PT80773B - Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem

Info

Publication number
PT80773B
PT80773B PT80773A PT8077385A PT80773B PT 80773 B PT80773 B PT 80773B PT 80773 A PT80773 A PT 80773A PT 8077385 A PT8077385 A PT 8077385A PT 80773 B PT80773 B PT 80773B
Authority
PT
Portugal
Prior art keywords
profarmacles
hydroxymorfinoan
derivatives
contain
preparation
Prior art date
Application number
PT80773A
Other languages
English (en)
Portuguese (pt)
Other versions
PT80773A (en
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PT80773A publication Critical patent/PT80773A/pt
Publication of PT80773B publication Critical patent/PT80773B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT80773A 1984-07-05 1985-07-04 Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem PT80773B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (2)

Publication Number Publication Date
PT80773A PT80773A (en) 1985-08-01
PT80773B true PT80773B (pt) 1987-10-20

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
PT80773A PT80773B (pt) 1984-07-05 1985-07-04 Processo para a preparacao dos profarmacos benzoatos substituidos de derivados de 3-hidroximorfinanos de compostos intermedios na sua preparacao e de composicoes farmaceuticas que os contem

Country Status (18)

Country Link
US (1) US4668685A (en:Method)
EP (1) EP0170090B1 (en:Method)
AU (1) AU578391B2 (en:Method)
CA (1) CA1301150C (en:Method)
DE (1) DE3573251D1 (en:Method)
DK (1) DK160501C (en:Method)
ES (1) ES8704443A1 (en:Method)
FI (1) FI83215C (en:Method)
GR (1) GR851653B (en:Method)
HK (1) HK39790A (en:Method)
HU (1) HU193995B (en:Method)
IE (1) IE58136B1 (en:Method)
IL (1) IL75721A (en:Method)
MX (1) MX160445A (en:Method)
NO (1) NO171209C (en:Method)
NZ (1) NZ212641A (en:Method)
PT (1) PT80773B (en:Method)
SU (2) SU1450742A3 (en:Method)

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US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
AU2005286733B2 (en) * 2004-09-23 2009-11-05 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP2289491A1 (en) * 2005-01-28 2011-03-02 Euro-Celtique S.A. Alcohol resistant dosage forms
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US8163701B2 (en) 2005-08-19 2012-04-24 Signature Therapeutics, Inc. Prodrugs of active agents
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JP5406288B2 (ja) * 2008-07-07 2014-02-05 ユーロ−セルティーク エス．エイ． 尿閉を治療するためのオピオイド拮抗薬の使用
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US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
WO2011008636A1 (en) * 2009-07-15 2011-01-20 Mallinckrodt Inc. 3-oxy-hydromorphone derivatives
TWI545124B (zh) * 2010-11-12 2016-08-11 鹽野義製藥股份有限公司 ６，７－不飽合－７－胺甲醯基嗎啡喃衍生物之結晶及其製造方法
MX362857B (es) 2011-10-26 2019-02-20 Kempharm Inc Star Acido benzoico, derivados de acido benzoico y conjugados de acido heteroarilcarboxilico de hidromorfona, profarmacos, metodos de elaboracion y uso de los mismos.
KR20160034352A (ko) 2013-07-23 2016-03-29 유로-셀티큐 에스.에이. 장내 세균총이상을 초래하고/하거나 장내 박테리아 전위에 대한 위험을 증가시키는 질환과 통증으로 인해 고통받고 있는 환자에서 통증을 치료하는데 사용하기 위한 옥시코돈과 날록손의 조합물
BR112017011069A2 (pt) 2014-11-25 2018-07-10 Kempharm Inc ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona
CA2969221C (en) 2014-12-02 2021-01-12 Travis Mickle Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
CA3149152A1 (en) 2019-08-11 2021-02-18 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates

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FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
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IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
GB1097167A (en) * 1966-05-31 1967-12-29 Shionogi & Co 3-hydroxy-6-oxo-n-phenethylmorphinan compounds and their production
CH560194A5 (en:Method) * 1967-08-25 1975-03-27 Hoffmann La Roche
US3654280A (en) * 1968-03-21 1972-04-04 Shionogi & Co L-n allylic-3-hydroxy-6-oxomorphinans
DE2323192A1 (de) * 1972-05-10 1973-12-13 Endo Lab Injizierbare, langwirkende antagonistpraeparate gegen narkotika und rauschgifte
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
JPS59184183A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルブチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エテノモルヒナン
JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
JPS59184163A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−１７−メチルモルヒナン
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Also Published As

Publication number Publication date
DK160501B (da) 1991-03-18
FI83215B (fi) 1991-02-28
DK306885A (da) 1986-01-06
IE851683L (en) 1986-01-05
DK160501C (da) 1991-08-26
FI852659A0 (fi) 1985-07-04
IL75721A (en) 1990-04-29
PT80773A (en) 1985-08-01
MX160445A (es) 1990-03-02
NO171209C (no) 1993-02-10
IL75721A0 (en) 1985-11-29
DE3573251D1 (en) 1989-11-02
IE58136B1 (en) 1993-07-14
NO852699L (no) 1986-01-06
AU578391B2 (en) 1988-10-20
ES8704443A1 (es) 1987-04-01
EP0170090B1 (en) 1989-09-27
ES544852A0 (es) 1987-04-01
HU193995B (en) 1987-12-28
US4668685A (en) 1987-05-26
FI852659L (fi) 1986-01-06
AU4451685A (en) 1986-01-09
GR851653B (en:Method) 1985-11-26
DK306885D0 (da) 1985-07-04
EP0170090A1 (en) 1986-02-05
SU1508960A3 (ru) 1989-09-15
HK39790A (en) 1990-06-01
HUT40132A (en) 1986-11-28
NZ212641A (en) 1988-10-28
NO171209B (no) 1992-11-02
CA1301150C (en) 1992-05-19
FI83215C (fi) 1991-06-10
SU1450742A3 (ru) 1989-01-07

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Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 920721 DU PONT MERCK PHARMACEUTIVAL COMPANY,THE US

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19930930