HRP20160276T1 - Pripravci za imuniziranje protiv bakterije staphylococcus aureus - Google Patents
Pripravci za imuniziranje protiv bakterije staphylococcus aureus Download PDFInfo
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- HRP20160276T1 HRP20160276T1 HRP20160276TT HRP20160276T HRP20160276T1 HR P20160276 T1 HRP20160276 T1 HR P20160276T1 HR P20160276T T HRP20160276T T HR P20160276TT HR P20160276 T HRP20160276 T HR P20160276T HR P20160276 T1 HRP20160276 T1 HR P20160276T1
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- Prior art keywords
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- vaccine
- dependent
- intended
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- Prior art date
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- 241000191967 Staphylococcus aureus Species 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001419 dependent effect Effects 0.000 claims 16
- 229960005486 vaccine Drugs 0.000 claims 16
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000002671 adjuvant Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229920002444 Exopolysaccharide Polymers 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical group [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000011850 water-based material Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (14)
1. Cjepivo koje sadrži antigen sta006, naznačeno time što je namijenjeno upotrebi u postupku zaštite od infekcije bakterijom S. aureus kod sisavca, gdje antigen sta006 sadrži aminokiselinski slijed: (i) (a) koji je 70% ili više istovjetan SEQ ID NO: 42; i/ili (b) sadrži fragment od najmanje n uzastopnih aminokiselina iz SEQ ID NO: 42, gdje je n 7 ili više; i (ii) gdje antigen sta006 može dovesti do proizvodnje protutijela koje prepoznaje SEQ ID NO: 42.
2. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, naznačeno time što dodatno sadrži adjuvans.
3. Cjepivo, naznačeno time što sadrži antigen sta006 i adjuvans, gdje antigen sta006 sadrži aminokiselinski slijed: (i) (a) koji je 70% ili više istovjetan SEQ ID NO: 42; i/ili (b) sadrži fragment od najmanje n uzastopnih aminokiselina iz SEQ ID NO: 42, gdje je n 7 ili više; i (ii) gdje antigen sta006 može dovesti do proizvodnje protutijela koje prepoznaje SEQ ID NO: 42.
4. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što antigen sta006 sadrži aminokiselinski slijed koji je 80%, 90% ili više istovjetan SEQ ID NO: 42.
5. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što antigen sta006 sadrži aminokiselinski slijed koji je 90% ili više istovjetan SEQ ID NO: 246.
6. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što antigen sta006 sadrži aminokiselinski slijed koji je 99% ili više istovjetan SEQ ID NO: 248.
7. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 2 i patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što je adjuvans aluminijev hidroksid.
8. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što cjepivo sadrži histidinski pufer ili fosfatni pufer.
9. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što dodatno sadrži jedan ili više konjugata egzopolisaharida iz bakterije S. aureus s proteinskim nosačem.
10. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevima 1, 2, 4-8, ili u skladu s patentnim zahtjevima 3-8, naznačeno time što dodatno sadrži jedan ili više konjugata polisaharida iz kapsule bakterije S. aureus s proteinskim nosačem.
11. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što je u liofiliziranom obliku.
12. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevima 1, 2, 4-10, ili u skladu s patentnim zahtjevima 3-10, naznačeno time što je u obliku vodene otopine.
13. Postupak priprave cjepiva u skladu s patentnim zahtjevom 12, naznačen time što se provodi rekonstituiranjem cjepiva u skladu s patentnim zahtjevom 11 materijalom na bazi vode.
14. Cjepivo, namijenjeno upotrebi u skladu s patentnim zahtjevom 1, te patentnim zahtjevima ovisnim o njemu, ili u skladu s patentnim zahtjevom 3 i patentnim zahtjevima ovisnim o njemu, naznačeno time što dodatno sadrži farmaceutski nosač i/ili pomoćnu tvar.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21270509P | 2009-04-14 | 2009-04-14 | |
US23407909P | 2009-08-14 | 2009-08-14 | |
EP12175868.4A EP2510947B1 (en) | 2009-04-14 | 2010-04-14 | Compositions for immunising against Staphylococcus aureus |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20160276T1 true HRP20160276T1 (hr) | 2016-04-08 |
Family
ID=42734088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160276TT HRP20160276T1 (hr) | 2009-04-14 | 2016-03-17 | Pripravci za imuniziranje protiv bakterije staphylococcus aureus |
Country Status (24)
Country | Link |
---|---|
US (5) | US8679505B2 (hr) |
EP (3) | EP2419129A2 (hr) |
JP (5) | JP5830009B2 (hr) |
KR (1) | KR20120034612A (hr) |
CN (2) | CN102647999A (hr) |
AU (1) | AU2010238255B2 (hr) |
BR (1) | BRPI1013780B8 (hr) |
CA (2) | CA3154626A1 (hr) |
CO (1) | CO6440592A2 (hr) |
DK (1) | DK2510947T3 (hr) |
ES (1) | ES2565377T3 (hr) |
HR (1) | HRP20160276T1 (hr) |
HU (1) | HUE028803T2 (hr) |
IL (1) | IL215593A0 (hr) |
MX (3) | MX2011010735A (hr) |
NZ (2) | NZ612315A (hr) |
PH (1) | PH12015500092A1 (hr) |
PL (1) | PL2510947T3 (hr) |
RU (2) | RU2508126C2 (hr) |
SG (2) | SG10201404076TA (hr) |
SI (1) | SI2510947T1 (hr) |
SM (1) | SMT201600117B (hr) |
WO (1) | WO2010119343A2 (hr) |
ZA (1) | ZA201302878B (hr) |
Families Citing this family (74)
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EP1751696A4 (en) * | 2004-05-06 | 2010-05-05 | Univ California | METHOD AND SYSTEM FOR ASSIGNING AND CLASSIFYING IMAGES |
EP2368569A3 (en) * | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
US9181329B2 (en) * | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
JP5830009B2 (ja) | 2009-04-14 | 2015-12-09 | ノバルティス アーゲー | Staphylococcusaureusに対して免疫化するための組成物 |
AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
JP2013523818A (ja) | 2010-04-05 | 2013-06-17 | ザ・ユニバーシティー・オブ・シカゴ | 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法 |
HRP20220068T1 (hr) * | 2010-05-05 | 2022-04-15 | New York University | Staphylococcus aureus leukocidini, terapijski pripravci, i njihova uporaba |
RS63817B1 (sr) | 2010-07-06 | 2023-01-31 | Glaxosmithkline Biologicals Sa | Čestice za isporuku slične virionu za molekule samoreplicirajuće rnk |
US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
WO2012006369A2 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation of large mammals with low doses of rna |
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EP2590626B1 (en) | 2010-07-06 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Liposomes with lipids having an advantageous pka-value for rna delivery |
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EP4119155A1 (en) | 2010-08-31 | 2023-01-18 | GlaxoSmithKline Biologicals S.A. | Pegylated liposomes for delivery of immunogen-encoding rna |
ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
TR201903651T4 (tr) | 2010-10-11 | 2019-04-22 | Glaxosmithkline Biologicals Sa | Antijen uygulama platformları. |
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ES2864764T3 (es) | 2011-05-11 | 2021-10-14 | Childrens Medical Center | Composición inmunogénica que presenta múltiples antígenos, y métodos y usos de la misma |
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