HK1218232A1 - 使用工程化鋅指蛋白核酸酶靶向斷裂t細胞受體基因 - Google Patents

使用工程化鋅指蛋白核酸酶靶向斷裂t細胞受體基因 Download PDF

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Publication number
HK1218232A1
HK1218232A1 HK16106201.4A HK16106201A HK1218232A1 HK 1218232 A1 HK1218232 A1 HK 1218232A1 HK 16106201 A HK16106201 A HK 16106201A HK 1218232 A1 HK1218232 A1 HK 1218232A1
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Hong Kong
Prior art keywords
cells
tcr
gene
cell
sequence
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HK16106201.4A
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English (en)
Chinese (zh)
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‧格雷戈里
P‧D‧格雷戈里
‧霍爾姆斯
M‧C‧霍尔姆斯
‧帕斯喬恩
D‧帕斯乔恩
張雷
张雷
‧伯尼尼
M‧C‧伯尼尼
‧格諾韋塞
P‧格诺韦塞
‧馬格納尼
Z‧马格纳尼
‧馬斯塔格里奧
S‧马斯塔格里奥
‧那爾蒂尼
L‧那尔蒂尼
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桑格摩生物科学股份有限公司
圣拉斐尔医院有限公司
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Publication of HK1218232A1 publication Critical patent/HK1218232A1/zh

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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HK16106201.4A 2013-03-21 2014-03-20 使用工程化鋅指蛋白核酸酶靶向斷裂t細胞受體基因 HK1218232A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361804076P 2013-03-21 2013-03-21
US61/804,076 2013-03-21
PCT/US2014/031360 WO2014153470A2 (en) 2013-03-21 2014-03-20 Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases

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HK1218232A1 true HK1218232A1 (zh) 2017-02-10

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US (2) US9937207B2 (enExample)
EP (1) EP2975942B1 (enExample)
JP (1) JP6346266B2 (enExample)
CN (1) CN105208866B (enExample)
AU (1) AU2014235968B2 (enExample)
CA (1) CA2906970C (enExample)
HK (1) HK1218232A1 (enExample)
IL (1) IL241583B (enExample)
WO (1) WO2014153470A2 (enExample)

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EP2975942B1 (en) 2018-08-08
JP6346266B2 (ja) 2018-06-20
CA2906970C (en) 2021-05-18
IL241583B (en) 2021-05-31
EP2975942A4 (en) 2016-11-09
CA2906970A1 (en) 2014-09-25
CN105208866A (zh) 2015-12-30
AU2014235968B2 (en) 2018-05-24
US9937207B2 (en) 2018-04-10
EP2975942A2 (en) 2016-01-27

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