LV10251B - Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole - Google Patents

Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole

Info

Publication number
LV10251B
LV10251B LVP-93-509A LV930509A LV10251B LV 10251 B LV10251 B LV 10251B LV 930509 A LV930509 A LV 930509A LV 10251 B LV10251 B LV 10251B
Authority
LV
Latvia
Prior art keywords
tetrahydrobenz
propyl
amino
preparation
indole
Prior art date
Application number
LVP-93-509A
Other languages
English (en)
Other versions
LV10251A (lv
Inventor
Thomas Joseph Kress
David Lee Varie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LV10251A publication Critical patent/LV10251A/xx
Publication of LV10251B publication Critical patent/LV10251B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LVP-93-509A 1990-02-26 1993-06-08 Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole LV10251B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (2)

Publication Number Publication Date
LV10251A LV10251A (lv) 1994-10-20
LV10251B true LV10251B (en) 1995-04-20

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-509A LV10251B (en) 1990-02-26 1993-06-08 Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole

Country Status (28)

Country Link
US (1) US5397799A (OSRAM)
EP (1) EP0444852B1 (OSRAM)
JP (1) JP3157007B2 (OSRAM)
KR (1) KR100208114B1 (OSRAM)
CN (1) CN1027503C (OSRAM)
AT (1) ATE126506T1 (OSRAM)
AU (1) AU629453B2 (OSRAM)
BR (1) BR9100767A (OSRAM)
CA (1) CA2037099C (OSRAM)
CY (1) CY1887A (OSRAM)
DE (1) DE69112099T2 (OSRAM)
DK (1) DK0444852T3 (OSRAM)
ES (1) ES2077796T3 (OSRAM)
FI (1) FI95464C (OSRAM)
GR (1) GR3017940T3 (OSRAM)
HK (1) HK175495A (OSRAM)
HU (1) HU217118B (OSRAM)
IE (1) IE67801B1 (OSRAM)
IL (1) IL97306A (OSRAM)
LV (1) LV10251B (OSRAM)
NO (1) NO174149C (OSRAM)
NZ (1) NZ237181A (OSRAM)
PT (1) PT96852B (OSRAM)
RU (2) RU2034837C1 (OSRAM)
SG (1) SG69975A1 (OSRAM)
TW (1) TW219933B (OSRAM)
YU (1) YU47594B (OSRAM)
ZA (1) ZA911258B (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5633273A (en) * 1991-03-28 1997-05-27 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd] indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (OSRAM) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
DK3357911T3 (da) 2006-06-26 2022-07-04 Akebia Therapeutics Inc Prolylhydroxylaseinhibitorer og fremgangsmåder til anvendelse
IN2012DN04949A (OSRAM) 2009-11-06 2015-09-25 Aerpio Therapeutics Inc
NO2686520T3 (OSRAM) 2011-06-06 2018-03-17
US8865748B2 (en) 2011-06-06 2014-10-21 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
ES2974273T3 (es) 2013-06-13 2024-06-26 Akebia Therapeutics Inc Composiciones y métodos para tratar la anemia
WO2015073779A1 (en) 2013-11-15 2015-05-21 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
US10150734B2 (en) 2015-01-23 2018-12-11 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
MX374909B (es) 2015-04-01 2025-03-06 Akebia Therapeutics Inc El uso del inhibidor de propil hidrolasa del factor inducible de hipoxia (hif) para el tratamiento o prevención de la anemia.
KR20210006967A (ko) 2018-05-09 2021-01-19 아케비아 테라퓨틱스 인코포레이티드 2-[[5-(3-클로로페닐)-3-하이드록시피리딘-2-카르보닐]아미노]아세트산을 제조하는 방법
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
KR910021375A (ko) 1991-12-20
FI910895A0 (fi) 1991-02-25
LV10251A (lv) 1994-10-20
NO910735D0 (no) 1991-02-25
HK175495A (en) 1995-11-24
CN1027503C (zh) 1995-01-25
AU629453B2 (en) 1992-10-01
NO174149B (no) 1993-12-13
IE67801B1 (en) 1996-05-01
KR100208114B1 (ko) 1999-07-15
CA2037099C (en) 2001-09-11
ZA911258B (en) 1992-10-28
NO174149C (no) 1994-03-23
SG69975A1 (en) 2000-01-25
FI910895L (fi) 1991-08-27
IL97306A (en) 1996-10-16
YU32791A (sh) 1994-01-20
FI95464C (fi) 1996-02-12
RU2083561C1 (ru) 1997-07-10
CA2037099A1 (en) 1991-08-27
GR3017940T3 (en) 1996-02-29
EP0444852A2 (en) 1991-09-04
IE910625A1 (en) 1991-08-28
FI95464B (fi) 1995-10-31
CN1054589A (zh) 1991-09-18
NO910735L (no) 1991-08-27
ES2077796T3 (es) 1995-12-01
JPH04217662A (ja) 1992-08-07
AU7197191A (en) 1991-08-29
YU47594B (sh) 1995-10-24
JP3157007B2 (ja) 2001-04-16
DK0444852T3 (da) 1995-12-11
BR9100767A (pt) 1991-10-29
EP0444852A3 (en) 1992-02-19
US5397799A (en) 1995-03-14
RU2034837C1 (ru) 1995-05-10
TW219933B (OSRAM) 1994-02-01
HU217118B (hu) 1999-11-29
CY1887A (en) 1996-04-05
HUT56542A (en) 1991-09-30
EP0444852B1 (en) 1995-08-16
DE69112099D1 (de) 1995-09-21
IL97306A0 (en) 1992-05-25
DE69112099T2 (de) 1996-02-08
ATE126506T1 (de) 1995-09-15
PT96852A (pt) 1991-10-31
NZ237181A (en) 1992-06-25
PT96852B (pt) 1998-07-31

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