BR112012004146A2 - "conjungados de dímeros de pirrol[1,4]benzodiazepina como agentes anticâncer" - Google Patents
"conjungados de dímeros de pirrol[1,4]benzodiazepina como agentes anticâncer"Info
- Publication number
- BR112012004146A2 BR112012004146A2 BR112012004146A BR112012004146A BR112012004146A2 BR 112012004146 A2 BR112012004146 A2 BR 112012004146A2 BR 112012004146 A BR112012004146 A BR 112012004146A BR 112012004146 A BR112012004146 A BR 112012004146A BR 112012004146 A2 BR112012004146 A2 BR 112012004146A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrol
- anticancer agents
- benzodiazepine dimer
- dimer conjugates
- conjugates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0904043A FR2949469A1 (fr) | 2009-08-25 | 2009-08-25 | Derives anticancereux, leur preparation et leur application en therapeutique |
| FR0904368A FR2949470B1 (fr) | 2009-08-25 | 2009-09-11 | Derives anticancereux, leur preparation et leur application therapeutique |
| PCT/FR2010/051709 WO2011023883A1 (fr) | 2009-08-25 | 2010-08-12 | Conjugues de dimeres de pyrrolo [1, 4 ] benzodiazepine en tant qu' anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012004146A2 true BR112012004146A2 (pt) | 2017-05-30 |
Family
ID=41720559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012004146A BR112012004146A2 (pt) | 2009-08-25 | 2010-08-12 | "conjungados de dímeros de pirrol[1,4]benzodiazepina como agentes anticâncer" |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8481042B2 (pt) |
| EP (1) | EP2470547B1 (pt) |
| JP (1) | JP5889189B2 (pt) |
| KR (1) | KR20130026405A (pt) |
| CN (1) | CN102753559B (pt) |
| AR (1) | AR078143A1 (pt) |
| AU (1) | AU2010288382B2 (pt) |
| BR (1) | BR112012004146A2 (pt) |
| CA (1) | CA2772102C (pt) |
| CL (2) | CL2012000489A1 (pt) |
| CO (1) | CO6612210A2 (pt) |
| CR (1) | CR20120085A (pt) |
| DO (1) | DOP2012000038A (pt) |
| EA (1) | EA026488B1 (pt) |
| EC (1) | ECSP12011688A (pt) |
| ES (1) | ES2484690T3 (pt) |
| FR (2) | FR2949469A1 (pt) |
| GT (1) | GT201200046A (pt) |
| HN (1) | HN2012000437A (pt) |
| IL (1) | IL218262A0 (pt) |
| MA (1) | MA33600B1 (pt) |
| MX (1) | MX2012002434A (pt) |
| MY (1) | MY157469A (pt) |
| NI (1) | NI201200031A (pt) |
| NZ (1) | NZ598401A (pt) |
| PE (1) | PE20120992A1 (pt) |
| SG (1) | SG178537A1 (pt) |
| TN (1) | TN2012000053A1 (pt) |
| TW (1) | TWI477275B (pt) |
| UA (1) | UA106507C2 (pt) |
| UY (1) | UY32854A (pt) |
| WO (1) | WO2011023883A1 (pt) |
| ZA (1) | ZA201201397B (pt) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA024118B1 (ru) | 2010-04-15 | 2016-08-31 | Сиэтл Дженетикс, Инк. | Конъюгаты пирролбензодиазепина направленного действия |
| AU2011239525B2 (en) | 2010-04-15 | 2015-04-09 | Medimmune Limited | Pyrrolobenzodiazepines used to treat proliferative diseases |
| EP2751120B1 (en) | 2011-09-20 | 2018-08-22 | MedImmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates |
| JP6393617B2 (ja) | 2011-10-14 | 2018-09-19 | シアトル ジェネティクス，インコーポレーテッド | ピロロベンゾジアゼピンおよび標的コンジュゲート |
| SG11201401021TA (en) | 2011-10-14 | 2014-08-28 | Spirogen Sarl | Pyrrolobenzodiazepines |
| US9388187B2 (en) | 2011-10-14 | 2016-07-12 | Medimmune Limited | Pyrrolobenzodiazepines |
| EP3309162A1 (en) | 2011-10-14 | 2018-04-18 | Seattle Genetics, Inc. | Targeted conjugates of pyrrolobenzodiazepines |
| US9717803B2 (en) | 2011-12-23 | 2017-08-01 | Innate Pharma | Enzymatic conjugation of polypeptides |
| US9504756B2 (en) | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| JP6423340B2 (ja) | 2012-05-15 | 2018-11-14 | シアトル ジェネティクス，インコーポレイティド | 自己安定化リンカー結合体 |
| US10132799B2 (en) | 2012-07-13 | 2018-11-20 | Innate Pharma | Screening of conjugated antibodies |
| WO2014057119A1 (en) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US10736903B2 (en) | 2012-10-12 | 2020-08-11 | Medimmune Limited | Pyrrolobenzodiazepine-anti-PSMA antibody conjugates |
| EP2906251B1 (en) | 2012-10-12 | 2017-09-27 | ADC Therapeutics SA | Pyrrolobenzodiazepine-anti-cd22 antibody conjugates |
| EP2906249B1 (en) | 2012-10-12 | 2018-06-27 | MedImmune Limited | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
| RS53818B1 (en) | 2012-10-12 | 2015-06-30 | Spirogen Sàrl | PIROLOBENZODIAZEPINI I NJIHOVI conjugated |
| US9931414B2 (en) | 2012-10-12 | 2018-04-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| CN104703630A (zh) | 2012-10-12 | 2015-06-10 | 斯皮罗根有限公司 | 吡咯并苯并二氮杂卓及其结合物 |
| PT2906253T (pt) | 2012-10-12 | 2018-11-05 | Medimmune Ltd | Conjugados de anticorpo anti-psma de pirrolobenzodiazepina |
| WO2014072482A1 (en) | 2012-11-09 | 2014-05-15 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
| EA027910B1 (ru) | 2013-03-13 | 2017-09-29 | Медимьюн Лимитед | Пирролобензодиазепины и их конъюгаты |
| CA2901312C (en) | 2013-03-13 | 2022-09-06 | Seattle Genetics, Inc. | Activated carbon filtration for purification of benzodiazepine adcs |
| JP6340019B2 (ja) * | 2013-03-13 | 2018-06-06 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
| EP2968582B1 (en) | 2013-03-15 | 2020-07-01 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
| WO2014202773A1 (en) | 2013-06-20 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
| JP6744212B2 (ja) | 2013-06-21 | 2020-08-19 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | ポリペプチドの酵素的結合 |
| WO2015052532A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
| EP3756663A1 (en) | 2013-10-15 | 2020-12-30 | Seagen Inc. | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| PT3082878T (pt) | 2013-12-19 | 2022-11-30 | Seagen Inc | Ligantes de carbamato de metileno para uso com conjugados de fármacos de marcação |
| US10464997B2 (en) | 2014-02-11 | 2019-11-05 | Seattle Genetics, Inc. | Selective reduction of proteins |
| WO2016008112A1 (en) | 2014-07-16 | 2016-01-21 | Medshine Discovery Inc. | Linkers and application towards adc thereof |
| BR112017004631A2 (pt) | 2014-09-12 | 2018-01-30 | Genentech, Inc. | anticorpo, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, métodos de tratamento, de inibição da proliferação de uma célula e de detecção de her2 humana e método para a detecção de um câncer |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| MX2017003472A (es) * | 2014-09-17 | 2017-10-31 | Genentech Inc | Inmunoconjugados que comprenden anticuerpos anti-her2. |
| JP6878287B2 (ja) | 2014-11-25 | 2021-05-26 | アーデーセー セラピューティクス ソシエテ アノニム | ピロロベンゾジアゼピン−抗体コンジュゲート |
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| CN107231804B (zh) | 2015-01-14 | 2019-11-26 | 百时美施贵宝公司 | 亚杂芳基桥连苯并二氮杂*二聚体、其缀合物及制备和使用方法 |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| US9688694B2 (en) | 2015-06-23 | 2017-06-27 | Bristol-Myers Squibb Company | Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EA201892040A1 (ru) | 2016-03-25 | 2019-04-30 | Сиэтл Дженетикс, Инк. | Способ получения пегилированных соединений лекарственный препарат - линкер и их промежуточных соединений |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EP3496747A4 (en) | 2016-08-09 | 2020-04-15 | Seattle Genetics, Inc. | CONJUGATES OF MEDICINES WITH SELF-STABILIZING PLACES WITH IMPROVED PHYSICAL CHEMICAL PROPERTIES |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| JP7244987B2 (ja) | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
| CA3046548A1 (en) | 2017-01-24 | 2018-08-02 | Innate Pharma | Nkp46 binding agents |
| EP3577138A1 (en) | 2017-02-06 | 2019-12-11 | Innate Pharma | Immunomodulatory antibody drug conjugates binding to a human mica polypeptide |
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| PL3612234T3 (pl) | 2017-04-20 | 2024-09-02 | Adc Therapeutics Sa | Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek |
| BR112019026564A2 (pt) | 2017-06-14 | 2020-06-30 | Adc Therapeutics Sa | regimes de dosagem para a administração de um adc anti-cd19 |
| CN111065638B (zh) | 2017-08-18 | 2021-04-09 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂䓬缀合物 |
| TW202404649A (zh) | 2017-09-29 | 2024-02-01 | 日商第一三共股份有限公司 | 抗體－吡咯并苯二氮呯衍生物複合體 |
| WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
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| JPWO2021060439A1 (pt) | 2019-09-26 | 2021-04-01 | ||
| KR20230008723A (ko) | 2020-04-10 | 2023-01-16 | 씨젠 인크. | 전하 변이체 링커 |
| EP4251207A1 (en) | 2020-11-25 | 2023-10-04 | Innate Pharma | Treatment of cancer |
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| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
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-
2009
- 2009-08-25 FR FR0904043A patent/FR2949469A1/fr active Pending
- 2009-09-11 FR FR0904368A patent/FR2949470B1/fr not_active Expired - Fee Related
-
2010
- 2010-08-12 ES ES10761055.2T patent/ES2484690T3/es active Active
- 2010-08-12 EA EA201270308A patent/EA026488B1/ru not_active IP Right Cessation
- 2010-08-12 UA UAA201203443A patent/UA106507C2/uk unknown
- 2010-08-12 CN CN201080048398.6A patent/CN102753559B/zh active Active
- 2010-08-12 KR KR1020127007518A patent/KR20130026405A/ko not_active Application Discontinuation
- 2010-08-12 BR BR112012004146A patent/BR112012004146A2/pt not_active Application Discontinuation
- 2010-08-12 EP EP10761055.2A patent/EP2470547B1/fr active Active
- 2010-08-12 MY MYPI2012000814A patent/MY157469A/en unknown
- 2010-08-12 WO PCT/FR2010/051709 patent/WO2011023883A1/fr active Application Filing
- 2010-08-12 AU AU2010288382A patent/AU2010288382B2/en not_active Ceased
- 2010-08-12 CA CA2772102A patent/CA2772102C/fr not_active Expired - Fee Related
- 2010-08-12 SG SG2012012431A patent/SG178537A1/en unknown
- 2010-08-12 PE PE2012000267A patent/PE20120992A1/es not_active Application Discontinuation
- 2010-08-12 NZ NZ598401A patent/NZ598401A/en not_active IP Right Cessation
- 2010-08-12 MX MX2012002434A patent/MX2012002434A/es active IP Right Grant
- 2010-08-12 JP JP2012526097A patent/JP5889189B2/ja active Active
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2013
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