005-03-03 | 2017-01-18 | Cjepivo protiv virusa varicela zoster |
| HRP20180988TT HRP20180988T1 (hr) | 2005-03-03 | 2018-06-26 | Cjepivo protiv virusa varicela-zoster |
| HRP20180989TT HRP20180989T1 (hr) | 2005-03-03 | 2018-06-26 | Cjepivo protiv virusa varicela-zoster |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150142TT HRP20150142T1 (hr) | 2005-03-03 | 2015-02-04 | Cjepivo protiv virusa varicella zoster |
| HRP20170081TT HRP20170081T1 (hr) | 2005-03-03 | 2017-01-18 | Cjepivo protiv virusa varicela zoster |
| HRP20180988TT HRP20180988T1 (hr) | 2005-03-03 | 2018-06-26 | Cjepivo protiv virusa varicela-zoster |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US20080171079A1 (hr) |
| EP (4) | EP1858917B8 (hr) |
| JP (2) | JP5420842B2 (hr) |
| KR (2) | KR101357204B1 (hr) |
| CN (2) | CN101189254B (hr) |
| AR (2) | AR052498A1 (hr) |
| AU (1) | AU2006222225B2 (hr) |
| BR (1) | BRPI0607840B1 (hr) |
| CA (2) | CA2882255C (hr) |
| CY (5) | CY1116108T1 (hr) |
| DK (4) | DK1858917T3 (hr) |
| EA (1) | EA011884B1 (hr) |
| ES (4) | ES2675054T3 (hr) |
| GB (1) | GB0504436D0 (hr) |
| HK (1) | HK1111427A1 (hr) |
| HR (4) | HRP20150142T1 (hr) |
| HU (4) | HUE032544T2 (hr) |
| IL (1) | IL185442A (hr) |
| LT (4) | LT2301955T (hr) |
| LU (1) | LUC00087I2 (hr) |
| MA (1) | MA29714B1 (hr) |
| MX (2) | MX346865B (hr) |
| MY (1) | MY148464A (hr) |
| NL (1) | NL300951I2 (hr) |
| NO (1) | NO341841B1 (hr) |
| NZ (1) | NZ561075A (hr) |
| PE (2) | PE20100658A1 (hr) |
| PL (4) | PL2281831T3 (hr) |
| PT (4) | PT1858917E (hr) |
| SI (4) | SI1858917T1 (hr) |
| TR (2) | TR201809397T4 (hr) |
| TW (1) | TWI403517B (hr) |
| UA (1) | UA94900C2 (hr) |
| WO (1) | WO2006094756A2 (hr) |
| ZA (1) | ZA200707144B (hr) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0504436D0 (en) * | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| CN101801412A (zh) * | 2007-07-19 | 2010-08-11 | 诺瓦瓦克斯股份有限公司 | 水痘带状疱疹病毒-病毒样颗粒(vlp)和抗原 |
| FR2952825B1 (fr) | 2009-11-24 | 2012-05-25 | Goaster Jacqueline Le | Utilisation d'un vaccin contre le virus vzv/hsv3 pour traiter les infections herpetiques par le virus hsv1 et/ou le virus hsv2 |
| PT2591114T (pt) | 2010-07-06 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Imunização de mamíferos de grande porte com doses baixas de arn |
| HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
| WO2012006378A1 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Liposomes with lipids having an advantageous pka- value for rna delivery |
| UA112970C2 (uk) * | 2010-08-05 | 2016-11-25 | Мерк Шарп Енд Доме Корп. | Інактивований вірус вітряної віспи, спосіб його одержання і застосування |
| LT4066855T (lt) | 2010-08-31 | 2023-03-10 | Glaxosmithkline Biologicals Sa | Pegilintos liposomos, skirtos imunogeną koduojančios rnr tiekimui |
| ES2716243T3 (es) | 2010-10-11 | 2019-06-11 | Glaxosmithkline Biologicals Sa | Plataformas de suministro de antígenos |
| ES2656050T3 (es) | 2011-07-06 | 2018-02-22 | Glaxosmithkline Biologicals Sa | Composiciones de combinación inmunogénica y usos de las mismas |
| US9849066B2 (en) | 2013-04-24 | 2017-12-26 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9962439B2 (en) | 2013-10-03 | 2018-05-08 | Nitto Denko Corporation | Injectable vaccine composition |
| JP6499420B2 (ja) * | 2014-11-13 | 2019-04-10 | 公益財団法人ヒューマンサイエンス振興財団 | ワクチン及び感染防御キット |
| US20180008700A1 (en) * | 2014-12-18 | 2018-01-11 | Glaxosmithkline Biologicals S.A. | Vaccination |
| BE1022523B1 (fr) * | 2014-12-18 | 2016-05-20 | Glaxosmithkline Biologicals Sa | Vaccination |
| EP4011451A1 (en) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Metapneumovirus mrna vaccines |
| TW201729838A (zh) * | 2015-10-22 | 2017-09-01 | 現代公司 | 用於水痘帶狀疱疹病毒 (vzv)之核酸疫苗 |
| US20180327436A1 (en) | 2015-11-06 | 2018-11-15 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| EP3538146A4 (en) | 2016-11-11 | 2020-07-15 | ModernaTX, Inc. | INFLUENZA VACCINE |
| WO2018097642A1 (ko) * | 2016-11-25 | 2018-05-31 | 재단법인 목암생명과학연구소 | 바리셀라 조스터 바이러스 백신 |
| KR102028463B1 (ko) | 2016-11-25 | 2019-10-04 | 재단법인 목암생명과학연구소 | 바리셀라 조스터 바이러스 백신 |
| CN107022559A (zh) * | 2016-12-08 | 2017-08-08 | 长春祈健生物制品有限公司 | 一种水痘‑带状疱疹病毒糖蛋白e胞外区蛋白的制备方法 |
| GB201621686D0 (en) | 2016-12-20 | 2017-02-01 | Glaxosmithkline Biologicals Sa | Novel methods for inducing an immune response |
| PE20191547A1 (es) * | 2016-12-26 | 2019-10-24 | Mogam Inst Biomedical Res | Composicion de vacuna contra el herpes zoster |
| CN108727503A (zh) * | 2017-04-18 | 2018-11-02 | 武汉博沃生物科技有限公司 | VZV重组gE-鞭毛素融合蛋白及其制备方法和应用 |
| CN110730666A (zh) * | 2017-04-25 | 2020-01-24 | 佐剂技术公司 | 三萜皂苷类似物 |
| SG11201909584QA (en) * | 2017-04-25 | 2019-11-28 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| US20210187098A1 (en) | 2017-04-28 | 2021-06-24 | Glaxosmithkline Biologicals Sa | Vaccination |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| CN111032080A (zh) | 2017-05-30 | 2020-04-17 | 葛兰素史密丝克莱恩生物有限公司 | 用于制造佐剂的新型方法 |
| US11324821B2 (en) | 2017-10-16 | 2022-05-10 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| WO2019106192A1 (en) | 2017-12-01 | 2019-06-06 | Glaxosmithkline Biologicals Sa | Saponin purification |
| CN108315344A (zh) * | 2018-02-14 | 2018-07-24 | 武汉博沃生物科技有限公司 | Vzv糖蛋白e基因表达载体及其重组酵母菌株与应用 |
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