HK1226107A1 - 用於檢測和定量細胞系和重組多肽產物中的宿主細胞蛋白的組合物和方法 - Google Patents

用於檢測和定量細胞系和重組多肽產物中的宿主細胞蛋白的組合物和方法

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Publication number
HK1226107A1
HK1226107A1 HK16114474A HK16114474A HK1226107A1 HK 1226107 A1 HK1226107 A1 HK 1226107A1 HK 16114474 A HK16114474 A HK 16114474A HK 16114474 A HK16114474 A HK 16114474A HK 1226107 A1 HK1226107 A1 HK 1226107A1
Authority
HK
Hong Kong
Prior art keywords
compositions
detecting
methods
recombinant polypeptide
polypeptide products
Prior art date
Application number
HK16114474A
Other languages
English (en)
Inventor
Feny Gunawan
Yi-Chun Hsiao
Denise C Krawitz
Margaret S Lin
Martin Vanderlaan
Rajesh Vij
Inn H Yuk
Judith Zhu-Shimoni
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1226107A1 publication Critical patent/HK1226107A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G01N2333/92—Triglyceride splitting, e.g. by means of lipase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
HK16114474A 2013-09-13 2016-12-20 用於檢測和定量細胞系和重組多肽產物中的宿主細胞蛋白的組合物和方法 HK1226107A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361877503P 2013-09-13 2013-09-13
US201461991228P 2014-05-09 2014-05-09

Publications (1)

Publication Number Publication Date
HK1226107A1 true HK1226107A1 (zh) 2017-09-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HK16114474A HK1226107A1 (zh) 2013-09-13 2016-12-20 用於檢測和定量細胞系和重組多肽產物中的宿主細胞蛋白的組合物和方法

Country Status (13)

Country Link
US (3) US9945858B2 (zh)
EP (2) EP3044323B1 (zh)
JP (2) JP6546178B2 (zh)
KR (2) KR102260855B1 (zh)
CN (1) CN105722992B (zh)
BR (1) BR112016004437A2 (zh)
CA (2) CA2920686C (zh)
ES (1) ES2915378T3 (zh)
HK (1) HK1226107A1 (zh)
MX (2) MX2016002799A (zh)
PL (1) PL3044323T3 (zh)
RU (1) RU2016107435A (zh)
WO (1) WO2015038884A2 (zh)

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TW202005694A (zh) 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
CN109307771A (zh) * 2018-09-14 2019-02-05 北京三元基因药业股份有限公司 亲和层析定量检测重组人α干扰素工艺中间体含量的方法
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CN113841051A (zh) * 2019-05-21 2021-12-24 瑞泽恩制药公司 识别和定量宿主细胞蛋白的方法
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KR102629162B1 (ko) 2022-11-04 2024-01-29 한국기초과학지원연구원 바이오의약품 품질관리를 위한 잔류 숙주세포 단백질 정량 분석 방법 및 시스템
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