HRP20030576B1 - Lithium complexes of n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof - Google Patents

Lithium complexes of n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof

Info

Publication number
HRP20030576B1
HRP20030576B1 HR20030576A HRP20030576A HRP20030576B1 HR P20030576 B1 HRP20030576 B1 HR P20030576B1 HR 20030576 A HR20030576 A HR 20030576A HR P20030576 A HRP20030576 A HR P20030576A HR P20030576 B1 HRP20030576 B1 HR P20030576B1
Authority
HR
Croatia
Prior art keywords
triscarboxymethyl
tetraazacyclododecane
dihydroxypropyl
hydroxymethyl
production
Prior art date
Application number
HR20030576A
Other languages
English (en)
Croatian (hr)
Inventor
Platzek Johannes
Blaskiewicz Peter
Petrov Orlin
Hoffmann Holger
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of HRP20030576A2 publication Critical patent/HRP20030576A2/hr
Publication of HRP20030576B1 publication Critical patent/HRP20030576B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20030576A 2000-12-15 2003-07-15 Lithium complexes of n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof HRP20030576B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (de) 2000-12-15 2001-12-05 Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung

Publications (2)

Publication Number Publication Date
HRP20030576A2 HRP20030576A2 (en) 2005-06-30
HRP20030576B1 true HRP20030576B1 (en) 2011-09-30

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030576A HRP20030576B1 (en) 2000-12-15 2003-07-15 Lithium complexes of n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof

Country Status (35)

Country Link
US (1) US6894151B2 (bg)
EP (1) EP1343770B1 (bg)
JP (1) JP4399163B2 (bg)
KR (1) KR100869627B1 (bg)
CN (1) CN1229357C (bg)
AR (1) AR035609A1 (bg)
AT (1) ATE430737T1 (bg)
AU (2) AU3165902A (bg)
BG (1) BG66117B1 (bg)
BR (1) BR0116219A (bg)
CA (1) CA2431976C (bg)
CY (1) CY1109280T1 (bg)
CZ (1) CZ304573B6 (bg)
DE (2) DE10064467C2 (bg)
DK (1) DK1343770T3 (bg)
EC (1) ECSP034676A (bg)
EE (1) EE05245B1 (bg)
ES (1) ES2325982T3 (bg)
HK (1) HK1064098A1 (bg)
HR (1) HRP20030576B1 (bg)
HU (1) HU229657B1 (bg)
IL (1) IL156432A0 (bg)
ME (1) ME00157B (bg)
MX (1) MXPA03005240A (bg)
NO (1) NO324864B1 (bg)
NZ (1) NZ526478A (bg)
PL (1) PL204181B1 (bg)
PT (1) PT1343770E (bg)
RS (1) RS51862B (bg)
RU (1) RU2003120513A (bg)
SK (1) SK287424B6 (bg)
TW (1) TWI302531B (bg)
UY (1) UY27056A1 (bg)
WO (1) WO2002048119A2 (bg)
ZA (1) ZA200305421B (bg)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007521254A (ja) * 2003-06-25 2007-08-02 ゲルベ 診断画像用化合物
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
WO2006002875A1 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
JP5518465B2 (ja) 2006-03-14 2014-06-11 マリンクロッド エルエルシー テトラアザ大員環誘導体の金属錯体
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
KR102003570B1 (ko) * 2011-04-21 2019-07-24 바이엘 인텔렉쳐 프로퍼티 게엠베하 고순도 가도부트롤의 제조
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448191A1 (de) * 1990-03-19 1991-09-25 Schering Aktiengesellschaft 1,4,7,10-Tetraazacyclododecan-butyltriole, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
WO1998055467A1 (de) * 1997-06-02 1998-12-10 Schering Aktiengesellschaft Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448191A1 (de) * 1990-03-19 1991-09-25 Schering Aktiengesellschaft 1,4,7,10-Tetraazacyclododecan-butyltriole, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
WO1998055467A1 (de) * 1997-06-02 1998-12-10 Schering Aktiengesellschaft Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen

Also Published As

Publication number Publication date
TWI302531B (en) 2008-11-01
BG66117B1 (bg) 2011-05-31
IL156432A0 (en) 2004-01-04
ZA200305421B (en) 2004-08-27
ATE430737T1 (de) 2009-05-15
BG107901A (bg) 2004-06-30
KR20030077555A (ko) 2003-10-01
MEP15708A (en) 2010-06-10
NO20032523L (no) 2003-06-04
WO2002048119A2 (de) 2002-06-20
NO324864B1 (no) 2007-12-17
PL366141A1 (en) 2005-01-24
RS51862B (sr) 2012-02-29
NO20032523D0 (no) 2003-06-04
US20020128472A1 (en) 2002-09-12
US6894151B2 (en) 2005-05-17
HUP0302563A3 (en) 2011-04-28
RU2003120513A (ru) 2004-12-27
CA2431976C (en) 2010-04-13
CZ304573B6 (cs) 2014-07-16
HU229657B1 (en) 2014-03-28
HRP20030576A2 (en) 2005-06-30
DE10064467A1 (de) 2002-07-11
MXPA03005240A (es) 2003-09-25
PT1343770E (pt) 2009-07-20
EE05245B1 (et) 2009-12-15
JP2004515545A (ja) 2004-05-27
EP1343770A2 (de) 2003-09-17
ME00157B (me) 2010-10-10
AU2002231659B2 (en) 2007-07-05
DK1343770T3 (da) 2009-08-10
KR100869627B1 (ko) 2008-11-21
BR0116219A (pt) 2006-02-21
JP4399163B2 (ja) 2010-01-13
EP1343770B1 (de) 2009-05-06
UY27056A1 (es) 2002-07-31
AU3165902A (en) 2002-06-24
NZ526478A (en) 2006-04-28
ECSP034676A (es) 2003-08-29
HK1064098A1 (en) 2005-01-21
CN1229357C (zh) 2005-11-30
WO2002048119A3 (de) 2002-11-07
CZ20031641A3 (cs) 2003-09-17
HUP0302563A2 (hu) 2003-12-29
DE50114889D1 (de) 2009-06-18
DE10064467C2 (de) 2002-10-31
CY1109280T1 (el) 2014-07-02
AR035609A1 (es) 2004-06-16
PL204181B1 (pl) 2009-12-31
SK287424B6 (sk) 2010-09-07
YU48103A (sh) 2006-05-25
CN1481371A (zh) 2004-03-10
CA2431976A1 (en) 2002-06-20
EE200300282A (et) 2003-10-15
ES2325982T3 (es) 2009-09-28
SK7292003A3 (en) 2003-11-04

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