HK110395A - Aspartic proteinase deficient filamentous fungi - Google Patents
Aspartic proteinase deficient filamentous fungiInfo
- Publication number
- HK110395A HK110395A HK110395A HK110395A HK110395A HK 110395 A HK110395 A HK 110395A HK 110395 A HK110395 A HK 110395A HK 110395 A HK110395 A HK 110395A HK 110395 A HK110395 A HK 110395A
- Authority
- HK
- Hong Kong
- Prior art keywords
- filamentous fungi
- aspartic proteinase
- deficient filamentous
- proteinase deficient
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
- C12R2001/665—Aspergillus awamori
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21423788A | 1988-07-01 | 1988-07-01 | |
PCT/US1989/002891 WO1990000192A1 (en) | 1988-07-01 | 1989-07-01 | Aspartic proteinase deficient filamentous fungi |
Publications (1)
Publication Number | Publication Date |
---|---|
HK110395A true HK110395A (en) | 1995-07-14 |
Family
ID=22798311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK110395A HK110395A (en) | 1988-07-01 | 1995-07-06 | Aspartic proteinase deficient filamentous fungi |
Country Status (8)
Country | Link |
---|---|
US (2) | US5840570A (xx) |
EP (1) | EP0429490B2 (xx) |
AT (1) | ATE117720T1 (xx) |
CA (1) | CA1333777C (xx) |
DE (1) | DE68920882T3 (xx) |
FI (1) | FI906442A0 (xx) |
HK (1) | HK110395A (xx) |
WO (1) | WO1990000192A1 (xx) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
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JP3133774B2 (ja) * | 1990-10-04 | 2001-02-13 | 日本食品化工株式会社 | 新規な宿主−ベクター系 |
EP0479301B1 (en) * | 1990-10-04 | 1996-07-31 | Nihon Shokuhin Kako Co., Ltd. | A host vector system |
US5997913A (en) * | 1990-12-10 | 1999-12-07 | Genencor International, Inc. | Method enhancing flavor and aroma in foods by overexpression of β-glucosidase |
US5846802A (en) * | 1992-04-15 | 1998-12-08 | Buxton; Frank | Fungal Protease |
ES2208637T3 (es) * | 1992-04-15 | 2004-06-16 | Novartis Ag | Nueva proteasa fungica. |
US5674728A (en) * | 1993-11-03 | 1997-10-07 | Novartis Corporation | Aspergillus niger vacuolar aspartyl protease |
AU2733895A (en) * | 1994-06-17 | 1996-01-15 | Novo Nordisk A/S | A fungus wherein the area gene has been modified and an area gene from aspergillus oryzae |
NL9401678A (nl) * | 1994-10-12 | 1996-05-01 | Evert Hovius | Methode van de zichzelf stabiliserende lus (Z.Z.S.L.). |
US5861280A (en) * | 1995-03-20 | 1999-01-19 | Novo Nordisk A/S | Host cell expressing reduced levels of a metalloprotease and methods using the host cell in protein production |
CN1160465C (zh) * | 1995-12-15 | 2004-08-04 | 诺沃奇梅兹有限公司 | 其中areA、pepC和/或pepE基因已被灭活的真菌 |
CN1120235C (zh) | 1996-03-27 | 2003-09-03 | 诺沃奇梅兹有限公司 | 碱性蛋白酶缺陷型丝状真菌 |
JP2000511429A (ja) * | 1996-06-05 | 2000-09-05 | ギスト ブロカデス ベスローテン フェンノートシャップ | 真菌メタロプロテアーゼ遺伝子 |
JP4091119B2 (ja) | 1996-09-19 | 2008-05-28 | ノボザイムス アクティーゼルスカブ | 新規な宿主細胞およびタンパク質生産方法 |
JP2002515252A (ja) * | 1998-05-15 | 2002-05-28 | ノボザイムス バイオテック,インコーポレイティド | 糸状菌変異体細胞においてポリペプチドを生産するための方法 |
US6806062B1 (en) | 1998-10-05 | 2004-10-19 | Novozymes A/S | Fungal transcriptional activator useful in methods for producing polypeptides |
CN100510067C (zh) | 1999-07-09 | 2009-07-08 | 诺维信公司 | 葡糖淀粉酶变体 |
JP2003526374A (ja) | 2000-03-14 | 2003-09-09 | ノボザイムス アクティーゼルスカブ | ポリペプチドの生成方法において有用な菌類転写活性化因子 |
AU2000260261A1 (en) * | 2000-07-03 | 2002-01-14 | Wageningen University | Method for the production of proteins and polypeptides using fungal cells, in particular aspergillus vadensis |
US20040219609A1 (en) * | 2002-07-12 | 2004-11-04 | Day Anthony G. | Methods for modulating proteins not previously known as proteases |
DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
EP1553963A4 (en) * | 2002-09-24 | 2006-05-03 | Burnham Inst | NOVEL AGENTS MODULATING EPH RECEPTOR ACTIVITY |
EP1852441B1 (en) * | 2002-09-24 | 2012-03-28 | The Burnham Institute | Agents that modulate EPH receptor activity |
CN101857867A (zh) * | 2003-11-06 | 2010-10-13 | 金克克国际有限公司 | 蛋白酶抑制剂及其变异体在丝状真菌中的表达 |
CN103421760A (zh) | 2003-11-19 | 2013-12-04 | 金克克国际有限公司 | 丝氨酸蛋白酶、编码丝氨酸酶的核酸以及包含它们的载体和宿主细胞 |
US7985569B2 (en) | 2003-11-19 | 2011-07-26 | Danisco Us Inc. | Cellulomonas 69B4 serine protease variants |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
US20090280534A1 (en) * | 2004-12-22 | 2009-11-12 | Novozymes A/S | Recombinant Production of Serum Albumin |
MX2007007862A (es) | 2004-12-30 | 2007-08-17 | Genencor Int | Proteasas fungales acidas. |
JP2008527985A (ja) | 2005-01-24 | 2008-07-31 | ディーエスエム アイピー アセッツ ビー.ブイ. | 糸状菌細胞において目的の化合物を産生させるための方法 |
CN101146822A (zh) | 2005-01-27 | 2008-03-19 | 伯纳姆研究所 | EphB受体结合肽 |
AP2007004141A0 (en) | 2005-03-16 | 2007-08-31 | Novozymes As | Recombinant expression of defensins in filamentousfunti |
EP2314668B1 (en) * | 2005-04-12 | 2016-11-09 | Danisco US Inc. | Gene inactivated mutants with altered protein production |
CN101292024B (zh) | 2005-10-17 | 2012-04-18 | 诺维信公司 | 用于表达抗体的真菌突变体的用途 |
US7688029B2 (en) * | 2005-11-08 | 2010-03-30 | Eveready Battery Company, Inc. | Portable battery powered appliance and method of operation |
US20080280328A1 (en) | 2005-11-18 | 2008-11-13 | Novozymes A/S | Glucoamylase Variants |
US7776339B2 (en) * | 2006-01-11 | 2010-08-17 | Active Organics, Lp | Extract of R. miehei |
JP5250850B2 (ja) | 2006-06-29 | 2013-07-31 | ディーエスエム アイピー アセッツ ビー.ブイ. | 改善されたポリペプチド発現を達成する方法 |
US20080026376A1 (en) | 2006-07-11 | 2008-01-31 | Huaming Wang | KEX2 cleavage regions of recombinant fusion proteins |
US8198046B2 (en) * | 2006-07-11 | 2012-06-12 | Danisco Us Inc. | KEX2 cleavage regions of recombinant fusion proteins |
CN101517084B (zh) * | 2006-09-22 | 2014-12-10 | 丹尼斯科美国公司 | 来自里氏木霉的乙酰乳酸合酶(als)选择性标记 |
CN101663384B (zh) * | 2007-02-28 | 2012-06-06 | 丹尼斯科美国公司 | 包含α-半乳糖苷酶的清洁组合物 |
WO2009035537A1 (en) * | 2007-09-07 | 2009-03-19 | Danisco Us Inc., Genencor Division | Beta-glucosidase enhanced filamentous fungal whole cellulase compositions and methods of use |
EP2195435B1 (en) | 2007-09-12 | 2012-10-10 | Danisco US Inc. | Trichoderma promoter |
BRPI0817541A2 (pt) * | 2007-10-12 | 2014-11-25 | Danisco Us Inc | Métodos e composições para a produção otimizada de substâncias orgânicas de micro-organismos de fermentação |
WO2009071530A1 (en) | 2007-12-06 | 2009-06-11 | Novozymes A/S | Fungal pepc inhibitor |
WO2009117689A1 (en) * | 2008-03-21 | 2009-09-24 | Danisco Us Inc., Genencor Division | Hemicellulase enriched compositions for enhancing hydrolysis of biomass |
US20090253173A1 (en) * | 2008-04-08 | 2009-10-08 | Danisco Us Inc., Genencor Division | Filamentous fungi with inactivated protease genes for altered protein production |
BRPI1008890A2 (pt) | 2009-02-20 | 2015-08-25 | Danisco Us Inc | Formulações de caldos de fermentação |
JP5932648B2 (ja) | 2009-09-23 | 2016-06-15 | ダニスコ・ユーエス・インク | 新規なグリコシルヒドロラーゼ酵素及びその用途 |
WO2011073883A1 (en) | 2009-12-14 | 2011-06-23 | Centre Hospitalier Universitaire Vaudois (Chuv) | Pichia pastoris deficient in endogenous secreted protease |
MX350399B (es) * | 2009-12-18 | 2017-09-06 | Novozymes Inc | Metodos para producir polipeptidos en mutantes de trichoderma deficientes en proteasa. |
US10138499B2 (en) | 2009-12-23 | 2018-11-27 | Danisco Us Inc. | Methods for improving the efficiency of simultaneous saccharification and fermentation reactions |
US20130302878A1 (en) | 2011-01-20 | 2013-11-14 | Novozymes A/S | Expression of plant peroxidases in filamentous fungi |
BR112013023757A2 (pt) | 2011-03-17 | 2017-06-06 | Danisco Us Inc | método para redução de viscosidade no processo de sacarificação |
WO2013048661A1 (en) | 2011-09-30 | 2013-04-04 | Codexis, Inc. | Fungal proteases |
CA2861697C (en) | 2012-01-05 | 2022-03-15 | Novartis Ag | Protease deficient filamentous fungal cells and methods of use thereof |
US9695454B2 (en) | 2012-05-23 | 2017-07-04 | Glykos Finland Oy | Production of fucosylated glycoproteins |
RU2016104064A (ru) | 2013-07-10 | 2017-08-15 | Новартис Аг | Клетки мицелиальных грибов с множественной недостаточностью протеаз и способы их использования |
US10513724B2 (en) | 2014-07-21 | 2019-12-24 | Glykos Finland Oy | Production of glycoproteins with mammalian-like N-glycans in filamentous fungi |
CN108138213A (zh) | 2015-02-20 | 2018-06-08 | 罗尔公司 | 控制蛋白酶产生的方法 |
DK3445776T3 (da) | 2016-04-19 | 2021-04-19 | Novozymes As | RLMA-inaktiveret filamentøs svampeværtscelle |
WO2018093752A1 (en) | 2016-11-15 | 2018-05-24 | Danisco Us Inc. | Filamentous fungi with improved protein production |
WO2018167153A1 (en) | 2017-03-17 | 2018-09-20 | Novozymes A/S | Improved filamentous fungal host cell |
WO2018172155A1 (en) | 2017-03-23 | 2018-09-27 | Novozymes A/S | Improved filamentous fungal host cells |
EP3864136A1 (en) | 2018-10-09 | 2021-08-18 | Novozymes A/S | Modified filamentous fungal host cell |
US20220025423A1 (en) | 2018-11-28 | 2022-01-27 | Novozymes A/S | Modified Filamentous Fungal Host Cells |
CN114555777A (zh) | 2019-07-26 | 2022-05-27 | 诺维信公司 | 经修饰的丝状真菌宿主细胞 |
Family Cites Families (13)
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---|---|---|---|---|
NZ208612A (en) * | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
US4758512A (en) * | 1984-03-06 | 1988-07-19 | President And Fellows Of Harvard College | Hosts and methods for producing recombinant products in high yields |
US4828994A (en) * | 1984-09-21 | 1989-05-09 | Genex Corporation | Bacillus strains with reduced extracellular protease levels |
US4963487A (en) * | 1985-01-03 | 1990-10-16 | Massachusetts Institute Of Technology | Method for deletion of a gene from a bacteria |
EP0221923A4 (en) * | 1985-03-29 | 1990-03-22 | Bioteknika International | SECRETION VECTOR. |
JPS6236183A (ja) * | 1985-06-20 | 1987-02-17 | ザ・サルク・インステイチユ−ト・バイオテクノロジ−/インダストリアル・アソシエイツ・インコ−ポレ−テツド | サツカロミセス・セレビシエからのポリペプチドの発現および分泌 |
EP0215594B2 (en) * | 1985-08-29 | 2003-10-15 | Genencor International, Inc. | Heterologous polypeptide expressed in filamentous fungi, processes for their preparation, and vectors for their preparation |
JPH0650985B2 (ja) * | 1985-12-27 | 1994-07-06 | サントリー株式会社 | 新規な大腸菌宿主 |
JP2599946B2 (ja) * | 1986-01-15 | 1997-04-16 | アムジェン,インコーポレイテツド | ズブチリシン類似体 |
GB8610600D0 (en) * | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
FI872102A (fi) * | 1986-06-06 | 1987-12-07 | Panlabs Inc | Expressionssystem hos filamentala fungi. |
US4709012A (en) | 1986-08-07 | 1987-11-24 | Washington University | Novel inhibitor peptides |
JPS6387975A (ja) | 1986-10-02 | 1988-04-19 | Agency Of Ind Science & Technol | 枯草菌菌株 |
-
1989
- 1989-06-30 CA CA000604556A patent/CA1333777C/en not_active Expired - Lifetime
- 1989-07-01 DE DE68920882T patent/DE68920882T3/de not_active Expired - Lifetime
- 1989-07-01 EP EP89908939A patent/EP0429490B2/en not_active Expired - Lifetime
- 1989-07-01 WO PCT/US1989/002891 patent/WO1990000192A1/en active IP Right Grant
- 1989-07-01 AT AT89908939T patent/ATE117720T1/de not_active IP Right Cessation
-
1990
- 1990-12-28 FI FI906442A patent/FI906442A0/fi not_active Application Discontinuation
-
1994
- 1994-11-23 US US08/345,018 patent/US5840570A/en not_active Expired - Lifetime
-
1995
- 1995-07-06 HK HK110395A patent/HK110395A/xx not_active IP Right Cessation
-
1998
- 1998-03-26 US US09/048,473 patent/US6509171B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0429490B2 (en) | 2004-09-22 |
EP0429490A1 (en) | 1991-06-05 |
DE68920882T2 (de) | 1995-08-17 |
EP0429490B1 (en) | 1995-01-25 |
FI906442A0 (fi) | 1990-12-28 |
DE68920882D1 (de) | 1995-03-09 |
CA1333777C (en) | 1995-01-03 |
WO1990000192A1 (en) | 1990-01-11 |
ATE117720T1 (de) | 1995-02-15 |
DE68920882T3 (de) | 2005-06-09 |
US5840570A (en) | 1998-11-24 |
US6509171B1 (en) | 2003-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20040701 |