HRP20020336B1 - New oxabispidine compounds useful in the treatment of cardiac arrhythmias - Google Patents

New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Info

Publication number
HRP20020336B1
HRP20020336B1 HR20020336A HRP20020336A HRP20020336B1 HR P20020336 B1 HRP20020336 B1 HR P20020336B1 HR 20020336 A HR20020336 A HR 20020336A HR P20020336 A HRP20020336 A HR P20020336A HR P20020336 B1 HRP20020336 B1 HR P20020336B1
Authority
HR
Croatia
Prior art keywords
aryl
alkyl
terminated
optionally substituted
halo
Prior art date
Application number
HR20020336A
Other languages
English (en)
Inventor
Bj�re Annika
Bj�rsne Magnus
Clading-Boel David
Hoffman Kurt-J�rgen
Pavey John
Pont�n Fritiof
Standlund Gert
Svensson Peder
Thomson Colin
Wilstermann Michael
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HRP20020336A2 publication Critical patent/HRP20020336A2/hr
Publication of HRP20020336B1 publication Critical patent/HRP20020336B1/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Spoj formule I, naznačen time, štoR1 predstavlja C1-12 alkil (koja alkilna skupina je po izboru supstituirana i/ili okončana s jednom ili više skupina odabranih od halo, cijano, nitro, aril, Het1, -C(O)R5a, -OR5b, -N(R6)R5c, -C(O)XR7, -C(O)N(R8)R5d i -S(O)2R9) ili R1 predstavlja -C(O)XR7, -C(O)N(R8)R5d ili -S(O)2R9;R5a do R5d neovisno predstavljaju, kod svakog pojavljivanja, H, C1-6 alkil (koja je potonja skupina po izboru supstituirana i/ili okončana s jednim ili više supstituenata odabranih od -OH, halo, cijano, nitro, aril i Het2), aril iliHet3 ili R5d, skupa s R8, predstavlja C3-6 alkilen (koja alkilenska skupina je po izboru prekinuta s nekim O atomom i/ili je po izboru supstituirana s jednom ili više C1-3 alkilnih skupina); R6 predstavlja H, C1-6 alkil (po izboru supstituiran i/iliokončan s jednim ili više supstituenata odabranihod -OH, halo, cijano, nitro i aril), aril, -C(O)R10a, -C(O)OR10b ili -C(O)N(H)R10c;R10a, R10b i R10c neovisno predstavljaju C1-6 alkil (po izboru supstituiran i/ili okončan s jednim ili više supstituenata odabranih od -OH, halo, cijano, nitro i aril), aril, ili R10a predstavlja H; R7 predstavlja C1-12 alkil (po izboru supstituiran i/ili okončan s jednim ili više supstituenata odabranih od -OH, halo, cijano, nitro, aril, C1-6 alkoksi i Het4);R8 predstavlja H, C1-12 alkil, C1-6 alkoksi (koje su potonje dvije skupina po izboru supstituirane i/iliokončane s jednim ili više supstituenata odabranih od -OH, halo, cijano, nitro, C1-4 alkil i C1-4 alkoksi), -D-aril, -D-ariloksi, -D-Het5, -D-N(H)C(O)R11a, -D-S(O)2R12a, -D-C(O)R11b, -D-C(O)OR12b, -D-C(O)N(R11c)R11d, ili R8, skupa s R5d, predstavljaC3-6 alkilene (koja alkilenska skupina je po izboru prekinuta s O atomom i/ili je po izboru supstituirana s jednom ili više C1-3 alkilnih skupina); R11a do R11d neovisno predstavljaju H, C1-6 alkil (po izboru supstituiran i/ili okončan s jednim ili više supstituenata odabranih od -OH, halo, cijano,nitro i aril), aril, ili R11c i R11d skupa predstavljaju C3-6 alkilen; R9, R12a i R12b neovisno predstavljaju C1-6 alkil (po izboru supstituiran i/ili okončan s jednim ili više supstituenata odabranih od -OH, halo, cijano, nitro i aril) ili aril; D predstavlja izravnu vezu ili C1-6 alkilen; X predstavlja O ili S; R2 predstavlja H, halo, C1-6 alkil, -OR13, -E-N(R14)R15 ili, skupa s R3, predstavlja=O; R3 predstavlja H, C1-6 alkil ili skupa s R2, predstavlja =O; R13 predstavlja H, C1-6 alkil, -E-aril, -E-Het6, -C(O)R16a, -C(O)OR16b ili -C(O)N(R17a)R17b;R14 predstavlja H, C1-6 alkil, -E-aril, -E-Het6, -C(O)R16a, -C(O)OR16b, -S(O)2R16c, -[C(O)]pN(R17a)R17b ili -C(NH)NH2;R15 predstavlja H, C1-6 alkil, -E-aril ili -C(O)R16d;R16a do R16d neovisnopredstavljaju, kod svakog pojavljivanja kada se koriste ovdje, C1-6 alkil (po izboru supstituiran i/ili okončan s jednim ili više supstituenata odabranih od halo, aril i Het7), aril, Het8, ili R16a iR16d neovisno predstavljaju H; R17a i R17b neovisno predstavljaju, kod svakog pojavljivanja kada se koriste
HR20020336A 1999-10-18 2002-04-16 New oxabispidine compounds useful in the treatment of cardiac arrhythmias HRP20020336B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds
PCT/SE2000/001994 WO2001028992A2 (en) 1999-10-18 2000-10-13 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Publications (2)

Publication Number Publication Date
HRP20020336A2 HRP20020336A2 (en) 2004-02-29
HRP20020336B1 true HRP20020336B1 (en) 2006-02-28

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020336A HRP20020336B1 (en) 1999-10-18 2002-04-16 New oxabispidine compounds useful in the treatment of cardiac arrhythmias

Country Status (41)

Country Link
US (6) US6559143B1 (hr)
EP (2) EP1559717A3 (hr)
JP (3) JP3973906B2 (hr)
KR (1) KR100796142B1 (hr)
CN (2) CN100379743C (hr)
AP (1) AP1536A (hr)
AR (2) AR026064A1 (hr)
AT (1) ATE292134T1 (hr)
AU (1) AU769513B2 (hr)
BG (1) BG65785B1 (hr)
BR (1) BR0014804A (hr)
CA (1) CA2386910A1 (hr)
CO (1) CO5271655A1 (hr)
CU (1) CU23210A3 (hr)
CZ (1) CZ20021328A3 (hr)
DE (1) DE60019158T2 (hr)
DK (1) DK1235831T3 (hr)
EA (1) EA005319B1 (hr)
EE (1) EE04854B1 (hr)
ES (1) ES2239047T3 (hr)
HK (1) HK1049003B (hr)
HR (1) HRP20020336B1 (hr)
HU (1) HUP0204085A3 (hr)
IL (5) IL149108A0 (hr)
IS (2) IS2224B (hr)
MX (1) MXPA02003848A (hr)
MY (1) MY130661A (hr)
NO (1) NO327977B1 (hr)
NZ (2) NZ518156A (hr)
OA (1) OA12067A (hr)
PL (1) PL354970A1 (hr)
PT (1) PT1235831E (hr)
RS (1) RS50760B (hr)
SE (1) SE9903759D0 (hr)
SI (1) SI1235831T1 (hr)
SK (1) SK286723B6 (hr)
TR (1) TR200201059T2 (hr)
TW (1) TWI283680B (hr)
UA (1) UA75052C2 (hr)
WO (1) WO2001028992A2 (hr)
ZA (1) ZA200202575B (hr)

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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
BR0214225A (pt) * 2001-11-22 2004-09-21 Astrazeneca Ab Processos para a preparação e para a formação de um composto, e, composto
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) * 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
AU2006258293B2 (en) * 2005-06-13 2010-06-17 Astrazeneca Ab New oxabispidine compounds for the treatment of cardiac arrhythmias
WO2006137771A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
AR053901A1 (es) * 2005-06-20 2007-05-23 Astrazeneca Ab Formas fisicas de oxabispidinas n,n'- disustituidas
EP1896486A4 (en) * 2005-06-20 2010-11-03 Astrazeneca Ab PROCESS FOR THE PREPARATION OF 3,7-DIHYDROXY-1,5-DIAZACYCLOOCTANESE
KR20080028435A (ko) * 2005-06-20 2008-03-31 아스트라제네카 아베 N,n’-이치환된 옥사비스피딘의 제조 방법
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation

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AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
SK5062002A3 (en) 2002-11-06
AR026064A1 (es) 2002-12-26
US7351821B2 (en) 2008-04-01
IL149108A0 (en) 2002-11-10
KR20020038956A (ko) 2002-05-24
BR0014804A (pt) 2002-06-11
HK1049003A1 (en) 2003-04-25
MY130661A (en) 2007-07-31
NO20021811D0 (no) 2002-04-17
US20070117799A1 (en) 2007-05-24
AU769513B2 (en) 2004-01-29
TR200201059T2 (tr) 2002-09-23
ZA200202575B (en) 2003-09-23
EA200200390A1 (ru) 2002-10-31
CA2386910A1 (en) 2001-04-26
AR039226A2 (es) 2005-02-09
CO5271655A1 (es) 2003-04-30
ES2239047T3 (es) 2005-09-16
MXPA02003848A (es) 2002-10-23
SI1235831T1 (hr) 2005-08-31
NO20021811L (no) 2002-06-06
RS50760B (sr) 2010-08-31
JP3973906B2 (ja) 2007-09-12
AP1536A (en) 2006-01-09
PT1235831E (pt) 2005-06-30
KR100796142B1 (ko) 2008-01-21
UA75052C2 (en) 2006-03-15
PL354970A1 (en) 2004-03-22
DE60019158D1 (de) 2005-05-04
YU29402A (sh) 2004-12-31
DE60019158T2 (de) 2006-02-02
HUP0204085A3 (en) 2006-01-30
HUP0204085A2 (hu) 2003-04-28
TWI283680B (en) 2007-07-11
IL149108A (en) 2009-12-24
CN101265262A (zh) 2008-09-17
CN100379743C (zh) 2008-04-09
HRP20020336A2 (en) 2004-02-29
IL183852A0 (en) 2009-02-11
US6559143B1 (en) 2003-05-06
EE200200203A (et) 2003-06-16
EP1559717A3 (en) 2009-04-29
BG106588A (en) 2003-01-31
AU1069101A (en) 2001-04-30
EP1559717A2 (en) 2005-08-03
IS6346A (is) 2002-04-17
WO2001028992A2 (en) 2001-04-26
US20030153564A1 (en) 2003-08-14
NZ518156A (en) 2004-05-28
EA005319B1 (ru) 2005-02-24
CU23210A3 (es) 2007-06-20
BG65785B1 (bg) 2009-11-30
IS8586A (is) 2006-12-27
IL183853A0 (en) 2009-02-11
US20060166980A1 (en) 2006-07-27
OA12067A (en) 2006-05-04
DK1235831T3 (da) 2005-06-27
NO327977B1 (no) 2009-11-02
SK286723B6 (sk) 2009-04-06
JP2006342182A (ja) 2006-12-21
US20090326221A1 (en) 2009-12-31
WO2001028992A3 (en) 2001-09-13
US7164017B2 (en) 2007-01-16
SE9903759D0 (sv) 1999-10-18
IL183854A0 (en) 2009-02-11
IS2224B (is) 2007-04-15
NZ531260A (en) 2005-08-26
JP2007204486A (ja) 2007-08-16
HK1049003B (zh) 2005-09-09
EP1235831B1 (en) 2005-03-30
US20060166979A1 (en) 2006-07-27
EE04854B1 (et) 2007-06-15
JP2003512352A (ja) 2003-04-02
ATE292134T1 (de) 2005-04-15
US7772229B2 (en) 2010-08-10
EP1235831A2 (en) 2002-09-04
AP2002002471A0 (en) 2002-06-30
CN1399639A (zh) 2003-02-26
CZ20021328A3 (cs) 2002-09-11

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