HK1208940A1 - Methods for non-invasive pre-natal ploidy calling - Google Patents

Methods for non-invasive pre-natal ploidy calling

Info

Publication number
HK1208940A1
HK1208940A1 HK15109616.8A HK15109616A HK1208940A1 HK 1208940 A1 HK1208940 A1 HK 1208940A1 HK 15109616 A HK15109616 A HK 15109616A HK 1208940 A1 HK1208940 A1 HK 1208940A1
Authority
HK
Hong Kong
Prior art keywords
natal
methods
ploidy calling
invasive pre
invasive
Prior art date
Application number
HK15109616.8A
Other languages
English (en)
Chinese (zh)
Inventor
Matthew Rabinowitz
George Gemelos
Milena Banjevic
Allison Ryan
Zachary Demko
Matthew Hill
Bernhard Zimmermann
Johan Baner
Original Assignee
Natera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natera Inc filed Critical Natera Inc
Publication of HK1208940A1 publication Critical patent/HK1208940A1/xx

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    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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HK15109616.8A 2010-05-18 2015-09-30 Methods for non-invasive pre-natal ploidy calling HK1208940A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39585010P 2010-05-18 2010-05-18
US39815910P 2010-06-21 2010-06-21
US201161462972P 2011-02-09 2011-02-09
US201161448547P 2011-03-02 2011-03-02
US201161516996P 2011-04-12 2011-04-12

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HK1208940A1 true HK1208940A1 (en) 2016-03-18

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HK15109617.7A HK1208941A1 (en) 2010-05-18 2015-09-30 Methods for non-invasive pre-natal ploidy calling
HK15109616.8A HK1208940A1 (en) 2010-05-18 2015-09-30 Methods for non-invasive pre-natal ploidy calling

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HK15109617.7A HK1208941A1 (en) 2010-05-18 2015-09-30 Methods for non-invasive pre-natal ploidy calling

Country Status (6)

Country Link
US (8) US8825412B2 (fr)
EP (3) EP2854057B1 (fr)
AU (1) AU2011255641A1 (fr)
CA (3) CA3207599A1 (fr)
HK (2) HK1208941A1 (fr)
WO (1) WO2011146632A1 (fr)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070178501A1 (en) * 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8515679B2 (en) 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) * 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US8532930B2 (en) * 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
WO2009105531A1 (fr) * 2008-02-19 2009-08-27 Gene Security Network, Inc. Procédés de génotypage cellulaire
CA2717320A1 (fr) 2008-03-11 2009-09-17 Sequenom, Inc. Tests adn pour determiner le sexe d'un bebe avant sa naissance
WO2009146335A1 (fr) * 2008-05-27 2009-12-03 Gene Security Network, Inc. Procédés de caractérisation d’embryon et de comparaison
CA3116156C (fr) 2008-08-04 2023-08-08 Natera, Inc. Procedes pour une classification d'allele et une classification de ploidie
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
CA2760439A1 (fr) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Procedes et compositions d'evaluation de marqueurs genetiques
EP2473638B1 (fr) 2009-09-30 2017-08-09 Natera, Inc. Méthode non invasive de détermination d'une ploïdie prénatale
DK2496717T3 (en) 2009-11-05 2017-07-24 Univ Hong Kong Chinese ANALYSIS OF BORN THROUGH FROM A MATERNAL BIOLOGICAL TEST
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2854057B1 (fr) 2010-05-18 2018-03-07 Natera, Inc. Procédés pour une classification de ploïdie prénatale non invasive
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10482556B2 (en) * 2010-06-20 2019-11-19 Univfy Inc. Method of delivering decision support systems (DSS) and electronic health records (EHR) for reproductive care, pre-conceptive care, fertility treatments, and other health conditions
PE20130983A1 (es) 2010-07-13 2013-09-14 Univfy Inc Metodo para evaluar el riesgo de nacimientos multiples en tratamientos de infertilidad
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
BR112013016193B1 (pt) 2010-12-22 2019-10-22 Natera Inc método ex vivo para determinar se um suposto pai é o pai biológico de um feto que está em gestação em uma gestante e relatório
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP3901955A1 (fr) * 2011-01-05 2021-10-27 The Chinese University Of Hong Kong Génotypage prénatal non invasif de chromosomes sexuels fétaux
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
WO2012177792A2 (fr) 2011-06-24 2012-12-27 Sequenom, Inc. Méthodes et procédés pour estimation non invasive de variation génétique
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
CA2850785C (fr) 2011-10-06 2022-12-13 Sequenom, Inc. Methodes et procedes pour evaluation non invasive de variations genetiques
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
EP2769007B1 (fr) 2011-10-19 2016-12-07 Nugen Technologies, Inc. Compositions et procédés pour l'amplification et le séquençage directionnels d'acide nucléique
PL2805280T3 (pl) 2012-01-20 2022-11-21 Sequenom, Inc. Procesy diagnostyczne będące czynnikiem warunków doświadczalnych
EP3578697B1 (fr) 2012-01-26 2024-03-06 Tecan Genomics, Inc. Compositions et procédés d'enrichissement de séquence d'acide nucléique ciblé et de génération de bibliothèques à haute efficacité
WO2013130848A1 (fr) * 2012-02-29 2013-09-06 Natera, Inc. Analyse améliorée par informatique d'échantillons de fœtus soumis à une contamination maternelle
EP4155401A1 (fr) 2012-03-02 2023-03-29 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
EP2825675B1 (fr) * 2012-03-13 2017-12-27 Patel, Abhijit Ajit Mesure des variants d'acide nucléique au moyen du séquençage hautement multiplexé, à très haut débit et à suppression d'erreur
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
ES2623089T3 (es) * 2012-04-06 2017-07-10 The Chinese University Of Hong Kong Diagnóstico prenatal no invasivo de trisomía fetal mediante el análisis de la relación alélica usando secuenciación masivamente paralela dirigida
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9193992B2 (en) * 2012-06-05 2015-11-24 Agilent Technologies, Inc. Method for determining ploidy of a cell
CN104619894B (zh) 2012-06-18 2017-06-06 纽亘技术公司 用于非期望核酸序列的阴性选择的组合物和方法
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CN104583421A (zh) 2012-07-19 2015-04-29 阿瑞奥萨诊断公司 遗传变体的基于多重的顺序连接的检测
AU2012385961B9 (en) 2012-07-24 2017-05-18 Natera, Inc. Highly multiplex PCR methods and compositions
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20150337388A1 (en) * 2012-12-17 2015-11-26 Virginia Tech Intellectual Properties, Inc. Methods and compositions for identifying global microsatellite instability and for characterizing informative microsatellite loci
RU2529784C2 (ru) * 2012-12-26 2014-09-27 Закрытое акционерное общество "Геноаналитика" Технология определения анеуплоидии методом секвенирования
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014168711A1 (fr) 2013-03-13 2014-10-16 Sequenom, Inc. Amorces pour analyse de la méthylation de l'adn
MX363345B (es) 2013-03-15 2019-03-20 Univ Hong Kong Chinese Determinación de genomas fetales para embarazos de múltiples fetos.
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
EP2978860B8 (fr) * 2013-03-27 2019-12-11 BlueGnome Ltd Évaluation du risque d'aneuploïdie
WO2014165596A1 (fr) 2013-04-03 2014-10-09 Sequenom, Inc. Procédés et systèmes d'évaluation non invasive de variations génétiques
CA3189752A1 (fr) 2013-05-24 2014-11-27 Sequenom, Inc. Methodes et systemes d'evaluation non invasive de variations genetiques
AU2014278730B2 (en) * 2013-06-13 2020-12-10 F. Hoffmann-La Roche Ag Statistical analysis for non-invasive sex chromosome aneuploidy determination
JP6473744B2 (ja) 2013-06-21 2019-02-20 セクエノム, インコーポレイテッド 遺伝子の変動の非侵襲的評価のための方法および処理
GB201318369D0 (en) * 2013-10-17 2013-12-04 Univ Leuven Kath Methods using BAF
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
PL3053071T3 (pl) 2013-10-04 2024-03-18 Sequenom, Inc. Metody i procesy nieinwazyjnej oceny zmienności genetycznych
WO2015054080A1 (fr) 2013-10-07 2015-04-16 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de modifications chromosomiques
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
EP3068883B1 (fr) 2013-11-13 2020-04-29 Nugen Technologies, Inc. Compositions et procédés pour l'identification d'une lecture de séquençage en double
WO2015131107A1 (fr) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Séquençage au bisulfite de représentation réduite avec adaptateurs de diversité
WO2015138774A1 (fr) 2014-03-13 2015-09-17 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
RU2583830C2 (ru) * 2014-04-21 2016-05-10 Закрытое акционерное общество "Геноаналитика" Способ неинвазивной пренатальной диагностики анеуплоидий плода
CN109971852A (zh) 2014-04-21 2019-07-05 纳特拉公司 检测染色体片段中的突变和倍性
KR20160010277A (ko) * 2014-07-18 2016-01-27 에스케이텔레콤 주식회사 산모의 무세포 dna의 차세대 서열분석을 통한 태아의 단일유전자 유전변이의 예측방법
US10119167B2 (en) 2014-07-18 2018-11-06 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
WO2016019042A1 (fr) 2014-07-30 2016-02-04 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
KR102538753B1 (ko) * 2014-09-18 2023-05-31 일루미나, 인코포레이티드 핵산 서열결정 데이터를 분석하기 위한 방법 및 시스템
JP2017536087A (ja) 2014-09-24 2017-12-07 グッド スタート ジェネティクス, インコーポレイテッド 遺伝子アッセイのロバストネスを増大させるためのプロセス制御
JP2017530720A (ja) * 2014-10-17 2017-10-19 グッド スタート ジェネティクス, インコーポレイテッド 着床前遺伝子スクリーニングおよび異数性検出
EP4095261A1 (fr) 2015-01-06 2022-11-30 Molecular Loop Biosciences, Inc. Criblage de variantes structurales
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US11111538B2 (en) 2015-05-22 2021-09-07 Nipd Genetics Public Company Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
WO2017210603A1 (fr) * 2016-06-03 2017-12-07 Illumina, Inc. Génotypage de loci polyploïdes
CA3030890A1 (fr) 2016-07-27 2018-02-01 Sequenom, Inc. Classifications de modifications du nombre de copies genetiques
EP3518974A4 (fr) 2016-09-29 2020-05-27 Myriad Women's Health, Inc. Dépistage prénatal non invasif utilisant une optimisation de profondeur itérative dynamique
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US11694768B2 (en) 2017-01-24 2023-07-04 Sequenom, Inc. Methods and processes for assessment of genetic variations
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN110392739B (zh) * 2017-03-20 2024-01-16 张立峰 检测dna突变的测序方法
US10941445B2 (en) 2017-03-24 2021-03-09 Bio-Rad Laboratories, Inc. Universal hairpin primers
CN107012226A (zh) * 2017-04-20 2017-08-04 司法部司法鉴定科学技术研究所 一种基于高通量测序的snp位点的检测试剂盒及其检测方法
US10176296B2 (en) 2017-05-17 2019-01-08 International Business Machines Corporation Algebraic phasing of polyploids
CN111433855A (zh) * 2017-07-18 2020-07-17 康捷尼科有限公司 筛查系统和方法
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
CA3080117A1 (fr) 2017-10-27 2019-05-02 Juno Diagnostics, Inc. Dispositifs, systemes et procedes pour biopsie liquide a volumes ultra-faibles
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020023882A1 (fr) * 2018-07-27 2020-01-30 Myriad Women's Health, Inc. Procédé de détection de variation génétique dans des séquences fortement homologues par alignement indépendant et appariement de lectures de séquence
US20210280270A1 (en) * 2018-09-07 2021-09-09 Illumina, Inc. Method to determine if a circulating fetal cell isolated from a pregnant mother is from either the current or a historical pregnancy
JP2022519159A (ja) 2018-12-17 2022-03-22 ナテラ, インコーポレイテッド 循環細胞の分析方法
SG11202108405VA (en) 2019-02-14 2021-08-30 Mirvie Inc Methods and systems for determining a pregnancy-related state of a subject
EP4118652A1 (fr) * 2020-03-12 2023-01-18 Vrije Universiteit Brussel Procédé d'analyse de matériel génétique
US20220246275A1 (en) * 2021-02-01 2022-08-04 Kpn Innovations, Llc. Systems and methods for generating a congenital nourishment program
CN118076750A (zh) 2021-08-02 2024-05-24 纳特拉公司 用于检测孕妇体内的赘生物的方法
CA3230790A1 (fr) 2021-09-01 2023-03-09 Natera, Inc. Procedes de depistage prenatal non invasifs
KR20230076686A (ko) * 2021-11-24 2023-05-31 테라젠지놈케어 주식회사 가상 데이터에 기반한 태아의 염색체이수성을 검출하는 방법

Family Cites Families (497)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4040785A (en) 1976-10-18 1977-08-09 Technicon Instruments Corporation Lysable blood preservative composition
US5242794A (en) 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4935342A (en) 1986-12-01 1990-06-19 Syngene, Inc. Method of isolating and purifying nucleic acids from biological samples
US4942124A (en) 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
US5153117A (en) 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5262329A (en) 1991-06-13 1993-11-16 Carver Jr Edward L Method for improved multiple species blood analysis
IL103935A0 (en) 1991-12-04 1993-05-13 Du Pont Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification
US5965362A (en) 1992-03-04 1999-10-12 The Regents Of The University Of California Comparative genomic hybridization (CGH)
GB9305984D0 (en) 1993-03-23 1993-05-12 Royal Free Hosp School Med Predictive assay
GB2279653B (en) 1993-07-05 1998-02-11 North Gen Hospital Nhs Trust Stabilisation of cells with an agent comprising a heavy metal compound
WO1995006137A1 (fr) 1993-08-27 1995-03-02 Australian Red Cross Society Detection de genes
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
SE9400522D0 (sv) 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
US5716776A (en) 1994-03-04 1998-02-10 Mark H. Bogart Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample
US5891734A (en) 1994-08-01 1999-04-06 Abbott Laboratories Method for performing automated analysis
US6025128A (en) 1994-09-29 2000-02-15 The University Of Tulsa Prediction of prostate cancer progression by analysis of selected predictive parameters
US6479235B1 (en) 1994-09-30 2002-11-12 Promega Corporation Multiplex amplification of short tandem repeat loci
US5648220A (en) 1995-02-14 1997-07-15 New England Medical Center Hospitals, Inc. Methods for labeling intracytoplasmic molecules
WO1996036736A2 (fr) 1995-05-19 1996-11-21 Abbott Laboratories Procede de detection d'acides nucleiques a large plage dynamique, utilisant une serie complexe d'amorces
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US5733729A (en) 1995-09-14 1998-03-31 Affymetrix, Inc. Computer-aided probability base calling for arrays of nucleic acid probes on chips
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
CA2248981C (fr) 1996-03-15 2009-11-24 The Penn State Research Foundation Detection d'acide nucleique extracellulaire lie a des tumeurs dans le plasma ou le serum sanguin a l'aide d'essais d'amplification d'acide nucleique
US6329179B1 (en) 1996-03-26 2001-12-11 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US6108635A (en) 1996-05-22 2000-08-22 Interleukin Genetics, Inc. Integrated disease information system
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5860917A (en) 1997-01-15 1999-01-19 Chiron Corporation Method and apparatus for predicting therapeutic outcomes
US5824467A (en) 1997-02-25 1998-10-20 Celtrix Pharmaceuticals Methods for predicting drug response
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
ATE280177T1 (de) 1997-03-20 2004-11-15 Hoffmann La Roche Modifizierte primer
ATE545710T1 (de) 1997-04-01 2012-03-15 Illumina Cambridge Ltd Verfahren zur vervielfältigung von nukleinsäuren
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US20020119478A1 (en) 1997-05-30 2002-08-29 Diagen Corporation Methods for detection of nucleic acid sequences in urine
US5994148A (en) 1997-06-23 1999-11-30 The Regents Of University Of California Method of predicting and enhancing success of IVF/ET pregnancy
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6124120A (en) 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
WO2000075302A2 (fr) 1999-04-30 2000-12-14 Cyclops Genome Sciences Limited Isolation d'acide nucleique
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
US7058517B1 (en) 1999-06-25 2006-06-06 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US6964847B1 (en) * 1999-07-14 2005-11-15 Packard Biosciences Company Derivative nucleic acids and uses thereof
NZ531466A (en) 1999-07-23 2005-06-24 Sec Dep Home Dept Use of single nucleotide polymorphisms (SNPs) to identify individuals in forensic investigations
GB9917307D0 (en) 1999-07-23 1999-09-22 Sec Dep Of The Home Department Improvements in and relating to analysis of DNA
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6251604B1 (en) 1999-08-13 2001-06-26 Genopsys, Inc. Random mutagenesis and amplification of nucleic acid
EP1244811A1 (fr) 1999-11-10 2002-10-02 Ligochem Inc. Methode permettant d'isoler un adn d'un milieu proteique et trousse utilisee pour realiser cette methode
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
DK1259643T3 (da) 2000-02-07 2009-02-23 Illumina Inc Fremgangsmåde til detektion af nukleinsyre ved anvendelse af universel priming
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7510834B2 (en) 2000-04-13 2009-03-31 Hidetoshi Inoko Gene mapping method using microsatellite genetic polymorphism markers
GB0009179D0 (en) 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
US6828098B2 (en) 2000-05-20 2004-12-07 The Regents Of The University Of Michigan Method of producing a DNA library using positional amplification based on the use of adaptors and nick translation
US20030009295A1 (en) 2001-03-14 2003-01-09 Victor Markowitz System and method for retrieving and using gene expression data from multiple sources
AU2001264811A1 (en) 2000-05-23 2001-12-03 Vincent P. Stanton Jr. Methods for genetic analysis of dna to detect sequence variances
US7087414B2 (en) 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
JP2004500867A (ja) 2000-06-07 2004-01-15 ベイラー カレッジ オブ メディシン アレイ利用型核酸ハイブリダイゼーションのための新規な組成物および方法
US7058616B1 (en) 2000-06-08 2006-06-06 Virco Bvba Method and system for predicting resistance of a disease to a therapeutic agent using a neural network
GB0016742D0 (en) 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
JP4287652B2 (ja) 2000-10-24 2009-07-01 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ ゲノムdnaの直接多重処理による性状分析
US20020107640A1 (en) 2000-11-14 2002-08-08 Ideker Trey E. Methods for determining the true signal of an analyte
EP1368369A4 (fr) 2000-11-15 2006-02-22 Hoffmann La Roche Methodes et reactifs permettant d'identifier des cellules embryonnaires rares dans le systeme circulatoire maternel
WO2002044411A1 (fr) 2000-12-01 2002-06-06 Rosetta Inpharmatics, Inc. Utilisation de profils dans la detection de l'aneuploidie
US7218764B2 (en) 2000-12-04 2007-05-15 Cytokinetics, Inc. Ploidy classification method
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
JP2002300894A (ja) 2001-02-01 2002-10-15 Inst Of Physical & Chemical Res 一塩基多型タイピング方法
US20020182622A1 (en) 2001-02-01 2002-12-05 Yusuke Nakamura Method for SNP (single nucleotide polymorphism) typing
CA2439402A1 (fr) 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Procede de reaction en chaine de la polymerase
US6489135B1 (en) 2001-04-17 2002-12-03 Atairgintechnologies, Inc. Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media
FR2824144B1 (fr) 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
US7392199B2 (en) 2001-05-01 2008-06-24 Quest Diagnostics Investments Incorporated Diagnosing inapparent diseases from common clinical tests using Bayesian analysis
AU2002305436A1 (en) 2001-05-09 2002-11-18 Virginia Commonwealth University Multiple sequencible and ligatible structures for genomic analysis
US20040126760A1 (en) 2001-05-17 2004-07-01 Natalia Broude Novel compositions and methods for carrying out multple pcr reactions on a single sample
US7026121B1 (en) 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20030054386A1 (en) 2001-06-22 2003-03-20 Stylianos Antonarakis Method for detecting diseases caused by chromosomal imbalances
WO2003010537A1 (fr) 2001-07-24 2003-02-06 Curagen Corporation Essais d'association sur population d'individus a base de polymorphisme d'un nucleotide simple (pns) et d'adn de type groupe
US7297778B2 (en) 2001-07-25 2007-11-20 Affymetrix, Inc. Complexity management of genomic DNA
WO2003009806A2 (fr) 2001-07-25 2003-02-06 Oncomedx Inc. Methodes d'evaluation d'affections pathologiques utilisant un arn extracellulaire
US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
EP1425294B2 (fr) 2001-08-23 2012-12-12 Veridex, LLC Analyse de cellules tumorales en circulation, de fragments et de debris associes
US6807491B2 (en) 2001-08-30 2004-10-19 Hewlett-Packard Development Company, L.P. Method and apparatus for combining gene predictions using bayesian networks
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
AUPR749901A0 (en) 2001-09-06 2001-09-27 Monash University Method of identifying chromosomal abnormalities and prenatal diagnosis
US7153656B2 (en) 2001-09-11 2006-12-26 Los Alamos National Security, Llc Nucleic acid sequence detection using multiplexed oligonucleotide PCR
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
EP1442139A4 (fr) * 2001-10-12 2005-01-26 Univ Queensland Selection et amplification de marqueurs genetiques multiples
US6617137B2 (en) 2001-10-15 2003-09-09 Molecular Staging Inc. Method of amplifying whole genomes without subjecting the genome to denaturing conditions
US7297485B2 (en) 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
CN100468058C (zh) 2001-12-11 2009-03-11 株式会社奈特克 血细胞分离体系
US7198897B2 (en) 2001-12-19 2007-04-03 Brandeis University Late-PCR
DE60123448T2 (de) 2001-12-24 2007-08-23 Prof. Wolfgang Holzgreve Verfahren zur nicht-invasiven Diagnose von Transplantationen und Transfusionen
US20040115629A1 (en) 2002-01-09 2004-06-17 Panzer Scott R Molecules for diagnostics and therapeutics
JP2005514956A (ja) 2002-01-18 2005-05-26 ジェンザイム・コーポレーション 胎児dnaの検出および対立遺伝子の定量化のための方法
JP2005516310A (ja) 2002-02-01 2005-06-02 ロゼッタ インファーマティクス エルエルシー 遺伝子を特定し、形質に関連する経路を明らかにするコンピュータ・システムおよび方法
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
EP1481097A4 (fr) 2002-03-01 2006-08-02 Ravgen Inc Analyse rapide de variations dans un genome
US20060229823A1 (en) 2002-03-28 2006-10-12 Affymetrix, Inc. Methods and computer software products for analyzing genotyping data
US20040096874A1 (en) 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes
WO2003093426A2 (fr) 2002-05-02 2003-11-13 University Of North Carolina At Chapel Hill Mutagenese in vitro, phenotypage et cartographie genetique
US20070178478A1 (en) 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20040009518A1 (en) 2002-05-14 2004-01-15 The Chinese University Of Hong Kong Methods for evaluating a disease condition by nucleic acid detection and fractionation
US20040229231A1 (en) 2002-05-28 2004-11-18 Frudakis Tony N. Compositions and methods for inferring ancestry
WO2003102595A1 (fr) 2002-05-31 2003-12-11 Genetype Pty Ltd Anticorps maternels servant de marqueurs de cellules foetales permettant d'identifier et d'enrichir les cellules foetales du sang maternel
WO2003106623A2 (fr) 2002-06-13 2003-12-24 New York University Teste precoce prenatal non effractif pour detecter des aneuploidies et des etats pathologiques hereditaires
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
US7097976B2 (en) 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US20050009069A1 (en) 2002-06-25 2005-01-13 Affymetrix, Inc. Computer software products for analyzing genotyping
CA2491117A1 (fr) 2002-06-28 2004-01-08 Orchid Biosciences, Inc. Methodes et compositions permettant d'analyser des echantillons affaiblis, au moyen de panels de polymorphismes nucleotidiques uniques
EP1388812A1 (fr) 2002-07-04 2004-02-11 Ronald E. Dr. Kates Procédé d'entraínement pour un système capable d'appentissage
UA53537C2 (en) 2002-07-15 2005-01-17 Amtech Ltd Ukrainian German Jo Injection syringe
US7459273B2 (en) 2002-10-04 2008-12-02 Affymetrix, Inc. Methods for genotyping selected polymorphism
AU2003285861A1 (en) 2002-10-07 2004-05-04 University Of Medicine And Dentistry Of New Jersey High throughput multiplex dna sequence amplifications
AU2003291481A1 (en) 2002-11-11 2004-06-03 Affymetrix, Inc. Methods for identifying dna copy number changes
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
EP1583904B1 (fr) 2003-01-02 2013-10-02 Wobben Properties GmbH Pale de rotor concue pour une installation d'energie eolienne
US7700325B2 (en) 2003-01-17 2010-04-20 Trustees Of Boston University Haplotype analysis
WO2004065628A1 (fr) 2003-01-21 2004-08-05 Guoliang Fu Detection multiplex quantitative d'acides nucleiques
WO2005003375A2 (fr) 2003-01-29 2005-01-13 454 Corporation Procede d'amplification et de sequençage d'acides nucleiques
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
AU2004217872B2 (en) 2003-03-05 2010-03-25 Genetic Technologies Limited Identification of fetal DNA and fetal cell markers in maternal plasma or serum
EP1606417A2 (fr) 2003-03-07 2005-12-21 Rubicon Genomics Inc. Immortalisation d'adn in vitro et amplification genomique complete a l'aide de bibliotheques generees a partir d'adn fragmente de maniere aleatoire
US20040197832A1 (en) 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
US20070059700A1 (en) 2003-05-09 2007-03-15 Shengce Tao Methods and compositions for optimizing multiplex pcr primers
WO2005000006A2 (fr) 2003-05-28 2005-01-06 Pioneer Hi-Bred International, Inc. Methode de selection vegetale
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
DK1660680T3 (da) 2003-07-31 2009-06-22 Sequenom Inc Fremgangsmåde til multipleks-polymerasekædereaktioner på höjt niveau og homogene masseforlængelsesreaktioner til genotypebestemmelse af polymorfismer
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
WO2005021793A1 (fr) 2003-08-29 2005-03-10 Pantarhei Bioscience B.V. Diagnostic prenatal du syndrome de down par detection de marqueurs arn foetaux dans le sang maternel
EP2354253A3 (fr) 2003-09-05 2011-11-16 Trustees of Boston University Procede de diagnostic prenatal non effractif
US20050053950A1 (en) 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
WO2005028645A1 (fr) 2003-09-24 2005-03-31 Kyushu Tlo Company, Limited Snp dans la region regulatrice 5' du gene mdr1
WO2005030999A1 (fr) 2003-09-25 2005-04-07 Dana-Farber Cancer Institute, Inc Procedes permettant de detecter des cellules specifiques d'un lignage
JP2007508017A (ja) 2003-10-08 2007-04-05 ザ トラスティーズ オブ ボストン ユニバーシティ 染色体異常の出生前診断のための方法
CA2482097C (fr) 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methodes pour isoler des acides nucleiques
ATE435301T1 (de) 2003-10-16 2009-07-15 Sequenom Inc Nicht invasiver nachweis fötaler genetischer merkmale
WO2005039389A2 (fr) 2003-10-22 2005-05-06 454 Corporation Caryotypage base sur des séquences
EP1678329A4 (fr) 2003-10-30 2008-07-02 Tufts New England Medical Ct Diagnostic prenatal a l'aide d'adn foetal acellulaire dans le liquide amniotique
US20050164252A1 (en) 2003-12-04 2005-07-28 Yeung Wah Hin A. Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell
WO2005071078A1 (fr) 2004-01-12 2005-08-04 Nimblegen Systems Inc. Procede de mise en oeuvre d'une amplification en chaine par polymerase dans un micro-reseau
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20100216151A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US7035740B2 (en) 2004-03-24 2006-04-25 Illumina, Inc. Artificial intelligence and global normalization methods for genotyping
JP4437050B2 (ja) 2004-03-26 2010-03-24 株式会社日立製作所 診断支援システム、診断支援方法および診断支援サービスの提供方法
WO2005094363A2 (fr) * 2004-03-30 2005-10-13 New York University Systeme, procede et dispositif logiciels de mise en phase d'haplotypes bi-alleles
WO2005100401A2 (fr) 2004-03-31 2005-10-27 Adnagen Ag Anticorps monoclonaux presentant une specificite pour des cellules erythrocytes embryonnaires
US7414118B1 (en) 2004-04-14 2008-08-19 Applied Biosystems Inc. Modified oligonucleotides and applications thereof
US7468249B2 (en) 2004-05-05 2008-12-23 Biocept, Inc. Detection of chromosomal disorders
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
AU2005255024C1 (en) 2004-06-14 2010-09-09 The Board Of Trustees Of The University Of Illinois Antibodies binding to CD34+/CD36+ fetal but not to adult cells
EP1786924A4 (fr) 2004-07-06 2008-10-01 Genera Biosystems Pty Ltd Procede de detection de l'aneuploidie
DE102004036285A1 (de) 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
US20060040300A1 (en) 2004-08-09 2006-02-23 Generation Biotech, Llc Method for nucleic acid isolation and amplification
JP2008511058A (ja) 2004-08-18 2008-04-10 アボツト・モレキユラー・インコーポレイテツド コンピュータシステムを用いるデータ品質および/または部分異数染色体の決定
US7634808B1 (en) 2004-08-20 2009-12-15 Symantec Corporation Method and apparatus to block fast-spreading computer worms that use DNS MX record queries
JP4810164B2 (ja) 2004-09-03 2011-11-09 富士フイルム株式会社 核酸分離精製方法
US8024128B2 (en) 2004-09-07 2011-09-20 Gene Security Network, Inc. System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data
US20060088574A1 (en) 2004-10-25 2006-04-27 Manning Paul B Nutritional supplements
US20060134662A1 (en) 2004-10-25 2006-06-22 Pratt Mark R Method and system for genotyping samples in a normalized allelic space
CA2585784A1 (fr) 2004-11-17 2006-05-26 Mosaic Reproductive Health And Genetics, Llc Procedes de determination de la competence de l'ovocyte humain
WO2006058236A2 (fr) 2004-11-24 2006-06-01 Neuromolecular Pharmaceuticals, Inc. Composition et methode pour traiter des affections neurologiques
US20070042384A1 (en) 2004-12-01 2007-02-22 Weiwei Li Method for isolating and modifying DNA from blood and body fluids
WO2006091979A2 (fr) 2005-02-25 2006-08-31 The Regents Of The University Of California Analyse complete de chromomes a cellule unique par caryotype
US7618777B2 (en) 2005-03-16 2009-11-17 Agilent Technologies, Inc. Composition and method for array hybridization
AU2006224973B9 (en) 2005-03-18 2010-02-11 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
CN101137760B (zh) 2005-03-18 2011-01-26 香港中文大学 检测染色体非整倍性的方法
US20060228721A1 (en) 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
ES2404311T3 (es) 2005-04-12 2013-05-27 454 Life Sciences Corporation Métodos para determinar variantes de secuencias usando secuenciación ultraprofunda
WO2006128192A2 (fr) 2005-05-27 2006-11-30 John Wayne Cancer Institute Utilisation d'adn en circulation libre pour le diagnostic, le pronostic et le traitement du cancer
EP1896617B1 (fr) 2005-05-31 2013-01-02 Life Technologies Corporation Amplification multiplexe d'acides nucléiques courts
EP1910537A1 (fr) 2005-06-06 2008-04-16 454 Life Sciences Corporation Séquençage d'extrémités appariées
WO2006138257A2 (fr) 2005-06-15 2006-12-28 Callida Genomics, Inc. Reseaux de molecules simples pour analyse genetique et chimique
ATE489473T1 (de) 2005-07-15 2010-12-15 Life Technologies Corp Analyse von boten-rna und mikro-rna im gleichen reaktionsansatz
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
RU2290078C1 (ru) 2005-07-25 2006-12-27 Евгений Владимирович Новичков Способ прогнозирования рецидива серозного рака яичников
US20070178501A1 (en) 2005-12-06 2007-08-02 Matthew Rabinowitz System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US20070027636A1 (en) 2005-07-29 2007-02-01 Matthew Rabinowitz System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8532930B2 (en) * 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US8515679B2 (en) 2005-12-06 2013-08-20 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
WO2007018601A1 (fr) 2005-08-02 2007-02-15 Rubicon Genomics, Inc. Compositions et methodes de traitement et d'amplification d'adn consistant a utiliser plusieurs enzymes dans une seule reaction
US7884119B2 (en) 2005-09-07 2011-02-08 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as Axl inhibitors
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0523276D0 (en) 2005-11-15 2005-12-21 London Bridge Fertility Chromosomal analysis by molecular karyotyping
EP3012760A1 (fr) 2005-11-26 2016-04-27 Natera, Inc. Systeme et procede de nettoyage de donnees genetiques bruitees, et utilisation de donnees genetiques, phenotypiques et cliniques pour faire des previsions
US20070172853A1 (en) 2005-12-02 2007-07-26 The General Hospital Corporation Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility
WO2007070482A2 (fr) 2005-12-14 2007-06-21 Xueliang Xia Procede de detection d'anormalites chromosomiques a l'aide de microreseaux pour le diagnostic genetique preimplantatoire
WO2007073171A2 (fr) 2005-12-22 2007-06-28 Keygene N.V. Strategies ameliorees pour etablir des profils de produits de transcription au moyen de technologies de sequençage a rendement eleve
ES2739483T3 (es) 2006-02-02 2020-01-31 Univ Leland Stanford Junior Detección genética fetal no invasiva mediante análisis digital
WO2007092538A2 (fr) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Procédés de confection de sondes nucléotidiques pour séquençage et synthèse
ATE514775T1 (de) 2006-02-08 2011-07-15 Illumina Cambridge Ltd Endenmodifikation zur verhinderung einer überrepräsentierung von fragmenten
US20100184043A1 (en) 2006-02-28 2010-07-22 University Of Louisville Research Foundation Detecting Genetic Abnormalities
ATE508209T1 (de) 2006-02-28 2011-05-15 Univ Louisville Res Found Erkennung von chromosomabnormalitäten im fötus mit hilfe der tandem-einzelnukleotid- polymorphismen
WO2007106545A2 (fr) 2006-03-13 2007-09-20 Veridex, Llc Propagation de cellules primaires
US20080038733A1 (en) 2006-03-28 2008-02-14 Baylor College Of Medicine Screening for down syndrome
JP2009072062A (ja) 2006-04-07 2009-04-09 Institute Of Physical & Chemical Research 核酸の5’末端を単離するための方法およびその適用
US20070243549A1 (en) 2006-04-12 2007-10-18 Biocept, Inc. Enrichment of circulating fetal dna
US7901884B2 (en) 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
EP2029777B1 (fr) 2006-05-31 2017-03-08 Sequenom, Inc. Procédés et compositions destinés à l'extraction d'un acide nucléique à partir d'un échantillon
WO2007146819A2 (fr) 2006-06-09 2007-12-21 Brigham And Women's Hospital, Inc. Procédés d'identification et d'utilisation d'échantillons constants pnu
EP2029779A4 (fr) 2006-06-14 2010-01-20 Living Microsystems Inc Utilisation de génotypage snp fortement parallèle pour diagnostic fétal
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP3406736B1 (fr) 2006-06-14 2022-09-07 Verinata Health, Inc. Procédés pour le diagnostic d'anomalies fétales
EP2589668A1 (fr) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN
CN101675169B (zh) 2006-06-14 2018-01-02 维里纳塔健康公司 使用样品拆分和dna标签进行稀有细胞分析
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
WO2008111990A1 (fr) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Analyse de cellules rares par division d'échantillon et utilisation de marqueurs d'adn
US20080026390A1 (en) 2006-06-14 2008-01-31 Roland Stoughton Diagnosis of Fetal Abnormalities by Comparative Genomic Hybridization Analysis
DK2029778T3 (en) 2006-06-14 2018-08-20 Verinata Health Inc DIAGNOSIS OF Fetal ABNORMITIES
US20080026451A1 (en) 2006-06-15 2008-01-31 Braman Jeffrey C System for isolating biomolecules from a sample
CA2655269A1 (fr) 2006-06-16 2007-12-21 Sequenom, Inc. Procedes et compositions destines a l'amplification, la detection et la quantification d'acide nucleique issu d'un echantillon
US20080182244A1 (en) 2006-08-04 2008-07-31 Ikonisys, Inc. Pre-Implantation Genetic Diagnosis Test
EP2057282A4 (fr) 2006-08-24 2010-10-27 Univ Massachusetts Medical Cartographie d'interactions genomiques
WO2008143627A2 (fr) 2006-09-14 2008-11-27 Ibis Biosciences, Inc. Procédé d'amplification ciblée de génome entier pour l'identification d'agents pathogènes
US20080085836A1 (en) 2006-09-22 2008-04-10 Kearns William G Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy
EP2094838A1 (fr) 2006-10-16 2009-09-02 Cellula, Inc. Procédés et compositions pour le développement différentiel de cellules foetales dans le sang maternel et leur utilisation
US20100184152A1 (en) 2006-10-23 2010-07-22 Vladislav Sandler Target-oriented whole genome amplification of nucleic acids
KR100825367B1 (ko) 2006-11-07 2008-04-28 전남대학교산학협력단 표지자로서 미토콘드리아 유전자 과변이부위를 이용하는조혈모세포이식 후 생착능 평가방법 및 키트
WO2008069906A2 (fr) 2006-11-14 2008-06-12 The Regents Of The University Of California Expression numérisée de l'analyse génétique
ATE527385T1 (de) 2006-11-16 2011-10-15 Genentech Inc Mit tumoren assoziierte genetische variationen
WO2008059578A1 (fr) 2006-11-16 2008-05-22 Olympus Corporation Procédé d'amplification pcr multiplex
WO2008079374A2 (fr) 2006-12-21 2008-07-03 Wang Eric T Procédés et compositions pour sélectionner et utiliser des polymorphismes d'un nucléotide simple
WO2008081451A2 (fr) 2007-01-03 2008-07-10 Monaliza Medical Ltd. Méthode et trousse d'analyse du matériel génétique d'un foetus
CN101688237A (zh) 2007-01-11 2010-03-31 伊拉兹马斯大学医疗中心 环状染色体构象捕获(4c)
US20100129792A1 (en) 2007-02-06 2010-05-27 Gerassimos Makrigiorgos Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions
AU2008213634B2 (en) 2007-02-08 2013-09-05 Sequenom, Inc. Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
WO2008115497A2 (fr) 2007-03-16 2008-09-25 Gene Security Network Système et procédé pour nettoyer des données génétiques bruyantes et déterminer un numéro de copie de chromosome
US8617816B2 (en) 2007-03-16 2013-12-31 454 Life Sciences, A Roche Company System and method for detection of HIV drug resistant variants
CA2680588A1 (fr) 2007-03-26 2008-10-02 Sequenom, Inc. Detection de sequence polymorphe amplifiee par endonuclease de restriction
JP5262230B2 (ja) 2007-03-28 2013-08-14 独立行政法人理化学研究所 新規多型検出法
ITTO20070307A1 (it) 2007-05-04 2008-11-05 Silicon Biosystems Spa Metodo e dispositivo per la diagnosi prenatale non-invasiva
KR20100038330A (ko) 2007-05-31 2010-04-14 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 입체구조적 방해 및 효소 관련 신호 증폭 기반의 고 특이성 및 고 민감도 검출
WO2008157264A2 (fr) 2007-06-15 2008-12-24 Sequenom, Inc. Procédés combinés pour la détection de l'aneuploïdie chromosomique
US20090023190A1 (en) 2007-06-20 2009-01-22 Kai Qin Lao Sequence amplification with loopable primers
AU2008272421B2 (en) 2007-07-03 2014-09-04 Genaphora Ltd. Chimeric primers for improved nucleic acid amplification reactions
WO2009009769A2 (fr) 2007-07-11 2009-01-15 Artemis Health, Inc. Diagnostic d'anomalies fœtales au moyen d'hématies nucléées
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
CN103849684A (zh) 2007-07-23 2014-06-11 香港中文大学 利用靶向扩增和测序的非侵入性胎儿基因组筛查
KR101376359B1 (ko) 2007-08-01 2014-03-27 다나-파버 캔서 인스티튜트 인크. 표적 서열 강화
WO2009019215A1 (fr) 2007-08-03 2009-02-12 Dkfz Deutsches Krebsforschungszentrum Methode de diagnostic prenatal mettant en œuvre des exosomes et cd24 comme marqueur
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
WO2009032779A2 (fr) 2007-08-29 2009-03-12 Sequenom, Inc. Procédés et compositions utilisés dans la séparation, en fonction de sa taille, de l'acide nucléique d'un échantillon
US8748100B2 (en) 2007-08-30 2014-06-10 The Chinese University Of Hong Kong Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
MX2010002556A (es) 2007-09-07 2010-08-02 Fluidigm Corp Metodos y sistemas para determinar la variacion del numero de copia.
WO2009036525A2 (fr) 2007-09-21 2009-03-26 Katholieke Universiteit Leuven Outils et procédés pour tests génétiques ayant recours à un séquençage de dernière génération
EP2191012A1 (fr) 2007-09-21 2010-06-02 Streck, Inc. Isolement d'acides nucléiques dans du sang total conservé
US20100086914A1 (en) 2008-10-03 2010-04-08 Roche Molecular Systems, Inc. High resolution, high throughput hla genotyping by clonal sequencing
JP2011500041A (ja) 2007-10-16 2011-01-06 エフ.ホフマン−ラ ロシュ アーゲー クローナルシークエンシングによる高分解能かつ高効率のhla遺伝子型決定法
WO2009064897A2 (fr) 2007-11-14 2009-05-22 Chronix Biomedical Détection de variations de séquences d'acides nucléiques dans l'acide nucléique circulant dans l'encéphalopathie spongiforme bovine
US20090143570A1 (en) 2007-11-30 2009-06-04 Ge Healthcare Bio-Sciences Corp. Method for isolation of genomic dna, rna and proteins from a single sample
FR2925480B1 (fr) 2007-12-21 2011-07-01 Gervais Danone Sa Procede d'enrichissement d'une eau en oxygene par voie electrolytique, eau ou boisson enrichie en oxygene et utilisations
EP2077337A1 (fr) 2007-12-26 2009-07-08 Eppendorf Array Technologies SA Composition d'amplification et de détection, procédé et kit
US8852864B2 (en) 2008-01-17 2014-10-07 Sequenom Inc. Methods and compositions for the analysis of nucleic acids
EP3699291A1 (fr) 2008-01-17 2020-08-26 Sequenom, Inc. Procédés d'analyse de séquence d'acide nucléique à molécule unique et compositions
BRPI0907050B1 (pt) 2008-02-01 2022-03-22 The General Hospital Corporation Método para detectar em um indivíduo a presença ou ausência de um ácido nucleico biomarcador predeterminado associado com câncer de próstata
US20100029498A1 (en) 2008-02-04 2010-02-04 Andreas Gnirke Selection of nucleic acids by solution hybridization to oligonucleotide baits
WO2009105531A1 (fr) 2008-02-19 2009-08-27 Gene Security Network, Inc. Procédés de génotypage cellulaire
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
CA2717320A1 (fr) 2008-03-11 2009-09-17 Sequenom, Inc. Tests adn pour determiner le sexe d'un bebe avant sa naissance
EP2227780A4 (fr) 2008-03-19 2011-08-03 Existence Genetics Llc Analyse génétique
AU2009228312B2 (en) 2008-03-26 2015-05-21 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
US8133672B2 (en) 2008-03-31 2012-03-13 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
CN102066573A (zh) 2008-04-03 2011-05-18 哈森阿尔法生物技术研究院 用于扩增多个靶标的扩增子拯救多重聚合酶链式反应
WO2009146335A1 (fr) 2008-05-27 2009-12-03 Gene Security Network, Inc. Procédés de caractérisation d’embryon et de comparaison
EP2128169A1 (fr) 2008-05-30 2009-12-02 Qiagen GmbH Procédé d'isolation d'acides nucléiques à chaînes courtes
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
CA3116156C (fr) * 2008-08-04 2023-08-08 Natera, Inc. Procedes pour une classification d'allele et une classification de ploidie
EP2326732A4 (fr) 2008-08-26 2012-11-14 Fluidigm Corp Procédés de dosage pour un débit amélioré d'échantillons et/ou de cibles
DE102008045705A1 (de) 2008-09-04 2010-04-22 Macherey, Nagel Gmbh & Co. Kg Handelsgesellschaft Verfahren zur Gewinnung von kurzer RNA sowie Kit hierfür
US8586310B2 (en) 2008-09-05 2013-11-19 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CA3073079C (fr) 2008-09-16 2023-09-26 Sequenom, Inc. Procedes et compositions pour enrichissement base sur la methylation en acide nucleique foetal dans un echantillon maternel, utiles pour les diagnostics prenatals non invasifs
WO2010033652A1 (fr) 2008-09-17 2010-03-25 Ge Healthcare Bio-Sciences Corp. Procédé d’isolement d’un petit arn
PL2562268T3 (pl) 2008-09-20 2017-06-30 The Board Of Trustees Of The Leland Stanford Junior University Nieinwazyjna diagnostyka aneuploidii płodu za pomocą sekwencjonowania
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US20110159499A1 (en) 2009-11-25 2011-06-30 Quantalife, Inc. Methods and compositions for detecting genetic material
US20110301221A1 (en) 2008-10-10 2011-12-08 Swedish Health Services Diagnosis, prognosis and treatment of glioblastoma multiforme
WO2010045617A2 (fr) 2008-10-17 2010-04-22 University Of Louisville Research Foundation Détection d'anomalies génétiques
GB2497007B (en) 2008-11-07 2013-08-07 Sequenta Inc Methods of monitoring disease conditions by analysis of the full repertoire of the V-D junction or D-J junction sequences of an individual
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
WO2011109440A1 (fr) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarqueurs pour théranostique
AU2009329946B2 (en) 2008-12-22 2016-01-07 Celula, Inc. Methods and genotyping panels for detecting alleles, genomes, and transcriptomes
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
WO2010088288A2 (fr) 2009-01-28 2010-08-05 Fluidigm Corporation Détermination de différences du nombre de copies par amplification
ES2649572T3 (es) 2009-02-18 2018-01-12 Streck Inc. Conservación de ácidos nucleicos fuera de las células
EP2411543B1 (fr) 2009-03-27 2017-04-19 Life Technologies Corporation Procédés, compositions, et kits pour détecter des variants alléliques
WO2010115044A2 (fr) 2009-04-02 2010-10-07 Fluidigm Corporation Marquage sélectif de courts fragments d'acides nucléiques et protection sélective de séquences cibles contre la dégradation
CA3018687C (fr) 2009-04-02 2021-07-13 Fluidigm Corporation Procede d'amplification a amorce multiple pour codage a barres d'acides nucleiques cibles
EP2414545B1 (fr) 2009-04-03 2017-01-11 Sequenom, Inc. Compositions constituées d'une préparation d'acides nucléiques et procédés associés
EP2417270B1 (fr) 2009-04-06 2017-09-20 The Johns Hopkins University Quantification de la méthylation de l'adn
WO2010127186A1 (fr) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Produits de construction d'acide nucléique et leurs procédés d'utilisation
US8481699B2 (en) 2009-07-14 2013-07-09 Academia Sinica Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing
US20130196862A1 (en) 2009-07-17 2013-08-01 Natera, Inc. Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination
US8563242B2 (en) 2009-08-11 2013-10-22 The Chinese University Of Hong Kong Method for detecting chromosomal aneuploidy
CN101643904B (zh) 2009-08-27 2011-04-27 北京北方微电子基地设备工艺研究中心有限责任公司 深硅刻蚀装置和深硅刻蚀设备的进气系统
WO2011032078A1 (fr) 2009-09-11 2011-03-17 Health Reseach Inc. Détection de souches x4 du vih-1 par test de suivi des hétéroduplexes
CA2770143C (fr) 2009-09-22 2015-11-03 F. Hoffmann-La Roche Ag Methode servant a determiner des haplotypes de kir associes a une maladie
CA2773186A1 (fr) 2009-09-24 2011-03-31 Qiagen Gaithersburg, Inc. Compositions, procedes, et kit d'isolement et d'analyse d'acides nucleiques en utilisant un materiau echangeur d'anions
EP2473638B1 (fr) 2009-09-30 2017-08-09 Natera, Inc. Méthode non invasive de détermination d'une ploïdie prénatale
AU2010311535B2 (en) 2009-10-26 2015-05-21 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
DK2496717T3 (en) 2009-11-05 2017-07-24 Univ Hong Kong Chinese ANALYSIS OF BORN THROUGH FROM A MATERNAL BIOLOGICAL TEST
US8703652B2 (en) 2009-11-06 2014-04-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive diagnosis of graft rejection in organ transplant patients
WO2011072086A1 (fr) 2009-12-08 2011-06-16 Hemaquest Pharmaceuticals, Inc. Procédés et régimes à faible dose pour traiter des troubles des globules rouges
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US8574842B2 (en) 2009-12-22 2013-11-05 The Board Of Trustees Of The Leland Stanford Junior University Direct molecular diagnosis of fetal aneuploidy
WO2011085491A1 (fr) 2010-01-15 2011-07-21 The University Of British Columbia Amplification multiplex pour la détection de variations d'acide nucléique
US20120270739A1 (en) 2010-01-19 2012-10-25 Verinata Health, Inc. Method for sample analysis of aneuploidies in maternal samples
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
PL2366031T3 (pl) 2010-01-19 2015-08-31 Verinata Health Inc Metody sekwencjonowania w diagnostyce prenatalnej
WO2011090556A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Procédés pour déterminer une fraction d'acide nucléique fœtal dans des échantillons maternels
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
EP2534263B1 (fr) 2010-02-09 2020-08-05 Unitaq Bio Procédés et compositions pour la détection universelle d'acides nucléiques
PT2539472E (pt) 2010-02-26 2015-09-24 Life Technologies Corp Pcr rápida para genotipagem de str
US9234240B2 (en) 2010-05-07 2016-01-12 The Board Of Trustees Of The Leland Stanford Junior University Measurement and comparison of immune diversity by high-throughput sequencing
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
EP2854057B1 (fr) 2010-05-18 2018-03-07 Natera, Inc. Procédés pour une classification de ploïdie prénatale non invasive
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190309358A1 (en) 2010-05-18 2019-10-10 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20140206552A1 (en) 2010-05-18 2014-07-24 Natera, Inc. Methods for preimplantation genetic diagnosis by sequencing
US20190323076A1 (en) 2010-05-18 2019-10-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20130123120A1 (en) 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190284623A1 (en) 2010-05-18 2019-09-19 Natera, Inc. Methods for non-invasive prenatal ploidy calling
WO2013052557A2 (fr) 2011-10-03 2013-04-11 Natera, Inc. Procédés pour diagnostic génétique préimplantatoire par séquençage
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US20110301854A1 (en) 2010-06-08 2011-12-08 Curry Bo U Method of Determining Allele-Specific Copy Number of a SNP
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20120190557A1 (en) 2011-01-25 2012-07-26 Aria Diagnostics, Inc. Risk calculation for evaluation of fetal aneuploidy
EP2426217A1 (fr) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Procédés analytiques pour acides nucléiques libres dans les cellules et applications
WO2012042374A2 (fr) 2010-10-01 2012-04-05 Anssi Jussi Nikolai Taipale Procédé de détermination du nombre ou de la concentration de molécules
WO2012058316A1 (fr) 2010-10-26 2012-05-03 Stanford University Dépistage génétique foetal non invasif par analyse de séquençage
ES2774447T3 (es) 2010-10-27 2020-07-21 Harvard College Métodos de uso de cebador de horquilla de extremos cohesivos
KR102185244B1 (ko) 2010-11-30 2020-12-02 더 차이니즈 유니버시티 오브 홍콩 암과 연관된 유전적 또는 분자적 이상들의 검출
EP2649199A2 (fr) 2010-12-07 2013-10-16 Stanford University Détermination non invasive de l'héritage fétal des haplotypes parentaux à l'échelle du génome
US20150064695A1 (en) 2010-12-17 2015-03-05 Celula Inc. Methods for screening and diagnosing genetic conditions
BR112013016193B1 (pt) 2010-12-22 2019-10-22 Natera Inc método ex vivo para determinar se um suposto pai é o pai biológico de um feto que está em gestação em uma gestante e relatório
KR20140024270A (ko) 2010-12-30 2014-02-28 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
WO2012103031A2 (fr) 2011-01-25 2012-08-02 Ariosa Diagnostics, Inc. Détection d'anomalies génétiques
BR112013020220B1 (pt) 2011-02-09 2020-03-17 Natera, Inc. Método para determinar o estado de ploidia de um cromossomo em um feto em gestação
EP3760732A1 (fr) 2011-02-09 2021-01-06 Natera, Inc. Procédés pour une classification de ploïdie prénatale non invasive
GB2488358A (en) 2011-02-25 2012-08-29 Univ Plymouth Enrichment of foetal DNA in maternal plasma
WO2012129363A2 (fr) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Détection et analyse d'acide nucléique d'une cellule isolée
CN103797129B (zh) 2011-04-12 2016-08-17 维里纳塔健康公司 使用多态计数来解析基因组分数
CN107368705B (zh) 2011-04-14 2021-07-13 完整基因有限公司 分析生物体的基因组dna的方法和计算机系统
EP3246416B1 (fr) 2011-04-15 2024-06-05 The Johns Hopkins University Système de séquençage sûr
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US9957558B2 (en) 2011-04-28 2018-05-01 Life Technologies Corporation Methods and compositions for multiplex PCR
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
US8945844B2 (en) 2011-07-11 2015-02-03 Samsung Electronics Co., Ltd. Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample
US20130024127A1 (en) 2011-07-19 2013-01-24 John Stuelpnagel Determination of source contributions using binomial probability calculations
GB201115095D0 (en) 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
JP5536729B2 (ja) 2011-09-20 2014-07-02 株式会社ソニー・コンピュータエンタテインメント 情報処理装置、アプリケーション提供システム、アプリケーション提供サーバ、アプリケーション提供方法、および情報処理方法
CN113388606A (zh) 2011-09-26 2021-09-14 凯杰有限公司 用于分离细胞外核酸的快速方法
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
AU2012321053B2 (en) 2011-10-07 2018-04-19 Murdoch Childrens Research Institute Diagnostic assay for tissue transplantation status
WO2013078470A2 (fr) 2011-11-22 2013-05-30 MOTIF, Active Isolation multiplex d'acides nucléiques associés à des protéines
WO2013086464A1 (fr) 2011-12-07 2013-06-13 The Broad Institute, Inc. Marqueurs associés au pronostic et à l'évolution de la leucémie lymphocytaire chronique
US20130190653A1 (en) 2012-01-25 2013-07-25 Angel Gabriel Alvarez Ramos Device for blood collection from the placenta and the umbilical cord
US9598728B2 (en) 2012-02-14 2017-03-21 Cornell University Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions
WO2013128281A1 (fr) 2012-02-28 2013-09-06 Population Genetics Technologies Ltd Procédé de fixation d'une contre-séquence à un échantillon d'acides nucléiques
WO2013130848A1 (fr) 2012-02-29 2013-09-06 Natera, Inc. Analyse améliorée par informatique d'échantillons de fœtus soumis à une contamination maternelle
EP2825675B1 (fr) 2012-03-13 2017-12-27 Patel, Abhijit Ajit Mesure des variants d'acide nucléique au moyen du séquençage hautement multiplexé, à très haut débit et à suppression d'erreur
EP2839036A4 (fr) 2012-04-19 2016-03-16 Wisconsin Med College Inc Surveillance hautement sensible utilisant une détection d'adn acellulaire
US9487828B2 (en) 2012-05-10 2016-11-08 The General Hospital Corporation Methods for determining a nucleotide sequence contiguous to a known target nucleotide sequence
AU2013266394B2 (en) 2012-05-21 2019-03-14 The Scripps Research Institute Methods of sample preparation
WO2013181651A1 (fr) 2012-06-01 2013-12-05 Omega Bio-Tek, Inc. Récupération de fragments d'acide nucléique sélective
WO2014004726A1 (fr) 2012-06-26 2014-01-03 Caifu Chen Procédés, compositions et kits pour le diagnostic, le pronostic et la surveillance d'un cancer
EP2877594B1 (fr) 2012-07-20 2019-12-04 Verinata Health, Inc. Détection et classification de variation du nombre de copies dans un génome foetal
AU2012385961B9 (en) 2012-07-24 2017-05-18 Natera, Inc. Highly multiplex PCR methods and compositions
US10988803B2 (en) 2014-12-29 2021-04-27 Life Genetics Lab, Llc Multiplexed assay for quantitating and assessing integrity of cell-free DNA in biological fluids for cancer diagnosis, prognosis and surveillance
US10993418B2 (en) 2012-08-13 2021-05-04 Life Genetics Lab, Llc Method for measuring tumor burden in patient derived xenograft (PDX) mice
US20140051585A1 (en) 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
WO2014035986A1 (fr) 2012-08-28 2014-03-06 Akonni Biosystems Inc. Procédé et kit de purification d'acides nucléiques
US20140065621A1 (en) 2012-09-04 2014-03-06 Natera, Inc. Methods for increasing fetal fraction in maternal blood
US10041127B2 (en) 2012-09-04 2018-08-07 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP3026124A1 (fr) 2012-10-31 2016-06-01 Genesupport SA Procédé non invasif permettant de détecter une aneuploïdie chromosomique f tale
US9523121B2 (en) 2013-01-13 2016-12-20 Uni Taq Bio Methods and compositions for PCR using blocked and universal primers
WO2014122288A1 (fr) 2013-02-08 2014-08-14 Qiagen Gmbh Procédé de séparation de l'adn suivant la taille
US9982255B2 (en) 2013-03-11 2018-05-29 Kailos Genetics, Inc. Capture methodologies for circulating cell free DNA
CN105408496A (zh) 2013-03-15 2016-03-16 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
EP2971135A4 (fr) 2013-03-15 2016-11-09 Immucor Gti Diagnostics Inc Procédés et compositions pour estimer le statut rénal à l'aide de l'adn acellulaire de l'urine
CN105229175A (zh) 2013-03-15 2016-01-06 雅培分子公司 用于扩增和测定rna融合基因变体的方法、区分它们的方法以及有关的引物、探针和试剂盒
CA3156663A1 (fr) 2013-03-15 2014-09-18 Verinata Health, Inc. Generation de bibliotheques d'adn acellulaire directement a partir du sang
CN113337604A (zh) 2013-03-15 2021-09-03 莱兰斯坦福初级大学评议会 循环核酸肿瘤标志物的鉴别和用途
US10385394B2 (en) 2013-03-15 2019-08-20 The Translational Genomics Research Institute Processes of identifying and characterizing X-linked disorders
US10072298B2 (en) 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
PT3004388T (pt) 2013-05-29 2019-01-29 Chronix Biomedical Deteção e quantificação de dna livre de células do dador na circulação de recetores de transplante de órgão
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
EP3049557B1 (fr) 2013-09-27 2021-05-05 University of Washington Procédés et systèmes d'échafaudage à grande échelle d'assemblages de génomes
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
ES2693217T3 (es) 2013-12-02 2018-12-10 Personal Genome Diagnostics Inc. Método para evaluar variantes minoritarias en una muestra
WO2015100427A1 (fr) 2013-12-28 2015-07-02 Guardant Health, Inc. Procédés et systèmes de détection de variants génétiques
US9580736B2 (en) 2013-12-30 2017-02-28 Atreca, Inc. Analysis of nucleic acids associated with single cells using nucleic acid barcodes
JP7016215B2 (ja) 2014-01-27 2022-02-04 ザ ジェネラル ホスピタル コーポレイション 配列決定のために核酸を調製する方法
EP3105349B1 (fr) 2014-02-11 2020-07-15 F. Hoffmann-La Roche AG Séquençage ciblé et filtrage uid
ES2726650T3 (es) 2014-03-14 2019-10-08 Caredx Inc Métodos de monitorización de terapias inmunosupresoras en un receptor de trasplante
EP3825421B1 (fr) 2014-03-25 2022-06-22 Quest Diagnostics Investments Incorporated Détection de fusions de gènes par expression différentielle intragénique (ide) à l'aide de seuils de cycle moyen
WO2015164432A1 (fr) 2014-04-21 2015-10-29 Natera, Inc. Détection de mutations et de la ploïdie dans des segments chromosomiques
CN109971852A (zh) 2014-04-21 2019-07-05 纳特拉公司 检测染色体片段中的突变和倍性
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
EP3161149B1 (fr) 2014-06-27 2020-06-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé utilisant l'adn et le miarn en tant que biomarqueurs de l'infécondité chez la femme
DK3164489T3 (da) 2014-07-03 2020-08-10 Rhodx Inc Mærkning og vurdering af en målsekvens
EP3169780B1 (fr) 2014-07-17 2020-02-12 Qiagen GmbH Procédé d'isolement d'arn ayant un rendement élevé
US10119167B2 (en) 2014-07-18 2018-11-06 Illumina, Inc. Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
IL296204B1 (en) 2014-10-08 2024-04-01 Univ Cornell A method for the detection and relative quantification of nucleic acid sequence, expression, variants, transition, copy number, or methylation changes, using a combination of nuclease, ligase, and polymerase reactions with protection against contamination
EP3209797B1 (fr) 2014-10-20 2018-12-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés de criblage d'un sujet atteint d'un cancer
US9783799B2 (en) 2014-10-24 2017-10-10 Abbott Molecular Inc. Enrichment of small nucleic acids
WO2016077313A1 (fr) 2014-11-11 2016-05-19 Bgi Shenzhen Séquençage en plusieurs passes
EP3227462B1 (fr) 2014-12-01 2020-04-22 The Broad Institute, Inc. Procédé de détermination in situ de proximité d'acide nucléique
GB201501907D0 (en) 2015-02-05 2015-03-25 Technion Res & Dev Foundation System and method for single cell genetic analysis
WO2016123698A1 (fr) 2015-02-06 2016-08-11 Uti Limited Partnership Test diagnostique pour l'évaluation posttransplantation du rejet potentiel d'organes de donneurs
WO2016138080A1 (fr) 2015-02-24 2016-09-01 Trustees Of Boston University Protection de codes à barres pendant une amplification d'adn au moyen d'épingles à cheveux moléculaires
EP3262189B1 (fr) 2015-02-27 2021-12-08 Becton, Dickinson and Company Procédés pour le marquage d'acides nucléiques au moyen de codes à barres en vue du séquençage
CN107406888A (zh) 2015-03-30 2017-11-28 赛卢拉研究公司 用于组合条形编码的方法和组合物
KR101850437B1 (ko) 2015-04-14 2018-04-20 이원다이애그노믹스(주) 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법
CN107580632B (zh) 2015-04-23 2021-12-28 贝克顿迪金森公司 用于全转录组扩增的方法和组合物
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
EA201792389A1 (ru) 2015-04-30 2018-05-31 Медикал Колледж Оф Висконсин, Инк. Пцр в реальном времени для мультиплексной оптимизированной амплификации с несоответствиями (moma) и для оценки неклеточной днк
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
JP7007197B2 (ja) 2015-06-05 2022-01-24 キアゲン ゲーエムベーハー サイズによってdnaを分離する方法
US20160371428A1 (en) 2015-06-19 2016-12-22 Natera, Inc. Systems and methods for determining aneuploidy risk using sample fetal fraction
CN107922959A (zh) 2015-07-02 2018-04-17 阿瑞玛基因组学公司 混合物样品的精确分子去卷积
GB201516047D0 (en) 2015-09-10 2015-10-28 Cancer Rec Tech Ltd Method
EP3356559A4 (fr) 2015-09-29 2019-03-06 Ludwig Institute for Cancer Research Ltd Typage et assemblage d'éléments génomiques discontinus
CA3002740A1 (fr) 2015-10-19 2017-04-27 Dovetail Genomics, Llc Procedes d'assemblage de genomes, phasage d'haplotypes et detection d'acide nucleique independant cible
CN105986030A (zh) 2016-02-03 2016-10-05 广州市基准医疗有限责任公司 甲基化dna检测方法
US10597717B2 (en) 2016-03-22 2020-03-24 Myriad Women's Health, Inc. Combinatorial DNA screening
WO2017173039A1 (fr) 2016-03-30 2017-10-05 Covaris, Inc. Extraction d'adncf à partir d'échantillons biologiques
EP3443066A4 (fr) 2016-04-14 2019-12-11 Guardant Health, Inc. Méthodes de détection précoce du cancer
CN109477138A (zh) 2016-04-15 2019-03-15 纳特拉公司 肺癌检测方法
WO2017190106A1 (fr) 2016-04-29 2017-11-02 Medical College Of Wisconsin, Inc. Nombre de cibles par amplification de mésappariement (moma) optimisée multiplexée (moa)
ES2870626T3 (es) 2016-05-24 2021-10-27 Translational Genomics Res Inst Métodos de marcado molecular y bibliotecas de secuenciación
WO2017205826A1 (fr) 2016-05-27 2017-11-30 Sequenom, Inc. Méthodes de détection de variations génétiques
CN109415764A (zh) 2016-07-01 2019-03-01 纳特拉公司 用于检测核酸突变的组合物和方法
SG11201811556RA (en) 2016-07-06 2019-01-30 Guardant Health Inc Methods for fragmentome profiling of cell-free nucleic acids
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
MX2019005199A (es) 2016-11-02 2019-10-14 Medical College Wisconsin Inc Métodos para evaluar el riesgo usando and libre de células total y específico.
SG11201903158RA (en) 2016-11-08 2019-05-30 Cellular Res Inc Methods for cell label classification
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
EP3571320B1 (fr) 2017-01-17 2022-04-06 Life Technologies Corporation Compositions et méthodes destinées au séquençage de répertoire immunologique
US10894976B2 (en) 2017-02-21 2021-01-19 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
CN110945136A (zh) 2017-06-20 2020-03-31 威斯康星州立大学医学院 使用总无细胞dna评估移植并发症风险
JP7323462B2 (ja) 2017-06-20 2023-08-08 ザ メディカル カレッジ オブ ウィスコンシン,インコーポレイテッド セルフリーdnaによる移植患者のモニタリング
WO2018237078A1 (fr) 2017-06-20 2018-12-27 The Medical College Of Wisconsin, Inc. Évaluation de conditions chez des sujets greffés à l'aide d'adn acellulaire spécifique d'un donneur
KR20200115450A (ko) 2017-08-07 2020-10-07 더 존스 홉킨스 유니버시티 암을 평가하고 치료하기 위한 방법 및 재료
EP4212631A1 (fr) 2017-09-01 2023-07-19 Life Technologies Corporation Compositions et méthodes pour séquençage de répertoire immunologique
US11091800B2 (en) 2017-09-20 2021-08-17 University Of Utah Research Foundation Size-selection of cell-free DNA for increasing family size during next-generation sequencing
JP2021506342A (ja) 2017-12-14 2021-02-22 ティーエーアイ ダイアグノスティックス インコーポレイテッドTai Diagnostics,Inc. 移植のための移植片適合性の評価
CN111699269A (zh) 2018-01-12 2020-09-22 纳特拉公司 新引物及其用途
WO2019161244A1 (fr) 2018-02-15 2019-08-22 Natera, Inc. Procédés pour isoler des acides nucléiques avec sélection de taille
EP3781714A1 (fr) 2018-04-14 2021-02-24 Natera, Inc. Procédés de détection et de surveillance du cancer au moyen d'une détection personnalisée d'adn tumoral circulant
US20210257048A1 (en) 2018-06-12 2021-08-19 Natera, Inc. Methods and systems for calling mutations
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
WO2020010255A1 (fr) 2018-07-03 2020-01-09 Natera, Inc. Procédés de détection d'adn acellulaire dérivé d'un donneur
CN112639982A (zh) 2018-07-17 2021-04-09 纳特拉公司 使用神经网络调用倍性状态的方法和系统
WO2020041449A1 (fr) 2018-08-21 2020-02-27 Zymo Research Corporation Procédés et compositions pour le suivi de la qualité d'un échantillon
US20200109449A1 (en) 2018-10-09 2020-04-09 Tai Diagnostics, Inc. Cell lysis assay for cell-free dna analysis
BR112021009706A2 (pt) 2018-11-21 2021-08-17 Karius, Inc. detecção e predição de doença infecciosa
JP2022519159A (ja) 2018-12-17 2022-03-22 ナテラ, インコーポレイテッド 循環細胞の分析方法
US11931674B2 (en) 2019-04-04 2024-03-19 Natera, Inc. Materials and methods for processing blood samples
WO2020214547A1 (fr) 2019-04-15 2020-10-22 Natera, Inc. Biopsie liquide améliorée utilisant une sélection de taille
US20220251654A1 (en) 2019-06-06 2022-08-11 Natera, Inc. Methods for detecting immune cell dna and monitoring immune system
US20220340963A1 (en) 2019-09-20 2022-10-27 Natera, Inc. Methods for assessing graft suitability for transplantation
US20230203573A1 (en) 2020-05-29 2023-06-29 Natera, Inc. Methods for detection of donor-derived cell-free dna

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US9334541B2 (en) 2016-05-10
US20140100134A1 (en) 2014-04-10
US8949036B2 (en) 2015-02-03
US20110288780A1 (en) 2011-11-24
US20140336060A1 (en) 2014-11-13
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US20180073080A1 (en) 2018-03-15
EP2854057A2 (fr) 2015-04-01
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US20150072872A1 (en) 2015-03-12
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US20180057885A1 (en) 2018-03-01
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US20140162269A1 (en) 2014-06-12
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US8825412B2 (en) 2014-09-02
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