UA106507C2 - Кон'югати димерів піроло[1,4]бензодіазепіну як протираковий засіб - Google Patents
Кон'югати димерів піроло[1,4]бензодіазепіну як протираковий засібInfo
- Publication number
- UA106507C2 UA106507C2 UAA201203443A UAA201203443A UA106507C2 UA 106507 C2 UA106507 C2 UA 106507C2 UA A201203443 A UAA201203443 A UA A201203443A UA A201203443 A UAA201203443 A UA A201203443A UA 106507 C2 UA106507 C2 UA 106507C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pyrrolo
- conjugates
- anticancer agent
- benzodiazepine dimers
- benzodiazepine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Винахід стосується нових кон'югатів димерів піроло[1,4]бензодіазепіну (І), які можуть бути використані як протиракові засоби. EMBED ISISServer (I)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0904043A FR2949469A1 (fr) | 2009-08-25 | 2009-08-25 | Derives anticancereux, leur preparation et leur application en therapeutique |
FR0904368A FR2949470B1 (fr) | 2009-08-25 | 2009-09-11 | Derives anticancereux, leur preparation et leur application therapeutique |
PCT/FR2010/051709 WO2011023883A1 (fr) | 2009-08-25 | 2010-08-12 | Conjugues de dimeres de pyrrolo [1, 4 ] benzodiazepine en tant qu' anticancereux |
Publications (1)
Publication Number | Publication Date |
---|---|
UA106507C2 true UA106507C2 (uk) | 2014-09-10 |
Family
ID=41720559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201203443A UA106507C2 (uk) | 2009-08-25 | 2010-08-12 | Кон'югати димерів піроло[1,4]бензодіазепіну як протираковий засіб |
Country Status (33)
Country | Link |
---|---|
US (2) | US8481042B2 (uk) |
EP (1) | EP2470547B1 (uk) |
JP (1) | JP5889189B2 (uk) |
KR (1) | KR20130026405A (uk) |
CN (1) | CN102753559B (uk) |
AR (1) | AR078143A1 (uk) |
AU (1) | AU2010288382B2 (uk) |
BR (1) | BR112012004146A2 (uk) |
CA (1) | CA2772102C (uk) |
CL (2) | CL2012000489A1 (uk) |
CO (1) | CO6612210A2 (uk) |
CR (1) | CR20120085A (uk) |
DO (1) | DOP2012000038A (uk) |
EA (1) | EA026488B1 (uk) |
EC (1) | ECSP12011688A (uk) |
ES (1) | ES2484690T3 (uk) |
FR (2) | FR2949469A1 (uk) |
GT (1) | GT201200046A (uk) |
HN (1) | HN2012000437A (uk) |
IL (1) | IL218262A0 (uk) |
MA (1) | MA33600B1 (uk) |
MX (1) | MX2012002434A (uk) |
MY (1) | MY157469A (uk) |
NI (1) | NI201200031A (uk) |
NZ (1) | NZ598401A (uk) |
PE (1) | PE20120992A1 (uk) |
SG (1) | SG178537A1 (uk) |
TN (1) | TN2012000053A1 (uk) |
TW (1) | TWI477275B (uk) |
UA (1) | UA106507C2 (uk) |
UY (1) | UY32854A (uk) |
WO (1) | WO2011023883A1 (uk) |
ZA (1) | ZA201201397B (uk) |
Families Citing this family (74)
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EP2789622B1 (en) | 2010-04-15 | 2017-03-01 | MedImmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
EA024118B1 (ru) | 2010-04-15 | 2016-08-31 | Сиэтл Дженетикс, Инк. | Конъюгаты пирролбензодиазепина направленного действия |
KR101860174B1 (ko) | 2011-09-20 | 2018-05-21 | 메디뮨 리미티드 | 표적 접합체 내의 내포를 위한 비대칭 이량체 pbd 화합물로서 피롤로벤조디아제핀 |
EP2751111B1 (en) | 2011-10-14 | 2017-04-26 | MedImmune Limited | Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases |
KR101961976B1 (ko) | 2011-10-14 | 2019-03-25 | 시애틀 지네틱스, 인크. | 피롤로벤조디아제핀 및 표적 접합체 |
ES2945932T3 (es) | 2011-10-14 | 2023-07-10 | Seagen Inc | Pirrolobenzodiazepinas y conjugados dirigidos |
AU2012322932B2 (en) | 2011-10-14 | 2016-11-10 | Medimmune Limited | Pyrrolobenzodiazepines |
CA2858806A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
MX368678B (es) | 2012-05-15 | 2019-10-11 | Seattle Genetics Inc | Conjugados enlazadores auto-estabilizantes. |
WO2014009426A2 (en) | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
KR101995620B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
NZ707534A (en) | 2012-10-12 | 2018-08-31 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
WO2014057072A1 (en) | 2012-10-12 | 2014-04-17 | Spirogen Sàrl | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
NZ707490A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
CA3060520C (en) | 2012-10-12 | 2022-05-17 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
CA2887894C (en) | 2012-10-12 | 2019-10-29 | Adc Therapeutics Sarl | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
LT2839860T (lt) | 2012-10-12 | 2019-07-10 | Medimmune Limited | Pirolobenzodiazepinai ir jų konjugatai |
US10736903B2 (en) | 2012-10-12 | 2020-08-11 | Medimmune Limited | Pyrrolobenzodiazepine-anti-PSMA antibody conjugates |
US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
EP3564259A3 (en) | 2012-11-09 | 2020-02-12 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
TWI680766B (zh) * | 2013-03-13 | 2020-01-01 | 英商梅迪繆思有限公司 | 吡咯并苯并二氮呯及其共軛物 |
ES2843786T3 (es) | 2013-03-13 | 2021-07-20 | Seagen Inc | Filtración con carbono activado para la purificación de ADC de benzodiazepina |
JP6340019B2 (ja) | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びそのコンジュゲート |
EP2968582B1 (en) | 2013-03-15 | 2020-07-01 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
EP3010547B1 (en) | 2013-06-20 | 2021-04-21 | Innate Pharma | Enzymatic conjugation of polypeptides |
EP3010548A1 (en) | 2013-06-21 | 2016-04-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
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GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
EA201892040A1 (ru) | 2016-03-25 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Способ получения пегилированных соединений лекарственный препарат - линкер и их промежуточных соединений |
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KR20240010534A (ko) | 2016-08-09 | 2024-01-23 | 씨젠 인크. | 개선된 물리화학적 특성을 갖는 자기 안정화 링커를 구비한 약물 접합체 |
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CN114450324B (zh) | 2019-09-26 | 2024-02-27 | 日油株式会社 | 具有肽连接子的异双官能单分散聚乙二醇 |
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KR20230158005A (ko) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출 |
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-
2009
- 2009-08-25 FR FR0904043A patent/FR2949469A1/fr active Pending
- 2009-09-11 FR FR0904368A patent/FR2949470B1/fr not_active Expired - Fee Related
-
2010
- 2010-08-12 KR KR1020127007518A patent/KR20130026405A/ko not_active Application Discontinuation
- 2010-08-12 BR BR112012004146A patent/BR112012004146A2/pt not_active Application Discontinuation
- 2010-08-12 MX MX2012002434A patent/MX2012002434A/es active IP Right Grant
- 2010-08-12 UA UAA201203443A patent/UA106507C2/uk unknown
- 2010-08-12 CA CA2772102A patent/CA2772102C/fr not_active Expired - Fee Related
- 2010-08-12 MY MYPI2012000814A patent/MY157469A/en unknown
- 2010-08-12 AU AU2010288382A patent/AU2010288382B2/en not_active Ceased
- 2010-08-12 EP EP10761055.2A patent/EP2470547B1/fr active Active
- 2010-08-12 JP JP2012526097A patent/JP5889189B2/ja active Active
- 2010-08-12 NZ NZ598401A patent/NZ598401A/en not_active IP Right Cessation
- 2010-08-12 PE PE2012000267A patent/PE20120992A1/es not_active Application Discontinuation
- 2010-08-12 SG SG2012012431A patent/SG178537A1/en unknown
- 2010-08-12 ES ES10761055.2T patent/ES2484690T3/es active Active
- 2010-08-12 EA EA201270308A patent/EA026488B1/ru not_active IP Right Cessation
- 2010-08-12 CN CN201080048398.6A patent/CN102753559B/zh active Active
- 2010-08-12 WO PCT/FR2010/051709 patent/WO2011023883A1/fr active Application Filing
- 2010-08-23 AR ARP100103066A patent/AR078143A1/es unknown
- 2010-08-24 UY UY0001032854A patent/UY32854A/es not_active Application Discontinuation
- 2010-08-24 TW TW099128330A patent/TWI477275B/zh not_active IP Right Cessation
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2012
- 2012-02-03 TN TNP2012000053A patent/TN2012000053A1/fr unknown
- 2012-02-08 DO DO2012000038A patent/DOP2012000038A/es unknown
- 2012-02-16 GT GT201200046A patent/GT201200046A/es unknown
- 2012-02-17 CR CR20120085A patent/CR20120085A/es unknown
- 2012-02-21 CO CO12029986A patent/CO6612210A2/es unknown
- 2012-02-22 IL IL218262A patent/IL218262A0/en unknown
- 2012-02-22 EC ECSP12011688 patent/ECSP12011688A/es unknown
- 2012-02-24 ZA ZA2012/01397A patent/ZA201201397B/en unknown
- 2012-02-24 CL CL2012000489A patent/CL2012000489A1/es unknown
- 2012-02-24 NI NI201200031A patent/NI201200031A/es unknown
- 2012-02-24 US US13/404,872 patent/US8481042B2/en active Active
- 2012-02-24 HN HN2012000437A patent/HN2012000437A/es unknown
- 2012-03-21 MA MA34711A patent/MA33600B1/fr unknown
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2013
- 2013-06-05 CL CL2013001609A patent/CL2013001609A1/es unknown
- 2013-06-21 US US13/923,544 patent/US20140155590A1/en not_active Abandoned
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