HRP20030527A2 - Pharmaceutical compositions comprising amlodipinemaleate - Google Patents
Pharmaceutical compositions comprising amlodipinemaleate Download PDFInfo
- Publication number
- HRP20030527A2 HRP20030527A2 HR20030527A HRP20030527A HRP20030527A2 HR P20030527 A2 HRP20030527 A2 HR P20030527A2 HR 20030527 A HR20030527 A HR 20030527A HR P20030527 A HRP20030527 A HR P20030527A HR P20030527 A2 HRP20030527 A2 HR P20030527A2
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- mixture
- amlodipine
- amlodipine maleate
- preparation according
- Prior art date
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- 229960000528 amlodipine Drugs 0.000 title claims description 88
- TZNOWAJJWCGILX-BTJKTKAUSA-N (z)-but-2-enedioic acid;3-o-ethyl 5-o-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound OC(=O)\C=C/C(O)=O.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl TZNOWAJJWCGILX-BTJKTKAUSA-N 0.000 title claims description 60
- 239000008194 pharmaceutical composition Substances 0.000 title description 11
- 239000000203 mixture Substances 0.000 claims description 59
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 43
- 238000002360 preparation method Methods 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 34
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims description 23
- 239000002775 capsule Substances 0.000 claims description 19
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 18
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 18
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 18
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 18
- 239000001506 calcium phosphate Substances 0.000 claims description 15
- 235000011010 calcium phosphates Nutrition 0.000 claims description 15
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 13
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 13
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 206010002383 Angina Pectoris Diseases 0.000 claims description 11
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical group [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 11
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 206010020772 Hypertension Diseases 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 206010019280 Heart failures Diseases 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 3
- 239000003002 pH adjusting agent Substances 0.000 claims description 3
- 238000005550 wet granulation Methods 0.000 claims description 3
- 239000004909 Moisturizer Substances 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 39
- 239000003826 tablet Substances 0.000 description 38
- 235000019359 magnesium stearate Nutrition 0.000 description 24
- 239000000243 solution Substances 0.000 description 17
- 239000000843 powder Substances 0.000 description 14
- 229920002472 Starch Polymers 0.000 description 11
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 description 11
- 239000008107 starch Substances 0.000 description 11
- 229940032147 starch Drugs 0.000 description 11
- 235000019698 starch Nutrition 0.000 description 11
- 229960004005 amlodipine besylate Drugs 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 229940023144 sodium glycolate Drugs 0.000 description 10
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 10
- 235000013312 flour Nutrition 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 239000012535 impurity Substances 0.000 description 8
- OWGHROPUZICLBA-DJZRFWRSSA-N (2s)-2-[2-[[4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin-2-yl]methoxy]ethylamino]butanedioic acid Chemical compound CCOC(=O)C1=C(COCCN[C@@H](CC(O)=O)C(O)=O)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl OWGHROPUZICLBA-DJZRFWRSSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000006731 degradation reaction Methods 0.000 description 6
- 239000000454 talc Substances 0.000 description 6
- 229910052623 talc Inorganic materials 0.000 description 6
- 239000003085 diluting agent Substances 0.000 description 5
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical group OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000007903 gelatin capsule Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 229920001903 high density polyethylene Polymers 0.000 description 4
- 239000004700 high-density polyethylene Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 239000000395 magnesium oxide Substances 0.000 description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 3
- 239000011976 maleic acid Substances 0.000 description 3
- 229940036132 norvasc Drugs 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 239000005033 polyvinylidene chloride Substances 0.000 description 3
- 239000007909 solid dosage form Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000000480 calcium channel blocker Substances 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 150000002688 maleic acid derivatives Chemical class 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- HTIQEAQVCYTUBX-KRWDZBQOSA-N (S)-amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-KRWDZBQOSA-N 0.000 description 1
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 description 1
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000006845 Michael addition reaction Methods 0.000 description 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 1
- 201000001068 Prinzmetal angina Diseases 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- 208000009325 Variant Angina Pectoris Diseases 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000004004 anti-anginal agent Substances 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 229940124345 antianginal agent Drugs 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 229960005370 atorvastatin Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960004530 benazepril Drugs 0.000 description 1
- 229960003619 benazepril hydrochloride Drugs 0.000 description 1
- VPSRQEHTHIMDQM-FKLPMGAJSA-N benazepril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 VPSRQEHTHIMDQM-FKLPMGAJSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940085304 dihydropyridine derivative selective calcium channel blockers with mainly vascular effects Drugs 0.000 description 1
- 125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960004844 lovastatin Drugs 0.000 description 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25856200P | 2000-12-29 | 2000-12-29 | |
| US80934601A | 2001-03-16 | 2001-03-16 | |
| AT0063401U AT5874U1 (de) | 2000-12-29 | 2001-08-09 | Pharmazeutische zubereitungen enthaltend amlodipinmaleat |
| PCT/NL2001/000606 WO2002053134A1 (en) | 2000-12-29 | 2001-08-15 | Pharmaceutical compositions comprising amlodipine maleate |
| BE2001/0706A BE1014449A6 (nl) | 2000-12-29 | 2001-11-05 | Farmaceutische verbindingen omvattende amlodipine maleaat. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20030527A2 true HRP20030527A2 (en) | 2005-06-30 |
Family
ID=29740874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030527A HRP20030527A2 (en) | 2000-12-29 | 2003-06-27 | Pharmaceutical compositions comprising amlodipinemaleate |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6919087B2 (xx) |
| EP (1) | EP1309317B1 (xx) |
| CN (1) | CN1268322C (xx) |
| AP (1) | AP2003002819A0 (xx) |
| AT (3) | AT5874U1 (xx) |
| AU (1) | AU2001290354B2 (xx) |
| BE (1) | BE1014449A6 (xx) |
| BR (1) | BR0116556A (xx) |
| CA (1) | CA2433035C (xx) |
| DE (2) | DE60118008T2 (xx) |
| DK (3) | DK1309317T3 (xx) |
| EA (1) | EA008101B1 (xx) |
| ES (1) | ES2258549T3 (xx) |
| FI (1) | FI6787U1 (xx) |
| HK (2) | HK1055904A1 (xx) |
| HR (1) | HRP20030527A2 (xx) |
| IL (1) | IL156691A0 (xx) |
| IS (1) | IS6833A (xx) |
| MA (1) | MA26968A1 (xx) |
| MX (1) | MXPA03005883A (xx) |
| NO (1) | NO20032517L (xx) |
| NZ (1) | NZ526505A (xx) |
| PL (1) | PL362668A1 (xx) |
| PT (1) | PT1309317E (xx) |
| RS (1) | RS53303A (xx) |
| UA (1) | UA78500C2 (xx) |
| WO (1) | WO2002053134A1 (xx) |
Families Citing this family (31)
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| GB2372036B (en) * | 2000-12-29 | 2004-05-19 | Bioorg Bv | Aspartate derivative of amlodipine |
| WO2002054062A2 (en) * | 2000-12-29 | 2002-07-11 | Pfizer Limited | Reference standards and processes for determining the purity or stability of amlodipine maleate |
| US20030027848A1 (en) * | 2001-06-15 | 2003-02-06 | Anne Billotte | Stabilized formulations |
| GB0114709D0 (en) * | 2001-06-15 | 2001-08-08 | Pfizer Ltd | Stabilised formulations of amlodipine maleate |
| WO2003032954A1 (en) * | 2001-10-17 | 2003-04-24 | Dr. Reddy's Laboratories Ltd. | Stabilized pharmaceutical formulations containing amlodipine maleate |
| US20030180354A1 (en) * | 2001-10-17 | 2003-09-25 | Dr. Reddy's Laboratories Limited | Amlodipine maleate formulations |
| US20030153617A1 (en) * | 2001-12-18 | 2003-08-14 | Dalen Frans Van | Simvastatin dosage forms |
| US20040072879A1 (en) * | 2002-10-10 | 2004-04-15 | Dr. Reddy's Laboratories Limited | Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine) |
| ES2263754T3 (es) * | 2002-12-31 | 2006-12-16 | Cimex Pharma Ag | Granulo estable y facil de procesar, en forma de amlodipina maleato. |
| CA2559670A1 (en) * | 2003-04-14 | 2004-10-28 | Gabor Pragai | Stable amlodipine maleate formulations |
| KR100604034B1 (ko) * | 2003-10-08 | 2006-07-24 | 주식회사유한양행 | 암로디핀 유리염기를 함유한 구강 속붕해정 및 그의 조성물 |
| CN103083318A (zh) * | 2004-11-05 | 2013-05-08 | 贝林格尔.英格海姆国际有限公司 | 包含替米沙坦和氨氯地平的双层片剂 |
| EP1833466A1 (en) * | 2004-12-28 | 2007-09-19 | Ranbaxy Laboratories Limited | Methods for the preparation of stable pharmaceutical solid dosage forms of atorvastatin and amlodipine |
| KR100825039B1 (ko) | 2005-01-21 | 2008-04-24 | 대원제약주식회사 | 안정성이 개선된 암로디핀 말레이트염 정제 |
| BRPI0607791A2 (pt) * | 2005-03-15 | 2010-03-23 | Lupin Ltd | composiÇÕes farmacÊuticas de amlodipina e benazepril |
| WO2007020079A2 (en) * | 2005-08-17 | 2007-02-22 | Synthon B.V. | Orally disintegratable simvastatin tablets |
| US8158146B2 (en) * | 2005-09-28 | 2012-04-17 | Teva Pharmaceutical Industries Ltd. | Stable combinations of amlodipine besylate and benazepril hydrochloride |
| WO2007040511A1 (en) * | 2005-09-28 | 2007-04-12 | Teva Pharmaceutical Industries Ltd. | Stable combinations of amlodipine besylate and benazepril hydrochloride |
| ES2303198T3 (es) * | 2005-09-28 | 2008-08-01 | Teva Pharmaceutical Industries Ltd. | Combinaciones estables de besilato de amlodipina e hidrocloruro de benazeprilo. |
| KR100689862B1 (ko) | 2005-10-04 | 2007-03-09 | 삼익제약주식회사 | 말레인산암로디핀을 포함하는 조성물 및 그의 제조 방법 |
| KR100795313B1 (ko) | 2006-09-05 | 2008-01-21 | 현대약품 주식회사 | 암로디핀 베실레이트를 포함하는 약학 조성물 |
| CN101161241B (zh) * | 2006-10-10 | 2010-05-26 | 扬子江药业集团上海海尼药业有限公司 | 苯磺酸氨氯地平片的制备工艺 |
| WO2008065485A2 (en) * | 2006-10-19 | 2008-06-05 | Torrent Pharmaceuticals Limited | Stable pharmaceutical compositions of a calcium channel blocker and an ace inhibitor |
| SG177924A1 (en) * | 2006-12-22 | 2012-02-28 | Genentech Inc | Dr6 antibodies inhibiting the binding of dr6 to app, and uses thereof in treating neurological disorders |
| HU230877B1 (hu) * | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
| EP2413931B1 (en) | 2009-01-23 | 2016-06-01 | Hanmi Science Co., Ltd. | Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same |
| TWI461213B (zh) * | 2009-11-05 | 2014-11-21 | Fmc Corp | 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物 |
| CN103054862B (zh) * | 2013-01-08 | 2014-09-17 | 江苏万高药业有限公司 | 一种含有马来酸氨氯地平的快速释放的口服固体制剂 |
| US10695329B2 (en) | 2016-10-07 | 2020-06-30 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
| WO2019200143A1 (en) | 2018-04-11 | 2019-10-17 | Silvergate Pharmaceuticals, Inc. | Amlodipine formulations |
| CN111728948A (zh) * | 2020-08-19 | 2020-10-02 | 湖北潜龙药业有限公司 | 一种苯磺酸氨氯地平片的制备工艺 |
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| DK161312C (da) | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| GB8306666D0 (en) | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
| US4687662A (en) * | 1985-08-30 | 1987-08-18 | Warner-Lambert Company | Therapeutic effervescent composition |
| GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
| US4983740A (en) | 1986-08-04 | 1991-01-08 | Adir Et Compagnie | Process for 1,4-dihydropyridine compounds |
| GB8710493D0 (en) | 1987-05-02 | 1987-06-03 | Pfizer Ltd | Dihydropyridines |
| US5155120A (en) | 1991-01-14 | 1992-10-13 | Pfizer Inc | Method for treating congestive heart failure |
| WO1993006082A1 (en) | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
| WO1993010779A1 (en) * | 1991-11-26 | 1993-06-10 | Sepracor, Inc. | Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine |
| US6057344A (en) | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
| AT399718B (de) * | 1992-04-16 | 1995-07-25 | Lek Tovarna Farmacevtskih | Inklusionskomplexe von optisch aktiven und racemischen 1,4-dihydropyridinen mit methyl-beta- cyclodextrin oder anderen cyclodextrinderivaten, ein verfahren zur herstellung von optisch aktiven dihydropyridinen und deren inklusionskomplexen und diese komplexe enthaltende pharmazeutische formulierungen |
| US5389654A (en) | 1992-11-26 | 1995-02-14 | Lek, Tovarna, Farmacevtskih In Kemicnih . . . | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
| GB9317773D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| WO1995034299A1 (en) * | 1994-06-10 | 1995-12-21 | Telor Ophthalmic Pharmaceuticals, Inc. | Inhibition of intraoperative miosis/production of mydriasis by calcium channel blockers |
| US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
| HU222497B1 (hu) * | 1996-12-18 | 2003-07-28 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Enalapril-maleátot tartalmazó stabilizált gyógyszerkészítmény és eljárás előállítására |
| HU221810B1 (hu) | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
| ZA9810320B (en) | 1997-11-14 | 2000-05-11 | Gea Farmaceutisk Fabrik As | Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose. |
| PL189666B1 (pl) | 1998-04-09 | 2005-09-30 | Adamed Sp Z Oo | Sposób otrzymywania benzenosulfonianu amlodypiny |
| JP3719874B2 (ja) * | 1998-04-24 | 2005-11-24 | サンスター株式会社 | 口腔用組成物 |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| ES2151850B1 (es) | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
| GB9827387D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel process |
| GB9827431D0 (en) | 1998-12-11 | 1999-02-03 | Smithkline Beecham Plc | Novel compound |
| GB0008332D0 (en) * | 2000-04-04 | 2000-05-24 | Pfizer Ltd | Treament |
| GB0020842D0 (en) * | 2000-08-23 | 2000-10-11 | Pfizer Ltd | Therapeutic compositions |
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2001
- 2001-08-09 AT AT0063401U patent/AT5874U1/de not_active IP Right Cessation
- 2001-08-15 PL PL01362668A patent/PL362668A1/xx not_active Application Discontinuation
- 2001-08-15 DK DK01970353T patent/DK1309317T3/da active
- 2001-08-15 MX MXPA03005883A patent/MXPA03005883A/es active IP Right Grant
- 2001-08-15 UA UA2003077117A patent/UA78500C2/uk unknown
- 2001-08-15 AU AU2001290354A patent/AU2001290354B2/en not_active Ceased
- 2001-08-15 NZ NZ526505A patent/NZ526505A/en unknown
- 2001-08-15 ES ES01970353T patent/ES2258549T3/es not_active Expired - Lifetime
- 2001-08-15 RS YU53303A patent/RS53303A/sr unknown
- 2001-08-15 WO PCT/NL2001/000606 patent/WO2002053134A1/en active IP Right Grant
- 2001-08-15 CA CA002433035A patent/CA2433035C/en not_active Expired - Fee Related
- 2001-08-15 AP APAP/P/2003/002819A patent/AP2003002819A0/en unknown
- 2001-08-15 BR BR0116556-9A patent/BR0116556A/pt not_active IP Right Cessation
- 2001-08-15 DE DE60118008T patent/DE60118008T2/de not_active Expired - Fee Related
- 2001-08-15 AT AT01970353T patent/ATE320244T1/de not_active IP Right Cessation
- 2001-08-15 EA EA200300740A patent/EA008101B1/ru not_active IP Right Cessation
- 2001-08-15 PT PT01970353T patent/PT1309317E/pt unknown
- 2001-08-15 EP EP01970353A patent/EP1309317B1/en not_active Expired - Lifetime
- 2001-08-15 IL IL15669101A patent/IL156691A0/xx unknown
- 2001-08-15 CN CNB018216692A patent/CN1268322C/zh not_active Expired - Fee Related
- 2001-08-27 US US09/938,816 patent/US6919087B2/en not_active Expired - Fee Related
- 2001-10-08 DE DE20116428U patent/DE20116428U1/de not_active Ceased
- 2001-11-05 BE BE2001/0706A patent/BE1014449A6/nl not_active IP Right Cessation
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2003
- 2003-05-26 MA MA27179A patent/MA26968A1/fr unknown
- 2003-05-30 IS IS6833A patent/IS6833A/is unknown
- 2003-06-04 NO NO20032517A patent/NO20032517L/no not_active Application Discontinuation
- 2003-06-27 HR HR20030527A patent/HRP20030527A2/hr not_active Application Discontinuation
- 2003-11-13 HK HK03108274A patent/HK1055904A1/xx not_active IP Right Cessation
- 2003-12-12 DK DK200300346U patent/DK200300346U4/da not_active IP Right Cessation
- 2003-12-12 DK DK200300347U patent/DK200300347U3/da not_active IP Right Cessation
- 2003-12-17 FI FI20030475U patent/FI6787U1/fi active IP Right Grant
- 2003-12-29 AT AT0093303U patent/AT7729U3/de not_active IP Right Cessation
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2004
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