SG11201505193SA - Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations - Google Patents

Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations

Info

Publication number
SG11201505193SA
SG11201505193SA SG11201505193SA SG11201505193SA SG11201505193SA SG 11201505193S A SG11201505193S A SG 11201505193SA SG 11201505193S A SG11201505193S A SG 11201505193SA SG 11201505193S A SG11201505193S A SG 11201505193SA SG 11201505193S A SG11201505193S A SG 11201505193SA
Authority
SG
Singapore
Prior art keywords
metal affinity
protein preparations
aggregate content
multifunctional metal
reducing aggregate
Prior art date
Application number
SG11201505193SA
Inventor
Peter Stanley Gagnon
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201505193SA publication Critical patent/SG11201505193SA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/288—Polar phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
SG11201505193SA 2013-02-06 2014-02-05 Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations SG11201505193SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361761653P 2013-02-06 2013-02-06
PCT/SG2014/000045 WO2014123483A1 (en) 2013-02-06 2014-02-05 Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations

Publications (1)

Publication Number Publication Date
SG11201505193SA true SG11201505193SA (en) 2015-08-28

Family

ID=51299981

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505193SA SG11201505193SA (en) 2013-02-06 2014-02-05 Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations

Country Status (7)

Country Link
US (1) US20160001262A1 (en)
EP (1) EP2953963A4 (en)
JP (1) JP2016513245A (en)
KR (1) KR20150112978A (en)
CN (1) CN105026416A (en)
SG (1) SG11201505193SA (en)
WO (1) WO2014123483A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160012975A (en) * 2013-06-04 2016-02-03 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Protein purification process

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19837294A1 (en) * 1998-08-18 2000-02-24 Bayer Ag Process for the production of selective exchangers
SE0004932D0 (en) * 2000-12-31 2000-12-31 Apbiotech Ab A method for mixed mode adsorption and mixed mode adsorbents
US7750129B2 (en) * 2004-02-27 2010-07-06 Ge Healthcare Bio-Sciences Ab Process for the purification of antibodies
US7691980B2 (en) * 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
DE102008012223A1 (en) * 2008-03-03 2009-09-10 Lanxess Deutschland Gmbh picolylamine resins
JP5999899B2 (en) * 2008-04-08 2016-09-28 バイオ−ラッド ラボラトリーズ インコーポレーティッド Chromatographic purification of antibodies
DE102008055821A1 (en) * 2008-04-14 2009-10-15 Sartorius Stedim Biotech Gmbh Cellulose hydrate membrane, process for its preparation and use thereof
WO2010071208A1 (en) * 2008-12-19 2010-06-24 武田薬品工業株式会社 Antibody purification method
WO2010131111A1 (en) * 2009-05-11 2010-11-18 Novartis Ag Antigen purification process for pertactin antigen
ES2534936T3 (en) * 2010-08-02 2015-04-30 Ratiopharm Gmbh Method for producing and purifying an active soluble sialyltransferase
CN104487447B (en) * 2012-05-31 2018-10-30 新加坡科技研究局 For reducing the affine surface of multi-functional metal of the mixing of the aggregation content in protein formulation field
WO2013180648A1 (en) * 2012-05-31 2013-12-05 Agency For Science, Technology And Research Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations

Also Published As

Publication number Publication date
KR20150112978A (en) 2015-10-07
EP2953963A1 (en) 2015-12-16
EP2953963A4 (en) 2016-11-09
US20160001262A1 (en) 2016-01-07
WO2014123483A1 (en) 2014-08-14
CN105026416A (en) 2015-11-04
JP2016513245A (en) 2016-05-12

Similar Documents

Publication Publication Date Title
HK1217502A1 (en) Il-11r binding proteins and uses thereof il-11r
SG11201505195TA (en) Methods For Reducing Aggregate Content In Protein Preparations
EP2855503A4 (en) Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations
PT2970456T (en) Methods and compositions for delivering mrna coded antibodies
EP2905290A4 (en) Heterodimeric protein composition
EP3027310A4 (en) Mixed metal iron oxides and uses thereof
EP3019514A4 (en) Compositions and methods relating to nucleic acid-protein complexes
ZA201307988B (en) Multi-capillary in-line rheometer for mineral slurries
PT3434760T (en) Methods for increasing mannose content of recombinant proteins
PT3058936T (en) Peptide composition and uses thereof
EP3019192A4 (en) Compositions and methods for increasing protein half-life in a serum
EP2855505A4 (en) Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations field
GB201421661D0 (en) Method for determining the concentration of iron ions in hydrocarbon compositions
GB201522774D0 (en) Antibody composition and buffer system therefor
EP2922871A4 (en) Methods and compositions for modified factor ix proteins
GB201320408D0 (en) Antibody polypeptides and uses therof
SG11201505193SA (en) Mixed multifunctional metal affinity surfaces for reducing aggregate content in protein preparations
EP2956469A4 (en) Methods and compositions for protein concentration
EP2961850A4 (en) In situ affinity maturation of antibodies
EP3049558A4 (en) Method and kit for generating high affinity binding agents
EP2985312A4 (en) Aggregate and composition
AU2013900389A0 (en) Il-11r binding proteins and uses thereof
GB201320209D0 (en) Improvements in or relating to protein Micro-nets