HRP20020336B1 - New oxabispidine compounds useful in the treatment of cardiac arrhythmias - Google Patents
New oxabispidine compounds useful in the treatment of cardiac arrhythmiasInfo
- Publication number
- HRP20020336B1 HRP20020336B1 HR20020336A HRP20020336A HRP20020336B1 HR P20020336 B1 HRP20020336 B1 HR P20020336B1 HR 20020336 A HR20020336 A HR 20020336A HR P20020336 A HRP20020336 A HR P20020336A HR P20020336 B1 HRP20020336 B1 HR P20020336B1
- Authority
- HR
- Croatia
- Prior art keywords
- aryl
- alkyl
- terminated
- optionally substituted
- halo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010003119 arrhythmia Diseases 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 14
- 125000005843 halogen group Chemical group 0.000 abstract 10
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 8
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000002947 alkylene group Chemical group 0.000 abstract 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9903759A SE9903759D0 (sv) | 1999-10-18 | 1999-10-18 | Pharmaceutically active compounds |
| PCT/SE2000/001994 WO2001028992A2 (en) | 1999-10-18 | 2000-10-13 | New oxabispidine compounds useful in the treatment of cardiac arrhythmias |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20020336A2 HRP20020336A2 (en) | 2004-02-29 |
| HRP20020336B1 true HRP20020336B1 (en) | 2006-02-28 |
Family
ID=20417401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020336A HRP20020336B1 (en) | 1999-10-18 | 2002-04-16 | New oxabispidine compounds useful in the treatment of cardiac arrhythmias |
Country Status (41)
| Country | Link |
|---|---|
| US (6) | US6559143B1 (de) |
| EP (2) | EP1235831B1 (de) |
| JP (3) | JP3973906B2 (de) |
| KR (1) | KR100796142B1 (de) |
| CN (2) | CN101265262A (de) |
| AP (1) | AP1536A (de) |
| AR (2) | AR026064A1 (de) |
| AT (1) | ATE292134T1 (de) |
| AU (1) | AU769513B2 (de) |
| BG (1) | BG65785B1 (de) |
| BR (1) | BR0014804A (de) |
| CA (1) | CA2386910A1 (de) |
| CO (1) | CO5271655A1 (de) |
| CU (1) | CU23210A3 (de) |
| CZ (1) | CZ20021328A3 (de) |
| DE (1) | DE60019158T2 (de) |
| DK (1) | DK1235831T3 (de) |
| EA (1) | EA005319B1 (de) |
| EE (1) | EE04854B1 (de) |
| ES (1) | ES2239047T3 (de) |
| HK (1) | HK1049003B (de) |
| HR (1) | HRP20020336B1 (de) |
| HU (1) | HUP0204085A3 (de) |
| IL (5) | IL149108A0 (de) |
| IS (2) | IS2224B (de) |
| MX (1) | MXPA02003848A (de) |
| MY (1) | MY130661A (de) |
| NO (1) | NO327977B1 (de) |
| NZ (2) | NZ531260A (de) |
| OA (1) | OA12067A (de) |
| PL (1) | PL354970A1 (de) |
| PT (1) | PT1235831E (de) |
| RS (1) | RS50760B (de) |
| SE (1) | SE9903759D0 (de) |
| SI (1) | SI1235831T1 (de) |
| SK (1) | SK286723B6 (de) |
| TR (1) | TR200201059T2 (de) |
| TW (1) | TWI283680B (de) |
| UA (1) | UA75052C2 (de) |
| WO (1) | WO2001028992A2 (de) |
| ZA (1) | ZA200202575B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE9903759D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| AR030756A1 (es) * | 2000-10-02 | 2003-09-03 | Astrazeneca Ab | Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas |
| SE0101329D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Pharmaceutical formulation |
| TWI259836B (en) * | 2001-04-12 | 2006-08-11 | Astrazeneca Ab | Modified release formulation suitable for antiarrhythmic compounds |
| SE0101324D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New process |
| SE0101327D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New crystalline forms |
| SE0101323D0 (sv) * | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | New process |
| BR0214225A (pt) * | 2001-11-22 | 2004-09-21 | Astrazeneca Ab | Processos para a preparação e para a formação de um composto, e, composto |
| SE0201373D0 (sv) * | 2002-05-06 | 2002-05-06 | Astrazeneca Ab | Combination therapy |
| SE0201374D0 (sv) * | 2002-05-06 | 2002-05-06 | Astrazeneca Ab | Pharmaceutical combination |
| SE0201662D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Pharmaceutical combination |
| GB0223712D0 (en) * | 2002-10-14 | 2002-11-20 | Astrazeneca Ab | Chemical intermediate |
| SE0401540D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| SE0401539D0 (sv) | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| AR057064A1 (es) * | 2005-06-13 | 2007-11-14 | Astrazeneca Ab | Compuestos para el tratamiento de arritmias cardiacas, formulacion farmaceutica y preparacion del compuesto |
| AR053901A1 (es) * | 2005-06-20 | 2007-05-23 | Astrazeneca Ab | Formas fisicas de oxabispidinas n,n'- disustituidas |
| WO2006137769A1 (en) * | 2005-06-20 | 2006-12-28 | Astrazeneca Ab | Process for the preparation of 3,7-dihydroxy-1,5-diazacyclooctanes |
| BRPI0611841A2 (pt) * | 2005-06-20 | 2016-08-30 | Astrazeneca Ab | processos para isolar um sal, para preparar um sal, e para a preparação de um composto |
| EP1915380A4 (de) * | 2005-06-20 | 2010-03-17 | Astrazeneca Ab | VERFAHREN ZUR HERSTELLUNG VON N,Ný-DISUBSTITUIERTEN OXABISPIDINEN |
| CN1330636C (zh) * | 2005-09-26 | 2007-08-08 | 鲁南制药集团股份有限公司 | 盐酸替罗非班中间体的合成方法 |
| TW200734342A (en) * | 2005-12-15 | 2007-09-16 | Astrazeneca Ab | New compounds for the treatment of cardiac arrhythmias |
| TW201004963A (en) * | 2008-07-03 | 2010-02-01 | Targacept Inc | Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands |
| GB2495308B (en) * | 2011-10-05 | 2014-09-10 | John Royce | Method and apparatus for cleaning a filter |
| PE20161035A1 (es) | 2013-03-15 | 2016-11-13 | Global Blood Therapeutics Inc | Compuestos y usos de estos para la modulacion de la hemoglobina |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| US10231970B2 (en) | 2014-09-30 | 2019-03-19 | NV Heterocycles | Methods of producing heteropolycycles via bis-epoxidation |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3196154A (en) * | 1962-05-17 | 1965-07-20 | Sterling Drug Inc | 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes |
| US3503939A (en) | 1967-03-29 | 1970-03-31 | Du Pont | Polyamides from heterocyclic diamines |
| CH488048A (de) | 1969-06-12 | 1970-03-31 | Inventa Ag | Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung |
| JPS5772977A (en) * | 1980-10-23 | 1982-05-07 | Dainippon Ink & Chem Inc | Fluorine-containing diepoxy compound and its preparation |
| DE3112055A1 (de) * | 1981-03-27 | 1982-10-07 | Basf Ag, 6700 Ludwigshafen | Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel |
| US4533713A (en) * | 1983-05-06 | 1985-08-06 | Minnesota Mining And Manufacturing Company | Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups |
| FI67320C (fi) * | 1983-05-09 | 1985-03-11 | Partek Ab | Foerfarande och glidgjutanordning foer gjutning av betongstycken |
| JPS6284071A (ja) * | 1985-10-07 | 1987-04-17 | Kanegafuchi Chem Ind Co Ltd | 新規グリシジル化合物及びその製造方法 |
| JPS6284070A (ja) * | 1985-10-07 | 1987-04-17 | Kanegafuchi Chem Ind Co Ltd | 新規なグリシジル化合物及びその製造法 |
| DE3732094A1 (de) | 1987-09-24 | 1989-04-06 | Basf Ag | Bispidinderivate als klasse iii-antiarrhythmika |
| US5140033A (en) | 1989-04-03 | 1992-08-18 | Bayer Aktiengesellschaft | Antibacterial 5-alkylquinolonecarboxylic acids |
| US5110933A (en) | 1989-11-13 | 1992-05-05 | Board Of Regents Of Oklahoma State University | Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof |
| FR2664270B1 (fr) * | 1990-07-09 | 1994-04-08 | Norsolor Sa | Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres. |
| JP2602745B2 (ja) * | 1991-06-26 | 1997-04-23 | 花王株式会社 | フレキシブルディスク用センターハブのピッキング装置 |
| US5468858A (en) * | 1993-10-28 | 1995-11-21 | The Board Of Regents Of Oklahoma State University Physical Sciences | N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents |
| US5831099A (en) * | 1995-03-10 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Army | Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same |
| SE9704709D0 (sv) * | 1997-12-17 | 1997-12-17 | Astra Ab | Pharmaceutically active compounds |
| SE9803517D0 (sv) * | 1998-10-15 | 1998-10-15 | Astra Ab | Pharmaceutical preparation |
| NZ514477A (en) | 1999-04-09 | 2003-04-29 | Astrazeneca Ab | Adamantane derivatives |
| SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| SE9904765D0 (sv) * | 1999-12-23 | 1999-12-23 | Astra Ab | Pharmaceutically-useful compounds |
| AR030756A1 (es) * | 2000-10-02 | 2003-09-03 | Astrazeneca Ab | Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas |
-
1999
- 1999-10-18 SE SE9903759A patent/SE9903759D0/xx unknown
-
2000
- 2000-10-06 TW TW089120910A patent/TWI283680B/zh not_active IP Right Cessation
- 2000-10-13 JP JP2001531792A patent/JP3973906B2/ja not_active Expired - Fee Related
- 2000-10-13 AU AU10691/01A patent/AU769513B2/en not_active Ceased
- 2000-10-13 DE DE60019158T patent/DE60019158T2/de not_active Expired - Lifetime
- 2000-10-13 NZ NZ531260A patent/NZ531260A/en unknown
- 2000-10-13 PT PT00971960T patent/PT1235831E/pt unknown
- 2000-10-13 SI SI200030681T patent/SI1235831T1/xx unknown
- 2000-10-13 UA UA2002043168A patent/UA75052C2/uk unknown
- 2000-10-13 TR TR2002/01059T patent/TR200201059T2/xx unknown
- 2000-10-13 PL PL00354970A patent/PL354970A1/xx not_active Application Discontinuation
- 2000-10-13 EE EEP200200203A patent/EE04854B1/xx not_active IP Right Cessation
- 2000-10-13 CN CNA2008100058488A patent/CN101265262A/zh active Pending
- 2000-10-13 NZ NZ518156A patent/NZ518156A/en unknown
- 2000-10-13 DK DK00971960T patent/DK1235831T3/da active
- 2000-10-13 KR KR1020027004902A patent/KR100796142B1/ko not_active IP Right Cessation
- 2000-10-13 WO PCT/SE2000/001994 patent/WO2001028992A2/en active Application Filing
- 2000-10-13 EP EP00971960A patent/EP1235831B1/de not_active Expired - Lifetime
- 2000-10-13 EP EP05006781A patent/EP1559717A3/de not_active Withdrawn
- 2000-10-13 CN CNB00816231XA patent/CN100379743C/zh not_active Expired - Fee Related
- 2000-10-13 MX MXPA02003848A patent/MXPA02003848A/es active IP Right Grant
- 2000-10-13 CA CA002386910A patent/CA2386910A1/en not_active Abandoned
- 2000-10-13 HU HU0204085A patent/HUP0204085A3/hu unknown
- 2000-10-13 IL IL14910800A patent/IL149108A0/xx unknown
- 2000-10-13 AP APAP/P/2002/002471A patent/AP1536A/en active
- 2000-10-13 BR BR0014804-0A patent/BR0014804A/pt not_active IP Right Cessation
- 2000-10-13 RS YUP-294/02A patent/RS50760B/sr unknown
- 2000-10-13 AT AT00971960T patent/ATE292134T1/de not_active IP Right Cessation
- 2000-10-13 SK SK506-2002A patent/SK286723B6/sk not_active IP Right Cessation
- 2000-10-13 OA OA1200200113A patent/OA12067A/en unknown
- 2000-10-13 CZ CZ20021328A patent/CZ20021328A3/cs unknown
- 2000-10-13 EA EA200200390A patent/EA005319B1/ru not_active IP Right Cessation
- 2000-10-13 ES ES00971960T patent/ES2239047T3/es not_active Expired - Lifetime
- 2000-10-16 US US09/688,251 patent/US6559143B1/en not_active Expired - Fee Related
- 2000-10-16 MY MYPI20004850A patent/MY130661A/en unknown
- 2000-10-17 AR ARP000105452A patent/AR026064A1/es active IP Right Grant
- 2000-10-17 CO CO00078740A patent/CO5271655A1/es not_active Application Discontinuation
-
2002
- 2002-04-02 ZA ZA200202575A patent/ZA200202575B/en unknown
- 2002-04-05 BG BG106588A patent/BG65785B1/bg unknown
- 2002-04-11 IL IL149108A patent/IL149108A/en not_active IP Right Cessation
- 2002-04-11 IL IL183854A patent/IL183854A0/en unknown
- 2002-04-16 CU CU20020079A patent/CU23210A3/es not_active IP Right Cessation
- 2002-04-16 HR HR20020336A patent/HRP20020336B1/xx not_active IP Right Cessation
- 2002-04-17 IS IS6346A patent/IS2224B/is unknown
- 2002-04-17 NO NO20021811A patent/NO327977B1/no not_active IP Right Cessation
- 2002-12-12 US US10/317,195 patent/US7164017B2/en not_active Expired - Fee Related
-
2003
- 2003-02-18 HK HK03101241.2A patent/HK1049003B/zh not_active IP Right Cessation
- 2003-04-02 AR ARP030101150A patent/AR039226A2/es unknown
-
2006
- 2006-03-22 US US11/385,861 patent/US20060166980A1/en not_active Abandoned
- 2006-03-22 US US11/385,833 patent/US7772229B2/en not_active Expired - Fee Related
- 2006-08-23 JP JP2006226089A patent/JP2006342182A/ja active Pending
- 2006-12-18 US US11/640,417 patent/US7351821B2/en not_active Expired - Fee Related
- 2006-12-27 IS IS8586A patent/IS8586A/is unknown
-
2007
- 2007-03-28 JP JP2007083302A patent/JP2007204486A/ja active Pending
- 2007-06-11 IL IL183853A patent/IL183853A0/en unknown
- 2007-06-11 IL IL183852A patent/IL183852A0/en unknown
-
2009
- 2009-09-01 US US12/585,029 patent/US20090326221A1/en not_active Abandoned
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| Date | Code | Title | Description |
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| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20090929 Year of fee payment: 10 |
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| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20101014 |