EA201270236A1 - Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения с магнием - Google Patents
Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения с магниемInfo
- Publication number
- EA201270236A1 EA201270236A1 EA201270236A EA201270236A EA201270236A1 EA 201270236 A1 EA201270236 A1 EA 201270236A1 EA 201270236 A EA201270236 A EA 201270236A EA 201270236 A EA201270236 A EA 201270236A EA 201270236 A1 EA201270236 A1 EA 201270236A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- indazole
- hydroxymethyl
- benzyl
- derivatives
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
- C07F3/02—Magnesium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Данное изобретение относится к способу превращения 1-бензил-3-гидроксиметил-1H-индазола общей формулы (II) в 1-бензил-3-гидроксиметил-1H-индазол общей формулы (I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09425314 | 2009-08-03 | ||
PCT/EP2010/060941 WO2011015502A1 (en) | 2009-08-03 | 2010-07-28 | Process for the preparation of 1-benzyl-3-hydroxymethyl- 1h- indazole and its derivatives and required magnesium intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201270236A1 true EA201270236A1 (ru) | 2012-09-28 |
EA019060B1 EA019060B1 (ru) | 2013-12-30 |
Family
ID=41353924
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270237A EA019672B1 (ru) | 2009-08-03 | 2010-07-28 | Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения, содержащие магний |
EA201270236A EA019060B1 (ru) | 2009-08-03 | 2010-07-28 | Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения с магнием |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270237A EA019672B1 (ru) | 2009-08-03 | 2010-07-28 | Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения, содержащие магний |
Country Status (22)
Country | Link |
---|---|
US (2) | US8350052B2 (ru) |
EP (2) | EP2462118B1 (ru) |
JP (3) | JP5640086B2 (ru) |
KR (2) | KR101735577B1 (ru) |
CN (3) | CN102471282A (ru) |
AR (2) | AR077668A1 (ru) |
AU (1) | AU2010280828B2 (ru) |
BR (2) | BR112012002130A2 (ru) |
CA (2) | CA2765461C (ru) |
DK (2) | DK2462118T3 (ru) |
EA (2) | EA019672B1 (ru) |
ES (2) | ES2480278T3 (ru) |
GE (2) | GEP20135879B (ru) |
HK (2) | HK1165409A1 (ru) |
IL (2) | IL216854A (ru) |
MX (2) | MX2012001520A (ru) |
PL (2) | PL2462118T3 (ru) |
PT (2) | PT2462119E (ru) |
SG (2) | SG176885A1 (ru) |
SI (2) | SI2462118T1 (ru) |
UA (2) | UA106988C2 (ru) |
WO (2) | WO2011015501A1 (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0907974A2 (pt) * | 2008-03-07 | 2015-08-04 | Acraf | Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças |
RU2645344C2 (ru) * | 2012-05-18 | 2018-02-21 | Санофи | Производные пиразола и их применение в качестве lpar5 антагонистов |
EP2850062B1 (en) | 2012-05-18 | 2017-07-19 | Sanofi | Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation |
CN104876872B (zh) * | 2015-04-24 | 2017-07-07 | 昆明理工大学 | 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用 |
EP3310353A4 (en) * | 2015-06-16 | 2019-02-06 | Translatum Medicus, Inc. | COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF EYE DISEASES |
CA3144861A1 (en) * | 2019-06-25 | 2020-12-30 | Translatum Medicus, Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
CN113929627A (zh) * | 2021-10-19 | 2022-01-14 | 吕梁学院 | 一种宾达利的合成方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB860303A (en) | 1958-06-20 | 1961-02-01 | Ici Ltd | Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª |
GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
IT1230441B (it) * | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
IT1253703B (it) | 1991-04-22 | 1995-08-23 | Angelini Francesco Ist Ricerca | Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie |
JP3159614B2 (ja) * | 1994-11-28 | 2001-04-23 | 三井化学株式会社 | クロロアルキルアミン塩酸塩の製造法 |
IT1276031B1 (it) | 1995-10-31 | 1997-10-24 | Angelini Ricerche Spa | Composizione farmaceutica per il trattamento delle malattie autoimmuni |
IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
JP2001081080A (ja) * | 1999-09-14 | 2001-03-27 | Nissan Chem Ind Ltd | 4(5)−クロロメチル−2−フェニル−1,2,3−トリアゾール誘導体の製造法 |
GB0028367D0 (en) * | 2000-11-21 | 2001-01-03 | Celltech Chiroscience Ltd | Chemical compounds |
JP2006137718A (ja) | 2004-11-12 | 2006-06-01 | Astellas Pharma Inc | インドール若しくはインダゾール誘導体 |
US7777035B2 (en) * | 2005-06-22 | 2010-08-17 | Chemocentryx, Inc. | Azaindazole compounds and methods of use |
EA017278B9 (ru) * | 2005-06-22 | 2013-01-30 | Кемосентрикс, Инк. | Соединения азаиндазола и способы применения |
US7858645B2 (en) * | 2006-11-01 | 2010-12-28 | Hoffmann-La Roche Inc. | Indazole derivatives |
ITMI20062254A1 (it) | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
MX2009008439A (es) * | 2007-02-12 | 2009-08-13 | Intermune Inc | Nuevos inhibidores de la replicacion del virus de hepatitis c. |
BRPI0812014A2 (pt) * | 2007-05-25 | 2014-11-18 | Elan Pharm Inc | Pirazolopirrolidinas como inibidores de gama secretase, composição farmacêutica compreendendo as mesmas e uso dos referidos compostos |
KR20100117686A (ko) * | 2008-02-29 | 2010-11-03 | 어레이 바이오파마 인크. | 피라졸[3,4-b]피리딘 raf 저해물질 |
US7919518B2 (en) | 2008-03-07 | 2011-04-05 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40 |
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2010
- 2010-07-28 JP JP2012523288A patent/JP5640086B2/ja not_active Expired - Fee Related
- 2010-07-28 EA EA201270237A patent/EA019672B1/ru not_active IP Right Cessation
- 2010-07-28 BR BR112012002130A patent/BR112012002130A2/pt not_active Application Discontinuation
- 2010-07-28 JP JP2012523289A patent/JP6200153B2/ja not_active Expired - Fee Related
- 2010-07-28 CN CN2010800344095A patent/CN102471282A/zh active Pending
- 2010-07-28 MX MX2012001520A patent/MX2012001520A/es active IP Right Grant
- 2010-07-28 KR KR1020127002338A patent/KR101735577B1/ko active IP Right Grant
- 2010-07-28 EP EP10735298.1A patent/EP2462118B1/en not_active Not-in-force
- 2010-07-28 SG SG2011093309A patent/SG176885A1/en unknown
- 2010-07-28 PL PL10735298T patent/PL2462118T3/pl unknown
- 2010-07-28 US US13/381,137 patent/US8350052B2/en not_active Expired - Fee Related
- 2010-07-28 PT PT107393449T patent/PT2462119E/pt unknown
- 2010-07-28 UA UAA201115300A patent/UA106988C2/ru unknown
- 2010-07-28 EA EA201270236A patent/EA019060B1/ru not_active IP Right Cessation
- 2010-07-28 KR KR1020127001575A patent/KR101736301B1/ko active IP Right Grant
- 2010-07-28 WO PCT/EP2010/060937 patent/WO2011015501A1/en active Application Filing
- 2010-07-28 PL PL10739344T patent/PL2462119T3/pl unknown
- 2010-07-28 DK DK10735298.1T patent/DK2462118T3/da active
- 2010-07-28 GE GEAP201012611A patent/GEP20135879B/en unknown
- 2010-07-28 EP EP10739344.9A patent/EP2462119B1/en not_active Not-in-force
- 2010-07-28 CN CN201080034391.9A patent/CN102471281B/zh not_active Expired - Fee Related
- 2010-07-28 US US13/377,588 patent/US8354544B2/en not_active Expired - Fee Related
- 2010-07-28 WO PCT/EP2010/060941 patent/WO2011015502A1/en active Application Filing
- 2010-07-28 AU AU2010280828A patent/AU2010280828B2/en not_active Ceased
- 2010-07-28 CA CA2765461A patent/CA2765461C/en not_active Expired - Fee Related
- 2010-07-28 BR BRBR112012001731-4A patent/BR112012001731A2/pt not_active Application Discontinuation
- 2010-07-28 CN CN201610870938.8A patent/CN106518769A/zh active Pending
- 2010-07-28 SI SI201030728T patent/SI2462118T1/sl unknown
- 2010-07-28 SG SG2011095023A patent/SG176950A1/en unknown
- 2010-07-28 GE GEAP201012610A patent/GEP20135878B/en unknown
- 2010-07-28 CA CA2766235A patent/CA2766235C/en not_active Expired - Fee Related
- 2010-07-28 ES ES10739344.9T patent/ES2480278T3/es active Active
- 2010-07-28 MX MX2012001519A patent/MX2012001519A/es active IP Right Grant
- 2010-07-28 PT PT107352981T patent/PT2462118E/pt unknown
- 2010-07-28 DK DK10739344.9T patent/DK2462119T3/da active
- 2010-07-28 SI SI201030729T patent/SI2462119T1/sl unknown
- 2010-07-28 UA UAA201115299A patent/UA106886C2/uk unknown
- 2010-07-28 ES ES10735298.1T patent/ES2481393T3/es active Active
- 2010-08-02 AR ARP100102816A patent/AR077668A1/es unknown
- 2010-08-02 AR ARP100102815A patent/AR077667A1/es unknown
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2011
- 2011-12-08 IL IL216854A patent/IL216854A/en not_active IP Right Cessation
- 2011-12-20 IL IL217097A patent/IL217097A/en not_active IP Right Cessation
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2012
- 2012-06-18 HK HK12105914.8A patent/HK1165409A1/xx not_active IP Right Cessation
- 2012-06-18 HK HK12105913.9A patent/HK1165408A1/xx not_active IP Right Cessation
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2015
- 2015-06-09 JP JP2015116951A patent/JP2015205900A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |