AT7729U2 - Pharmazeutische zusammensetzungen enthaltend amlodipinmaleat - Google Patents

Pharmazeutische zusammensetzungen enthaltend amlodipinmaleat Download PDF

Info

Publication number
AT7729U2
AT7729U2 AT0093303U AT9332003U AT7729U2 AT 7729 U2 AT7729 U2 AT 7729U2 AT 0093303 U AT0093303 U AT 0093303U AT 9332003 U AT9332003 U AT 9332003U AT 7729 U2 AT7729 U2 AT 7729U2
Authority
AT
Austria
Prior art keywords
amlodipinmaleat
pharmaceutical compositions
compositions containing
microns
amlodipine maleate
Prior art date
Application number
AT0093303U
Other languages
English (en)
Other versions
AT7729U3 (de
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29740874&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT7729(U2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of AT7729U2 publication Critical patent/AT7729U2/de
Publication of AT7729U3 publication Critical patent/AT7729U3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Vorgesehen wird eine pharmazeutische Amlodipinmaleat-Zusammensetzung mit guter Stabilität bei Formulierung mit einem pH innerhalb des Bereichs von 5,5 bis 7, gemessen als eine 20 Gew.-% wässrige Aufschlämmung. Die Stabilität kann auch unterstützt werden durch Herstellung der pharmazeutischen Zusammensetzung aus Amlodipinmaleatteilchen mit einer durchschnittlichen Teilchengröße von mehr als 20 Mikron, vorzugsweise mehr als 100 Mikron.
AT0093303U 2000-12-29 2003-12-29 Pharmazeutische zusammensetzungen enthaltend amlodipinmaleat AT7729U3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25856200P 2000-12-29 2000-12-29
US80934601A 2001-03-16 2001-03-16
AT0063401U AT5874U1 (de) 2000-12-29 2001-08-09 Pharmazeutische zubereitungen enthaltend amlodipinmaleat
BE2001/0706A BE1014449A6 (nl) 2000-12-29 2001-11-05 Farmaceutische verbindingen omvattende amlodipine maleaat.

Publications (2)

Publication Number Publication Date
AT7729U2 true AT7729U2 (de) 2005-08-25
AT7729U3 AT7729U3 (de) 2006-01-15

Family

ID=29740874

Family Applications (3)

Application Number Title Priority Date Filing Date
AT0063401U AT5874U1 (de) 2000-12-29 2001-08-09 Pharmazeutische zubereitungen enthaltend amlodipinmaleat
AT01970353T ATE320244T1 (de) 2000-12-29 2001-08-15 Pharmazeutische zusammensetzungen mit amlodipinmaleat
AT0093303U AT7729U3 (de) 2000-12-29 2003-12-29 Pharmazeutische zusammensetzungen enthaltend amlodipinmaleat

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT0063401U AT5874U1 (de) 2000-12-29 2001-08-09 Pharmazeutische zubereitungen enthaltend amlodipinmaleat
AT01970353T ATE320244T1 (de) 2000-12-29 2001-08-15 Pharmazeutische zusammensetzungen mit amlodipinmaleat

Country Status (26)

Country Link
US (1) US6919087B2 (de)
EP (1) EP1309317B1 (de)
CN (1) CN1268322C (de)
AP (1) AP2003002819A0 (de)
AT (3) AT5874U1 (de)
AU (1) AU2001290354B2 (de)
BE (1) BE1014449A6 (de)
BR (1) BR0116556A (de)
CA (1) CA2433035C (de)
DE (2) DE60118008T2 (de)
DK (3) DK1309317T3 (de)
EA (1) EA008101B1 (de)
ES (1) ES2258549T3 (de)
FI (1) FI6787U1 (de)
HR (1) HRP20030527A2 (de)
IL (1) IL156691A0 (de)
IS (1) IS6833A (de)
MA (1) MA26968A1 (de)
MX (1) MXPA03005883A (de)
NO (1) NO20032517L (de)
NZ (1) NZ526505A (de)
PL (1) PL362668A1 (de)
PT (1) PT1309317E (de)
RS (1) RS53303A (de)
UA (1) UA78500C2 (de)
WO (1) WO2002053134A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053540A1 (en) * 2000-12-29 2002-07-11 Pfizer Limited Aspartate derivative of amlodipine as calcium channel antagonist
GB2371862B (en) * 2000-12-29 2004-07-14 Bioorg Bv Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
US20030027848A1 (en) * 2001-06-15 2003-02-06 Anne Billotte Stabilized formulations
GB0114709D0 (en) * 2001-06-15 2001-08-08 Pfizer Ltd Stabilised formulations of amlodipine maleate
WO2003032954A1 (en) * 2001-10-17 2003-04-24 Dr. Reddy's Laboratories Ltd. Stabilized pharmaceutical formulations containing amlodipine maleate
US20030180354A1 (en) * 2001-10-17 2003-09-25 Dr. Reddy's Laboratories Limited Amlodipine maleate formulations
WO2003055467A1 (en) * 2001-12-18 2003-07-10 Synthon B.V. Simvastatin dosage forms
US20040072879A1 (en) * 2002-10-10 2004-04-15 Dr. Reddy's Laboratories Limited Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine)
DK1435239T3 (da) * 2002-12-31 2006-07-31 Cimex Pharma Ag Stabiliseret og let forarbejdeligt granulat af amlodipin--maleat
CA2559670A1 (en) * 2003-04-14 2004-10-28 Gabor Pragai Stable amlodipine maleate formulations
KR100604034B1 (ko) * 2003-10-08 2006-07-24 주식회사유한양행 암로디핀 유리염기를 함유한 구강 속붕해정 및 그의 조성물
EA013053B1 (ru) * 2004-11-05 2010-02-26 Бёрингер Ингельхайм Интернациональ Гмбх Двуслойная таблетка, содержащая телмисартан и амлодипин
EP1833466A1 (de) * 2004-12-28 2007-09-19 Ranbaxy Laboratories Limited Verfahren zur herstelulng von stabilen pharmazeutischen soliden dosierformen von atorvastatin und amlodipin
KR100825039B1 (ko) 2005-01-21 2008-04-24 대원제약주식회사 안정성이 개선된 암로디핀 말레이트염 정제
US10130624B2 (en) * 2005-03-15 2018-11-20 Lupin Limited Pharmaceutical compositions of amlodipine and benazepril
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
AU2005336956A1 (en) * 2005-09-28 2007-04-12 Teva Pharmaceutical Industries Ltd. Stable combinations of amlodipine besylate and benazepril hydrochloride
PT1797885E (pt) * 2005-09-28 2008-05-20 Teva Pharma Combinações estáveis de besilato de amlodipina e cloridrato de benazepril
US8158146B2 (en) * 2005-09-28 2012-04-17 Teva Pharmaceutical Industries Ltd. Stable combinations of amlodipine besylate and benazepril hydrochloride
KR100689862B1 (ko) 2005-10-04 2007-03-09 삼익제약주식회사 말레인산암로디핀을 포함하는 조성물 및 그의 제조 방법
KR100795313B1 (ko) 2006-09-05 2008-01-21 현대약품 주식회사 암로디핀 베실레이트를 포함하는 약학 조성물
CN101161241B (zh) * 2006-10-10 2010-05-26 扬子江药业集团上海海尼药业有限公司 苯磺酸氨氯地平片的制备工艺
WO2008065485A2 (en) * 2006-10-19 2008-06-05 Torrent Pharmaceuticals Limited Stable pharmaceutical compositions of a calcium channel blocker and an ace inhibitor
RU2009128039A (ru) * 2006-12-22 2011-01-27 Дженентек, Инк. (Us) Антагонисты dr6 и способы их применения в лечении неврологических нарушений
HU230877B1 (hu) * 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
CN102292085B (zh) 2009-01-23 2017-01-18 韩美科学株式会社 包含氨氯地平和氯沙坦的固体药物组合物及其制备方法
TWI461213B (zh) * 2009-11-05 2014-11-21 Fmc Corp 作為藥物賦形劑之微晶纖維素及磷酸鈣之組合物
CN103054862B (zh) * 2013-01-08 2014-09-17 江苏万高药业有限公司 一种含有马来酸氨氯地平的快速释放的口服固体制剂
WO2018067959A1 (en) 2016-10-07 2018-04-12 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
US10799453B2 (en) 2018-04-11 2020-10-13 Silvergate Pharmaceuticals, Inc. Amlodipine formulations
CN111728948A (zh) * 2020-08-19 2020-10-02 湖北潜龙药业有限公司 一种苯磺酸氨氯地平片的制备工艺

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8306666D0 (en) 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4687662A (en) * 1985-08-30 1987-08-18 Warner-Lambert Company Therapeutic effervescent composition
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4983740A (en) 1986-08-04 1991-01-08 Adir Et Compagnie Process for 1,4-dihydropyridine compounds
GB8710493D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Dihydropyridines
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
WO1993006082A1 (en) 1991-09-13 1993-04-01 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropyridines
WO1993010779A1 (en) * 1991-11-26 1993-06-10 Sepracor, Inc. Methods and compositions for treating hypertension, angina and other disorders using optically pure (-) amlodipine
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
AT399718B (de) * 1992-04-16 1995-07-25 Lek Tovarna Farmacevtskih Inklusionskomplexe von optisch aktiven und racemischen 1,4-dihydropyridinen mit methyl-beta- cyclodextrin oder anderen cyclodextrinderivaten, ein verfahren zur herstellung von optisch aktiven dihydropyridinen und deren inklusionskomplexen und diese komplexe enthaltende pharmazeutische formulierungen
US5389654A (en) 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
GB9317773D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
WO1995034299A1 (en) * 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition of intraoperative miosis/production of mydriasis by calcium channel blockers
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
HU222497B1 (hu) * 1996-12-18 2003-07-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Enalapril-maleátot tartalmazó stabilizált gyógyszerkészítmény és eljárás előállítására
HU221810B1 (hu) 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
ZA9810320B (en) 1997-11-14 2000-05-11 Gea Farmaceutisk Fabrik As Process for the preparation of 1,4-dihydropyridines and novel compounds of use for such purpose.
PL189666B1 (pl) 1998-04-09 2005-09-30 Adamed Sp Z Oo Sposób otrzymywania benzenosulfonianu amlodypiny
JP3719874B2 (ja) * 1998-04-24 2005-11-24 サンスター株式会社 口腔用組成物
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
ES2151850B1 (es) 1998-10-26 2001-08-16 Esteve Quimica Sa Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente.
GB9827387D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel process
GB9827431D0 (en) 1998-12-11 1999-02-03 Smithkline Beecham Plc Novel compound
GB0008332D0 (en) * 2000-04-04 2000-05-24 Pfizer Ltd Treament
GB0020842D0 (en) * 2000-08-23 2000-10-11 Pfizer Ltd Therapeutic compositions

Also Published As

Publication number Publication date
CA2433035C (en) 2006-04-25
MA26968A1 (fr) 2004-12-20
ES2258549T3 (es) 2006-09-01
DE60118008T2 (de) 2006-10-26
UA78500C2 (en) 2007-04-10
NO20032517D0 (no) 2003-06-04
AP2003002819A0 (en) 2003-06-30
AT5874U1 (de) 2003-01-27
EA200300740A1 (ru) 2003-10-30
WO2002053134A1 (en) 2002-07-11
PT1309317E (pt) 2006-06-30
IS6833A (is) 2003-05-30
CN1268322C (zh) 2006-08-09
DK200300346U1 (da) 2003-12-12
NO20032517L (no) 2003-06-20
DE60118008D1 (de) 2006-05-11
US20020176889A1 (en) 2002-11-28
HRP20030527A2 (en) 2005-06-30
EA008101B1 (ru) 2007-04-27
EP1309317A1 (de) 2003-05-14
HK1055904A1 (en) 2004-01-30
DK1309317T3 (da) 2006-06-19
DK200300347U3 (da) 2004-03-12
NZ526505A (en) 2005-04-29
HK1064601A1 (en) 2005-02-04
DE20116428U1 (de) 2002-01-10
ATE320244T1 (de) 2006-04-15
AT7729U3 (de) 2006-01-15
CA2433035A1 (en) 2002-07-11
BR0116556A (pt) 2004-02-17
FIU20030475U0 (fi) 2003-12-17
IL156691A0 (en) 2004-01-04
PL362668A1 (en) 2004-11-02
MXPA03005883A (es) 2005-04-19
FI6787U1 (fi) 2005-09-14
RS53303A (sr) 2006-10-27
US6919087B2 (en) 2005-07-19
DK200300346U4 (da) 2004-04-23
AU2001290354B2 (en) 2006-09-21
EP1309317B1 (de) 2006-03-15
CN1486176A (zh) 2004-03-31
BE1014449A6 (nl) 2003-10-07

Similar Documents

Publication Publication Date Title
AT7729U2 (de) Pharmazeutische zusammensetzungen enthaltend amlodipinmaleat
WO2006124670A3 (en) Coated metal oxide nanoparticles and methods for producing same
IL220142A0 (en) Glycoprotein compositions
CA2409394A1 (en) Process for the production of hard metal grade powder
AU2002216204A1 (en) Perfume compositions
HRP20080410A2 (en) Crystalline composition containing escitalopram
DE69915650D1 (de) Granuläre zusammensetzungen
JP6017905B2 (ja) 口腔用組成物
EP0119737A3 (de) Arzneimittel und dessen Herstellung
CA2119434A1 (en) Compositions containing sunscreens
CA2070541A1 (en) Liquid crystal composition, liquid crystal element and process for the preparation of liquid crystal element
CA2016221A1 (en) Compositions
US20140038933A1 (en) Composition and Method For Preventing Discoloration of Pyrithione Containing Compositions
WO2004094315A3 (fr) Procede de fabrication d’hydroxosulfates de cuivre et compositions fongicides cupriques les contenant
TR200001792T2 (tr) Mikron büyüklüğünde parçacıklar halinde öğütülmüş çifte devirli ilaçları içeren ilaç olarak kullanılabilen kimyasal karışımlar
EP1108487A3 (de) Schmiermittel enthaltende Formmasse zur Herstellung pulvermetallischer oder keramischer Erzeugnisse
US5496555A (en) Personal cleaning composition
DE69203214T2 (de) Flüssige Geschirrspülzusammensetzung.
JP2003516937A5 (de)
KR890000010A (ko) 진드기구충 제제물
EP1117364B1 (de) Flüssige zahnreinigungsmittel
RU2004103070A (ru) Композиция связующего для наносимого валиком клейстерного состава
WO2001072287B1 (de) Verwendung von ectoin oder ectoin-derivaten zur prophylaxe und/oder behandlung von uv-induzierter immunsuppression
DE60227830D1 (de) Mensetzung, verfahren zu ihrer herstellung und die zusatzstoffzusammensetzung enthaltendes nahrungsmittelprodukt
EP1321508A3 (de) Duftstoffzusammensetzung enthaltend 3-(3-Hexenyl)-2-Cyclopentenon

Legal Events

Date Code Title Description
MM9K Lapse due to non-payment of renewal fee