HRP20100635T1 - Polučvrste mukoadhezivne formulacije - Google Patents
Polučvrste mukoadhezivne formulacije Download PDFInfo
- Publication number
- HRP20100635T1 HRP20100635T1 HR20100635T HRP20100635T HRP20100635T1 HR P20100635 T1 HRP20100635 T1 HR P20100635T1 HR 20100635 T HR20100635 T HR 20100635T HR P20100635 T HRP20100635 T HR P20100635T HR P20100635 T1 HRP20100635 T1 HR P20100635T1
- Authority
- HR
- Croatia
- Prior art keywords
- formulation
- amount
- weight
- accordance
- estriol
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 39
- 238000009472 formulation Methods 0.000 title claims abstract 35
- 230000003232 mucoadhesive effect Effects 0.000 title claims abstract 3
- 239000007787 solid Substances 0.000 title claims abstract 3
- 229920000642 polymer Polymers 0.000 claims abstract 11
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims abstract 6
- 229960001348 estriol Drugs 0.000 claims abstract 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract 5
- 230000003472 neutralizing effect Effects 0.000 claims abstract 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract 4
- 229920002125 Sokalan® Polymers 0.000 claims abstract 4
- 239000000227 bioadhesive Substances 0.000 claims abstract 4
- 239000003995 emulsifying agent Substances 0.000 claims abstract 4
- 230000003381 solubilizing effect Effects 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract 3
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 claims abstract 3
- 229940086737 allyl sucrose Drugs 0.000 claims abstract 3
- KUQWZSZYIQGTHT-UHFFFAOYSA-N hexa-1,5-diene-3,4-diol Chemical compound C=CC(O)C(O)C=C KUQWZSZYIQGTHT-UHFFFAOYSA-N 0.000 claims abstract 3
- 230000000887 hydrating effect Effects 0.000 claims abstract 2
- 239000004584 polyacrylic acid Substances 0.000 claims abstract 2
- 239000000080 wetting agent Substances 0.000 claims abstract 2
- -1 methylglucose ether derivatives Chemical class 0.000 claims 5
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000006185 dispersion Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000003755 preservative agent Substances 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 2
- 229920003171 Poly (ethylene oxide) Chemical class 0.000 claims 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 2
- 239000002535 acidifier Substances 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000012153 distilled water Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 230000036571 hydration Effects 0.000 claims 2
- 238000006703 hydration reaction Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- 238000009736 wetting Methods 0.000 claims 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 1
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 206010071018 Urogenital atrophy Diseases 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 238000001879 gelation Methods 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229940075507 glyceryl monostearate Drugs 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 235000010446 mineral oil Nutrition 0.000 claims 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229950005134 polycarbophil Drugs 0.000 claims 1
- 229920000223 polyglycerol Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Adhesive Tapes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200301672A ES2237298B1 (es) | 2003-07-16 | 2003-07-16 | Formulaciones mucoadhesivas semisolidas. |
| PCT/ES2004/000336 WO2005007194A1 (es) | 2003-07-16 | 2004-07-16 | Formulaciones mucoadhesivas semisólidas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100635T1 true HRP20100635T1 (hr) | 2010-12-31 |
Family
ID=34072910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100635T HRP20100635T1 (hr) | 2003-07-16 | 2010-11-24 | Polučvrste mukoadhezivne formulacije |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8663688B2 (sl) |
| EP (2) | EP1652535B1 (sl) |
| JP (1) | JP4891765B2 (sl) |
| AT (1) | ATE482723T1 (sl) |
| CY (1) | CY1110954T1 (sl) |
| DE (1) | DE602004029369D1 (sl) |
| DK (1) | DK1652535T3 (sl) |
| ES (2) | ES2237298B1 (sl) |
| HR (1) | HRP20100635T1 (sl) |
| PL (1) | PL1652535T3 (sl) |
| PT (1) | PT1652535E (sl) |
| SI (1) | SI1652535T1 (sl) |
| WO (1) | WO2005007194A1 (sl) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2237298B1 (es) | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
| EP1667619A4 (en) | 2003-09-19 | 2007-10-10 | Drugtech Corp | PHARMACEUTICAL FEEDING SYSTEM |
| EP1896078A1 (en) * | 2005-06-16 | 2008-03-12 | Warner Chilcott Company, Inc. | Estrogen compositions for vaginal administration |
| WO2006138686A1 (en) * | 2005-06-16 | 2006-12-28 | Warner Chilcott Company, Inc. | Estrogen compositions for vaginal administration |
| EP1898880A2 (en) * | 2005-06-16 | 2008-03-19 | Warner Chilcott Company Inc. | Gel compositions for topical administration |
| MX2008001687A (es) * | 2005-08-12 | 2008-02-19 | Drugtech Corp | Composiciones de estrogenos y metodos terapeuticos de uso. |
| CA2637608A1 (en) * | 2006-01-20 | 2007-07-26 | Pear Tree Pharmaceuticals, Inc. | Method of treating atrophic vaginitis |
| EP2018164B1 (de) | 2006-05-12 | 2017-03-01 | Christian Noe | Verwendung von kombinationspräparaten, umfassend antimykotika |
| WO2007143607A2 (en) * | 2006-06-02 | 2007-12-13 | Pear Tree Women's Health Care | Method of treating atrophic vaginitis |
| WO2008005783A2 (en) * | 2006-06-30 | 2008-01-10 | Drugtech Corporation | Treatment of non- infectious inflammatory vulvovaginitis with a bioadhesive clindamycin composition |
| ES2310968B1 (es) * | 2007-06-25 | 2010-02-08 | Italfarmaco, S.A. | Uso de estriol en bajas dosis. |
| ES2344673B1 (es) * | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
| KR20110043661A (ko) * | 2008-08-12 | 2011-04-27 | 노바베이 파마슈티칼즈, 인코포레이티드 | 항미생물 젤 제형물 |
| BRPI0803568B8 (pt) * | 2008-08-14 | 2021-05-25 | Biolab San Us Farm Ltda | composição mucoaderente |
| ES2344675B1 (es) * | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
| US8834927B2 (en) * | 2010-04-01 | 2014-09-16 | Pharmanest Ab | Thermogelling anaesthetic compositions |
| CN102293735B (zh) * | 2011-08-19 | 2013-05-01 | 辽宁万嘉医药科技有限公司 | 一种抗真菌咪唑类药物缓释凝胶和制备方法 |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| LT2782584T (lt) | 2011-11-23 | 2021-09-10 | Therapeuticsmd, Inc. | Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas |
| CN102600288B (zh) * | 2012-04-20 | 2014-03-05 | 广西源安堂药业有限公司 | 一种治疗阴道炎的复方黄松凝胶药物及其制备方法 |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10045935B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
| KR101358993B1 (ko) | 2012-09-05 | 2014-02-06 | 임혜선 | 네일 프린팅용 트랜스퍼 솔루션 및 이를 이용한 네일 프린팅 방법 |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| AU2015296609A1 (en) | 2014-07-29 | 2016-12-22 | Therapeuticsmd, Inc. | Transdermal cream |
| US20160175271A1 (en) * | 2014-12-19 | 2016-06-23 | Gavis Pharmaceuticals | Rectal suppository for ulcerative colitis |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| JP7055754B2 (ja) * | 2016-01-07 | 2022-04-18 | ヴィラマル リミテッド | 角質層および血清中の薬物濃度を最大にするための経皮送達用ゲル組成物ならびにそれを使用する方法 |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| CA3117842A1 (en) | 2018-10-26 | 2020-04-30 | Viramal Limited | Mucoadhesive gel composition |
| EP3659583B1 (en) | 2018-11-30 | 2023-06-07 | Viramal Limited | A method of preparing a gelling agent, the gelling agent obtained thereby, and the use of said gelling agent |
| CN110151680A (zh) * | 2019-04-10 | 2019-08-23 | 重庆医药高等专科学校 | 雌三醇凝胶产品及制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU565354B2 (en) | 1983-11-14 | 1987-09-10 | Bio-Mimetics Inc. | Bioadhesive compositions and methods of treatment therewith |
| NZ222698A (en) | 1987-01-08 | 1990-02-26 | Squibb & Sons Inc | Bioadhesive suppository formulations comprising a medicament, water, a hydrocolloid and low melting point base |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| JP2510052B2 (ja) | 1989-10-31 | 1996-06-26 | コロンビア ラボラトリーズ インコーポレイテッド | 組織与湿組成物及び方法 |
| EP0431719B1 (en) | 1989-10-31 | 1994-11-09 | Columbia Laboratories, Inc. | Vaginal tissue moisturizing composition |
| US5543150A (en) * | 1993-09-15 | 1996-08-06 | Columbia Laboratories, Inc. | Method of progesterone delivery and affect thereof |
| US5667492A (en) | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| AT408067B (de) * | 1995-03-17 | 2001-08-27 | Gebro Pharma Gmbh | Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung |
| US5741525A (en) | 1995-10-24 | 1998-04-21 | Marshall University Research Corporation | Vaginal pharmaceutical hydrogen peroxide composition |
| AU714797B2 (en) | 1996-06-14 | 2000-01-13 | Mcneil-Ppc, Inc. | Moisture containing compositions that are spreadable onto and adherable to biomembranes, methods of making and use thereof |
| IT1284874B1 (it) | 1996-08-02 | 1998-05-22 | Farmigea Spa | Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici |
| US5942243A (en) | 1996-11-12 | 1999-08-24 | Polytherapeutics, Inc. | Mucoadhesive compositions for administration of biologically active agents to animal tissue |
| CA2271843A1 (en) | 1996-11-14 | 1998-05-22 | Lipomedica Ehf. | Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections |
| DE69819748T2 (de) | 1997-09-12 | 2004-09-30 | Columbia Laboratories (Bermuda) Ltd. | Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen |
| US6159491A (en) | 1999-02-12 | 2000-12-12 | Biovector Technologies, Inc. | Prolonged release bioadhesive vaginal gel dosage form |
| AU4673099A (en) | 1999-02-26 | 2000-09-14 | Chiron Corporation | Use of bioadhesives and adjuvants for the mucosal delivery of antigens |
| SE522260C2 (sv) | 1999-10-01 | 2004-01-27 | Ericsson Telefon Ab L M | Metod, system och säkerhetsadapter för att exekvera säker dataöverföring i ett trådlöst nät |
| UA74168C2 (uk) | 1999-10-05 | 2005-11-15 | Коламбіа Леборетеріс (Бермуда) Лімітед | Лікування ендометріозу або безпліддя, або покращення плідності та застосування бета-адренергічного агоніста для виробництва лікарського засобу |
| WO2001028515A1 (en) * | 1999-10-22 | 2001-04-26 | Líf-Hlaup ehf. Bio-Gels Pharmaceuticals Inc. | Pharmaceutical composition for treatment of mucosal epithelial ulceration and/or erosion |
| AR030312A1 (es) * | 2000-08-03 | 2003-08-20 | Antares Pharma Ipl Ag | Composicion novedosa para la administracion transdermica y/o transmucosica de compuestos activos, que asegura adecuados niveles terapeuticos |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US7709026B2 (en) * | 2001-10-29 | 2010-05-04 | Columbia Laboratories, Inc. | Low concentration of peroxide for treating or preventing vaginal infections |
| US6967194B1 (en) * | 2002-09-18 | 2005-11-22 | Susan Matsuo | Bio-identical hormones and method of use |
| ES2237298B1 (es) | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
-
2003
- 2003-07-16 ES ES200301672A patent/ES2237298B1/es not_active Expired - Fee Related
-
2004
- 2004-07-16 SI SI200431522T patent/SI1652535T1/sl unknown
- 2004-07-16 EP EP04742064A patent/EP1652535B1/en not_active Expired - Lifetime
- 2004-07-16 ES ES04742064T patent/ES2353694T3/es not_active Expired - Lifetime
- 2004-07-16 DE DE602004029369T patent/DE602004029369D1/de not_active Expired - Lifetime
- 2004-07-16 EP EP09161078A patent/EP2100612A3/en not_active Withdrawn
- 2004-07-16 DK DK04742064.1T patent/DK1652535T3/da active
- 2004-07-16 JP JP2006519939A patent/JP4891765B2/ja not_active Expired - Lifetime
- 2004-07-16 AT AT04742064T patent/ATE482723T1/de active
- 2004-07-16 WO PCT/ES2004/000336 patent/WO2005007194A1/es active Application Filing
- 2004-07-16 PL PL04742064T patent/PL1652535T3/pl unknown
- 2004-07-16 US US10/565,062 patent/US8663688B2/en active Active
- 2004-07-16 PT PT04742064T patent/PT1652535E/pt unknown
-
2010
- 2010-11-24 HR HR20100635T patent/HRP20100635T1/hr unknown
- 2010-11-25 CY CY20101101079T patent/CY1110954T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2237298A1 (es) | 2005-07-16 |
| ES2237298B1 (es) | 2006-11-01 |
| DK1652535T3 (da) | 2010-11-15 |
| US8663688B2 (en) | 2014-03-04 |
| ATE482723T1 (de) | 2010-10-15 |
| SI1652535T1 (sl) | 2010-12-31 |
| ES2353694T3 (es) | 2011-03-04 |
| PT1652535E (pt) | 2010-11-18 |
| JP4891765B2 (ja) | 2012-03-07 |
| JP2007528864A (ja) | 2007-10-18 |
| WO2005007194A1 (es) | 2005-01-27 |
| EP1652535A1 (en) | 2006-05-03 |
| EP2100612A3 (en) | 2010-06-02 |
| EP2100612A2 (en) | 2009-09-16 |
| CY1110954T1 (el) | 2015-06-11 |
| PL1652535T3 (pl) | 2011-03-31 |
| DE602004029369D1 (de) | 2010-11-11 |
| EP1652535B1 (en) | 2010-09-29 |
| US20060240111A1 (en) | 2006-10-26 |
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