PL2462119T3 - Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich - Google Patents

Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich

Info

Publication number
PL2462119T3
PL2462119T3 PL10739344T PL10739344T PL2462119T3 PL 2462119 T3 PL2462119 T3 PL 2462119T3 PL 10739344 T PL10739344 T PL 10739344T PL 10739344 T PL10739344 T PL 10739344T PL 2462119 T3 PL2462119 T3 PL 2462119T3
Authority
PL
Poland
Prior art keywords
indazole
hydroxymethyl
benzyl
derivatives
preparation
Prior art date
Application number
PL10739344T
Other languages
English (en)
Inventor
Torchiarolo Giuliano Caracciolo
Tommaso Iacoangeli
Guido Furlotti
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of PL2462119T3 publication Critical patent/PL2462119T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL10739344T 2009-08-03 2010-07-28 Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich PL2462119T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09425314 2009-08-03
PCT/EP2010/060937 WO2011015501A1 (en) 2009-08-03 2010-07-28 Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
EP10739344.9A EP2462119B1 (en) 2009-08-03 2010-07-28 Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates

Publications (1)

Publication Number Publication Date
PL2462119T3 true PL2462119T3 (pl) 2014-10-31

Family

ID=41353924

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10739344T PL2462119T3 (pl) 2009-08-03 2010-07-28 Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich
PL10735298T PL2462118T3 (pl) 2009-08-03 2010-07-28 Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL10735298T PL2462118T3 (pl) 2009-08-03 2010-07-28 Sposób wytwarzania 1-benzylo-3-hydroksymetylo-1H-indazolu i jego pochodnych oraz potrzebnych magnezowych związków pośrednich

Country Status (21)

Country Link
US (2) US8354544B2 (pl)
EP (2) EP2462118B1 (pl)
JP (3) JP6200153B2 (pl)
KR (2) KR101735577B1 (pl)
CN (3) CN102471281B (pl)
AR (2) AR077667A1 (pl)
AU (1) AU2010280828B2 (pl)
BR (2) BR112012002130A2 (pl)
CA (2) CA2766235C (pl)
DK (2) DK2462119T3 (pl)
EA (2) EA019672B1 (pl)
ES (2) ES2480278T3 (pl)
GE (2) GEP20135879B (pl)
IL (2) IL216854A (pl)
MX (2) MX2012001520A (pl)
PL (2) PL2462119T3 (pl)
PT (2) PT2462118E (pl)
SG (2) SG176885A1 (pl)
SI (2) SI2462118T1 (pl)
UA (2) UA106886C2 (pl)
WO (2) WO2011015501A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2262778B8 (en) * 2008-03-07 2020-01-01 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
EP2882715B1 (en) 2012-05-18 2016-11-09 Sanofi Pyrazole derivatives and their use as lpar5 antagonists
JP2015521183A (ja) 2012-05-18 2015-07-27 サノフイ ピリジン誘導体および病理学的血栓形成に関連する状態の治療へのその使用
CN104876872B (zh) * 2015-04-24 2017-07-07 昆明理工大学 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用
US20180221339A1 (en) * 2015-06-16 2018-08-09 Translatum Medicus, Inc. Compositions and methods for treating and diagnosing ocular disorders
EP3990433A4 (en) 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860303A (en) 1958-06-20 1961-02-01 Ici Ltd Pharmaceutical compositions comprising ª‡-aryloxy-aliphatic carboxylic acids and/or ª
GB8707051D0 (en) * 1986-04-15 1987-04-29 Ici America Inc Heterocyclic carboxamides
IT1230441B (it) * 1989-02-07 1991-10-23 Acraf Eteri della serie dell'indazolo
IT1253703B (it) 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
JP3159614B2 (ja) * 1994-11-28 2001-04-23 三井化学株式会社 クロロアルキルアミン塩酸塩の製造法
IT1276031B1 (it) 1995-10-31 1997-10-24 Angelini Ricerche Spa Composizione farmaceutica per il trattamento delle malattie autoimmuni
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
JP2001081080A (ja) * 1999-09-14 2001-03-27 Nissan Chem Ind Ltd ４（５）−クロロメチル−２−フェニル−１，２，３−トリアゾール誘導体の製造法
GB0028367D0 (en) * 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
JP2006137718A (ja) 2004-11-12 2006-06-01 Astellas Pharma Inc インドール若しくはインダゾール誘導体
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
MX2007015917A (es) * 2005-06-22 2008-03-10 Chemocentryx Inc Compuestos de azaindazol y metodos de uso.
US7858645B2 (en) * 2006-11-01 2010-12-28 Hoffmann-La Roche Inc. Indazole derivatives
ITMI20062254A1 (it) 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
EP2134683A2 (en) * 2007-02-12 2009-12-23 Intermune, Inc. Novel inhibitors hepatitis c virus replication
AU2008256940A1 (en) * 2007-05-25 2008-12-04 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
CL2009000448A1 (es) * 2008-02-29 2009-11-27 Genentech Inc Compuestos derivados de 3-sulfonilamino-n-(1h-pirazolo-[3,4-b]piridin-5il)benzamida; procesos de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento del cancer, tal como sarcoma, carcinoma, adenoma, entre otros.
PL2254870T3 (pl) * 2008-03-07 2016-07-29 Acraf Pochodne 1-benzylo-3-hydroksymetyloindazolu i ich zastosowanie w leczeniu chorób opartych na ekspresji MCP-1, CX3CR1

Also Published As

Publication number Publication date
MX2012001519A (es) 2012-06-01
CN102471281B (zh) 2014-10-15
WO2011015502A1 (en) 2011-02-10
PT2462119E (pt) 2014-07-25
US8354544B2 (en) 2013-01-15
EA201270236A1 (ru) 2012-09-28
CN106518769A (zh) 2017-03-22
AU2010280827A1 (en) 2012-01-12
PT2462118E (pt) 2014-07-25
US8350052B2 (en) 2013-01-08
ES2480278T3 (es) 2014-07-25
US20120149912A1 (en) 2012-06-14
AU2010280827B2 (en) 2016-02-25
GEP20135878B (en) 2013-07-10
AR077667A1 (es) 2011-09-14
DK2462118T3 (da) 2014-08-25
KR20120042871A (ko) 2012-05-03
PL2462118T3 (pl) 2014-10-31
EP2462118A1 (en) 2012-06-13
KR101736301B1 (ko) 2017-05-29
CA2766235A1 (en) 2011-02-10
JP2013501020A (ja) 2013-01-10
AR077668A1 (es) 2011-09-14
CN102471282A (zh) 2012-05-23
EA201270237A1 (ru) 2012-12-28
EA019672B1 (ru) 2014-05-30
IL217097A (en) 2014-02-27
SI2462119T1 (sl) 2014-10-30
CN102471281A (zh) 2012-05-23
IL216854A0 (en) 2012-02-29
SI2462118T1 (sl) 2014-10-30
EA019060B1 (ru) 2013-12-30
US20120184752A1 (en) 2012-07-19
MX2012001520A (es) 2012-06-01
JP2015205900A (ja) 2015-11-19
SG176885A1 (en) 2012-01-30
JP5640086B2 (ja) 2014-12-10
KR101735577B1 (ko) 2017-05-15
KR20120071380A (ko) 2012-07-02
IL216854A (en) 2016-02-29
EP2462119B1 (en) 2014-06-11
UA106988C2 (uk) 2014-11-10
BR112012001731A2 (pt) 2015-09-01
BR112012002130A2 (pt) 2015-09-15
CA2766235C (en) 2017-04-04
AU2010280827A8 (en) 2016-04-07
CA2765461C (en) 2017-04-11
JP6200153B2 (ja) 2017-09-20
HK1165409A1 (en) 2012-10-05
CA2765461A1 (en) 2011-02-10
GEP20135879B (en) 2013-07-10
HK1165408A1 (en) 2012-10-05
AU2010280828A1 (en) 2012-01-19
EP2462118B1 (en) 2014-06-11
UA106886C2 (uk) 2014-10-27
DK2462119T3 (da) 2014-09-01
WO2011015501A1 (en) 2011-02-10
SG176950A1 (en) 2012-02-28
IL217097A0 (en) 2012-02-29
ES2481393T3 (es) 2014-07-30
AU2010280828B2 (en) 2016-02-25
JP2013501019A (ja) 2013-01-10
EP2462119A1 (en) 2012-06-13

Similar Documents

Publication Publication Date Title
IL206664A0 (en) Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
IL215999A0 (en) Processes for the preparation of rivaroxaban and intermediates thereof
PL2614825T3 (pl) Sposób wytwarzania pochodnych tiazolu
ZA201202504B (en) Process for the preparation of calcobutrol
ZA201201542B (en) Novel polymorphs of rebaudioside c and methods for making and using the same
EP2444398A4 (en) NEW INTERMEDIATE PRODUCTS FROM VORICONAZOLE AND PRODUCTION PROCESS FOR VORICONAZOLE THEREWITH
PL390042A1 (pl) Sposób wytwarzania kwasu chlebowego
IL216650A0 (en) Process for the preparation and purification of etravirine and intermediates thereof
IL217097A0 (en) Process for the preparation of 1-benzyl-3-hydroxymethyl- 1h- indazole and its derivatives and required magnesium intermediates
PL388931A1 (pl) Sposób otrzymywania fluorokarbofunkcyjnych silseskwioksanów
SI2189442T1 (sl) Postopek in intermediati za pripravo aliskirena
IL219138A0 (en) Process for the preparation of 4-sulfinyl-pyrazole derivatives
IL214764A0 (en) Process for the preparation of pyrazole derivatives
EP2643308A4 (en) PROCESS FOR THE PREPARATION OF TAUROLIDINE AND ITS INTERMEDIATE PRODUCTS
IL218384A0 (en) Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof
EG27000A (en) Process for the preparation of ibodutant (MEN15596) and related intermediates
SI2387557T1 (sl) Postopek za pripravo N-(5-(3-dimetilamino-akriloil)-2-fluorofenil)-N-metil-acetamida
IL217460A0 (en) Novel process for the preparation of 4-aminobut-2-enolides
PL389013A1 (pl) Nowe winylo-alkinylopodstawione związki germanu oraz sposób otrzymywania winylo-alkinylopodstawionych związków germanu
IL220160A (en) A process for the preparation of defrasirox
PL389568A1 (pl) Sposób otrzymywania 2-metyloglicydolu
PL388950A1 (pl) Sposób wytwarzania polikaprolaktonu
HUP0900209A2 (en) Process for the preparation of cyclohexanol derivatives