HK175495A - Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole - Google Patents

Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole Download PDF

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Publication number
HK175495A
HK175495A HK175495A HK175495A HK175495A HK 175495 A HK175495 A HK 175495A HK 175495 A HK175495 A HK 175495A HK 175495 A HK175495 A HK 175495A HK 175495 A HK175495 A HK 175495A
Authority
HK
Hong Kong
Prior art keywords
indole
amino
hippurate
tetrahydrobenz
aminocarbonyl
Prior art date
Application number
HK175495A
Other languages
German (de)
English (en)
French (fr)
Inventor
Joseph Kress Thomas
Lee Varie David
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HK175495A publication Critical patent/HK175495A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK175495A 1990-02-26 1995-11-16 Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole HK175495A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (1)

Publication Number Publication Date
HK175495A true HK175495A (en) 1995-11-24

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
HK175495A HK175495A (en) 1990-02-26 1995-11-16 Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole

Country Status (28)

Country Link
US (1) US5397799A (OSRAM)
EP (1) EP0444852B1 (OSRAM)
JP (1) JP3157007B2 (OSRAM)
KR (1) KR100208114B1 (OSRAM)
CN (1) CN1027503C (OSRAM)
AT (1) ATE126506T1 (OSRAM)
AU (1) AU629453B2 (OSRAM)
BR (1) BR9100767A (OSRAM)
CA (1) CA2037099C (OSRAM)
CY (1) CY1887A (OSRAM)
DE (1) DE69112099T2 (OSRAM)
DK (1) DK0444852T3 (OSRAM)
ES (1) ES2077796T3 (OSRAM)
FI (1) FI95464C (OSRAM)
GR (1) GR3017940T3 (OSRAM)
HK (1) HK175495A (OSRAM)
HU (1) HU217118B (OSRAM)
IE (1) IE67801B1 (OSRAM)
IL (1) IL97306A (OSRAM)
LV (1) LV10251B (OSRAM)
NO (1) NO174149C (OSRAM)
NZ (1) NZ237181A (OSRAM)
PT (1) PT96852B (OSRAM)
RU (2) RU2034837C1 (OSRAM)
SG (1) SG69975A1 (OSRAM)
TW (1) TW219933B (OSRAM)
YU (1) YU47594B (OSRAM)
ZA (1) ZA911258B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
US5627199A (en) * 1991-03-28 1997-05-06 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz [CD] indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (OSRAM) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
DK3357911T3 (da) 2006-06-26 2022-07-04 Akebia Therapeutics Inc Prolylhydroxylaseinhibitorer og fremgangsmåder til anvendelse
PT2496084E (pt) * 2009-11-06 2015-08-21 Aerpio Therapeutics Inc Métodos para aumentar a estabilização de fator-1 alfa indutivel por hipoxia
NO2686520T3 (OSRAM) 2011-06-06 2018-03-17
JP2014522410A (ja) 2011-06-06 2014-09-04 アケビア セラピューティクス インコーポレイテッド がん治療のための方法として低酸素誘導因子−２αを安定化するための、化合物および組成物
MY204336A (en) 2013-06-13 2024-08-23 Akebia Therapeutics Inc Compositions and methods for treating anemia
EP3578546A1 (en) 2013-11-15 2019-12-11 Akebia Therapeutics Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
AU2016209126A1 (en) 2015-01-23 2017-08-10 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
BR112017021097B1 (pt) 2015-04-01 2024-01-02 Akebia Therapeutics, Inc Formulação de dosagem oral e seu uso
MX2020011845A (es) 2018-05-09 2021-01-15 Akebia Therapeutics Inc Proceso para preparar acido 2-[[5-(3-clorofenil)-3-hidroxipiridina -2-carbonil]amino]acetico.
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
FI910895L (fi) 1991-08-27
DE69112099T2 (de) 1996-02-08
CA2037099C (en) 2001-09-11
EP0444852A2 (en) 1991-09-04
FI95464B (fi) 1995-10-31
NO910735D0 (no) 1991-02-25
DK0444852T3 (da) 1995-12-11
PT96852B (pt) 1998-07-31
FI910895A0 (fi) 1991-02-25
TW219933B (OSRAM) 1994-02-01
ATE126506T1 (de) 1995-09-15
CA2037099A1 (en) 1991-08-27
IE67801B1 (en) 1996-05-01
HU217118B (hu) 1999-11-29
LV10251B (en) 1995-04-20
LV10251A (lv) 1994-10-20
SG69975A1 (en) 2000-01-25
NO910735L (no) 1991-08-27
IE910625A1 (en) 1991-08-28
NZ237181A (en) 1992-06-25
AU629453B2 (en) 1992-10-01
JP3157007B2 (ja) 2001-04-16
CN1027503C (zh) 1995-01-25
FI95464C (fi) 1996-02-12
CN1054589A (zh) 1991-09-18
AU7197191A (en) 1991-08-29
PT96852A (pt) 1991-10-31
ZA911258B (en) 1992-10-28
EP0444852B1 (en) 1995-08-16
BR9100767A (pt) 1991-10-29
ES2077796T3 (es) 1995-12-01
YU47594B (sh) 1995-10-24
US5397799A (en) 1995-03-14
GR3017940T3 (en) 1996-02-29
KR910021375A (ko) 1991-12-20
CY1887A (en) 1996-04-05
NO174149C (no) 1994-03-23
IL97306A0 (en) 1992-05-25
DE69112099D1 (de) 1995-09-21
NO174149B (no) 1993-12-13
YU32791A (sh) 1994-01-20
EP0444852A3 (en) 1992-02-19
RU2083561C1 (ru) 1997-07-10
JPH04217662A (ja) 1992-08-07
KR100208114B1 (ko) 1999-07-15
IL97306A (en) 1996-10-16
HUT56542A (en) 1991-09-30
RU2034837C1 (ru) 1995-05-10

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20070226