HUP0300198A2 - Tiokolkicin és bakkatin kondenzációs származékai és ilyen vegyületeket tartalmazó, tumor elleni hatású gyógyászati készítmények - Google Patents
Tiokolkicin és bakkatin kondenzációs származékai és ilyen vegyületeket tartalmazó, tumor elleni hatású gyógyászati készítményekInfo
- Publication number
- HUP0300198A2 HUP0300198A2 HU0300198A HUP0300198A HUP0300198A2 HU P0300198 A2 HUP0300198 A2 HU P0300198A2 HU 0300198 A HU0300198 A HU 0300198A HU P0300198 A HUP0300198 A HU P0300198A HU P0300198 A2 HUP0300198 A2 HU P0300198A2
- Authority
- HU
- Hungary
- Prior art keywords
- thiocolchicine
- baccatin
- antitumor agents
- derivatives
- general formula
- Prior art date
Links
- 229930190007 Baccatin Natural products 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 230000005494 condensation Effects 0.000 title 1
- 238000009833 condensation Methods 0.000 title 1
- CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 title 1
- NUNCOHUMTCDISK-AWEZNQCLSA-N (7s)-7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5h-benzo[a]heptalen-9-one Chemical class C1([C@@H](N)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC NUNCOHUMTCDISK-AWEZNQCLSA-N 0.000 abstract 1
- YWLXLRUDGLRYDR-SKXCCXORSA-N 10-dab iii Chemical class O([C@H]1C2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-SKXCCXORSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány az (I) általános képletű N-dezacetil-tiokolkicin-származékokra és 10-dezacetil-bakkatin III származékokra vonatkozik.Az (I) általános képletben n értéke 0 és 8 közötti egész szám; Rjelentése a), b), c), d) vagy e) képletű csoport, és az utóbbiképletekben R1 és R2 egymástól függetlenül hidrogénatomot vagy (II)képletű csoportot jelentenek. A találmány szerinti (I) általánosképletű vegyületek antiproliferativ hatásúak, így felhasználhatóktumor elleni hatású gyógyászati készítmények hatóanyagaiként. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000553A IT1319168B1 (it) | 2000-03-17 | 2000-03-17 | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
| PCT/EP2001/002740 WO2001068089A1 (en) | 2000-03-17 | 2001-03-12 | Condensation derivatives of thiocolchicine and baccatin as antitumor agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0300198A2 true HUP0300198A2 (hu) | 2003-06-28 |
| HUP0300198A3 HUP0300198A3 (en) | 2005-02-28 |
| HU229257B1 HU229257B1 (en) | 2013-10-28 |
Family
ID=11444500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300198A HU229257B1 (en) | 2000-03-17 | 2001-03-12 | Condensation derivatives of thiocolchicine and baccatin as antitumor agents |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6683109B2 (hu) |
| EP (1) | EP1263431B1 (hu) |
| JP (1) | JP2003526665A (hu) |
| KR (1) | KR100766161B1 (hu) |
| CN (1) | CN1204886C (hu) |
| AU (2) | AU5037701A (hu) |
| CA (1) | CA2403168C (hu) |
| CZ (1) | CZ301626B6 (hu) |
| DK (1) | DK1263431T3 (hu) |
| ES (1) | ES2305067T3 (hu) |
| HK (1) | HK1051973A1 (hu) |
| HU (1) | HU229257B1 (hu) |
| IL (1) | IL151714A0 (hu) |
| IT (1) | IT1319168B1 (hu) |
| NO (1) | NO329422B1 (hu) |
| PL (1) | PL357376A1 (hu) |
| PT (1) | PT1263431E (hu) |
| RU (1) | RU2264393C2 (hu) |
| SI (1) | SI1263431T1 (hu) |
| SK (1) | SK286849B6 (hu) |
| WO (1) | WO2001068089A1 (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR030188A1 (es) | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| US6825236B2 (en) * | 2003-04-14 | 2004-11-30 | California Pacific Medical Center | Colchicine derivatives |
| HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| WO2005087222A1 (en) | 2004-03-05 | 2005-09-22 | Florida State University Research Foundation, Inc. | C7 lactyloxy-substituted taxanes |
| JP2011517455A (ja) | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
| AU2400692A (en) * | 1991-07-19 | 1993-02-23 | Hybritech Incorporated | Trifunctional compounds having specificity for multi-drug resistant cells |
| WO1993011120A1 (en) * | 1991-11-27 | 1993-06-10 | Zynaxis Technologies, Incorporated | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles |
| US5426224A (en) * | 1993-03-18 | 1995-06-20 | The University Of North Carolina At Chapel Hill | Mammalian DNA topoisomerase II inhibitor and method |
| WO1997024459A1 (en) * | 1995-12-29 | 1997-07-10 | Phanos Technologoes, Inc. | Method for reducing unwanted cellular adhesions |
| NZ332475A (en) * | 1996-05-08 | 2000-05-26 | Upjohn Co | silylated baccatin derivatives, 3-(substituted amino)-3-phenyl-(2R,3S)-isoserinate derivatives, the oxazolidine ester thereof and other immediates used to prepare baccatin derivatives |
-
2000
- 2000-03-17 IT IT2000MI000553A patent/IT1319168B1/it active
-
2001
- 2001-03-12 PL PL01357376A patent/PL357376A1/xx not_active Application Discontinuation
- 2001-03-12 CA CA2403168A patent/CA2403168C/en not_active Expired - Fee Related
- 2001-03-12 IL IL15171401A patent/IL151714A0/xx not_active IP Right Cessation
- 2001-03-12 WO PCT/EP2001/002740 patent/WO2001068089A1/en active IP Right Grant
- 2001-03-12 SK SK1311-2002A patent/SK286849B6/sk not_active IP Right Cessation
- 2001-03-12 AU AU5037701A patent/AU5037701A/xx active Pending
- 2001-03-12 HU HU0300198A patent/HU229257B1/hu not_active IP Right Cessation
- 2001-03-12 SI SI200130838T patent/SI1263431T1/sl unknown
- 2001-03-12 KR KR1020027011946A patent/KR100766161B1/ko not_active IP Right Cessation
- 2001-03-12 CZ CZ20023084A patent/CZ301626B6/cs not_active IP Right Cessation
- 2001-03-12 JP JP2001566653A patent/JP2003526665A/ja active Pending
- 2001-03-12 ES ES01923660T patent/ES2305067T3/es not_active Expired - Lifetime
- 2001-03-12 RU RU2002124523/04A patent/RU2264393C2/ru not_active IP Right Cessation
- 2001-03-12 PT PT01923660T patent/PT1263431E/pt unknown
- 2001-03-12 AU AU2001250377A patent/AU2001250377B2/en not_active Ceased
- 2001-03-12 DK DK01923660T patent/DK1263431T3/da active
- 2001-03-12 EP EP01923660A patent/EP1263431B1/en not_active Expired - Lifetime
- 2001-03-12 CN CNB018064434A patent/CN1204886C/zh not_active Expired - Fee Related
-
2002
- 2002-08-02 US US10/210,134 patent/US6683109B2/en not_active Expired - Fee Related
- 2002-09-12 NO NO20024353A patent/NO329422B1/no not_active IP Right Cessation
-
2003
- 2003-06-16 HK HK03104269A patent/HK1051973A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |