HK1165409A1 - Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h- - Google Patents

Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-

Info

Publication number
HK1165409A1
HK1165409A1 HK12105914.8A HK12105914A HK1165409A1 HK 1165409 A1 HK1165409 A1 HK 1165409A1 HK 12105914 A HK12105914 A HK 12105914A HK 1165409 A1 HK1165409 A1 HK 1165409A1
Authority
HK
Hong Kong
Prior art keywords
indazole
hydroxymethyl
benzyl
derivatives
preparation
Prior art date
Application number
HK12105914.8A
Other languages
English (en)
Chinese (zh)
Inventor
Torchiarolo Giuliano Caracciolo
Tommaso Iacoangeli
Guido Furlotti
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of HK1165409A1 publication Critical patent/HK1165409A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK12105914.8A 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h- HK1165409A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09425314 2009-08-03
PCT/EP2010/060937 WO2011015501A1 (en) 2009-08-03 2010-07-28 Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates

Publications (1)

Publication Number Publication Date
HK1165409A1 true HK1165409A1 (en) 2012-10-05

Family

ID=41353924

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12105914.8A HK1165409A1 (en) 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-
HK12105913.9A HK1165408A1 (en) 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK12105913.9A HK1165408A1 (en) 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-

Country Status (22)

Country Link
US (2) US8354544B2 (uk)
EP (2) EP2462118B1 (uk)
JP (3) JP5640086B2 (uk)
KR (2) KR101735577B1 (uk)
CN (3) CN102471282A (uk)
AR (2) AR077667A1 (uk)
AU (1) AU2010280828B2 (uk)
BR (2) BR112012002130A2 (uk)
CA (2) CA2766235C (uk)
DK (2) DK2462119T3 (uk)
EA (2) EA019060B1 (uk)
ES (2) ES2481393T3 (uk)
GE (2) GEP20135878B (uk)
HK (2) HK1165409A1 (uk)
IL (2) IL216854A (uk)
MX (2) MX2012001519A (uk)
PL (2) PL2462118T3 (uk)
PT (2) PT2462119E (uk)
SG (2) SG176950A1 (uk)
SI (2) SI2462118T1 (uk)
UA (2) UA106988C2 (uk)
WO (2) WO2011015502A1 (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101640844B1 (ko) * 2008-03-07 2016-07-19 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1, ｃｘ3ｃｒ1 및 ｐ40의 발현을 기초로 한 질환들의 치료에서 이의 용도
JP2015521183A (ja) 2012-05-18 2015-07-27 サノフイ ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
CN104302625B (zh) 2012-05-18 2017-04-19 赛诺菲 吡唑衍生物及其作为lpar5拮抗剂的用途
CN104876872B (zh) * 2015-04-24 2017-07-07 昆明理工大学 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用
WO2016203313A1 (en) * 2015-06-16 2016-12-22 Translatum Medicus, Inc. Compositions and methods for treating and diagnosing ocular disorders
CA3144861A1 (en) 2019-06-25 2020-12-30 Translatum Medicus, Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB8707051D0 (en) * 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides
IT1230441B (it) * 1989-02-07 1991-10-23 Acraf Eteri della serie dell'indazolo
IT1253703B (it) 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
JP3159614B2 (ja) * 1994-11-28 2001-04-23 三井化学株式会社 クロロアルキルアミン塩酸塩の製造法
IT1276031B1 (it) 1995-10-31 1997-10-24 Angelini Ricerche Spa Composizione farmaceutica per il trattamento delle malattie autoimmuni
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
JP2001081080A (ja) * 1999-09-14 2001-03-27 Nissan Chem Ind Ltd ４（５）−クロロメチル−２−フェニル−１，２，３−トリアゾール誘導体の製造法
GB0028367D0 (en) * 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
JP2006137718A (ja) 2004-11-12 2006-06-01 Astellas Pharma Inc インドール若しくはインダゾール誘導体
US20070010523A1 (en) * 2005-06-22 2007-01-11 Chemocentryx, Inc. Azaindazole compounds and methods of use
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
US7858645B2 (en) * 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
US20090047246A1 (en) * 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
ATE523511T1 (de) * 2007-05-25 2011-09-15 Elan Pharm Inc Pyrazolopyrrolidine als inhibitoren von gamma- sekretase
TW200940539A (en) * 2008-02-29 2009-10-01 Array Biopharma Inc RAF inhibitor compounds and methods of use thereof
KR101581828B1 (ko) * 2008-03-07 2015-12-31 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 신규한 1-벤질-3-하이드록시메틸인다졸 유도체들 및 ｍｃｐ-1, ｃｘ3ｃｒ1 및 ｐ40의 발현을 기초로 한 질환들의 치료에서 이의 용도

Also Published As

Publication number Publication date
EA201270237A1 (ru) 2012-12-28
IL216854A0 (en) 2012-02-29
EA019060B1 (ru) 2013-12-30
US20120184752A1 (en) 2012-07-19
SI2462118T1 (sl) 2014-10-30
GEP20135879B (en) 2013-07-10
CN102471281B (zh) 2014-10-15
PT2462119E (pt) 2014-07-25
IL217097A0 (en) 2012-02-29
JP6200153B2 (ja) 2017-09-20
DK2462119T3 (da) 2014-09-01
AR077668A1 (es) 2011-09-14
US8354544B2 (en) 2013-01-15
CA2766235A1 (en) 2011-02-10
GEP20135878B (en) 2013-07-10
EP2462119B1 (en) 2014-06-11
US20120149912A1 (en) 2012-06-14
EP2462118A1 (en) 2012-06-13
CN102471281A (zh) 2012-05-23
AU2010280827A1 (en) 2012-01-12
IL216854A (en) 2016-02-29
EP2462118B1 (en) 2014-06-11
JP2013501020A (ja) 2013-01-10
PL2462118T3 (pl) 2014-10-31
AU2010280827B2 (en) 2016-02-25
CA2766235C (en) 2017-04-04
PT2462118E (pt) 2014-07-25
SI2462119T1 (sl) 2014-10-30
JP2013501019A (ja) 2013-01-10
AU2010280828A1 (en) 2012-01-19
SG176950A1 (en) 2012-02-28
EP2462119A1 (en) 2012-06-13
MX2012001520A (es) 2012-06-01
CA2765461C (en) 2017-04-11
SG176885A1 (en) 2012-01-30
PL2462119T3 (pl) 2014-10-31
BR112012001731A2 (pt) 2015-09-01
CN102471282A (zh) 2012-05-23
AR077667A1 (es) 2011-09-14
CA2765461A1 (en) 2011-02-10
KR101735577B1 (ko) 2017-05-15
KR101736301B1 (ko) 2017-05-29
US8350052B2 (en) 2013-01-08
UA106988C2 (uk) 2014-11-10
WO2011015502A1 (en) 2011-02-10
EA019672B1 (ru) 2014-05-30
JP2015205900A (ja) 2015-11-19
UA106886C2 (uk) 2014-10-27
AU2010280828B2 (en) 2016-02-25
JP5640086B2 (ja) 2014-12-10
KR20120042871A (ko) 2012-05-03
AU2010280827A8 (en) 2016-04-07
ES2480278T3 (es) 2014-07-25
ES2481393T3 (es) 2014-07-30
CN106518769A (zh) 2017-03-22
KR20120071380A (ko) 2012-07-02
EA201270236A1 (ru) 2012-09-28
MX2012001519A (es) 2012-06-01
BR112012002130A2 (pt) 2015-09-15
HK1165408A1 (en) 2012-10-05
IL217097A (en) 2014-02-27
DK2462118T3 (da) 2014-08-25
WO2011015501A1 (en) 2011-02-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180728