HK39790A - Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes - Google Patents

Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes

Info

Publication number
HK39790A
HK39790A HK397/90A HK39790A HK39790A HK 39790 A HK39790 A HK 39790A HK 397/90 A HK397/90 A HK 397/90A HK 39790 A HK39790 A HK 39790A HK 39790 A HK39790 A HK 39790A
Authority
HK
Hong Kong
Prior art keywords
hydroxymorphinans
intermediates
processes
prodrug derivatives
ester prodrug
Prior art date
Application number
HK397/90A
Other languages
English (en)
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of HK39790A publication Critical patent/HK39790A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK397/90A 1984-07-05 1990-05-24 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes HK39790A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (1)

Publication Number Publication Date
HK39790A true HK39790A (en) 1990-06-01

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
HK397/90A HK39790A (en) 1984-07-05 1990-05-24 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes

Country Status (18)

Country Link
US (1) US4668685A (en:Method)
EP (1) EP0170090B1 (en:Method)
AU (1) AU578391B2 (en:Method)
CA (1) CA1301150C (en:Method)
DE (1) DE3573251D1 (en:Method)
DK (1) DK160501C (en:Method)
ES (1) ES8704443A1 (en:Method)
FI (1) FI83215C (en:Method)
GR (1) GR851653B (en:Method)
HK (1) HK39790A (en:Method)
HU (1) HU193995B (en:Method)
IE (1) IE58136B1 (en:Method)
IL (1) IL75721A (en:Method)
MX (1) MX160445A (en:Method)
NO (1) NO171209C (en:Method)
NZ (1) NZ212641A (en:Method)
PT (1) PT80773B (en:Method)
SU (2) SU1450742A3 (en:Method)

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DE60236171D1 (de) * 2001-08-23 2010-06-10 Organon Nv Verfahren for zur herstellung eines 14-hydroxynormorphinon-derivats
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EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
WO2006034343A2 (en) * 2004-09-23 2006-03-30 Alexander Michalow methods for regulating neurotransmitter systems by inducing counteradaptationS
BRPI0606339A2 (pt) * 2005-01-28 2009-06-16 Euro Celtique Sa formas farmacêuticas resistentes a álcool
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
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ME03298B (me) 2009-03-10 2019-07-20 Euro Celtique Sa Farmaceutske kombinacije sa trenutnim oslobađanjem које obuhvataju oksikodon i nalokson
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
DK2639234T3 (da) 2010-11-12 2019-09-23 Shionogi & Co Krystallinsk 6,7-umættet 7-carbamoylmorphinanderivat og fremgangsmåde til fremstilling heraf
US8816083B2 (en) 2011-10-26 2014-08-26 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
KR20160034352A (ko) 2013-07-23 2016-03-29 유로-셀티큐 에스.에이. 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
MX2017006520A (es) 2014-11-25 2017-08-09 Kempharm Inc * Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico.
CA2969221C (en) 2014-12-02 2021-01-12 Travis Mickle Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
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US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
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Also Published As

Publication number Publication date
US4668685A (en) 1987-05-26
GR851653B (en:Method) 1985-11-26
IE851683L (en) 1986-01-05
IE58136B1 (en) 1993-07-14
AU4451685A (en) 1986-01-09
SU1450742A3 (ru) 1989-01-07
IL75721A0 (en) 1985-11-29
DK306885A (da) 1986-01-06
ES544852A0 (es) 1987-04-01
PT80773A (en) 1985-08-01
EP0170090B1 (en) 1989-09-27
NO171209C (no) 1993-02-10
DK160501C (da) 1991-08-26
NO852699L (no) 1986-01-06
HU193995B (en) 1987-12-28
EP0170090A1 (en) 1986-02-05
FI83215C (fi) 1991-06-10
ES8704443A1 (es) 1987-04-01
PT80773B (pt) 1987-10-20
DE3573251D1 (en) 1989-11-02
DK306885D0 (da) 1985-07-04
HUT40132A (en) 1986-11-28
FI852659L (fi) 1986-01-06
IL75721A (en) 1990-04-29
NZ212641A (en) 1988-10-28
NO171209B (no) 1992-11-02
DK160501B (da) 1991-03-18
SU1508960A3 (ru) 1989-09-15
FI852659A0 (fi) 1985-07-04
MX160445A (es) 1990-03-02
FI83215B (fi) 1991-02-28
AU578391B2 (en) 1988-10-20
CA1301150C (en) 1992-05-19

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