SK286849B6 - Kondenzačné deriváty tiokolchicínu a bakatínu, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Kondenzačné deriváty tiokolchicínu a bakatínu, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

Info

Publication number
SK286849B6
SK286849B6 SK1311-2002A SK13112002A SK286849B6 SK 286849 B6 SK286849 B6 SK 286849B6 SK 13112002 A SK13112002 A SK 13112002A SK 286849 B6 SK286849 B6 SK 286849B6
Authority
SK
Slovakia
Prior art keywords
formula
thiocolchicine
baccatin
mmol
compounds
Prior art date
Application number
SK1311-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK13112002A3 (sk
Inventor
Ezio Bombardelli
Alessandro Pontiroli
Original Assignee
Indena S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A. filed Critical Indena S.P.A.
Publication of SK13112002A3 publication Critical patent/SK13112002A3/sk
Publication of SK286849B6 publication Critical patent/SK286849B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1311-2002A 2000-03-17 2001-03-12 Kondenzačné deriváty tiokolchicínu a bakatínu, farmaceutický prostriedok s ich obsahom a ich použitie SK286849B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI000553A IT1319168B1 (it) 2000-03-17 2000-03-17 Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
PCT/EP2001/002740 WO2001068089A1 (en) 2000-03-17 2001-03-12 Condensation derivatives of thiocolchicine and baccatin as antitumor agents

Publications (2)

Publication Number Publication Date
SK13112002A3 SK13112002A3 (sk) 2003-02-04
SK286849B6 true SK286849B6 (sk) 2009-06-05

Family

ID=11444500

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1311-2002A SK286849B6 (sk) 2000-03-17 2001-03-12 Kondenzačné deriváty tiokolchicínu a bakatínu, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (21)

Country Link
US (1) US6683109B2 (hu)
EP (1) EP1263431B1 (hu)
JP (1) JP2003526665A (hu)
KR (1) KR100766161B1 (hu)
CN (1) CN1204886C (hu)
AU (2) AU5037701A (hu)
CA (1) CA2403168C (hu)
CZ (1) CZ301626B6 (hu)
DK (1) DK1263431T3 (hu)
ES (1) ES2305067T3 (hu)
HK (1) HK1051973A1 (hu)
HU (1) HU229257B1 (hu)
IL (1) IL151714A0 (hu)
IT (1) IT1319168B1 (hu)
NO (1) NO329422B1 (hu)
PL (1) PL357376A1 (hu)
PT (1) PT1263431E (hu)
RU (1) RU2264393C2 (hu)
SI (1) SI1263431T1 (hu)
SK (1) SK286849B6 (hu)
WO (1) WO2001068089A1 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
CA2354471A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C10 ester substituted taxanes
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
JP2011517455A (ja) 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
CA2113578A1 (en) * 1991-07-19 1993-02-04 Ann E. Huang Trifunctional compounds having specificity for multi-drug resistant cells
AU3221993A (en) * 1991-11-27 1993-06-28 Phanos Technologies, Inc. Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
US5426224A (en) * 1993-03-18 1995-06-20 The University Of North Carolina At Chapel Hill Mammalian DNA topoisomerase II inhibitor and method
WO1997024459A1 (en) * 1995-12-29 1997-07-10 Phanos Technologoes, Inc. Method for reducing unwanted cellular adhesions
CZ293508B6 (cs) * 1996-05-08 2004-05-12 Pharmaciaá@Áupjohnácompany Fenylisoserinestery silylového baccatinu III

Also Published As

Publication number Publication date
NO329422B1 (no) 2010-10-18
US20030073734A1 (en) 2003-04-17
KR100766161B1 (ko) 2007-10-10
HK1051973A1 (en) 2003-08-29
HU229257B1 (en) 2013-10-28
IT1319168B1 (it) 2003-09-26
IL151714A0 (en) 2003-04-10
CZ301626B6 (cs) 2010-05-05
HUP0300198A2 (hu) 2003-06-28
HUP0300198A3 (en) 2005-02-28
JP2003526665A (ja) 2003-09-09
PT1263431E (pt) 2008-08-04
AU2001250377B2 (en) 2004-09-16
EP1263431B1 (en) 2008-05-28
CN1204886C (zh) 2005-06-08
EP1263431A1 (en) 2002-12-11
SK13112002A3 (sk) 2003-02-04
CN1416342A (zh) 2003-05-07
ES2305067T3 (es) 2008-11-01
RU2264393C2 (ru) 2005-11-20
ITMI20000553A0 (it) 2000-03-17
NO20024353D0 (no) 2002-09-12
NO20024353L (no) 2002-09-12
ITMI20000553A1 (it) 2001-09-17
RU2002124523A (ru) 2004-01-10
WO2001068089A1 (en) 2001-09-20
CA2403168C (en) 2010-06-15
CA2403168A1 (en) 2001-09-20
AU5037701A (en) 2001-09-24
DK1263431T3 (da) 2008-09-29
KR20020081432A (ko) 2002-10-26
US6683109B2 (en) 2004-01-27
PL357376A1 (en) 2004-07-26
SI1263431T1 (sl) 2008-08-31

Similar Documents

Publication Publication Date Title
EP0559018B1 (en) Taxane derivatives, their preparation and use in oncology
SK10097A3 (en) Semi-synthetic taxane, preparation method and use thereof, intermediate product, pharmaceutical composition containing same
KR100388877B1 (ko) 10-데아세틸바카틴Ⅲ과10-데아세틸-14β-하이드록시바카틴Ⅲ 유도체, 그들의제조 방법 및 그들을 함유한 약제학적 조성물
CN114591201A (zh) 具有HDACi药效团的β-榄香烯衍生物及其制备方法和应用
SK286849B6 (sk) Kondenzačné deriváty tiokolchicínu a bakatínu, farmaceutický prostriedok s ich obsahom a ich použitie
EP0784613B1 (en) Colchicine derivatives and the therapeutical use thereof
CA2403110C (en) N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them
AU2001250377A1 (en) Condensation derivatives of thiocolchicine and baccatin as antitumor agents
ES2336010T3 (es) Derivados de n-desacetiltiocolchicina, su uso y formulaciones farmaceuticas que los contienen.
AU2001248341A1 (en) N-deacetylthiocolchicine derivatives and pharmaceutical compositions containing them
JP2003520792A (ja) 抗腫瘍活性及び抗脈管形成活性を有する半合成タキサン類

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20150312