HRP20160196T1 - Viskoelastični gelovi kao nova punila - Google Patents
Viskoelastični gelovi kao nova punila Download PDFInfo
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- HRP20160196T1 HRP20160196T1 HRP20160196T HRP20160196T HRP20160196T1 HR P20160196 T1 HRP20160196 T1 HR P20160196T1 HR P20160196 T HRP20160196 T HR P20160196T HR P20160196 T HRP20160196 T HR P20160196T HR P20160196 T1 HRP20160196 T1 HR P20160196T1
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- Prior art keywords
- reported
- hbc
- hyadd
- biomaterials
- mixing
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- 239000000945 filler Substances 0.000 title claims 4
- 239000000499 gel Substances 0.000 title 1
- 229920002674 hyaluronan Polymers 0.000 claims 11
- 229960003160 hyaluronic acid Drugs 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 10
- 239000012620 biological material Substances 0.000 claims 8
- 238000002156 mixing Methods 0.000 claims 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 239000000843 powder Substances 0.000 claims 5
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 230000036571 hydration Effects 0.000 claims 3
- 238000006703 hydration reaction Methods 0.000 claims 3
- 239000012266 salt solution Substances 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 2
- 239000012670 alkaline solution Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000007865 diluting Methods 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 2
- 238000011049 filling Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 229960004194 lidocaine Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 238000007493 shaping process Methods 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 claims 1
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 1
- HSEMFIZWXHQJAE-UHFFFAOYSA-N Amide-Hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(N)=O HSEMFIZWXHQJAE-UHFFFAOYSA-N 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000000265 homogenisation Methods 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000013557 residual solvent Substances 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/005—Processes for mixing polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
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- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (15)
1. Biomaterijali naznačeni time da se mogu dobiti miješanjem
– heksadecilamid hialuronske kiseline (HYADD) s
– derivatom (HBC) hialuronske kiseline umrežene s 1,4-butandiol-diglicidil-eterom (BDDE)
u masenom omjeru između 10:90 i 90:10, a koji su nova punila i/ili produkti za oblikovanje tijela.
2. Biomaterijali kako su prijavljeni u patentnom zahtjevu 1, naznačeni time da maseni omjer jest od 90:10 do 50:50, a koji su biorevitalizirajuća punila.
3. Biomaterijali kako su prijavljeni u patentnom zahtjevu 1, naznačeni time da maseni omjer jest od 10:90 do 50:50, a da imaju učinak povećanja volumena.
4. Biomaterijali kako su prijavljeni u patentnom zahtjevu 3, naznačeni time da maseni omjer jest od 25:75.
5. Postupak miješanja HYADD s HBC pripravljen postupkom koji obuhvaća sljedeće korake:
a) otapanje diepoksida BDDE u alkalnoj otopini u stehiometrijskom omjeru od 2.5 do 25 molarnih % ponavljajućih jedinica hialuronske kiseline, nakon čega slijedi
b) disperzija hialuronske kiseline (HA) u otopini navedenoj u koraku a) pri sobnoj temperaturi,
c) poticanje reakcije aktiviranjem toplinom otopine navedene u koraku b), zagrijavajući je pri temperaturi između 35 i 55 °C tijekom 2 do 36 sati,
d) ekstruzija mase dobivene preko metalnog sita da bi se smanjila veličina čestica na približno 600 µm,
e) hidratiranje gela dobivenog razrijeđivanjem vodom od 3 do 20 puta,
f) korekcija pH do neutralnog vodenom otopinom HCl,
g) taloženje s organskim otapalom topljivim u vodi do dobivanja produkta u obliku praška,
h) pranje organskim otapalima koja sadrže vodu,
i) sušenje pod vakuumom dok zaostala otapala nisu uklonjena do 400 ppm i dobiven prašak HBC,
naznačen time da postupak miješanja obuhvaća sljedeće korake:
j) miješanje praška HYADD s praškom HBC u omjeru HYADD:HBC između 90:10 i 10:90,
k) hidratiranje s otopinom soli ili fosfatnim puferom čime se postiže ukupna koncentracija HA između 12 i 27 mg/mL,
l) ekstruzija pri temperaturi između 25 i 65 °C kroz sito otvora između 50 i 500 µm,
m) punjenje injekcije,
n) sterilizacija zagrijavanjem u zasićenoj pari pri temepraturi između 120 i 124 °C najmanje 10 minuta.
6. Postupak kako je prijavljen u patentnom zahtjevu 5, naznačen time da je organsko otapalo topljivo u vodi iz koraka g) odabrano iz sljedeće skupine: etanol, metanol, izopropanol, n-propanol, dioksan, acetonitiril, aceton i/ili njihove smjese.
7. Postupak kako je prijavljen u patentnom zahtjevu 5, naznačen time da su organska otapala iz koraka h) odabrana iz sljedeće skupine: etanol, metanol, izopropanol, n-propanol, dioksan, acetonitiril, aceton i/ili njihove smjese.
8. Postupak miješanja HYADD s HBC pripravljen postupkom koji obuhvaća sljedeće korake:
a) otapanje diepoksida BDDE u alkalnoj otopini u stehiometrijskom omjeru od 2.5 do 25 molarnih % ponavljajućih jedinica hialuronske kiseline, nakon čega slijedi
b) disperzija HA u otopini navedenoj u koraku a) pri sobnoj temperaturi,
c) poticanje reakcije aktiviranjem toplinom otopine navedene u koraku b), zagrijavajući je pri temperaturi između 35 i 55 °C tijekom 2 do 36 sati,
d) korekcija pH do neutralnog vodenom otopinom HCl,
e) hidratiranje gela dobivenog razrijeđivanjem vodom od 3 do 20 puta,
naznačen time da postupak miješanja obuhvaća sljedeće korake:
f) miješanje gela ili praška HYADD s HBC u obliku gela omjera HYADD:HBC između 90:10 i 10:90,
g) usitnjavanje i homogeniziranje prolaskom kroz filter s koeficijentom retencije veličine čestica između 25 i 150 µm,
h) punjenje injekcije,
i) sterilizacija zagrijavanjem zasićenom parom pri temperaturi između 120 i 124 °C najmanje 10 minuta.
9. Postupak kako je prijavljen u patentnom zahtjevu 5 ili 6, naznačen time da HA koja se koristi za pripravu derivata HBC i HYADD ima srednju molekulsku masu između 400 i 3×106 Da.
10. Postupak kako je prijavljen u patentnom zahtjevu 9, naznačen time da HA ima srednju molekulsku masu između 1×105 Da i 1×106 Da.
11. Postupak kako je prijavljen u patentnom zahtjevu 9, naznačen time da HA ima srednju molekulsku masu između 200000 i 1×106 Da.
12. Biomaterijali kako su prijavljeni u prethodnim patentnim zahtjevima, naznačeni time da vezikul jest otopina soli.
13. Biomaterijali kako su prijavljeni u prethodnim patentnim zahtjevima, naznačeni time da sadrže lidokain.
14. Biomaterijali kako su prijavljeni u patentnim zahtjevima 12 i 13 koji sadrže lidokain, naznačeni time da vezikul sadrži otopinu soli.
15. Biomaterijali kako su prijavljeni u prethodnim patentnim zahtjevima, naznačeni time da se koriste kao nova punila i/ili novi produkti za oblikovanje tijela, u tretmanu mrlja na koži, u dermatologiji, u dermokozmetologiji i/ili estetskoj kirurgiji.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD2009A000246A IT1395392B1 (it) | 2009-08-27 | 2009-08-27 | Geli viscoelastici come nuovi filler |
| EP14170084.9A EP2772273B9 (en) | 2009-08-27 | 2010-08-25 | Viscoelastic gels as novel fillers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160196T1 true HRP20160196T1 (hr) | 2016-03-25 |
Family
ID=42046298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140981TT HRP20140981T4 (hr) | 2009-08-27 | 2010-08-25 | Viskoelastični gelovi kao nova punila |
| HRP20160196T HRP20160196T1 (hr) | 2009-08-27 | 2016-02-25 | Viskoelastični gelovi kao nova punila |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140981TT HRP20140981T4 (hr) | 2009-08-27 | 2010-08-25 | Viskoelastični gelovi kao nova punila |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8846640B2 (hr) |
| EP (2) | EP2772273B9 (hr) |
| JP (1) | JP5976537B2 (hr) |
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Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0819075A2 (pt) | 2007-11-16 | 2014-10-07 | Vicept Therapeutics Inc | Método para tratar púrpura em um indivíduo e método para diminuir a púrpura em um indivíduo antes de um procedimento cirúrgico |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| AU2009288118B2 (en) | 2008-09-02 | 2014-12-11 | Allergan, Inc. | Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| WO2011110894A2 (en) | 2010-03-12 | 2011-09-15 | Allergan Industrie Sas | Fluid composition for improving skin conditions |
| PL3078388T3 (pl) | 2010-03-22 | 2019-08-30 | Allergan, Inc. | Usieciowane hydrożele do powiększania tkanek miękkich |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| FR2968305B1 (fr) | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| KR102015676B1 (ko) | 2011-06-03 | 2019-10-21 | 알러간, 인코포레이티드 | 항산화제를 포함하는 피부 충전제 조성물 |
| ES2899992T3 (es) * | 2011-08-10 | 2022-03-15 | Glycores 2000 Srl | Acido hialurónico reticulado de bajo peso molecular resistente a la degradación |
| US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
| CN104105474B (zh) * | 2011-09-14 | 2018-04-06 | 阿勒根公司 | 用于细纹治疗的真皮填充剂组合物 |
| KR101428145B1 (ko) * | 2011-11-24 | 2014-08-08 | (주)아모레퍼시픽 | 수불용성 겔 조성물 및 그 제조방법 |
| ITPD20120098A1 (it) | 2012-03-30 | 2013-10-01 | Fidia Farmaceutici | "nuove formulazioni faramaceutiche contenenti condroitin solfato e derivati dell'acido ialuronico" |
| ITMI20120732A1 (it) * | 2012-05-03 | 2013-11-04 | B S Srl | Polisaccaridi reticolati a memoria di forma |
| JP6174690B2 (ja) * | 2012-06-15 | 2017-08-02 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | ヒアルロン酸に基づく組成物の調製方法 |
| FR2997085B1 (fr) * | 2012-10-24 | 2015-05-29 | Teoxane | Procede de preparation d'un gel reticule |
| ITPD20120360A1 (it) * | 2012-11-30 | 2014-05-31 | Fidia Farmaceutici | "nuovi geli viscoelastici in chirurgia oftalmica" |
| US20140315828A1 (en) | 2013-04-22 | 2014-10-23 | Allergan, Inc. | Cross-linked silk-hyaluronic acid compositions |
| ITPD20130110A1 (it) * | 2013-04-24 | 2014-10-25 | Fidia Farmaceutici | Composizioni farmaceutiche comprendenti acido ialuronico per il trattamento del black disc |
| MX368941B (es) * | 2013-06-28 | 2019-10-22 | Galderma Sa | Un procedimiento para preparar un producto de ácido hialurónico entrelazado. |
| WO2015005345A1 (ja) * | 2013-07-08 | 2015-01-15 | 電気化学工業株式会社 | コアシェル型架橋ヒアルロン酸ゲル粒子、その製造方法及び医用材料 |
| EP3035903B1 (en) | 2013-08-20 | 2018-08-22 | Anutra Medical, Inc. | Syringe fill system and method |
| USD763433S1 (en) | 2014-06-06 | 2016-08-09 | Anutra Medical, Inc. | Delivery system cassette |
| USD774182S1 (en) | 2014-06-06 | 2016-12-13 | Anutra Medical, Inc. | Anesthetic delivery device |
| USD750768S1 (en) | 2014-06-06 | 2016-03-01 | Anutra Medical, Inc. | Fluid administration syringe |
| WO2016051219A1 (en) | 2014-09-30 | 2016-04-07 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
| FR3029928B1 (fr) | 2014-12-15 | 2018-03-09 | Teoxane | Gel reticule |
| RU2610006C1 (ru) * | 2016-03-23 | 2017-02-07 | Наталья Павловна Михайлова | Способ липотерапии |
| CA3033536A1 (en) | 2016-08-24 | 2018-03-01 | Allergan, Inc. | Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation |
| EP3609483A4 (en) * | 2017-04-12 | 2021-01-20 | Urigen Pharmaceuticals, Inc. | ITEM OF MANUFACTURING CONSISTING OF LOCAL ANESTHETICS, BUFFER AND GLYCOSAMINOGLYCANE IN A SYRINGE OF IMPROVED STABILITY |
| MX2020006651A (es) * | 2017-12-22 | 2020-11-06 | Nestle Skin Health Sa | Producto inyectable en gel. |
| PL3731808T3 (pl) * | 2017-12-29 | 2024-03-18 | Matex Lab S.P.A. | Sposób przygotowania wypełniacza na bazie kwasu hialuronowego obejmujący etap zobojętnienia |
| IT201800001890A1 (it) | 2018-01-25 | 2019-07-25 | Fidia Farm Spa | Composizioni farmaceutiche per il trattamento del dolore postoperatorio |
| WO2020184744A1 (ko) * | 2019-03-08 | 2020-09-17 | 주식회사 지씨에스 | 복합체의 제조 방법 |
| IT202000005692A1 (it) | 2020-03-17 | 2021-09-17 | Fidia Farm Spa | Bio-inchiostro per stampa 3D, relativo coniugato e processo di preparazione di un intermedio costituito da un linker fotoreattivo |
| KR102417671B1 (ko) * | 2020-04-28 | 2022-07-06 | 충남대학교산학협력단 | 자가가교 시스템을 가지는 히알루론산 기반 연조직 충전 조성물 및 이의 제조방법 |
| RU2746877C1 (ru) * | 2020-07-23 | 2021-04-21 | Роман Дмитриевич Лебедев | Пористый фильтрующий элемент и способ его изготовления |
| KR102640893B1 (ko) * | 2021-11-12 | 2024-02-27 | 주식회사 유영제약 | 히알루론산 가교물을 포함하는 조성물의 제조방법 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8501022L (sv) * | 1985-03-01 | 1986-09-02 | Pharmacia Ab | Format alster och forfarande for dess framstellning |
| IT1198449B (it) | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| IT1288290B1 (it) * | 1996-06-21 | 1998-09-11 | Fidia Spa In Amministrazione S | Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie |
| IT1296689B1 (it) * | 1997-11-06 | 1999-07-14 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico aventi proprieta viscoelastiche e loro uso in campo biomedico-sanitario |
| ITPD980169A1 (it) * | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| IT1303735B1 (it) * | 1998-11-11 | 2001-02-23 | Falorni Italia Farmaceutici S | Acidi ialuronici reticolati e loro usi medici. |
| IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
| CA2567532C (en) * | 2004-05-20 | 2013-10-01 | Mentor Corporation | Methods for making injectable polymer hydrogels |
| ITPD20050056A1 (it) | 2005-03-02 | 2006-09-03 | Fidia Farmaceutici | Derivati ammidici del'acido ialuronico in osteoartrosi |
| ITPD20050146A1 (it) * | 2005-05-20 | 2006-11-21 | Fidia Farmaceutici | Fillers riassorbibili costituiti da liposomi e acido ialuronico e o suoi derivati |
| FR2909560B1 (fr) * | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| JP5165281B2 (ja) * | 2007-06-01 | 2013-03-21 | 株式会社バイオベルデ | ２反応剤型の医療用含水ゲル形成剤、及び、これより得られるヒアルロン酸ゲル |
| FR2918377B1 (fr) * | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
| ATE544786T1 (de) † | 2007-09-28 | 2012-02-15 | Shiseido Co Ltd | Quellbares vernetztes hyaluronsäurepulver und herstellungsverfahren dafür |
| WO2009043111A1 (en) * | 2007-10-04 | 2009-04-09 | Ultraceuticals R & D Pty Ltd | Composition and method for dermal regeneration |
| US8394782B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| FR2924615B1 (fr) * | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| US9109051B2 (en) * | 2007-12-19 | 2015-08-18 | Evonik Goldschmidt Gmbh | Crosslinked hyaluronic acid in emulsion |
| CN101538377A (zh) † | 2008-03-20 | 2009-09-23 | 上海昊海生物科技有限公司 | 一种交联透明质酸凝胶及其制备方法 |
| US8357795B2 (en) * | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
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