DK2639234T3 - Krystallinsk 6,7-umættet 7-carbamoylmorphinanderivat og fremgangsmåde til fremstilling heraf - Google Patents
Krystallinsk 6,7-umættet 7-carbamoylmorphinanderivat og fremgangsmåde til fremstilling heraf Download PDFInfo
- Publication number
- DK2639234T3 DK2639234T3 DK11839554.0T DK11839554T DK2639234T3 DK 2639234 T3 DK2639234 T3 DK 2639234T3 DK 11839554 T DK11839554 T DK 11839554T DK 2639234 T3 DK2639234 T3 DK 2639234T3
- Authority
- DK
- Denmark
- Prior art keywords
- morphinand
- crystallic
- carbamoyl
- saturated
- derivative
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/08—Halides
- B01J27/10—Chlorides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010253688 | 2010-11-12 | ||
| PCT/JP2011/076034 WO2012063933A1 (ja) | 2010-11-12 | 2011-11-11 | ６，７－不飽和－７－カルバモイルモルヒナン誘導体の結晶およびその製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2639234T3 true DK2639234T3 (da) | 2019-09-23 |
Family
ID=46051070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11839554.0T DK2639234T3 (da) | 2010-11-12 | 2011-11-11 | Krystallinsk 6,7-umættet 7-carbamoylmorphinanderivat og fremgangsmåde til fremstilling heraf |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US9108975B2 (da) |
| EP (2) | EP3560929B1 (da) |
| JP (2) | JP5070364B2 (da) |
| KR (2) | KR101500915B1 (da) |
| CN (2) | CN105131003B (da) |
| AU (2) | AU2011327113B9 (da) |
| BR (1) | BR112013011593B1 (da) |
| CA (1) | CA2814195C (da) |
| CY (1) | CY1123670T1 (da) |
| DK (1) | DK2639234T3 (da) |
| ES (1) | ES2746207T3 (da) |
| HR (1) | HRP20191597T1 (da) |
| HU (1) | HUE044933T2 (da) |
| IL (2) | IL225725A (da) |
| LT (1) | LT2639234T (da) |
| MX (2) | MX338392B (da) |
| PH (1) | PH12015501226B1 (da) |
| PL (1) | PL2639234T3 (da) |
| PT (1) | PT2639234T (da) |
| RS (1) | RS59256B1 (da) |
| RU (2) | RU2643807C1 (da) |
| SI (1) | SI2639234T1 (da) |
| TW (2) | TWI545124B (da) |
| UA (1) | UA115028C2 (da) |
| WO (1) | WO2012063933A1 (da) |
| ZA (1) | ZA201301726B (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| RU2643807C1 (ru) * | 2010-11-12 | 2018-02-06 | Сионоги Энд Ко., Лтд. | Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения |
| ES2903149T3 (es) | 2012-05-14 | 2022-03-31 | Shionogi & Co | Preparación que contiene derivado de 7-carbamoilmorfinano 6,7-insaturado |
| WO2014091295A1 (en) | 2012-12-14 | 2014-06-19 | Purdue Pharma L.P. | Pyridonemorphinan analogs and biological activity on opioid receptors |
| TW201434836A (zh) | 2012-12-14 | 2014-09-16 | Purdue Pharma Lp | 包含氮之嗎啡喃衍生物及其用途 |
| EP2941430B1 (en) | 2012-12-28 | 2017-04-26 | Purdue Pharma LP | 7,8-cyclicmorphinan analogs |
| WO2014102593A1 (en) | 2012-12-28 | 2014-07-03 | Purdue Pharma L.P. | Substituted morphinans and the use thereof |
| BR112015020667A2 (pt) * | 2013-03-15 | 2017-07-18 | Genzyme Corp | método de preparar inibidores de glucosilceramida sintase |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
| WO2015097546A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Propellane-based compounds and their use as opioid receptor modulators |
| JP7076171B2 (ja) * | 2016-12-26 | 2022-05-27 | 塩野義製薬株式会社 | 含量均一性を改善した製剤の製造方法 |
| KR102201609B1 (ko) * | 2019-04-19 | 2021-01-12 | 연성정밀화학(주) | 날데메딘의 제조방법 |
| EP4062973A4 (en) * | 2019-11-20 | 2023-11-29 | Shionogi & Co., Ltd | SOLID FORMULATION CONTAINING 6,7-UNSATURATED-7-CARBAMOYL MORPHINAND DERIVATIVE |
| MX2023001014A (es) | 2020-07-24 | 2023-03-01 | Genzyme Corp | Composiciones farmaceuticas que comprenden venglustat. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2801509A1 (de) * | 1978-01-12 | 1979-07-19 | Schering Ag | 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| WO2001002375A1 (en) | 1999-07-01 | 2001-01-11 | Chemrx Advanced Technologies, Inc. | Process for synthesizing oxadiazoles |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| RU2643807C1 (ru) * | 2010-11-12 | 2018-02-06 | Сионоги Энд Ко., Лтд. | Кристаллы производных 6,7-ненасыщенного-7-карбамоилморфинана и способ их получения |
-
2011
- 2011-11-11 RU RU2016113269A patent/RU2643807C1/ru not_active IP Right Cessation
- 2011-11-11 WO PCT/JP2011/076034 patent/WO2012063933A1/ja active Application Filing
- 2011-11-11 HU HUE11839554 patent/HUE044933T2/hu unknown
- 2011-11-11 UA UAA201307448A patent/UA115028C2/uk unknown
- 2011-11-11 CA CA2814195A patent/CA2814195C/en active Active
- 2011-11-11 TW TW100141268A patent/TWI545124B/zh active
- 2011-11-11 KR KR1020147011039A patent/KR101500915B1/ko active IP Right Grant
- 2011-11-11 KR KR1020137014943A patent/KR101486686B1/ko active IP Right Grant
- 2011-11-11 BR BR112013011593-9A patent/BR112013011593B1/pt active IP Right Grant
- 2011-11-11 SI SI201131781T patent/SI2639234T1/sl unknown
- 2011-11-11 MX MX2013005241A patent/MX338392B/es active IP Right Grant
- 2011-11-11 PL PL11839554T patent/PL2639234T3/pl unknown
- 2011-11-11 DK DK11839554.0T patent/DK2639234T3/da active
- 2011-11-11 ES ES11839554T patent/ES2746207T3/es active Active
- 2011-11-11 JP JP2012512162A patent/JP5070364B2/ja active Active
- 2011-11-11 US US13/884,770 patent/US9108975B2/en active Active
- 2011-11-11 RS RSP20191184 patent/RS59256B1/sr unknown
- 2011-11-11 TW TW105118949A patent/TWI597282B/zh active
- 2011-11-11 CN CN201510332439.9A patent/CN105131003B/zh active Active
- 2011-11-11 CN CN201180064907.9A patent/CN103298819B/zh active Active
- 2011-11-11 PT PT11839554T patent/PT2639234T/pt unknown
- 2011-11-11 MX MX2015008305A patent/MX348228B/es unknown
- 2011-11-11 EP EP19162034.3A patent/EP3560929B1/en active Active
- 2011-11-11 AU AU2011327113A patent/AU2011327113B9/en active Active
- 2011-11-11 EP EP11839554.0A patent/EP2639234B1/en active Active
- 2011-11-11 LT LTEP11839554.0T patent/LT2639234T/lt unknown
- 2011-11-11 RU RU2013126801A patent/RU2607084C2/ru active
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2012
- 2012-03-06 JP JP2012049520A patent/JP5191574B2/ja active Active
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2013
- 2013-03-06 ZA ZA2013/01726A patent/ZA201301726B/en unknown
- 2013-04-11 IL IL225725A patent/IL225725A/en active IP Right Grant
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2015
- 2015-06-01 PH PH12015501226A patent/PH12015501226B1/en unknown
- 2015-08-04 US US14/818,130 patent/US9315512B2/en active Active
- 2015-08-04 US US14/818,152 patent/US9296756B2/en active Active
- 2015-08-31 AU AU2015221439A patent/AU2015221439B2/en not_active Ceased
- 2015-12-17 IL IL243188A patent/IL243188A/en active IP Right Grant
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2016
- 2016-03-15 US US15/071,147 patent/US9464094B2/en active Active
- 2016-09-09 US US15/261,836 patent/US9902732B2/en active Active
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2017
- 2017-11-15 US US15/814,358 patent/US9951082B2/en active Active
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2019
- 2019-09-04 HR HRP20191597 patent/HRP20191597T1/hr unknown
- 2019-09-26 CY CY20191101018T patent/CY1123670T1/el unknown
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