HK1165408A1 - Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h- - Google Patents

Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-

Info

Publication number
HK1165408A1
HK1165408A1 HK12105913.9A HK12105913A HK1165408A1 HK 1165408 A1 HK1165408 A1 HK 1165408A1 HK 12105913 A HK12105913 A HK 12105913A HK 1165408 A1 HK1165408 A1 HK 1165408A1
Authority
HK
Hong Kong
Prior art keywords
indazole
hydroxymethyl
benzyl
derivatives
preparation
Prior art date
Application number
HK12105913.9A
Other languages
English (en)
Chinese (zh)
Inventor
Torchiarolo Giuliano Caracciolo
Tommaso Iacoangeli
Guido Furlotti
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of HK1165408A1 publication Critical patent/HK1165408A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK12105913.9A 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h- HK1165408A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09425314 2009-08-03
PCT/EP2010/060941 WO2011015502A1 (en) 2009-08-03 2010-07-28 Process for the preparation of 1-benzyl-3-hydroxymethyl- 1h- indazole and its derivatives and required magnesium intermediates

Publications (1)

Publication Number Publication Date
HK1165408A1 true HK1165408A1 (en) 2012-10-05

Family

ID=41353924

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12105913.9A HK1165408A1 (en) 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-
HK12105914.8A HK1165409A1 (en) 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK12105914.8A HK1165409A1 (en) 2009-08-03 2012-06-18 Process for the preparation of 1-benzyl-3-hydroxymethyl-1h-indazole and its derivatives and required magnesium intermediates 1--3--1h-

Country Status (22)

Country Link
US (2) US8350052B2 (xx)
EP (2) EP2462118B1 (xx)
JP (3) JP5640086B2 (xx)
KR (2) KR101735577B1 (xx)
CN (3) CN106518769A (xx)
AR (2) AR077667A1 (xx)
AU (1) AU2010280828B2 (xx)
BR (2) BR112012002130A2 (xx)
CA (2) CA2765461C (xx)
DK (2) DK2462118T3 (xx)
EA (2) EA019672B1 (xx)
ES (2) ES2480278T3 (xx)
GE (2) GEP20135878B (xx)
HK (2) HK1165408A1 (xx)
IL (2) IL216854A (xx)
MX (2) MX2012001519A (xx)
PL (2) PL2462118T3 (xx)
PT (2) PT2462119E (xx)
SG (2) SG176950A1 (xx)
SI (2) SI2462119T1 (xx)
UA (2) UA106886C2 (xx)
WO (2) WO2011015501A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5509100B2 (ja) * 2008-03-07 2014-06-04 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ 新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体及びそのＭＣＰ−１，ＣＸ３ＣＲ１及びｐ４０の発現に基づく疾病の治療への使用
RU2645344C2 (ru) * 2012-05-18 2018-02-21 Санофи Производные пиразола и их применение в качестве lpar5 антагонистов
JP2015521183A (ja) 2012-05-18 2015-07-27 サノフイ ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
CN104876872B (zh) * 2015-04-24 2017-07-07 昆明理工大学 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用
WO2016203313A1 (en) * 2015-06-16 2016-12-22 Translatum Medicus, Inc. Compositions and methods for treating and diagnosing ocular disorders
CA3144861A1 (en) 2019-06-25 2020-12-30 Translatum Medicus, Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB8707051D0 (en) * 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides
IT1230441B (it) * 1989-02-07 1991-10-23 Acraf Eteri della serie dell'indazolo
IT1253703B (it) 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
JP3159614B2 (ja) * 1994-11-28 2001-04-23 三井化学株式会社 クロロアルキルアミン塩酸塩の製造法
IT1276031B1 (it) 1995-10-31 1997-10-24 Angelini Ricerche Spa Composizione farmaceutica per il trattamento delle malattie autoimmuni
IT1293795B1 (it) * 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
JP2001081080A (ja) * 1999-09-14 2001-03-27 Nissan Chem Ind Ltd ４（５）−クロロメチル−２−フェニル−１，２，３−トリアゾール誘導体の製造法
GB0028367D0 (en) * 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
JP2006137718A (ja) 2004-11-12 2006-06-01 Astellas Pharma Inc インドール若しくはインダゾール誘導体
DK1906965T3 (en) * 2005-06-22 2015-08-03 Chemocentryx Inc Azaindazol compounds and methods of use thereof
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
US7858645B2 (en) * 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
US20090047246A1 (en) * 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
AU2008256940A1 (en) * 2007-05-25 2008-12-04 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
MX2010009411A (es) * 2008-02-29 2010-11-30 Array Biopharma Inc Compuestos del inhibidor de raf y métodos de uso de los mismos.
BRPI0907976A2 (pt) * 2008-03-07 2015-08-04 Acraf Composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças

Also Published As

Publication number Publication date
UA106988C2 (uk) 2014-11-10
UA106886C2 (uk) 2014-10-27
IL217097A0 (en) 2012-02-29
DK2462119T3 (da) 2014-09-01
AR077668A1 (es) 2011-09-14
CN102471281A (zh) 2012-05-23
EP2462119B1 (en) 2014-06-11
MX2012001519A (es) 2012-06-01
SI2462119T1 (sl) 2014-10-30
EP2462119A1 (en) 2012-06-13
CN106518769A (zh) 2017-03-22
EA201270236A1 (ru) 2012-09-28
AR077667A1 (es) 2011-09-14
IL216854A0 (en) 2012-02-29
JP5640086B2 (ja) 2014-12-10
BR112012001731A2 (pt) 2015-09-01
US8354544B2 (en) 2013-01-15
PL2462118T3 (pl) 2014-10-31
BR112012002130A2 (pt) 2015-09-15
IL217097A (en) 2014-02-27
CA2765461A1 (en) 2011-02-10
US20120184752A1 (en) 2012-07-19
AU2010280828B2 (en) 2016-02-25
JP2013501019A (ja) 2013-01-10
EA201270237A1 (ru) 2012-12-28
EP2462118B1 (en) 2014-06-11
AU2010280827A8 (en) 2016-04-07
KR101736301B1 (ko) 2017-05-29
CA2766235C (en) 2017-04-04
PT2462118E (pt) 2014-07-25
AU2010280827B2 (en) 2016-02-25
JP2015205900A (ja) 2015-11-19
JP2013501020A (ja) 2013-01-10
WO2011015502A1 (en) 2011-02-10
ES2480278T3 (es) 2014-07-25
SG176885A1 (en) 2012-01-30
MX2012001520A (es) 2012-06-01
CN102471282A (zh) 2012-05-23
SG176950A1 (en) 2012-02-28
US8350052B2 (en) 2013-01-08
JP6200153B2 (ja) 2017-09-20
AU2010280828A1 (en) 2012-01-19
EP2462118A1 (en) 2012-06-13
CN102471281B (zh) 2014-10-15
PL2462119T3 (pl) 2014-10-31
HK1165409A1 (en) 2012-10-05
US20120149912A1 (en) 2012-06-14
KR20120071380A (ko) 2012-07-02
PT2462119E (pt) 2014-07-25
GEP20135878B (en) 2013-07-10
AU2010280827A1 (en) 2012-01-12
SI2462118T1 (sl) 2014-10-30
KR20120042871A (ko) 2012-05-03
CA2766235A1 (en) 2011-02-10
KR101735577B1 (ko) 2017-05-15
DK2462118T3 (da) 2014-08-25
EA019672B1 (ru) 2014-05-30
ES2481393T3 (es) 2014-07-30
EA019060B1 (ru) 2013-12-30
CA2765461C (en) 2017-04-11
WO2011015501A1 (en) 2011-02-10
GEP20135879B (en) 2013-07-10
IL216854A (en) 2016-02-29

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180728