BR9100767A - Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino - Google Patents

Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino

Info

Publication number
BR9100767A
BR9100767A BR919100767A BR9100767A BR9100767A BR 9100767 A BR9100767 A BR 9100767A BR 919100767 A BR919100767 A BR 919100767A BR 9100767 A BR9100767 A BR 9100767A BR 9100767 A BR9100767 A BR 9100767A
Authority
BR
Brazil
Prior art keywords
amino
preparation
tetrahidrobenz
hypurate
propil
Prior art date
Application number
BR919100767A
Other languages
English (en)
Portuguese (pt)
Inventor
Thomas Joseph Kress
David Lee Varie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9100767A publication Critical patent/BR9100767A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR919100767A 1990-02-26 1991-02-26 Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino BR9100767A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (1)

Publication Number Publication Date
BR9100767A true BR9100767A (pt) 1991-10-29

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
BR919100767A BR9100767A (pt) 1990-02-26 1991-02-26 Composto,formulacao farmaceutica e metodo para a preparacao de hipurato de 4-(di-n-propil)amino-1,3,4,5-tetrahidrobenz(cd)indol cristalino

Country Status (28)

Country Link
US (1) US5397799A (OSRAM)
EP (1) EP0444852B1 (OSRAM)
JP (1) JP3157007B2 (OSRAM)
KR (1) KR100208114B1 (OSRAM)
CN (1) CN1027503C (OSRAM)
AT (1) ATE126506T1 (OSRAM)
AU (1) AU629453B2 (OSRAM)
BR (1) BR9100767A (OSRAM)
CA (1) CA2037099C (OSRAM)
CY (1) CY1887A (OSRAM)
DE (1) DE69112099T2 (OSRAM)
DK (1) DK0444852T3 (OSRAM)
ES (1) ES2077796T3 (OSRAM)
FI (1) FI95464C (OSRAM)
GR (1) GR3017940T3 (OSRAM)
HK (1) HK175495A (OSRAM)
HU (1) HU217118B (OSRAM)
IE (1) IE67801B1 (OSRAM)
IL (1) IL97306A (OSRAM)
LV (1) LV10251B (OSRAM)
NO (1) NO174149C (OSRAM)
NZ (1) NZ237181A (OSRAM)
PT (1) PT96852B (OSRAM)
RU (2) RU2034837C1 (OSRAM)
SG (1) SG69975A1 (OSRAM)
TW (1) TW219933B (OSRAM)
YU (1) YU47594B (OSRAM)
ZA (1) ZA911258B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5633273A (en) * 1991-03-28 1997-05-27 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd] indoles
TW248556B (OSRAM) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
TR201900548T4 (tr) 2006-06-26 2019-02-21 Akebia Therapeutics Inc Prolil hidroksilaz inhibitörleri ve kullanım yöntemleri.
EP2649998B1 (en) * 2009-11-06 2015-03-04 Aerpio Therapeutics Inc. Prolyl hydroxylase inhibitors
NO2686520T3 (OSRAM) 2011-06-06 2018-03-17
WO2012170442A1 (en) 2011-06-06 2012-12-13 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
WO2014200773A2 (en) 2013-06-13 2014-12-18 Akebia Therapeutics , Inc. Compositions and methods for treating anemia
RU2016123382A (ru) 2013-11-15 2017-12-20 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения
BR112017015852A2 (pt) 2015-01-23 2018-03-27 Akebia Therapeutics Inc forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1
TWI881714B (zh) 2015-04-01 2025-04-21 美商阿克比治療有限公司 用於治療貧血之組合物及方法
KR20210006967A (ko) 2018-05-09 2021-01-19 아케비아 테라퓨틱스 인코포레이티드 2-[[5-(3-클로로페닐)-3-하이드록시피리딘-2-카르보닐]아미노]아세트산을 제조하는 방법
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
IE910625A1 (en) 1991-08-28
HUT56542A (en) 1991-09-30
DK0444852T3 (da) 1995-12-11
EP0444852B1 (en) 1995-08-16
AU7197191A (en) 1991-08-29
JP3157007B2 (ja) 2001-04-16
ES2077796T3 (es) 1995-12-01
NO174149C (no) 1994-03-23
EP0444852A2 (en) 1991-09-04
RU2034837C1 (ru) 1995-05-10
PT96852A (pt) 1991-10-31
FI95464B (fi) 1995-10-31
NO174149B (no) 1993-12-13
CN1027503C (zh) 1995-01-25
IL97306A0 (en) 1992-05-25
EP0444852A3 (en) 1992-02-19
NZ237181A (en) 1992-06-25
PT96852B (pt) 1998-07-31
DE69112099T2 (de) 1996-02-08
IL97306A (en) 1996-10-16
YU47594B (sh) 1995-10-24
KR910021375A (ko) 1991-12-20
IE67801B1 (en) 1996-05-01
US5397799A (en) 1995-03-14
HU217118B (hu) 1999-11-29
NO910735D0 (no) 1991-02-25
RU2083561C1 (ru) 1997-07-10
CY1887A (en) 1996-04-05
LV10251B (en) 1995-04-20
YU32791A (sh) 1994-01-20
KR100208114B1 (ko) 1999-07-15
CA2037099A1 (en) 1991-08-27
SG69975A1 (en) 2000-01-25
DE69112099D1 (de) 1995-09-21
LV10251A (lv) 1994-10-20
ZA911258B (en) 1992-10-28
CN1054589A (zh) 1991-09-18
HK175495A (en) 1995-11-24
GR3017940T3 (en) 1996-02-29
FI910895A0 (fi) 1991-02-25
CA2037099C (en) 2001-09-11
AU629453B2 (en) 1992-10-01
ATE126506T1 (de) 1995-09-15
NO910735L (no) 1991-08-27
FI910895L (fi) 1991-08-27
JPH04217662A (ja) 1992-08-07
FI95464C (fi) 1996-02-12
TW219933B (OSRAM) 1994-02-01

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal