HN2012000437A - Nuevos agentes anticancer y la preparacion de dichos agentes - Google Patents
Nuevos agentes anticancer y la preparacion de dichos agentesInfo
- Publication number
- HN2012000437A HN2012000437A HN2012000437A HN2012000437A HN2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A HN 2012000437 A HN2012000437 A HN 2012000437A
- Authority
- HN
- Honduras
- Prior art keywords
- agents
- preparation
- new anticancer
- anticancer agents
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Abstract
LA INVENCION SE REFIERE A NUEVOS CONJUGADOS DE DIMEROS DE PIRROLO 1,4 BENZODIAZEPINA QUE PUEDEN SER UTILIZADOS COMO COMPUESTOS ANTICANCEROSOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0904043A FR2949469A1 (fr) | 2009-08-25 | 2009-08-25 | Derives anticancereux, leur preparation et leur application en therapeutique |
FR0904368A FR2949470B1 (fr) | 2009-08-25 | 2009-09-11 | Derives anticancereux, leur preparation et leur application therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2012000437A true HN2012000437A (es) | 2015-03-02 |
Family
ID=41720559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2012000437A HN2012000437A (es) | 2009-08-25 | 2012-02-24 | Nuevos agentes anticancer y la preparacion de dichos agentes |
Country Status (33)
Country | Link |
---|---|
US (2) | US8481042B2 (es) |
EP (1) | EP2470547B1 (es) |
JP (1) | JP5889189B2 (es) |
KR (1) | KR20130026405A (es) |
CN (1) | CN102753559B (es) |
AR (1) | AR078143A1 (es) |
AU (1) | AU2010288382B2 (es) |
BR (1) | BR112012004146A2 (es) |
CA (1) | CA2772102C (es) |
CL (2) | CL2012000489A1 (es) |
CO (1) | CO6612210A2 (es) |
CR (1) | CR20120085A (es) |
DO (1) | DOP2012000038A (es) |
EA (1) | EA026488B1 (es) |
EC (1) | ECSP12011688A (es) |
ES (1) | ES2484690T3 (es) |
FR (2) | FR2949469A1 (es) |
GT (1) | GT201200046A (es) |
HN (1) | HN2012000437A (es) |
IL (1) | IL218262A0 (es) |
MA (1) | MA33600B1 (es) |
MX (1) | MX2012002434A (es) |
MY (1) | MY157469A (es) |
NI (1) | NI201200031A (es) |
NZ (1) | NZ598401A (es) |
PE (1) | PE20120992A1 (es) |
SG (1) | SG178537A1 (es) |
TN (1) | TN2012000053A1 (es) |
TW (1) | TWI477275B (es) |
UA (1) | UA106507C2 (es) |
UY (1) | UY32854A (es) |
WO (1) | WO2011023883A1 (es) |
ZA (1) | ZA201201397B (es) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2012011900A (es) | 2010-04-15 | 2013-03-21 | Seattle Genetics Inc | Conjugados de pirrolobenzodiazepina diana. |
JP5875083B2 (ja) | 2010-04-15 | 2016-03-02 | メディミューン リミテッド | 増殖性疾患治療用ピロロベンゾジアゼピン |
MX341524B (es) | 2011-09-20 | 2016-08-24 | Medimmune Ltd | Pirrolobenzodiazepinas como compuestos pbd dimericos asimetricos para inclusion en conjugados dirigidos. |
BR112014008981A2 (pt) | 2011-10-14 | 2017-05-02 | Spirogen Sàrl | pirrolobenzodiazepinas |
BR112014008888A2 (pt) | 2011-10-14 | 2017-04-18 | Seattle Genetics Inc | pirrolobenzodiazepinas |
EP3309162A1 (en) | 2011-10-14 | 2018-04-18 | Seattle Genetics, Inc. | Targeted conjugates of pyrrolobenzodiazepines |
ES2687246T3 (es) | 2011-10-14 | 2018-10-24 | Seattle Genetics, Inc. | Pirrolobenzodiazepinas y conjugados dirigidos |
CA2858806A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
EA037203B1 (ru) | 2012-05-15 | 2021-02-18 | Сиэтл Джинетикс, Инк. | Конъюгаты антитело-лекарственное средство с самостабилизирующимися линкерами |
EP2872894B1 (en) | 2012-07-13 | 2019-04-17 | Innate Pharma | Screening of conjugated antibodies |
WO2014057072A1 (en) | 2012-10-12 | 2014-04-17 | Spirogen Sàrl | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
ES2670937T3 (es) | 2012-10-12 | 2018-06-04 | Medimmune Limited | Conjugados de anticuerpo-pirrolobenzodiazepina |
US10751346B2 (en) | 2012-10-12 | 2020-08-25 | Medimmune Limited | Pyrrolobenzodiazepine—anti-PSMA antibody conjugates |
JP6392763B2 (ja) | 2012-10-12 | 2018-09-19 | エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa | ピロロベンゾジアゼピン−抗体結合体 |
EP2906297B1 (en) | 2012-10-12 | 2017-12-06 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
RS56520B1 (sr) | 2012-10-12 | 2018-02-28 | Adc Therapeutics Sa | Pirolobenzodiazepin-anti-cd22 konjugati antitela |
PT3470086T (pt) | 2012-10-12 | 2021-02-01 | Medimmune Ltd | Pirrolobenzodiazepinas e conjugados das mesmas |
CA2941485C (en) | 2012-10-12 | 2018-06-12 | Philip Wilson Howard | Pyrrolobenzodiazepines and conjugates thereof |
ES2680153T3 (es) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas |
WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
EP3441072B1 (en) | 2013-03-13 | 2020-12-30 | Seagen Inc. | Activated carbon filtration for purification of benzodiazepine adcs |
BR112015023070B1 (pt) * | 2013-03-13 | 2022-06-07 | Genentech, Inc. | Conjugados e compostos de pirrolobenzodiazepinas, composição farmacêutica que compreende os mesmo, bem como seus usos para o tratamento de uma doença proliferativa |
JP6340019B2 (ja) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
WO2014140300A1 (en) | 2013-03-15 | 2014-09-18 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
KR20160042871A (ko) | 2013-06-21 | 2016-04-20 | 이나뜨 파르마, 에스.아. | 폴리펩티드의 효소적 콘쥬게이션 |
EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
EP3054983B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
JP6747971B2 (ja) | 2013-10-15 | 2020-08-26 | シアトル ジェネティックス, インコーポレイテッド | 改善されたリガンド−薬物コンジュゲート薬物動態のためのpeg化薬物−リンカー |
TW202313119A (zh) | 2013-12-19 | 2023-04-01 | 美商西雅圖遺傳學公司 | 與標的-藥物結合物併用之亞甲基胺基甲酸酯連接物 |
CA2938450C (en) | 2014-02-11 | 2023-10-17 | Seattle Genetics, Inc. | Selective reduction of proteins |
WO2016008112A1 (en) | 2014-07-16 | 2016-01-21 | Medshine Discovery Inc. | Linkers and application towards adc thereof |
US9518118B2 (en) | 2014-09-12 | 2016-12-13 | Genentech, Inc. | Anti-HER2 antibodies and immunoconjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CA2957148A1 (en) * | 2014-09-17 | 2016-03-24 | Genentech, Inc. | Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines |
EP3223854A1 (en) | 2014-11-25 | 2017-10-04 | ADC Therapeutics SA | Pyrrolobenzodiazepine-antibody conjugates |
KR20170102980A (ko) | 2015-01-14 | 2017-09-12 | 브리스톨-마이어스 스큅 컴퍼니 | 벤조디아제핀 이량체, 그의 접합체, 및 제조 및 사용 방법 |
CA2973355A1 (en) | 2015-01-14 | 2016-07-21 | Bristol-Myers Squibb Company | Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
JP2018518506A (ja) | 2015-06-23 | 2018-07-12 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 大環状ベンゾジアゼピン二量体、その結合体の製造および使用 |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
EA201892040A1 (ru) | 2016-03-25 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Способ получения пегилированных соединений лекарственный препарат - линкер и их промежуточных соединений |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
TW201808343A (zh) | 2016-08-09 | 2018-03-16 | 美商西雅圖遺傳學公司 | 具有改善之生理化學性質之具自我穩定連接子之藥物結合物 |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
JP7244987B2 (ja) | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
US11377492B2 (en) | 2017-01-24 | 2022-07-05 | Innate Pharma | NKp46 binding agents |
WO2018141959A1 (en) | 2017-02-06 | 2018-08-09 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
MX2019009428A (es) | 2017-02-08 | 2019-10-07 | Adc Therapeutics Sa | Conjugados de pirrolobenzodiazepinas y anticuerpos. |
JP2020512312A (ja) | 2017-03-24 | 2020-04-23 | シアトル ジェネティックス, インコーポレイテッド | グルクロニド薬物−リンカーの調製のためのプロセスおよびその中間体 |
HUE059828T2 (hu) | 2017-04-18 | 2023-01-28 | Medimmune Ltd | Pirrolobenzodiazepin konjugátumok |
JP7408396B2 (ja) | 2017-04-20 | 2024-01-05 | アーデーセー セラピューティクス ソシエテ アノニム | 併用療法 |
BR112019026564A2 (pt) | 2017-06-14 | 2020-06-30 | Adc Therapeutics Sa | regimes de dosagem para a administração de um adc anti-cd19 |
LT3668874T (lt) | 2017-08-18 | 2022-03-25 | Medimmune Limited | Pirolobenzodiazepino konjugatai |
CN111164208B (zh) | 2017-09-29 | 2023-08-04 | 第一三共株式会社 | 抗体-吡咯并苯并二氮杂卓衍生物偶联物 |
WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) * | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CN114450324B (zh) | 2019-09-26 | 2024-02-27 | 日油株式会社 | 具有肽连接子的异双官能单分散聚乙二醇 |
BR112022020332A2 (pt) | 2020-04-10 | 2022-12-13 | Seagen Inc | Composto conjugado anticorpo-droga, composição, método de tratamento de câncer e de um distúrbio autoimune |
JP2024501121A (ja) | 2020-11-25 | 2024-01-11 | イナート・ファルマ・ソシエテ・アノニム | 癌の処置 |
TW202300179A (zh) | 2021-03-18 | 2023-01-01 | 美商西根公司 | 內化的生物活性化合物偶聯物選擇性釋放藥物 |
EP4308170A1 (en) | 2021-03-18 | 2024-01-24 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
WO2023227660A1 (en) | 2022-05-25 | 2023-11-30 | Innate Pharma | Nectin-4 binding agents |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1516743A (fr) | 1966-04-01 | 1968-02-05 | Rhone Poulenc Sa | Nouvel antibiotique et son procédé de préparation par culture de streptomyces croceus |
GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
GB9205051D0 (en) * | 1992-03-09 | 1992-04-22 | Cancer Res Campaign Tech | Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them |
KR19990029749A (ko) * | 1997-09-17 | 1999-04-26 | 미우라 아끼라 | 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체 |
GB9818731D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Compounds |
PT1413582E (pt) * | 1998-08-27 | 2006-07-31 | Spirogen Ltd | Pirrolobenzodiazepinas dimericas |
CZ305160B6 (cs) * | 2001-06-08 | 2015-05-27 | Ipsen Pharma S.A.S. | Chimérické somatostatin-dopaminové analogy |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US7230101B1 (en) | 2002-08-28 | 2007-06-12 | Gpc Biotech, Inc. | Synthesis of methotrexate-containing heterodimeric molecules |
NZ539395A (en) | 2002-11-07 | 2009-01-31 | Immunogen Inc | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
CA2525130C (en) | 2003-05-20 | 2014-04-15 | Immunogen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
NZ580855A (en) | 2003-07-21 | 2012-03-30 | Immunogen Inc | A CA6 antigen-specific cytotoxic conjugate and methods of using the same |
WO2005040170A2 (en) | 2003-10-22 | 2005-05-06 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto |
EP1723152B1 (en) | 2004-03-09 | 2015-02-11 | Spirogen Sàrl | Pyrrolobenzodiazepines |
EP1669358A1 (en) | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
US7638491B2 (en) | 2004-12-22 | 2009-12-29 | Ambrx, Inc. | Therapies using non-natural amino acids and polypeptides |
EP1945647B9 (en) * | 2005-11-08 | 2012-11-14 | Immunogen, Inc. | Processes for preparation of maytansinol |
PT1813614E (pt) * | 2006-01-25 | 2012-01-09 | Sanofi Sa | Agentes citotóxicos compreendendo novos derivados de tomaimicina |
EP1832577A1 (en) | 2006-03-07 | 2007-09-12 | Sanofi-Aventis | Improved prodrugs of CC-1065 analogs |
WO2007127440A2 (en) | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
EP1864682A1 (en) | 2006-06-09 | 2007-12-12 | Sanofi-Aventis | Leptomycin derivatives |
ZA200900545B (en) * | 2006-07-18 | 2010-03-31 | Sanofi Aventis | Antagonist antibody against EPHA2 for the treatment of cancer |
EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
PL2019104T3 (pl) * | 2007-07-19 | 2014-03-31 | Sanofi Sa | Środki cytotoksyczne obejmujące nowe pochodne tomaymycyny i ich zastosowanie terapeutyczne |
EP2185188B1 (en) | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
SG189817A1 (en) * | 2008-04-30 | 2013-05-31 | Immunogen Inc | Potent conjugates and hydrophilic linkers |
CA3014224C (en) * | 2009-02-05 | 2022-05-24 | Immunogen, Inc. | Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives |
UY32913A (es) * | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero |
FR2963007B1 (fr) * | 2010-07-26 | 2013-04-05 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application therapeutique |
-
2009
- 2009-08-25 FR FR0904043A patent/FR2949469A1/fr active Pending
- 2009-09-11 FR FR0904368A patent/FR2949470B1/fr not_active Expired - Fee Related
-
2010
- 2010-08-12 SG SG2012012431A patent/SG178537A1/en unknown
- 2010-08-12 CN CN201080048398.6A patent/CN102753559B/zh active Active
- 2010-08-12 BR BR112012004146A patent/BR112012004146A2/pt not_active Application Discontinuation
- 2010-08-12 WO PCT/FR2010/051709 patent/WO2011023883A1/fr active Application Filing
- 2010-08-12 JP JP2012526097A patent/JP5889189B2/ja active Active
- 2010-08-12 MX MX2012002434A patent/MX2012002434A/es active IP Right Grant
- 2010-08-12 NZ NZ598401A patent/NZ598401A/en not_active IP Right Cessation
- 2010-08-12 CA CA2772102A patent/CA2772102C/fr not_active Expired - Fee Related
- 2010-08-12 EA EA201270308A patent/EA026488B1/ru not_active IP Right Cessation
- 2010-08-12 EP EP10761055.2A patent/EP2470547B1/fr active Active
- 2010-08-12 AU AU2010288382A patent/AU2010288382B2/en not_active Ceased
- 2010-08-12 UA UAA201203443A patent/UA106507C2/uk unknown
- 2010-08-12 MY MYPI2012000814A patent/MY157469A/en unknown
- 2010-08-12 ES ES10761055.2T patent/ES2484690T3/es active Active
- 2010-08-12 KR KR1020127007518A patent/KR20130026405A/ko not_active Application Discontinuation
- 2010-08-12 PE PE2012000267A patent/PE20120992A1/es not_active Application Discontinuation
- 2010-08-23 AR ARP100103066A patent/AR078143A1/es unknown
- 2010-08-24 UY UY0001032854A patent/UY32854A/es not_active Application Discontinuation
- 2010-08-24 TW TW099128330A patent/TWI477275B/zh not_active IP Right Cessation
-
2012
- 2012-02-03 TN TNP2012000053A patent/TN2012000053A1/fr unknown
- 2012-02-08 DO DO2012000038A patent/DOP2012000038A/es unknown
- 2012-02-16 GT GT201200046A patent/GT201200046A/es unknown
- 2012-02-17 CR CR20120085A patent/CR20120085A/es unknown
- 2012-02-21 CO CO12029986A patent/CO6612210A2/es unknown
- 2012-02-22 IL IL218262A patent/IL218262A0/en unknown
- 2012-02-22 EC ECSP12011688 patent/ECSP12011688A/es unknown
- 2012-02-24 ZA ZA2012/01397A patent/ZA201201397B/en unknown
- 2012-02-24 NI NI201200031A patent/NI201200031A/es unknown
- 2012-02-24 HN HN2012000437A patent/HN2012000437A/es unknown
- 2012-02-24 CL CL2012000489A patent/CL2012000489A1/es unknown
- 2012-02-24 US US13/404,872 patent/US8481042B2/en active Active
- 2012-03-21 MA MA34711A patent/MA33600B1/fr unknown
-
2013
- 2013-06-05 CL CL2013001609A patent/CL2013001609A1/es unknown
- 2013-06-21 US US13/923,544 patent/US20140155590A1/en not_active Abandoned
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