DK160501C - Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne - Google Patents

Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Info

Publication number
DK160501C
DK160501C DK306885A DK306885A DK160501C DK 160501 C DK160501 C DK 160501C DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A DK 160501 C DK160501 C DK 160501C
Authority
DK
Denmark
Prior art keywords
hydroxymorphinanes
testers
sugar
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK306885A
Other languages
Danish (da)
English (en)
Other versions
DK306885A (da
DK160501B (da
DK306885D0 (da
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK306885D0 publication Critical patent/DK306885D0/da
Publication of DK306885A publication Critical patent/DK306885A/da
Publication of DK160501B publication Critical patent/DK160501B/da
Application granted granted Critical
Publication of DK160501C publication Critical patent/DK160501C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK306885A 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne DK160501C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US62792384 1984-07-05
US73346485 1985-05-14
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (4)

Publication Number Publication Date
DK306885D0 DK306885D0 (da) 1985-07-04
DK306885A DK306885A (da) 1986-01-06
DK160501B DK160501B (da) 1991-03-18
DK160501C true DK160501C (da) 1991-08-26

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
DK306885A DK160501C (da) 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Country Status (18)

Country Link
US (1) US4668685A (en:Method)
EP (1) EP0170090B1 (en:Method)
AU (1) AU578391B2 (en:Method)
CA (1) CA1301150C (en:Method)
DE (1) DE3573251D1 (en:Method)
DK (1) DK160501C (en:Method)
ES (1) ES8704443A1 (en:Method)
FI (1) FI83215C (en:Method)
GR (1) GR851653B (en:Method)
HK (1) HK39790A (en:Method)
HU (1) HU193995B (en:Method)
IE (1) IE58136B1 (en:Method)
IL (1) IL75721A (en:Method)
MX (1) MX160445A (en:Method)
NO (1) NO171209C (en:Method)
NZ (1) NZ212641A (en:Method)
PT (1) PT80773B (en:Method)
SU (2) SU1450742A3 (en:Method)

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US6225321B1 (en) * 1997-06-05 2001-05-01 Oliver Yoa-Pu Hu Long analgesic acting nalbuphine polyester derivative and method of use
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US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
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US6569449B1 (en) 2000-11-13 2003-05-27 University Of Kentucky Research Foundation Transdermal delivery of opioid antagonist prodrugs
EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
BRPI0211899B8 (pt) * 2001-08-23 2021-05-25 Akzo Nobel Nv processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
TWI334779B (en) 2002-04-05 2010-12-21 Euro Celtique Sa Pharmaceutical preparation containing oxycodone and naloxone
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
CN101065014A (zh) * 2004-09-23 2007-10-31 亚历山大·米哈洛 通过诱导逆适应调节神经递质系统的方法
BRPI0606339A2 (pt) * 2005-01-28 2009-06-16 Euro Celtique Sa formas farmacêuticas resistentes a álcool
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
WO2007022535A2 (en) 2005-08-19 2007-02-22 Pharmacofore, Inc. Prodrugs of active agents
GB0606124D0 (en) * 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
CN101627014B (zh) * 2007-03-09 2013-04-24 株式会社绿十字 用于预防或治疗帕金森病的(+)-3-羟基吗啡喃的口服可生物利用前药
ES2635733T3 (es) * 2008-07-07 2017-10-04 Euro-Celtique S.A. Uso de antagonistas opioideos para tratar la retención urinaria
TR201900199T4 (tr) 2009-03-10 2019-02-21 Euro Celtique Sa Oksikodon ve nalokson içeren çabuk salımlı farmasötik bileşimler.
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
HUE044933T2 (hu) * 2010-11-12 2019-11-28 Shionogi & Co Kristályos 6,7-telítetlen-7-karbamoil-morfinán származék, és az elõállítására szolgáló eljárás
CN104136031B (zh) 2011-10-26 2016-05-04 凯姆制药公司 氢吗啡酮的苯甲酸缀合物、苯甲酸衍生物缀合物和杂芳基羧酸缀合物、其前药、制备和使用方法
MY183489A (en) 2013-07-23 2021-02-22 Euro Celtique Sa A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
RU2683317C2 (ru) 2014-11-25 2019-03-28 Кемфарм, Инк. Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой
JP6462877B2 (ja) 2014-12-02 2019-01-30 ケムファーム・インコーポレーテッド オキシモルホンの安息香酸、安息香酸誘導体及びヘテロアリールカルボン酸結合体、プロドラッグ、その製造法及び使用
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
WO2020012248A1 (en) 2018-07-13 2020-01-16 Alkermes Pharma Ireland Limited Novel naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods
WO2021029914A1 (en) 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates

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US3254088A (en) * 1961-03-14 1966-05-31 Lewenstein Morphine derivative
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH543514A (de) * 1967-08-25 1973-10-31 Hoffmann La Roche Verfahren zur Herstellung von Morphinanderivaten
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59186987A (ja) * 1983-04-06 1984-10-23 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン

Also Published As

Publication number Publication date
GR851653B (en:Method) 1985-11-26
DK306885A (da) 1986-01-06
EP0170090A1 (en) 1986-02-05
US4668685A (en) 1987-05-26
HUT40132A (en) 1986-11-28
FI83215C (fi) 1991-06-10
SU1450742A3 (ru) 1989-01-07
EP0170090B1 (en) 1989-09-27
NO852699L (no) 1986-01-06
HK39790A (en) 1990-06-01
FI852659L (fi) 1986-01-06
FI83215B (fi) 1991-02-28
AU578391B2 (en) 1988-10-20
IE58136B1 (en) 1993-07-14
IE851683L (en) 1986-01-05
MX160445A (es) 1990-03-02
NO171209C (no) 1993-02-10
FI852659A0 (fi) 1985-07-04
AU4451685A (en) 1986-01-09
IL75721A0 (en) 1985-11-29
NZ212641A (en) 1988-10-28
NO171209B (no) 1992-11-02
ES544852A0 (es) 1987-04-01
ES8704443A1 (es) 1987-04-01
PT80773A (en) 1985-08-01
SU1508960A3 (ru) 1989-09-15
DK160501B (da) 1991-03-18
CA1301150C (en) 1992-05-19
DE3573251D1 (en) 1989-11-02
IL75721A (en) 1990-04-29
PT80773B (pt) 1987-10-20
DK306885D0 (da) 1985-07-04
HU193995B (en) 1987-12-28

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