HK1203393A1 - Chimeric antigen receptors targeting b-cell maturation antigen - Google Patents

Chimeric antigen receptors targeting b-cell maturation antigen Download PDF

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Publication number
HK1203393A1
HK1203393A1 HK15104056.6A HK15104056A HK1203393A1 HK 1203393 A1 HK1203393 A1 HK 1203393A1 HK 15104056 A HK15104056 A HK 15104056A HK 1203393 A1 HK1203393 A1 HK 1203393A1
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Prior art keywords
cell maturation
antigen
cells
receptors targeting
chimeric antigen
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HK15104056.6A
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English (en)
Chinese (zh)
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James Noble KOCHENDERFER
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The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
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Application filed by The United States Of America, As Represented By The Secretary, Department Of Health And Human Services filed Critical The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Publication of HK1203393A1 publication Critical patent/HK1203393A1/xx

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2121/00—Preparations for use in therapy
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Hematology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15104056.6A 2012-04-11 2013-03-15 Chimeric antigen receptors targeting b-cell maturation antigen HK1203393A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261622600P 2012-04-11 2012-04-11
US61/622,600 2012-04-11
PCT/US2013/032029 WO2013154760A1 (en) 2012-04-11 2013-03-15 Chimeric antigen receptors targeting b-cell maturation antigen

Publications (1)

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HK1203393A1 true HK1203393A1 (en) 2015-10-30

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HK15104056.6A HK1203393A1 (en) 2012-04-11 2013-03-15 Chimeric antigen receptors targeting b-cell maturation antigen

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US (20) US9765342B2 (https=)
EP (3) EP4653456A3 (https=)
JP (6) JP6359520B2 (https=)
KR (5) KR20220029757A (https=)
CN (3) CN110331154A (https=)
AU (5) AU2013246443B2 (https=)
BR (1) BR112014024893B8 (https=)
CA (1) CA2869562C (https=)
EA (2) EA033110B1 (https=)
HK (1) HK1203393A1 (https=)
IL (4) IL278003B2 (https=)
IS (1) IS9056A (https=)
MX (3) MX394639B (https=)
NZ (1) NZ700362A (https=)
RU (2) RU2650805C2 (https=)
SG (1) SG11201406414WA (https=)
WO (1) WO2013154760A1 (https=)

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JP2022058345A (ja) 2022-04-12
EA201491837A1 (ru) 2015-03-31
KR102229945B1 (ko) 2021-03-18
IL290471B2 (en) 2025-12-01

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