SI2462119T1 - Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati - Google Patents

Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati

Info

Publication number
SI2462119T1
SI2462119T1 SI201030729T SI201030729T SI2462119T1 SI 2462119 T1 SI2462119 T1 SI 2462119T1 SI 201030729 T SI201030729 T SI 201030729T SI 201030729 T SI201030729 T SI 201030729T SI 2462119 T1 SI2462119 T1 SI 2462119T1
Authority
SI
Slovenia
Prior art keywords
indazole
hydroxymethyl
benzyl
derivatives
preparation
Prior art date
Application number
SI201030729T
Other languages
English (en)
Inventor
Torchiarolo Giuliano Caracciolo
Tommaso Iacoangeli
Guido Furlotti
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Publication of SI2462119T1 publication Critical patent/SI2462119T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/02—Magnesium compounds
SI201030729T 2009-08-03 2010-07-28 Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati SI2462119T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09425314 2009-08-03
PCT/EP2010/060937 WO2011015501A1 (en) 2009-08-03 2010-07-28 Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
EP10739344.9A EP2462119B1 (en) 2009-08-03 2010-07-28 Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates

Publications (1)

Publication Number Publication Date
SI2462119T1 true SI2462119T1 (sl) 2014-10-30

Family

ID=41353924

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201030728T SI2462118T1 (sl) 2009-08-03 2010-07-28 Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati
SI201030729T SI2462119T1 (sl) 2009-08-03 2010-07-28 Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201030728T SI2462118T1 (sl) 2009-08-03 2010-07-28 Postopek za pripravo 1-benzil-3-hidroksimetil-1H-indazola in njegovih derivatov ter potrebni magnezijevi intermediati

Country Status (22)

Country Link
US (2) US8350052B2 (sl)
EP (2) EP2462118B1 (sl)
JP (3) JP5640086B2 (sl)
KR (2) KR101735577B1 (sl)
CN (3) CN102471282A (sl)
AR (2) AR077668A1 (sl)
AU (1) AU2010280828B2 (sl)
BR (2) BR112012002130A2 (sl)
CA (2) CA2765461C (sl)
DK (2) DK2462118T3 (sl)
EA (2) EA019672B1 (sl)
ES (2) ES2480278T3 (sl)
GE (2) GEP20135879B (sl)
HK (2) HK1165409A1 (sl)
IL (2) IL216854A (sl)
MX (2) MX2012001520A (sl)
PL (2) PL2462118T3 (sl)
PT (2) PT2462119E (sl)
SG (2) SG176885A1 (sl)
SI (2) SI2462118T1 (sl)
UA (2) UA106988C2 (sl)
WO (2) WO2011015501A1 (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0907974A2 (pt) * 2008-03-07 2015-08-04 Acraf Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças
RU2645344C2 (ru) * 2012-05-18 2018-02-21 Санофи Производные пиразола и их применение в качестве lpar5 антагонистов
EP2850062B1 (en) 2012-05-18 2017-07-19 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CN104876872B (zh) * 2015-04-24 2017-07-07 昆明理工大学 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用
EP3310353A4 (en) * 2015-06-16 2019-02-06 Translatum Medicus, Inc. COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF EYE DISEASES
CA3144861A1 (en) * 2019-06-25 2020-12-30 Translatum Medicus, Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB8707051D0 (en) * 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides
IT1230441B (it) * 1989-02-07 1991-10-23 Acraf Eteri della serie dell'indazolo
IT1253703B (it) 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
JP3159614B2 (ja) * 1994-11-28 2001-04-23 三井化学株式会社 クロロアルキルアミン塩酸塩の製造法
IT1276031B1 (it) 1995-10-31 1997-10-24 Angelini Ricerche Spa Composizione farmaceutica per il trattamento delle malattie autoimmuni
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
JP2001081080A (ja) * 1999-09-14 2001-03-27 Nissan Chem Ind Ltd ４（５）−クロロメチル−２−フェニル−１，２，３−トリアゾール誘導体の製造法
GB0028367D0 (en) * 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
JP2006137718A (ja) 2004-11-12 2006-06-01 Astellas Pharma Inc インドール若しくはインダゾール誘導体
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
EA017278B9 (ru) * 2005-06-22 2013-01-30 Кемосентрикс, Инк. Соединения азаиндазола и способы применения
US7858645B2 (en) * 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
MX2009008439A (es) * 2007-02-12 2009-08-13 Intermune Inc Nuevos inhibidores de la replicacion del virus de hepatitis c.
BRPI0812014A2 (pt) * 2007-05-25 2014-11-18 Elan Pharm Inc Pirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos
KR20100117686A (ko) * 2008-02-29 2010-11-03 어레이 바이오파마 인크. 피라졸[3,4-ｂ]피리딘 ｒａｆ 저해물질
US7919518B2 (en) 2008-03-07 2011-04-05 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40

Also Published As

Publication number Publication date
CA2765461C (en) 2017-04-11
JP2013501019A (ja) 2013-01-10
KR101735577B1 (ko) 2017-05-15
AR077667A1 (es) 2011-09-14
PT2462119E (pt) 2014-07-25
AU2010280828B2 (en) 2016-02-25
ES2481393T3 (es) 2014-07-30
AR077668A1 (es) 2011-09-14
BR112012002130A2 (pt) 2015-09-15
HK1165408A1 (en) 2012-10-05
CA2766235A1 (en) 2011-02-10
US8354544B2 (en) 2013-01-15
EA201270236A1 (ru) 2012-09-28
US20120149912A1 (en) 2012-06-14
KR101736301B1 (ko) 2017-05-29
DK2462118T3 (da) 2014-08-25
CN102471282A (zh) 2012-05-23
PT2462118E (pt) 2014-07-25
IL217097A0 (en) 2012-02-29
AU2010280828A1 (en) 2012-01-19
JP2013501020A (ja) 2013-01-10
SG176950A1 (en) 2012-02-28
DK2462119T3 (da) 2014-09-01
MX2012001520A (es) 2012-06-01
EA201270237A1 (ru) 2012-12-28
IL216854A (en) 2016-02-29
US20120184752A1 (en) 2012-07-19
PL2462118T3 (pl) 2014-10-31
EP2462119B1 (en) 2014-06-11
EP2462119A1 (en) 2012-06-13
AU2010280827A1 (en) 2012-01-12
CN102471281A (zh) 2012-05-23
WO2011015502A1 (en) 2011-02-10
HK1165409A1 (en) 2012-10-05
EP2462118A1 (en) 2012-06-13
SI2462118T1 (sl) 2014-10-30
MX2012001519A (es) 2012-06-01
CN102471281B (zh) 2014-10-15
AU2010280827B2 (en) 2016-02-25
EP2462118B1 (en) 2014-06-11
CA2766235C (en) 2017-04-04
KR20120071380A (ko) 2012-07-02
WO2011015501A1 (en) 2011-02-10
KR20120042871A (ko) 2012-05-03
CN106518769A (zh) 2017-03-22
AU2010280827A8 (en) 2016-04-07
ES2480278T3 (es) 2014-07-25
CA2765461A1 (en) 2011-02-10
SG176885A1 (en) 2012-01-30
UA106886C2 (uk) 2014-10-27
IL216854A0 (en) 2012-02-29
GEP20135879B (en) 2013-07-10
UA106988C2 (uk) 2014-11-10
EA019672B1 (ru) 2014-05-30
PL2462119T3 (pl) 2014-10-31
JP6200153B2 (ja) 2017-09-20
US8350052B2 (en) 2013-01-08
JP2015205900A (ja) 2015-11-19
JP5640086B2 (ja) 2014-12-10
EA019060B1 (ru) 2013-12-30
IL217097A (en) 2014-02-27
BR112012001731A2 (pt) 2015-09-01
GEP20135878B (en) 2013-07-10

Similar Documents

Publication Publication Date Title
IL206664A0 (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
IL215999A0 (en) Processes for the preparation of rivaroxaban and intermediates thereof
PL2604267T3 (pl) Sposób wytwarzania pochodnych tiazolu
ZA201202504B (en) Process for the preparation of calcobutrol
EP2444398A4 (en) NEW INTERMEDIATE PRODUCTS FROM VORICONAZOLE AND PRODUCTION PROCESS FOR VORICONAZOLE THEREWITH
PL390042A1 (pl) Sposób wytwarzania kwasu chlebowego
EP2407461A4 (en) PROCESS FOR PREPARING 1-ALKYL-5-BENZOYL-1H-TETRAZOL DERIVATIVES
HK1165408A1 (en) Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-
SI2189442T1 (sl) Postopek in intermediati za pripravo aliskirena
IL219138A0 (en) Process for the preparation of 4-sulfinyl-pyrazole derivatives
IL214764A0 (en) Process for the preparation of pyrazole derivatives
PL388931A1 (pl) Sposób otrzymywania fluorokarbofunkcyjnych silseskwioksanów
IL218384A0 (en) Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof
IL217460A0 (en) Novel process for the preparation of 4-aminobut-2-enolides
SI2387557T1 (sl) Postopek za pripravo N-(5-(3-dimetilamino-akriloil)-2-fluorofenil)-N-metil-acetamida
EG27000A (en) Process for the preparation of ibodutant (MEN15596) and related intermediates
IL220160A (en) A process for the preparation of defrasirox
PL389568A1 (pl) Sposób otrzymywania 2-metyloglicydolu
PL388950A1 (pl) Sposób wytwarzania polikaprolaktonu