SG11201505195TA - Methods For Reducing Aggregate Content In Protein Preparations - Google Patents
Methods For Reducing Aggregate Content In Protein PreparationsInfo
- Publication number
- SG11201505195TA SG11201505195TA SG11201505195TA SG11201505195TA SG11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA SG 11201505195T A SG11201505195T A SG 11201505195TA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- protein preparations
- aggregate content
- reducing aggregate
- reducing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761646P | 2013-02-06 | 2013-02-06 | |
| PCT/SG2014/000046 WO2014123484A1 (en) | 2013-02-06 | 2014-02-05 | Methods For Reducing Aggregate Content In Protein Preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201505195TA true SG11201505195TA (en) | 2015-08-28 |
Family
ID=51299982
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201706205RA SG10201706205RA (en) | 2013-02-06 | 2014-02-05 | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
| SG11201505460WA SG11201505460WA (en) | 2013-02-06 | 2014-02-05 | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
| SG11201505195TA SG11201505195TA (en) | 2013-02-06 | 2014-02-05 | Methods For Reducing Aggregate Content In Protein Preparations |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201706205RA SG10201706205RA (en) | 2013-02-06 | 2014-02-05 | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
| SG11201505460WA SG11201505460WA (en) | 2013-02-06 | 2014-02-05 | Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9975919B2 (en) |
| EP (2) | EP2953962A4 (en) |
| JP (2) | JP6363621B2 (en) |
| KR (2) | KR20150115745A (en) |
| CN (2) | CN105026417A (en) |
| SG (3) | SG10201706205RA (en) |
| WO (2) | WO2014123484A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2902799B1 (en) | 2006-06-27 | 2012-10-26 | Millipore Corp | METHOD AND UNIT FOR PREPARING A SAMPLE FOR THE MICROBIOLOGICAL ANALYSIS OF A LIQUID |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| US20100267933A1 (en) | 2006-12-21 | 2010-10-21 | Moya Wilson | Purification of proteins |
| DK2370561T3 (en) | 2008-12-16 | 2019-10-21 | Emd Millipore Corp | Stirring tank reactor and process |
| EP3597671B1 (en) | 2010-05-17 | 2022-09-21 | EMD Millipore Corporation | Stimulus responsive polymers for the purification of biomolecules |
| WO2014133458A1 (en) * | 2013-02-26 | 2014-09-04 | Agency For Science, Technology And Research | Protein purification in the presence of nonionic organic polymers and electropositive surfaces |
| CN105008384A (en) * | 2013-02-28 | 2015-10-28 | 新加坡科技研究局 | Protein purification in the presence of nonionic organic polymers at elevated conductivity |
| SG11201607098SA (en) | 2014-02-27 | 2016-09-29 | Agency Science Tech & Res | Antibody purification process |
| CN109311937A (en) * | 2016-06-15 | 2019-02-05 | 新加坡科技研究局 | Method of the enhancing for the chromatographic performance of protein purification |
| EP3995196B1 (en) * | 2020-11-04 | 2023-08-09 | Sartorius BIA Separations d.o.o. | Purification process for lipid-membrane-enclosed complex assemblages |
| CN117347617A (en) * | 2022-06-27 | 2024-01-05 | 菲鹏生物股份有限公司 | Diluent and application thereof, and method for determining analyte in sample |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL34079A (en) * | 1969-04-01 | 1973-02-28 | Upjohn Co | Purification of ypsilon-globulins |
| AU527784B2 (en) | 1978-05-26 | 1983-03-24 | Bang, Hans Olaf Dr. | Treatment of thromboembolic conditions withall-z)-5, 8, 11, 14, 17-eicosapentaenoic acid |
| US5283339A (en) * | 1988-11-23 | 1994-02-01 | California Institute Of Technology | Immobilized metal aqueous two-phase extraction and precipitation |
| US5691132A (en) | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
| DE19544297A1 (en) * | 1995-11-28 | 1997-06-05 | Behringwerke Ag | Process for the removal of aromatic compounds from product-containing solutions |
| US6503716B1 (en) * | 2000-11-28 | 2003-01-07 | Pe Corporation (Ny) | Compositions and methods for extracting a nucleic acid |
| GB0101049D0 (en) * | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| US7176308B2 (en) | 2002-06-17 | 2007-02-13 | Verification Technologies, Inc. | Processes for preparing novel methylene blue derivative |
| WO2005120700A2 (en) | 2004-06-14 | 2005-12-22 | Novo Nordisk A/S | Peptide purification by means of hard metal ion affinity chromatography |
| US20090306342A1 (en) | 2005-12-30 | 2009-12-10 | Bio-Layer Pty Limited | Binding of molecules |
| US7691980B2 (en) * | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| AU2008209404B2 (en) | 2007-01-22 | 2012-08-16 | Genentech, Inc. | Polyelectrolyte precipitation and purification of antibodies |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| CN102119168A (en) * | 2008-06-03 | 2011-07-06 | 帕特里有限公司 | Process for purification of antibodies |
| EP2241886A1 (en) * | 2009-04-15 | 2010-10-20 | Beckman Coulter Biomedical Limited | Homogeneous agglutination immunoassay method and kit for such method |
| WO2011140406A1 (en) | 2010-05-07 | 2011-11-10 | Millipore Corporation | Enhanced clarification media |
| CN103717284B (en) * | 2011-06-08 | 2016-02-24 | 新加坡科技研究局 | By retraining common hydration chromatogram purification biological products |
| WO2013158279A1 (en) * | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| KR20150023297A (en) | 2012-05-31 | 2015-03-05 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | Selective binding of biological targets to solid phase ureides |
| KR102065355B1 (en) | 2012-05-31 | 2020-01-13 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations |
| SG11201407812SA (en) * | 2012-05-31 | 2014-12-30 | Agency Science Tech & Res | Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives |
| US8921113B2 (en) * | 2012-12-21 | 2014-12-30 | Dionex Corporation | Buffer kit and method of generating a linear pH gradient |
-
2014
- 2014-02-05 KR KR1020157020166A patent/KR20150115745A/en active Search and Examination
- 2014-02-05 WO PCT/SG2014/000046 patent/WO2014123484A1/en active Application Filing
- 2014-02-05 EP EP14748942.1A patent/EP2953962A4/en not_active Withdrawn
- 2014-02-05 JP JP2015555969A patent/JP6363621B2/en not_active Expired - Fee Related
- 2014-02-05 SG SG10201706205RA patent/SG10201706205RA/en unknown
- 2014-02-05 WO PCT/SG2014/000048 patent/WO2014123486A1/en active Application Filing
- 2014-02-05 CN CN201480007804.2A patent/CN105026417A/en active Pending
- 2014-02-05 SG SG11201505460WA patent/SG11201505460WA/en unknown
- 2014-02-05 US US14/766,129 patent/US9975919B2/en not_active Expired - Fee Related
- 2014-02-05 SG SG11201505195TA patent/SG11201505195TA/en unknown
- 2014-02-05 KR KR1020157022485A patent/KR20150113027A/en active Search and Examination
- 2014-02-05 CN CN201480007315.7A patent/CN105051055A/en active Pending
- 2014-02-05 EP EP14749160.9A patent/EP2953964A4/en not_active Withdrawn
- 2014-02-05 US US14/766,123 patent/US9988418B2/en not_active Expired - Fee Related
- 2014-02-05 JP JP2015555967A patent/JP6410734B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SG10201706205RA (en) | 2017-08-30 |
| US9988418B2 (en) | 2018-06-05 |
| JP2016506952A (en) | 2016-03-07 |
| CN105026417A (en) | 2015-11-04 |
| SG11201505460WA (en) | 2015-08-28 |
| KR20150115745A (en) | 2015-10-14 |
| EP2953962A1 (en) | 2015-12-16 |
| US9975919B2 (en) | 2018-05-22 |
| EP2953962A4 (en) | 2016-10-19 |
| US20150368354A1 (en) | 2015-12-24 |
| EP2953964A1 (en) | 2015-12-16 |
| WO2014123486A1 (en) | 2014-08-14 |
| JP2016508499A (en) | 2016-03-22 |
| JP6410734B2 (en) | 2018-10-24 |
| CN105051055A (en) | 2015-11-11 |
| US20150376230A1 (en) | 2015-12-31 |
| EP2953964A4 (en) | 2016-09-14 |
| JP6363621B2 (en) | 2018-07-25 |
| KR20150113027A (en) | 2015-10-07 |
| WO2014123484A1 (en) | 2014-08-14 |
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