HK1251655A1 - 通过线粒体分析预测对阿伏西地的应答 - Google Patents

通过线粒体分析预测对阿伏西地的应答 Download PDF

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Publication number
HK1251655A1
HK1251655A1 HK18111001.4A HK18111001A HK1251655A1 HK 1251655 A1 HK1251655 A1 HK 1251655A1 HK 18111001 A HK18111001 A HK 18111001A HK 1251655 A1 HK1251655 A1 HK 1251655A1
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Hong Kong
Prior art keywords
alvocidib
predicting response
mitochondrial profiling
mitochondrial
profiling
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HK18111001.4A
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English (en)
Chinese (zh)
Inventor
L. WARNER Steven
J. Bearss David
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Tolero Pharmaceuticals, Inc.
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Publication of HK1251655A1 publication Critical patent/HK1251655A1/zh

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/13—Amines
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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HK18111001.4A 2015-04-20 2016-04-20 通过线粒体分析预测对阿伏西地的应答 HK1251655A1 (zh)

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US201562150138P 2015-04-20 2015-04-20
US62/150,138 2015-04-20

Related Parent Applications (1)

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HK42020014517.5A Division HK40022688B (en) 2015-04-20 2018-08-27 Predicting response to alvocidib by mitochondrial profiling

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US (4) US9901574B2 (https=)
EP (2) EP3611506B1 (https=)
JP (1) JP6851978B2 (https=)
KR (1) KR20180018507A (https=)
CN (1) CN107995863A (https=)
AU (1) AU2016252609B2 (https=)
BR (1) BR112017022666A8 (https=)
CA (1) CA2982928A1 (https=)
HK (1) HK1251655A1 (https=)
IL (1) IL255029B (https=)
MX (1) MX2017013383A (https=)
RU (1) RU2717829C2 (https=)
WO (1) WO2016172214A1 (https=)

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TWI810397B (zh) * 2018-11-14 2023-08-01 瑞典商阿斯特捷利康公司 治療癌症之方法
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TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
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