HRP20120656T1 - Derivati indazolil amida za liječenje poremećaja posredovanih glukokortikoidnim receptorom - Google Patents
Derivati indazolil amida za liječenje poremećaja posredovanih glukokortikoidnim receptorom Download PDFInfo
- Publication number
- HRP20120656T1 HRP20120656T1 HRP20120656TT HRP20120656T HRP20120656T1 HR P20120656 T1 HRP20120656 T1 HR P20120656T1 HR P20120656T T HRP20120656T T HR P20120656TT HR P20120656 T HRP20120656 T HR P20120656T HR P20120656 T1 HRP20120656 T1 HR P20120656T1
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- HR
- Croatia
- Prior art keywords
- fluorophenyl
- oxy
- indazol
- propan
- phenyl
- Prior art date
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- YDTDKKULPWTHRV-UHFFFAOYSA-N 1H-indazol-3-amine Chemical class C1=CC=C2C(N)=NNC2=C1 YDTDKKULPWTHRV-UHFFFAOYSA-N 0.000 title 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 title 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 39
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 34
- 239000001257 hydrogen Substances 0.000 claims abstract 34
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 27
- -1 cyano, hydroxy Chemical group 0.000 claims abstract 26
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 125000005843 halogen group Chemical group 0.000 claims abstract 17
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims abstract 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 13
- 125000001424 substituent group Chemical group 0.000 claims abstract 13
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims abstract 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 11
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 9
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 8
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims abstract 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 6
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims abstract 4
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 4
- 125000005842 heteroatom Chemical group 0.000 claims abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 3
- 125000002098 pyridazinyl group Chemical group 0.000 claims abstract 3
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims abstract 3
- 125000004001 thioalkyl group Chemical group 0.000 claims abstract 3
- 125000006642 (C1-C6) cyanoalkyl group Chemical group 0.000 claims abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims abstract 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 2
- 125000001544 thienyl group Chemical group 0.000 claims abstract 2
- 125000004537 indazol-5-yl group Chemical group N1N=CC2=CC(=CC=C12)* 0.000 claims 37
- 150000002431 hydrogen Chemical group 0.000 claims 16
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 10
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 8
- 125000000172 C5-C10 aryl group Chemical group 0.000 claims 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 239000004202 carbamide Substances 0.000 claims 3
- YDRQCGICZKAGCQ-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide Chemical compound C1=NC(OC)=CC=C1[C@H]([C@H](C)NC(=O)C1CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 YDRQCGICZKAGCQ-LMKMVOKYSA-N 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 claims 2
- 102220517591 Methyl-CpG-binding domain protein 3-like 2B_R11C_mutation Human genes 0.000 claims 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 2
- FCNQMDSJHADDFT-WNSKOXEYSA-N azd5423 Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(F)(F)F)=C1 FCNQMDSJHADDFT-WNSKOXEYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000001294 propane Substances 0.000 claims 2
- VLJNHYLEOZPXFW-UHFFFAOYSA-N pyrrolidine-2-carboxamide Chemical compound NC(=O)C1CCCN1 VLJNHYLEOZPXFW-UHFFFAOYSA-N 0.000 claims 2
- 102200001405 rs377584435 Human genes 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- LXZJZIGYMSHMQA-YPBQGGFRSA-N (2r)-2-amino-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]propanamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)[C@@H](C)N)=C1 LXZJZIGYMSHMQA-YPBQGGFRSA-N 0.000 claims 1
- HRWDKWJNLQWXTN-QLODZENZSA-N (2r)-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxypropanamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)[C@@H](C)O)=C1 HRWDKWJNLQWXTN-QLODZENZSA-N 0.000 claims 1
- BBPYNFWLTXLUSD-DXMSMQRWSA-N (2r)-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-hydroxypropanamide Chemical compound O([C@@H]([C@H](C)NC(=O)[C@H](O)C)C=1C=CC(=CC=1)C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BBPYNFWLTXLUSD-DXMSMQRWSA-N 0.000 claims 1
- HRWDKWJNLQWXTN-TZPNTHKFSA-N (2s)-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxypropanamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)[C@H](C)O)=C1 HRWDKWJNLQWXTN-TZPNTHKFSA-N 0.000 claims 1
- BBPYNFWLTXLUSD-YWTKSJFSSA-N (2s)-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-hydroxypropanamide Chemical compound O([C@@H]([C@H](C)NC(=O)[C@@H](O)C)C=1C=CC(=CC=1)C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BBPYNFWLTXLUSD-YWTKSJFSSA-N 0.000 claims 1
- UYXMGAVXZFLAMS-UAVUOLJFSA-N (2s)-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2-hydroxypropanamide Chemical compound O([C@@H]([C@H](C)NC(=O)[C@@H](O)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UYXMGAVXZFLAMS-UAVUOLJFSA-N 0.000 claims 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- OBMBKMQUDOCLMJ-PPHZAIPVSA-N 1-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-3-(furan-2-ylmethyl)thiourea Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC=CC=1)C(=S)NCC1=CC=CO1 OBMBKMQUDOCLMJ-PPHZAIPVSA-N 0.000 claims 1
- DYOUBVJDXDNLBS-WNSKOXEYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-(3-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C(=C(F)C=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 DYOUBVJDXDNLBS-WNSKOXEYSA-N 0.000 claims 1
- TYALSQCWMYLCJE-PSLXWICFSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-(3-fluoro-4-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]acetamide Chemical compound C1=C(F)C(OC)=CC=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 TYALSQCWMYLCJE-PSLXWICFSA-N 0.000 claims 1
- BVRWAYGRCQDZDD-WNSKOXEYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-(3-fluoro-4-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(F)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BVRWAYGRCQDZDD-WNSKOXEYSA-N 0.000 claims 1
- HNKFDVMFQXFDNT-WNSKOXEYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-(4-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C(=CC(F)=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HNKFDVMFQXFDNT-WNSKOXEYSA-N 0.000 claims 1
- CYKBMQIJCSWGIT-PSLXWICFSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-(5-fluoro-2-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]acetamide Chemical compound COC1=CC=C(F)C=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 CYKBMQIJCSWGIT-PSLXWICFSA-N 0.000 claims 1
- PHYRJXQLDMWOPN-WNSKOXEYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-(5-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C(=CC=C(F)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PHYRJXQLDMWOPN-WNSKOXEYSA-N 0.000 claims 1
- XOGPSCMIWHWJLI-FYSMJZIKSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)-6-methylindazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide Chemical compound COC1=CC=CC([C@@H](OC=2C(=CC=3N(C=4C=CC(F)=CC=4)N=CC=3C=2)C)[C@H](C)NC(=O)C(F)(F)F)=C1 XOGPSCMIWHWJLI-FYSMJZIKSA-N 0.000 claims 1
- JOZVFROTCUPPGG-HJPURHCSSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)-6-methylindazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C(=CC=12)C)=CC=1C=NN2C1=CC=C(F)C=C1 JOZVFROTCUPPGG-HJPURHCSSA-N 0.000 claims 1
- CFIGOSQQWFWIHK-BVZFJXPGSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C(=CC(C)=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 CFIGOSQQWFWIHK-BVZFJXPGSA-N 0.000 claims 1
- FTUSURRLTGETKI-WNSKOXEYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]acetamide Chemical compound COC1=CC=CC=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 FTUSURRLTGETKI-WNSKOXEYSA-N 0.000 claims 1
- YCQOQNREKKLDAX-FPTDNZKUSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-hydroxyphenyl)propan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(O)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YCQOQNREKKLDAX-FPTDNZKUSA-N 0.000 claims 1
- FFRVDTYVHUYEEM-OWJWWREXSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxy-4-methylsulfanylphenyl)propan-2-yl]acetamide Chemical compound C1=C(SC)C(OC)=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(F)(F)F)=C1 FFRVDTYVHUYEEM-OWJWWREXSA-N 0.000 claims 1
- NFLAABWNWRXLQK-HJPURHCSSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(C)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 NFLAABWNWRXLQK-HJPURHCSSA-N 0.000 claims 1
- WAMYUDJQTHBZTP-GKVSMKOHSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethylphenyl)propan-2-yl]acetamide Chemical compound C1=C(C)C(OC)=C(C)C=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 WAMYUDJQTHBZTP-GKVSMKOHSA-N 0.000 claims 1
- UCBZPSOSPPXUNI-GKVSMKOHSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-propylphenyl)propan-2-yl]acetamide Chemical compound C1=CC(CCC)=CC=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 UCBZPSOSPPXUNI-GKVSMKOHSA-N 0.000 claims 1
- PWKJVVLBXRWXFQ-QLXKLKPCSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-naphthalen-2-ylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C2C=CC=CC2=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PWKJVVLBXRWXFQ-QLXKLKPCSA-N 0.000 claims 1
- UITKQZZSZUEHEA-NYHFZMIOSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UITKQZZSZUEHEA-NYHFZMIOSA-N 0.000 claims 1
- BUJJKQLZSGDFSD-LMKMVOKYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-quinolin-3-ylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C2C=CC=CC2=NC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BUJJKQLZSGDFSD-LMKMVOKYSA-N 0.000 claims 1
- MNYJSLAQJHMSJK-NYHFZMIOSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]sulfanyl-1-phenylpropan-2-yl]acetamide Chemical compound S([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MNYJSLAQJHMSJK-NYHFZMIOSA-N 0.000 claims 1
- MFYZXYQSKBENST-HJPURHCSSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-[3-(hydroxymethyl)phenyl]indazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=CC(CO)=C1 MFYZXYQSKBENST-HJPURHCSSA-N 0.000 claims 1
- BFEDEQACFCFJAW-DCFHFQCYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-[3-(morpholin-4-ylmethyl)phenyl]indazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C(C=1)=CC=CC=1CN1CCOCC1 BFEDEQACFCFJAW-DCFHFQCYSA-N 0.000 claims 1
- OOQWESKBMHHSGA-HJPURHCSSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-[4-(hydroxymethyl)phenyl]indazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(CO)C=C1 OOQWESKBMHHSGA-HJPURHCSSA-N 0.000 claims 1
- SBKBPBDGBAHDBR-DCFHFQCYSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-[1-[4-(morpholin-4-ylmethyl)phenyl]indazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C(C=C1)=CC=C1CN1CCOCC1 SBKBPBDGBAHDBR-DCFHFQCYSA-N 0.000 claims 1
- VCCOMXZBKRKPDV-LIRRHRJNSA-N 2,2,2-trifluoro-n-[(1r,2s)-1-phenyl-1-(1-propan-2-ylindazol-5-yl)oxypropan-2-yl]acetamide Chemical compound C1([C@H]([C@H](C)NC(=O)C(F)(F)F)OC=2C=C3C=NN(C3=CC=2)C(C)C)=CC=CC=C1 VCCOMXZBKRKPDV-LIRRHRJNSA-N 0.000 claims 1
- QTLUBQMNDOTYCD-HJPURHCSSA-N 2,2,2-trifluoro-n-[(2s,3r)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxybutan-2-yl]acetamide Chemical compound C([C@@H]([C@@H](NC(=O)C(F)(F)F)C)OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)OC1=CC=CC=C1 QTLUBQMNDOTYCD-HJPURHCSSA-N 0.000 claims 1
- RBMSDFZESZHPEN-QMHKHESXSA-N 2,2,2-trifluoro-n-[(2s,3r)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenylbutan-2-yl]acetamide Chemical compound C([C@H]([C@@H](NC(=O)C(F)(F)F)C)OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C1=CC=CC=C1 RBMSDFZESZHPEN-QMHKHESXSA-N 0.000 claims 1
- QTLUBQMNDOTYCD-QMHKHESXSA-N 2,2,2-trifluoro-n-[(2s,3s)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxybutan-2-yl]acetamide Chemical compound C([C@H]([C@@H](NC(=O)C(F)(F)F)C)OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)OC1=CC=CC=C1 QTLUBQMNDOTYCD-QMHKHESXSA-N 0.000 claims 1
- CRDWDIIHKXWSQQ-NYHFZMIOSA-N 2,2-dichloro-n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]acetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(Cl)Cl)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 CRDWDIIHKXWSQQ-NYHFZMIOSA-N 0.000 claims 1
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- RTZCKDSKMAZQQP-SOKVYYICSA-N [2-[[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]amino]-2-oxoethyl] acetate Chemical compound C1=CC(SC)=CC=C1[C@H]([C@H](C)NC(=O)COC(C)=O)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 RTZCKDSKMAZQQP-SOKVYYICSA-N 0.000 claims 1
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- IFBHJIZTWMSEGK-GKVSMKOHSA-N ethyl 2-[[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]amino]-2-oxoacetate Chemical compound O([C@@H]([C@H](C)NC(=O)C(=O)OCC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IFBHJIZTWMSEGK-GKVSMKOHSA-N 0.000 claims 1
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- KYIKLPKRKRPJAR-HJPURHCSSA-N methyl 2-[[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]amino]-2-oxoacetate Chemical compound O([C@@H]([C@H](C)NC(=O)C(=O)OC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KYIKLPKRKRPJAR-HJPURHCSSA-N 0.000 claims 1
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- XQTMGQRERAEKFF-QLXKLKPCSA-N n-[(1r,2s)-1-(1,3-benzodioxol-5-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C2OCOC2=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 XQTMGQRERAEKFF-QLXKLKPCSA-N 0.000 claims 1
- XXRHWNAPZSDPLZ-QLXKLKPCSA-N n-[(1r,2s)-1-(1,3-benzodioxol-5-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C2OCOC2=CC=1)C(=O)C1=NC=C(C)S1 XXRHWNAPZSDPLZ-QLXKLKPCSA-N 0.000 claims 1
- CQBALJDPBRLJCV-BTYIYWSLSA-N n-[(1r,2s)-1-(1-cyclopentylindazol-5-yl)oxy-1-phenylpropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1CCCC1 CQBALJDPBRLJCV-BTYIYWSLSA-N 0.000 claims 1
- VUMYFEIUOZGYQM-OWJWWREXSA-N n-[(1r,2s)-1-(2,3-dihydro-1-benzofuran-6-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C2OCCC2=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VUMYFEIUOZGYQM-OWJWWREXSA-N 0.000 claims 1
- DTJOSIQCTDNMBS-XDHUDOTRSA-N n-[(1r,2s)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C(=CC(C)=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 DTJOSIQCTDNMBS-XDHUDOTRSA-N 0.000 claims 1
- XSKRZTUZVATCAP-SIBVEZHUSA-N n-[(1r,2s)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-fluoro-2-methylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)F)C)C=1C(=CC(C)=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 XSKRZTUZVATCAP-SIBVEZHUSA-N 0.000 claims 1
- LJQMWZKPEVHXNV-PPHZAIPVSA-N n-[(1r,2s)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C(=CC(C)=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LJQMWZKPEVHXNV-PPHZAIPVSA-N 0.000 claims 1
- WRQSLVAJEFTWTG-DCFHFQCYSA-N n-[(1r,2s)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC(C)=CC=1)C)C(=O)C1=NC=C(C)S1 WRQSLVAJEFTWTG-DCFHFQCYSA-N 0.000 claims 1
- OMGGDNPNMDVXJQ-XDHUDOTRSA-N n-[(1r,2s)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C(=CC=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OMGGDNPNMDVXJQ-XDHUDOTRSA-N 0.000 claims 1
- ZYCBAEZGUGOLQW-BVZFJXPGSA-N n-[(1r,2s)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-difluoropropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(F)F)C)C=1C(=CC=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZYCBAEZGUGOLQW-BVZFJXPGSA-N 0.000 claims 1
- NGZGMTNTQWYQBX-DCFHFQCYSA-N n-[(1r,2s)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C(=CC=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 NGZGMTNTQWYQBX-DCFHFQCYSA-N 0.000 claims 1
- FNODXVXFCUTVCL-SIBVEZHUSA-N n-[(1r,2s)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-fluoro-2-methylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)F)C)C=1C(=CC=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FNODXVXFCUTVCL-SIBVEZHUSA-N 0.000 claims 1
- FUPGXMUABSOSLB-PPHZAIPVSA-N n-[(1r,2s)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C(=CC=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FUPGXMUABSOSLB-PPHZAIPVSA-N 0.000 claims 1
- PULUWYLUKUBEDZ-DCFHFQCYSA-N n-[(1r,2s)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-3-hydroxy-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)CO)C)C=1C(=CC=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PULUWYLUKUBEDZ-DCFHFQCYSA-N 0.000 claims 1
- KQPNFNMNLNDHDE-GKVSMKOHSA-N n-[(1r,2s)-1-(2-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C(=CC=CC=1)Cl)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KQPNFNMNLNDHDE-GKVSMKOHSA-N 0.000 claims 1
- PHTVYDROORYOQK-LMKMVOKYSA-N n-[(1r,2s)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(F)C(F)=CC=1)C(=O)C1(C)CC1 PHTVYDROORYOQK-LMKMVOKYSA-N 0.000 claims 1
- HGMFBXRXQCDIOB-XMHCIUCPSA-N n-[(1r,2s)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(F)C(F)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HGMFBXRXQCDIOB-XMHCIUCPSA-N 0.000 claims 1
- FFVNTNKEMBXFDL-PSLXWICFSA-N n-[(1r,2s)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-difluoropropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(F)F)C)C=1C=C(F)C(F)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FFVNTNKEMBXFDL-PSLXWICFSA-N 0.000 claims 1
- OTATWPABHQOBFC-LMKMVOKYSA-N n-[(1r,2s)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(F)C(F)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OTATWPABHQOBFC-LMKMVOKYSA-N 0.000 claims 1
- KABLZLLKDRDEGG-OWJWWREXSA-N n-[(1r,2s)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-fluoro-2-methylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)F)C)C=1C=C(F)C(F)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KABLZLLKDRDEGG-OWJWWREXSA-N 0.000 claims 1
- PFUHHKRQJKLFBY-MQNRADLISA-N n-[(1r,2s)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=C(F)C(F)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PFUHHKRQJKLFBY-MQNRADLISA-N 0.000 claims 1
- RGSHNCJVLNCMQN-DCFHFQCYSA-N n-[(1r,2s)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(C)C(C)=CC=1)C(=O)C1(C)CC1 RGSHNCJVLNCMQN-DCFHFQCYSA-N 0.000 claims 1
- BZBJTOYOCVXMSG-XDHUDOTRSA-N n-[(1r,2s)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(C)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BZBJTOYOCVXMSG-XDHUDOTRSA-N 0.000 claims 1
- DNXYPHCRGIDYSA-DCFHFQCYSA-N n-[(1r,2s)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(C)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 DNXYPHCRGIDYSA-DCFHFQCYSA-N 0.000 claims 1
- DOKRFXQYUQFMGK-SIBVEZHUSA-N n-[(1r,2s)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-fluoro-2-methylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)F)C)C=1C=C(C)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 DOKRFXQYUQFMGK-SIBVEZHUSA-N 0.000 claims 1
- FMFFKCGCGRYWFU-PPHZAIPVSA-N n-[(1r,2s)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=C(C)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FMFFKCGCGRYWFU-PPHZAIPVSA-N 0.000 claims 1
- JKXYCRXIQIONTE-DCFHFQCYSA-N n-[(1r,2s)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(C)C(C)=CC=1)C(=O)C1=NC=C(C)S1 JKXYCRXIQIONTE-DCFHFQCYSA-N 0.000 claims 1
- UWLPQVPRSCYQPD-LMKMVOKYSA-N n-[(1r,2s)-1-(3-chloro-5-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(Cl)C=C(F)C=1)C(=O)C1(C)CC1 UWLPQVPRSCYQPD-LMKMVOKYSA-N 0.000 claims 1
- OOPGIRDMKDMZMX-XMHCIUCPSA-N n-[(1r,2s)-1-(3-chloro-5-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(Cl)C=C(F)C=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OOPGIRDMKDMZMX-XMHCIUCPSA-N 0.000 claims 1
- OCIGORFSXKFZBB-PSLXWICFSA-N n-[(1r,2s)-1-(3-chloro-5-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-difluoropropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(F)F)C)C=1C=C(Cl)C=C(F)C=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OCIGORFSXKFZBB-PSLXWICFSA-N 0.000 claims 1
- VNMOYXGQXVYLIG-LMKMVOKYSA-N n-[(1r,2s)-1-(3-chloro-5-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(Cl)C=C(F)C=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VNMOYXGQXVYLIG-LMKMVOKYSA-N 0.000 claims 1
- OBMGISMPKDLONN-LMKMVOKYSA-N n-[(1r,2s)-1-(3-chloro-5-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(Cl)C=C(F)C=1)C(=O)C1=NC=C(C)S1 OBMGISMPKDLONN-LMKMVOKYSA-N 0.000 claims 1
- CUMBPYQMMGRGMY-GKVSMKOHSA-N n-[(1r,2s)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(Cl)C=CC=1)C(=O)C1(C)CC1 CUMBPYQMMGRGMY-GKVSMKOHSA-N 0.000 claims 1
- KVOBNWYMDKJIAZ-WNSKOXEYSA-N n-[(1r,2s)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-difluoropropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(F)F)C)C=1C=C(Cl)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KVOBNWYMDKJIAZ-WNSKOXEYSA-N 0.000 claims 1
- FRUDSMHKXGLRTJ-GKVSMKOHSA-N n-[(1r,2s)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(Cl)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FRUDSMHKXGLRTJ-GKVSMKOHSA-N 0.000 claims 1
- WREPPFRFBLVCNA-FYSMJZIKSA-N n-[(1r,2s)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-fluoro-2-methylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)F)C)C=1C=C(Cl)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WREPPFRFBLVCNA-FYSMJZIKSA-N 0.000 claims 1
- HVAFIIVSXGVCJH-GKVSMKOHSA-N n-[(1r,2s)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-3-hydroxy-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)CO)C)C=1C=C(Cl)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HVAFIIVSXGVCJH-GKVSMKOHSA-N 0.000 claims 1
- ZYEADNKDSCKTTK-GKVSMKOHSA-N n-[(1r,2s)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(Cl)C=CC=1)C(=O)C1=NC=C(C)S1 ZYEADNKDSCKTTK-GKVSMKOHSA-N 0.000 claims 1
- HKEOAGDLAXBHBB-FYSMJZIKSA-N n-[(1r,2s)-1-(3-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound CCC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(F)(F)F)=C1 HKEOAGDLAXBHBB-FYSMJZIKSA-N 0.000 claims 1
- UVWRHLHMKDARPS-QYBDOPJKSA-N n-[(1r,2s)-1-(3-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C(=C(F)C=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UVWRHLHMKDARPS-QYBDOPJKSA-N 0.000 claims 1
- RDXCOHNJPOGUKE-QLXKLKPCSA-N n-[(1r,2s)-1-(3-fluoro-4-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound C1=C(F)C(OC)=CC=C1[C@H]([C@H](C)NC(=O)C1(C)CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 RDXCOHNJPOGUKE-QLXKLKPCSA-N 0.000 claims 1
- KOADHTBCAXXTST-QLXKLKPCSA-N n-[(1r,2s)-1-(3-fluoro-4-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound C1=C(F)C(OC)=CC=C1[C@H]([C@H](C)NC(=O)C(C)(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 KOADHTBCAXXTST-QLXKLKPCSA-N 0.000 claims 1
- SJMLQCMGQUPDBC-QMTYFTJSSA-N n-[(1r,2s)-1-(3-fluoro-4-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=C(F)C(OC)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 SJMLQCMGQUPDBC-QMTYFTJSSA-N 0.000 claims 1
- UPTPLPLGEWOGQO-QLXKLKPCSA-N n-[(1r,2s)-1-(3-fluoro-4-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound C1=C(F)C(OC)=CC=C1[C@H]([C@H](C)NC(=O)C=1SC(C)=CN=1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 UPTPLPLGEWOGQO-QLXKLKPCSA-N 0.000 claims 1
- QJOWMMBEBQGIRT-QYBDOPJKSA-N n-[(1r,2s)-1-(3-fluoro-4-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(F)C(C)=CC=1)C(=O)C1(C)CC1 QJOWMMBEBQGIRT-QYBDOPJKSA-N 0.000 claims 1
- XJVCBWPBHNGOOI-QLXKLKPCSA-N n-[(1r,2s)-1-(3-fluoro-4-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=C(F)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 XJVCBWPBHNGOOI-QLXKLKPCSA-N 0.000 claims 1
- FXTPJNZTTZROSJ-QYBDOPJKSA-N n-[(1r,2s)-1-(3-fluoro-4-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-3-hydroxy-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)CO)C)C=1C=C(F)C(C)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FXTPJNZTTZROSJ-QYBDOPJKSA-N 0.000 claims 1
- NSECGRPYBXBBBX-JYFHCDHNSA-N n-[(1r,2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-3-methoxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)COC)COC)C=1C=C(F)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 NSECGRPYBXBBBX-JYFHCDHNSA-N 0.000 claims 1
- IPPNPSSLJDZMLP-RPLLCQBOSA-N n-[(1r,2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-3-methoxypropan-2-yl]furan-2-carboxamide Chemical compound N([C@@H](COC)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(F)C=CC=1)C(=O)C1=CC=CO1 IPPNPSSLJDZMLP-RPLLCQBOSA-N 0.000 claims 1
- WCOSFSSYTRGPQR-GKVSMKOHSA-N n-[(1r,2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(F)C=CC=1)C(=O)C1(C)CC1 WCOSFSSYTRGPQR-GKVSMKOHSA-N 0.000 claims 1
- VFYKPZHZFFOYAH-GKVSMKOHSA-N n-[(1r,2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(F)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VFYKPZHZFFOYAH-GKVSMKOHSA-N 0.000 claims 1
- KYGLFMAVCOOERQ-LMKMVOKYSA-N n-[(1r,2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=C(F)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KYGLFMAVCOOERQ-LMKMVOKYSA-N 0.000 claims 1
- DYQTXNSPRYPQTR-GKVSMKOHSA-N n-[(1r,2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-3-hydroxy-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)CO)C)C=1C=C(F)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 DYQTXNSPRYPQTR-GKVSMKOHSA-N 0.000 claims 1
- RGAWLLPWMOKQSG-XMHCIUCPSA-N n-[(1r,2s)-1-(4-chloro-3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(F)C(Cl)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 RGAWLLPWMOKQSG-XMHCIUCPSA-N 0.000 claims 1
- ZILBWYQOVWLPFJ-WNSKOXEYSA-N n-[(1r,2s)-1-(4-chloro-3-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=C(C)C(Cl)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZILBWYQOVWLPFJ-WNSKOXEYSA-N 0.000 claims 1
- QXURKTLCFYYOHZ-QYBDOPJKSA-N n-[(1r,2s)-1-(4-chloro-3-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(C)C(Cl)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 QXURKTLCFYYOHZ-QYBDOPJKSA-N 0.000 claims 1
- MOHWRBZCCUKHFC-GKVSMKOHSA-N n-[(1r,2s)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC(Cl)=CC=1)C(=O)C1(C)CC1 MOHWRBZCCUKHFC-GKVSMKOHSA-N 0.000 claims 1
- XULIBDSPWFOOEN-FPTDNZKUSA-N n-[(1r,2s)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC(Cl)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 XULIBDSPWFOOEN-FPTDNZKUSA-N 0.000 claims 1
- SCALZRMLROKALV-WNSKOXEYSA-N n-[(1r,2s)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-difluoropropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(F)F)C)C=1C=CC(Cl)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 SCALZRMLROKALV-WNSKOXEYSA-N 0.000 claims 1
- RHQDASBAMULPKG-GKVSMKOHSA-N n-[(1r,2s)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=CC(Cl)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 RHQDASBAMULPKG-GKVSMKOHSA-N 0.000 claims 1
- OTWXWHAOWBUIPC-LMKMVOKYSA-N n-[(1r,2s)-1-(4-cyclopropylsulfanylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC(SC2CC2)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OTWXWHAOWBUIPC-LMKMVOKYSA-N 0.000 claims 1
- MHHMZLYOOFXBMN-FYSMJZIKSA-N n-[(1r,2s)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound C1=CC(CC)=CC=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 MHHMZLYOOFXBMN-FYSMJZIKSA-N 0.000 claims 1
- JBTVTEFBQUVIRK-PPHZAIPVSA-N n-[(1r,2s)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound C1=CC(CC)=CC=C1[C@H]([C@H](C)NC(=O)C(C)(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 JBTVTEFBQUVIRK-PPHZAIPVSA-N 0.000 claims 1
- HXDMNMBRPLEMSI-PPHZAIPVSA-N n-[(1r,2s)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-methylpropanamide Chemical compound C1=CC(CC)=CC=C1[C@H]([C@H](C)NC(=O)C(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 HXDMNMBRPLEMSI-PPHZAIPVSA-N 0.000 claims 1
- GNMBSIOXDYGXIO-FYSMJZIKSA-N n-[(1r,2s)-1-(4-ethylsulfanylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound C1=CC(SCC)=CC=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 GNMBSIOXDYGXIO-FYSMJZIKSA-N 0.000 claims 1
- JGRGONQBVVOFSB-QYBDOPJKSA-N n-[(1r,2s)-1-(4-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC(F)=CC=1)C)C(=O)C1(C)CC1 JGRGONQBVVOFSB-QYBDOPJKSA-N 0.000 claims 1
- KATCWPHKRSCDCY-QYBDOPJKSA-N n-[(1r,2s)-1-(4-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C(=CC(F)=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KATCWPHKRSCDCY-QYBDOPJKSA-N 0.000 claims 1
- INHHYSNWXVQTDE-QYBDOPJKSA-N n-[(1r,2s)-1-(4-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-3-hydroxy-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)CO)C)C=1C(=CC(F)=CC=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 INHHYSNWXVQTDE-QYBDOPJKSA-N 0.000 claims 1
- NMIDJHUQIAYVIH-QYBDOPJKSA-N n-[(1r,2s)-1-(4-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC(F)=CC=1)C)C(=O)C1=NC=C(C)S1 NMIDJHUQIAYVIH-QYBDOPJKSA-N 0.000 claims 1
- NYKYRNPYLUWTQM-MMTVBGGISA-N n-[(1r,2s)-1-(4-tert-butylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC(=CC=1)C(C)(C)C)C(=O)C1(C)CC1 NYKYRNPYLUWTQM-MMTVBGGISA-N 0.000 claims 1
- VSOHLDDGZSAAJJ-GKVSMKOHSA-N n-[(1r,2s)-1-(4-tert-butylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC(=CC=1)C(C)(C)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VSOHLDDGZSAAJJ-GKVSMKOHSA-N 0.000 claims 1
- LAEOSLXPJNNHLP-MMTVBGGISA-N n-[(1r,2s)-1-(4-tert-butylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=CC(=CC=1)C(C)(C)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LAEOSLXPJNNHLP-MMTVBGGISA-N 0.000 claims 1
- TXGRJANXPKBFBY-QLXKLKPCSA-N n-[(1r,2s)-1-(5-fluoro-2-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound COC1=CC=C(F)C=C1[C@H]([C@H](C)NC(=O)C1(C)CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 TXGRJANXPKBFBY-QLXKLKPCSA-N 0.000 claims 1
- DAXYHLQSTRLVNC-QLXKLKPCSA-N n-[(1r,2s)-1-(5-fluoro-2-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2-dimethylpropanamide Chemical compound COC1=CC=C(F)C=C1[C@H]([C@H](C)NC(=O)C(C)(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 DAXYHLQSTRLVNC-QLXKLKPCSA-N 0.000 claims 1
- FLRRTIRRSRUZPO-QLXKLKPCSA-N n-[(1r,2s)-1-(5-fluoro-2-methoxyphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound COC1=CC=C(F)C=C1[C@H]([C@H](C)NC(=O)C=1SC(C)=CN=1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 FLRRTIRRSRUZPO-QLXKLKPCSA-N 0.000 claims 1
- LULTVTUFLFQYQU-QYBDOPJKSA-N n-[(1r,2s)-1-(5-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC=C(F)C=1)C)C(=O)C1(C)CC1 LULTVTUFLFQYQU-QYBDOPJKSA-N 0.000 claims 1
- HCRFRXTYEONOSZ-QYBDOPJKSA-N n-[(1r,2s)-1-(5-fluoro-2-methylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC=C(F)C=1)C)C(=O)C1=NC=C(C)S1 HCRFRXTYEONOSZ-QYBDOPJKSA-N 0.000 claims 1
- QHOYQISDXKHVBX-WNSKOXEYSA-N n-[(1r,2s)-1-[1-(4-chlorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2,2-trifluoroacetamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(Cl)=CC=2)[C@H](C)NC(=O)C(F)(F)F)=C1 QHOYQISDXKHVBX-WNSKOXEYSA-N 0.000 claims 1
- XQQUQHOFFVJFOO-FYSMJZIKSA-N n-[(1r,2s)-1-[1-(4-chlorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2-difluoropropanamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(Cl)=CC=2)[C@H](C)NC(=O)C(C)(F)F)=C1 XQQUQHOFFVJFOO-FYSMJZIKSA-N 0.000 claims 1
- IBUUVCZEFTXHEA-PPHZAIPVSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)-6-methylindazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound COC1=CC=CC([C@@H](OC=2C(=CC=3N(C=4C=CC(F)=CC=4)N=CC=3C=2)C)[C@H](C)NC(=O)C(C)(C)C)=C1 IBUUVCZEFTXHEA-PPHZAIPVSA-N 0.000 claims 1
- RXKGTYVQAVZVAE-SIBVEZHUSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)-6-methylindazol-5-yl]oxy-1-phenylpropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=CC=CC=1)C(C(=CC=12)C)=CC=1C=NN2C1=CC=C(F)C=C1 RXKGTYVQAVZVAE-SIBVEZHUSA-N 0.000 claims 1
- VYBCECYGMNRCEQ-GKVSMKOHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)-6-methylindazol-5-yl]oxy-1-phenylpropan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)C)C=1C=CC=CC=1)C(C(=CC=12)C)=CC=1C=NN2C1=CC=C(F)C=C1 VYBCECYGMNRCEQ-GKVSMKOHSA-N 0.000 claims 1
- IXYHHOIDMWESGG-KMRXNPHXSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC(C)=C(C)C=1)C)C(=O)C1(C)CC1 IXYHHOIDMWESGG-KMRXNPHXSA-N 0.000 claims 1
- UTSAXHCVFGMKFB-KMRXNPHXSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C(=CC(C)=C(C)C=1)C)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UTSAXHCVFGMKFB-KMRXNPHXSA-N 0.000 claims 1
- HBZSHDYBQHVBBP-KMRXNPHXSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C(=CC(C)=C(C)C=1)C)C(=O)C1=NC=C(C)S1 HBZSHDYBQHVBBP-KMRXNPHXSA-N 0.000 claims 1
- DLXMACPAHKTABS-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound COC1=CC=CC=C1[C@H]([C@H](C)NC(=O)C1(C)CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 DLXMACPAHKTABS-QYBDOPJKSA-N 0.000 claims 1
- BAYPVDGAWNMNLW-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound COC1=CC=CC=C1[C@H]([C@H](C)NC(=O)C(C)(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 BAYPVDGAWNMNLW-QYBDOPJKSA-N 0.000 claims 1
- MPEYDDVUTIDHLB-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound COC1=CC=CC=C1[C@H]([C@H](C)NC(=O)C=1SC(C)=CN=1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 MPEYDDVUTIDHLB-QYBDOPJKSA-N 0.000 claims 1
- ARWKAVJBNHFKQA-AHKZPQOWSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)butan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)CC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ARWKAVJBNHFKQA-AHKZPQOWSA-N 0.000 claims 1
- FYCRSIUDXPTKAD-JYFHCDHNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)butan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)CC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FYCRSIUDXPTKAD-JYFHCDHNSA-N 0.000 claims 1
- OKOFBKFZBXXETG-XTEPFMGCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)pentan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)CCC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OKOFBKFZBXXETG-XTEPFMGCSA-N 0.000 claims 1
- NYLRABSSLJGROT-RPLLCQBOSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)pentan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)CCC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 NYLRABSSLJGROT-RPLLCQBOSA-N 0.000 claims 1
- HHCKXETZEONANU-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,2-oxazole-3-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=NOC=C2)=C1 HHCKXETZEONANU-QLXKLKPCSA-N 0.000 claims 1
- XWKVDJPXXJDJLR-SLQAJWMNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,3-benzothiazole-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2SC3=CC=CC=C3N=2)=C1 XWKVDJPXXJDJLR-SLQAJWMNSA-N 0.000 claims 1
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- SSSRTLVTXXEVGY-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,3-oxazole-4-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2N=COC=2)=C1 SSSRTLVTXXEVGY-QLXKLKPCSA-N 0.000 claims 1
- RBGRWAONVSOYFP-GKVSMKOHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,3-thiazole-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2SC=CN=2)=C1 RBGRWAONVSOYFP-GKVSMKOHSA-N 0.000 claims 1
- NWUVJXKIJBDCOS-VKGTZQKMSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,5-dimethylpyrazole-3-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=NN(C)C(C)=C2)=C1 NWUVJXKIJBDCOS-VKGTZQKMSA-N 0.000 claims 1
- WOXQCXWDFSWVNL-GEFUHLBYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1-benzothiophene-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2SC3=CC=CC=C3C=2)=C1 WOXQCXWDFSWVNL-GEFUHLBYSA-N 0.000 claims 1
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- ZSHMRFVPLVHQEL-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1-methyltriazole-4-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2N=NN(C)C=2)=C1 ZSHMRFVPLVHQEL-QLXKLKPCSA-N 0.000 claims 1
- LJAGTFUVKFQDCV-SLQAJWMNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1h-benzimidazole-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2NC3=CC=CC=C3N=2)=C1 LJAGTFUVKFQDCV-SLQAJWMNSA-N 0.000 claims 1
- GZXAXVCEPCCXBQ-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1h-imidazole-5-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2N=CNC=2)=C1 GZXAXVCEPCCXBQ-QLXKLKPCSA-N 0.000 claims 1
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- OQGAHLUAFVPVLV-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(C)(C)C)=C1 OQGAHLUAFVPVLV-QYBDOPJKSA-N 0.000 claims 1
- HKCVYBJKNTXYGE-VKGTZQKMSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-(2-methoxyethoxy)acetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COCCOC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HKCVYBJKNTXYGE-VKGTZQKMSA-N 0.000 claims 1
- FHNGPUHTUWRJIA-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxyacetamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)CO)=C1 FHNGPUHTUWRJIA-LMKMVOKYSA-N 0.000 claims 1
- HSPMUWBKTJSOGU-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=C(OC)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HSPMUWBKTJSOGU-QLXKLKPCSA-N 0.000 claims 1
- OAJYVEUPFAMGEN-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-methylpropanamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(C)C)=C1 OAJYVEUPFAMGEN-QYBDOPJKSA-N 0.000 claims 1
- PEBJTQFFGULQQD-MYUZEXMDSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-3-methoxythiophene-2-carboxamide Chemical compound C1=CSC(C(=O)N[C@@H](C)[C@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C=2C=C(OC)C=CC=2)=C1OC PEBJTQFFGULQQD-MYUZEXMDSA-N 0.000 claims 1
- VKAYQWFPVOCYJI-PPHZAIPVSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-3-methylthiophene-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=C(C=CS2)C)=C1 VKAYQWFPVOCYJI-PPHZAIPVSA-N 0.000 claims 1
- SKAIPPANMWWUCT-SLQAJWMNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4,5-dimethylfuran-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2OC(C)=C(C)C=2)=C1 SKAIPPANMWWUCT-SLQAJWMNSA-N 0.000 claims 1
- HQUJBNQLZYLPEY-SLQAJWMNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4-(trifluoromethyl)benzamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2C=CC(=CC=2)C(F)(F)F)=C1 HQUJBNQLZYLPEY-SLQAJWMNSA-N 0.000 claims 1
- NKJUMLLMTNMGPQ-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4-methyl-1,3-thiazole-5-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=C(N=CS2)C)=C1 NKJUMLLMTNMGPQ-QLXKLKPCSA-N 0.000 claims 1
- FSDOYDKBEJMNIY-SLQAJWMNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-(methoxymethyl)thiophene-2-carboxamide Chemical compound S1C(COC)=CC=C1C(=O)N[C@@H](C)[C@@H](C=1C=C(OC)C=CC=1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 FSDOYDKBEJMNIY-SLQAJWMNSA-N 0.000 claims 1
- XXHCIZUKZPVUOM-MYUZEXMDSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=NOC(C)=C2)=C1 XXHCIZUKZPVUOM-MYUZEXMDSA-N 0.000 claims 1
- KELYWULSZQMZDU-SOKVYYICSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,2-oxazole-4-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=C(ON=C2)C)=C1 KELYWULSZQMZDU-SOKVYYICSA-N 0.000 claims 1
- DYBDMWIRAGIORY-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2OC(C)=NN=2)=C1 DYBDMWIRAGIORY-LMKMVOKYSA-N 0.000 claims 1
- TVVQXAFZBKYJEH-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2SC(C)=CN=2)=C1 TVVQXAFZBKYJEH-QYBDOPJKSA-N 0.000 claims 1
- CSXURSGGXNZWNP-SOKVYYICSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3-thiazole-4-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=C(SC=N2)C)=C1 CSXURSGGXNZWNP-SOKVYYICSA-N 0.000 claims 1
- QHNOQXLEDJHUSC-VKGTZQKMSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methylthiophene-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2SC(C)=CC=2)=C1 QHNOQXLEDJHUSC-VKGTZQKMSA-N 0.000 claims 1
- RFPBDVDZCUXTSC-GKVSMKOHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-n',n'-dimethyloxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(=O)N(C)C)=C1 RFPBDVDZCUXTSC-GKVSMKOHSA-N 0.000 claims 1
- YADSBMTVZPWFEA-VKGTZQKMSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]cyclopentanecarboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2CCCC2)=C1 YADSBMTVZPWFEA-VKGTZQKMSA-N 0.000 claims 1
- DHDOUQBAPCNMFL-MYUZEXMDSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]furan-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2OC=CC=2)=C1 DHDOUQBAPCNMFL-MYUZEXMDSA-N 0.000 claims 1
- IZXXGPPCXUKIJP-WRGVRERRSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]pyrazolo[1,5-a]pyridine-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=NN3C=CC=CC3=C2)=C1 IZXXGPPCXUKIJP-WRGVRERRSA-N 0.000 claims 1
- KKXVWGKDEZNTGV-VKGTZQKMSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]pyridine-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2N=CC=CC=2)=C1 KKXVWGKDEZNTGV-VKGTZQKMSA-N 0.000 claims 1
- JGBIGPRWSYNXRX-MYUZEXMDSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]pyrimidine-4-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2N=CN=CC=2)=C1 JGBIGPRWSYNXRX-MYUZEXMDSA-N 0.000 claims 1
- FRFIBGKOAMCGIE-MYUZEXMDSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C=2SC=CC=2)=C1 FRFIBGKOAMCGIE-MYUZEXMDSA-N 0.000 claims 1
- BCOVPFOKPOFXMT-MYUZEXMDSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-3-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2=CSC=C2)=C1 BCOVPFOKPOFXMT-MYUZEXMDSA-N 0.000 claims 1
- JUYZHFVETIGBAI-SIBVEZHUSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(C)C=CC=1)C(=O)C1(C)CC1 JUYZHFVETIGBAI-SIBVEZHUSA-N 0.000 claims 1
- SHUFRHWZNGVQAX-SIBVEZHUSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=C(C)C=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 SHUFRHWZNGVQAX-SIBVEZHUSA-N 0.000 claims 1
- ODPKEXLIIQYNCT-SIBVEZHUSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=C(C)C=CC=1)C(=O)C1=NC=C(C)S1 ODPKEXLIIQYNCT-SIBVEZHUSA-N 0.000 claims 1
- GSRARBZKOFISMP-PPHZAIPVSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-2-methylphenyl)propan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound CC1=CC(OC)=CC=C1[C@H]([C@H](C)NC(=O)C1(C)CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 GSRARBZKOFISMP-PPHZAIPVSA-N 0.000 claims 1
- DPRGTHGNHXUJMG-MMTVBGGISA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethylphenyl)propan-2-yl]-1-methylcyclopropane-1-carboxamide Chemical compound C1=C(C)C(OC)=C(C)C=C1[C@H]([C@H](C)NC(=O)C1(C)CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 DPRGTHGNHXUJMG-MMTVBGGISA-N 0.000 claims 1
- FHMFWSHVOSXXBJ-MMTVBGGISA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethylphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide Chemical compound C1=C(C)C(OC)=C(C)C=C1[C@H]([C@H](C)NC(=O)C=1SC(C)=CN=1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 FHMFWSHVOSXXBJ-MMTVBGGISA-N 0.000 claims 1
- UTIAAIRJWCYRAO-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxyphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound C1=CC(OC)=CC=C1[C@H]([C@H](C)NC(=O)C(C)(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 UTIAAIRJWCYRAO-QYBDOPJKSA-N 0.000 claims 1
- FCIMXXBBOCXVRL-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]-2-hydroxyacetamide Chemical compound C1=CC(SC)=CC=C1[C@H]([C@H](C)NC(=O)CO)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 FCIMXXBBOCXVRL-LMKMVOKYSA-N 0.000 claims 1
- IFCQQPAPZSVFTN-QLXKLKPCSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=CC(SC)=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IFCQQPAPZSVFTN-QLXKLKPCSA-N 0.000 claims 1
- WWWKKFOVJNHTTL-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfonylphenyl)propan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)C)C=1C=CC(=CC=1)S(C)(=O)=O)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WWWKKFOVJNHTTL-LMKMVOKYSA-N 0.000 claims 1
- PBCKRCUAGFEUDK-MMTVBGGISA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-propylphenyl)propan-2-yl]-2,2-dimethylpropanamide Chemical compound C1=CC(CCC)=CC=C1[C@H]([C@H](C)NC(=O)C(C)(C)C)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 PBCKRCUAGFEUDK-MMTVBGGISA-N 0.000 claims 1
- UGXFIWUDUGTYFR-FYSMJZIKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-1-hydroxycyclopropane-1-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC(=CC=1)C(F)(F)F)C(=O)C1(O)CC1 UGXFIWUDUGTYFR-FYSMJZIKSA-N 0.000 claims 1
- PCQDBIVQNKOKDN-OWJWWREXSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)C)C=1C=CC(=CC=1)C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PCQDBIVQNKOKDN-OWJWWREXSA-N 0.000 claims 1
- USVDDASFSHKANS-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=CC(=CC=1)C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 USVDDASFSHKANS-LMKMVOKYSA-N 0.000 claims 1
- IOXNCRCNSPCAHN-LMKMVOKYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]propanamide Chemical compound O([C@@H]([C@H](C)NC(=O)CC)C=1C=CC(=CC=1)C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IOXNCRCNSPCAHN-LMKMVOKYSA-N 0.000 claims 1
- MCRCEIUYWZNBLE-AZGAKELHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylbutan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)CC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MCRCEIUYWZNBLE-AZGAKELHSA-N 0.000 claims 1
- HOQZRKDYNVZZOC-WIOPSUGQSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylbutan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)CC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HOQZRKDYNVZZOC-WIOPSUGQSA-N 0.000 claims 1
- FWNMLDIZUQELRC-AHKZPQOWSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpentan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)CCC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FWNMLDIZUQELRC-AHKZPQOWSA-N 0.000 claims 1
- ATZZBNBEMBUHAD-JYFHCDHNSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpentan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)CCC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ATZZBNBEMBUHAD-JYFHCDHNSA-N 0.000 claims 1
- JZIVIKFFTCIHGU-BVZFJXPGSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2,2-dimethylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)C)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 JZIVIKFFTCIHGU-BVZFJXPGSA-N 0.000 claims 1
- KYKHSQPKRKXQFW-XDHUDOTRSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2-hydroxy-2-methylpropanamide Chemical compound O([C@@H]([C@@H](NC(=O)C(C)(C)O)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KYKHSQPKRKXQFW-XDHUDOTRSA-N 0.000 claims 1
- DGKMFVORYILZDU-FYSMJZIKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2-hydroxyacetamide Chemical compound O([C@@H]([C@@H](NC(=O)CO)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 DGKMFVORYILZDU-FYSMJZIKSA-N 0.000 claims 1
- AWRRQOMNYKXVJW-GKVSMKOHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2-methoxyacetamide Chemical compound O([C@@H]([C@H](C)NC(=O)COC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 AWRRQOMNYKXVJW-GKVSMKOHSA-N 0.000 claims 1
- YYDVGKXZBSRNET-BVZFJXPGSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2-methylpropanamide Chemical compound O([C@@H]([C@H](C)NC(=O)C(C)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YYDVGKXZBSRNET-BVZFJXPGSA-N 0.000 claims 1
- RQLBLLQGEKLEHK-JRPXNJEYSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2-phenylacetamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC=CC=1)C(=O)CC1=CC=CC=C1 RQLBLLQGEKLEHK-JRPXNJEYSA-N 0.000 claims 1
- BUFVZNUJJVOXAZ-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-3-methoxypropanamide Chemical compound O([C@@H]([C@H](C)NC(=O)CCOC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BUFVZNUJJVOXAZ-QYBDOPJKSA-N 0.000 claims 1
- NTIWGYAIYKDWAV-FYSMJZIKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC=CC=1)C(=O)C1=NN=C(C)O1 NTIWGYAIYKDWAV-FYSMJZIKSA-N 0.000 claims 1
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- YDHPXRDVQADYFY-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]butanamide Chemical compound O([C@@H]([C@H](C)NC(=O)CCC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YDHPXRDVQADYFY-QYBDOPJKSA-N 0.000 claims 1
- PZVBGSMYBYFZRP-QYBDOPJKSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]cyclobutanecarboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC=CC=1)C(=O)C1CCC1 PZVBGSMYBYFZRP-QYBDOPJKSA-N 0.000 claims 1
- LHGZZJGIBXDYEH-GKVSMKOHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]cyclopropanecarboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C=1C=CC=CC=1)C(=O)C1CC1 LHGZZJGIBXDYEH-GKVSMKOHSA-N 0.000 claims 1
- MVPPFJVQZYVRTK-GKVSMKOHSA-N n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl]propanamide Chemical compound O([C@@H]([C@H](C)NC(=O)CC)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MVPPFJVQZYVRTK-GKVSMKOHSA-N 0.000 claims 1
- UKBXCLRTSVJLGG-RBZFPXEDSA-N n-[(1r,2s)-1-[1-(6-chloropyridazin-3-yl)indazol-5-yl]oxy-1-phenylpropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=C(Cl)N=N1 UKBXCLRTSVJLGG-RBZFPXEDSA-N 0.000 claims 1
- NIKKERZGOSHRSJ-BVZFJXPGSA-N n-[(1r,2s)-1-[1-[3-[(dimethylamino)methyl]phenyl]indazol-5-yl]oxy-1-phenylpropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC=CC=1)C(C=C1C=N2)=CC=C1N2C1=CC=CC(CN(C)C)=C1 NIKKERZGOSHRSJ-BVZFJXPGSA-N 0.000 claims 1
- UOSGTNPTWNYWGF-GKVSMKOHSA-N n-[(1r,2s)-1-[4-(ethylsulfanylmethyl)phenyl]-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2,2,2-trifluoroacetamide Chemical compound C1=CC(CSCC)=CC=C1[C@H]([C@H](C)NC(=O)C(F)(F)F)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 UOSGTNPTWNYWGF-GKVSMKOHSA-N 0.000 claims 1
- BHHHDYNUGFIMDX-MYUZEXMDSA-N n-[(1r,2s)-1-[4-(ethylsulfanylmethyl)phenyl]-1-[1-(4-fluorophenyl)indazol-5-yl]oxypropan-2-yl]-2-hydroxyacetamide Chemical compound C1=CC(CSCC)=CC=C1[C@H]([C@H](C)NC(=O)CO)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 BHHHDYNUGFIMDX-MYUZEXMDSA-N 0.000 claims 1
- GAFLJEVTHSEZIF-XMHCIUCPSA-N n-[(1r,2s)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]-2,2,2-trifluoroacetamide Chemical compound O([C@@H]([C@@H](NC(=O)C(F)(F)F)C)C=1C=CC(F)=CC=1)C(C(=CC=12)Cl)=CC=1C=NN2C1=CC=C(F)C=C1 GAFLJEVTHSEZIF-XMHCIUCPSA-N 0.000 claims 1
- MTFVJNGCHVSRJN-HAWMADMCSA-N n-[(1r,2s)-1-[[3-(4-fluorophenyl)-1h-indazol-5-yl]oxy]-1-(3-methoxyphenyl)propan-2-yl]-3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxamide Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C(C=4C=CC(F)=CC=4)=NNC3=CC=2)[C@H](C)NC(=O)C2=C(C=C(S2)C(F)(F)F)O)=C1 MTFVJNGCHVSRJN-HAWMADMCSA-N 0.000 claims 1
- MDZBVUPJXYLDMJ-BVZFJXPGSA-N n-[(1r,2s)-1-phenyl-1-(1-pyridin-3-ylindazol-5-yl)oxypropan-2-yl]furan-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=NC=CC=1)C=1C=CC=CC=1)C(=O)C1=CC=CO1 MDZBVUPJXYLDMJ-BVZFJXPGSA-N 0.000 claims 1
- NVVYDBFOKXFKJQ-BVZFJXPGSA-N n-[(1r,2s)-1-phenyl-1-(1-pyridin-4-ylindazol-5-yl)oxypropan-2-yl]furan-2-carboxamide Chemical compound N([C@@H](C)[C@H](OC=1C=C2C=NN(C2=CC=1)C=1C=CN=CC=1)C=1C=CC=CC=1)C(=O)C1=CC=CO1 NVVYDBFOKXFKJQ-BVZFJXPGSA-N 0.000 claims 1
- YDRQCGICZKAGCQ-PUAOIOHZSA-N n-[(1s,2r)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide Chemical compound C1=NC(OC)=CC=C1[C@@H]([C@@H](C)NC(=O)C1CC1)OC1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 YDRQCGICZKAGCQ-PUAOIOHZSA-N 0.000 claims 1
- YJSZJXGGDUYBNI-XADRRFQNSA-N n-[(2s)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-3-hydroxypropan-2-yl]-2-methoxyacetamide Chemical compound C=1C=CC(F)=CC=1C([C@H](CO)NC(=O)COC)OC(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YJSZJXGGDUYBNI-XADRRFQNSA-N 0.000 claims 1
- LMDAHWZRYQWPOI-AFMDSPMNSA-N n-[(2s,3r)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenylbutan-2-yl]-2,2-dimethylpropanamide Chemical compound C([C@H]([C@@H](NC(=O)C(C)(C)C)C)OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C1=CC=CC=C1 LMDAHWZRYQWPOI-AFMDSPMNSA-N 0.000 claims 1
- QEZTVRKSHNBDSD-BXKMTCNYSA-N n-[(2s,3r)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenylbutan-2-yl]-2-hydroxyacetamide Chemical compound C([C@H]([C@@H](NC(=O)CO)C)OC=1C=C2C=NN(C2=CC=1)C=1C=CC(F)=CC=1)C1=CC=CC=C1 QEZTVRKSHNBDSD-BXKMTCNYSA-N 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- SOWBFZRMHSNYGE-UHFFFAOYSA-M oxamate Chemical compound NC(=O)C([O-])=O SOWBFZRMHSNYGE-UHFFFAOYSA-M 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- RVVYLXHNVPWPLE-QYBDOPJKSA-N tert-butyl 2-[[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]amino]-2-oxoacetate Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C(=O)OC(C)(C)C)=C1 RVVYLXHNVPWPLE-QYBDOPJKSA-N 0.000 claims 1
- OFEDVMNLLWFGGY-CWNJYSJBSA-N tert-butyl 3-[[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]carbamoyl]pyrrolidine-1-carboxylate Chemical compound COC1=CC=CC([C@@H](OC=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)[C@H](C)NC(=O)C2CN(CC2)C(=O)OC(C)(C)C)=C1 OFEDVMNLLWFGGY-CWNJYSJBSA-N 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004971 nitroalkyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
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JO2754B1 (en) * | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
SA109300309B1 (ar) | 2008-05-20 | 2013-01-22 | باير شيرنج فارما ايه جي | مشتقات فينيل وبنزو داي أوكسينيل إندازول بها استبدال |
WO2009142589A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
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WO2010008341A1 (en) * | 2008-07-16 | 2010-01-21 | Astrazeneca Ab | A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
WO2010138421A1 (en) * | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | HEXAHYDROCYCLOPENTYL[f]INDAZOLE REVERSED AMIDES AND DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS |
EP2549875B1 (en) * | 2010-03-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
RU2013153466A (ru) | 2011-06-29 | 2015-08-10 | Астразенека Аб | Кристаллическая форма производных индазолиламида для лечения опосредованных глюкокортикоидными рецепторами расстройств |
MX2016004945A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
CN105636446B (zh) | 2013-10-17 | 2018-07-13 | 美国陶氏益农公司 | 制备杀虫化合物的方法 |
JP2016535010A (ja) | 2013-10-17 | 2016-11-10 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
MX2016004940A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
EP3057430A4 (en) | 2013-10-17 | 2017-09-13 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
KR20160074540A (ko) | 2013-10-17 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
KR20160072155A (ko) | 2013-10-17 | 2016-06-22 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
CN106488909A (zh) | 2014-07-31 | 2017-03-08 | 美国陶氏益农公司 | 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法 |
CA2954747A1 (en) | 2014-07-31 | 2016-02-04 | Dow Agrosciences Lcc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
CA2954631A1 (en) | 2014-07-31 | 2016-02-04 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
CA2958058A1 (en) | 2014-08-19 | 2016-02-25 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
CA2960985A1 (en) | 2014-09-12 | 2016-03-17 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine |
FR3026105B1 (fr) * | 2014-09-24 | 2019-04-19 | Greenpharma | Composition contenant au moins un inhibiteur de certaines chimiokines, son procede d'obtention et son utilisation dermocosmetique ou pharmaceutique |
WO2016046260A1 (en) * | 2014-09-26 | 2016-03-31 | Astrazeneca | 1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as sgrm modulators |
JP6749399B2 (ja) * | 2015-09-15 | 2020-09-02 | レオ ファーマ アクティーゼルスカブ | 局所薬物送達のための非ステロイド性グルココルチコイド受容体モジュレーター |
WO2017161518A1 (en) * | 2016-03-23 | 2017-09-28 | Astrazeneca Ab | New physical form |
US10233155B2 (en) | 2016-12-29 | 2019-03-19 | Dow Agrosciences Llc | Processes for the preparation of pesticide compounds |
US10100033B2 (en) | 2016-12-29 | 2018-10-16 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
EA202091429A1 (ru) | 2017-12-18 | 2020-10-27 | Грюненталь Гмбх | Замещенные амиды i пирролидина |
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