HK1098762A1 - Il-18 binding proteins il-18 - Google Patents
Il-18 binding proteins il-18Info
- Publication number
- HK1098762A1 HK1098762A1 HK07101057.1A HK07101057A HK1098762A1 HK 1098762 A1 HK1098762 A1 HK 1098762A1 HK 07101057 A HK07101057 A HK 07101057A HK 1098762 A1 HK1098762 A1 HK 1098762A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hil
- antibodies
- activity
- antibody
- binding proteins
- Prior art date
Links
- 102000044166 interleukin-18 binding protein Human genes 0.000 title abstract 2
- 108010070145 interleukin-18 binding protein Proteins 0.000 title abstract 2
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 abstract 7
- 102000043959 human IL18 Human genes 0.000 abstract 7
- 230000000694 effects Effects 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001627 detrimental effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/71—Decreased effector function due to an Fc-modification
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/706,689 US20050100965A1 (en) | 2003-11-12 | 2003-11-12 | IL-18 binding proteins |
PCT/US2004/037971 WO2005047307A2 (en) | 2003-11-12 | 2004-11-12 | Il-18 binding proteins |
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HK1098762A1 true HK1098762A1 (en) | 2007-07-27 |
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HK07101057.1A HK1098762A1 (en) | 2003-11-12 | 2007-01-30 | Il-18 binding proteins il-18 |
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US (1) | US20050100965A1 (de) |
EP (5) | EP2395020A3 (de) |
JP (4) | JP5054977B2 (de) |
KR (4) | KR20060123148A (de) |
CN (4) | CN102659944A (de) |
AT (1) | ATE555130T1 (de) |
AU (1) | AU2004290073B2 (de) |
BR (1) | BRPI0416255A (de) |
CA (2) | CA2805859A1 (de) |
CY (1) | CY1112893T1 (de) |
DK (1) | DK1685152T3 (de) |
ES (1) | ES2385484T3 (de) |
HK (1) | HK1098762A1 (de) |
IL (2) | IL175422A0 (de) |
NZ (2) | NZ582097A (de) |
PL (1) | PL1685152T3 (de) |
PT (1) | PT1685152E (de) |
SI (1) | SI1685152T1 (de) |
WO (1) | WO2005047307A2 (de) |
ZA (1) | ZA200603733B (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
TWI422387B (zh) | 2006-05-25 | 2014-01-11 | Glaxo Group Ltd | 免疫球蛋白 |
SG10201510384UA (en) | 2006-09-13 | 2016-01-28 | Abbvie Inc | Cell culture improvements |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
EP2500414A1 (de) * | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Verbesserungen an Zellkulturen |
ES2609924T3 (es) * | 2006-11-21 | 2017-04-25 | Abbott Laboratories | Anticuerpos monoclonales neutralizantes contra el receptor de Nogo-66 (NGR) y usos de los mismos |
HUE029635T2 (en) | 2007-09-26 | 2017-03-28 | Chugai Pharmaceutical Co Ltd | A method for modifying an isoelectric point of an antibody by amino acid substitution in CDR |
JP2011511777A (ja) * | 2008-01-30 | 2011-04-14 | アボット・ラボラトリーズ | 抗体断片を結晶化するための組成物及び方法 |
DK2708559T3 (en) | 2008-04-11 | 2018-06-14 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of repeatedly binding two or more antigen molecules |
JP2009284771A (ja) * | 2008-05-27 | 2009-12-10 | Takara Bio Inc | 抗体産生細胞の作製方法 |
EA201290630A1 (ru) | 2010-02-09 | 2013-03-29 | Глаксо Груп Лимитед | Лечение расстройства обмена веществ |
EP3456740A1 (de) | 2010-11-04 | 2019-03-20 | Boehringer Ingelheim International GmbH | Anti-il-23-antikörper |
TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
KR20140003467A (ko) | 2010-12-20 | 2014-01-09 | 메디뮨 리미티드 | 항il-18 항체 및 그의 용도 |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
KR102196009B1 (ko) | 2011-10-25 | 2021-01-04 | 프로테나 바이오사이언시즈 리미티드 | 항체 제형 및 방법 |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
EP4039275A1 (de) * | 2012-05-03 | 2022-08-10 | Boehringer Ingelheim International GmbH | Anti-il-23p19-antikörper |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
EP3721900A1 (de) | 2012-08-24 | 2020-10-14 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-spezifische variante der fc-region |
JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
BR112015004467A2 (pt) | 2012-09-02 | 2017-03-21 | Abbvie Inc | método para controlar a heterogeneidade de proteínas |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
JOP20200308A1 (ar) * | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
CN104884452A (zh) | 2012-11-20 | 2015-09-02 | 沃泰克斯药物股份有限公司 | 用作吲哚胺2,3-二氧化酶的抑制剂的化合物 |
US10570199B2 (en) | 2012-11-21 | 2020-02-25 | Km Biologics Co., Ltd. | Human antibody against IL-18 |
KR101780575B1 (ko) | 2013-02-14 | 2017-09-21 | 건국대학교 산학협력단 | 신규한 인터루킨-33 수용체와 결합 단백질 조성물 및 그 용도 |
AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
CA3175360C (en) * | 2013-05-31 | 2024-05-28 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind pd-1 |
AU2014317035B2 (en) * | 2013-09-05 | 2020-02-27 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) in inflammatory diseases |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
US11384378B2 (en) * | 2014-06-04 | 2022-07-12 | Amgen Inc. | Methods for harvesting mammalian cell cultures |
US10507241B2 (en) | 2014-07-24 | 2019-12-17 | Boehringer Ingelheim International Gmbh | Biomarkers useful in the treatment of IL-23A related diseases |
SG11201701423RA (en) | 2014-09-03 | 2017-03-30 | Boehringer Ingelheim Int | Compound targeting il-23a and tnf-alpha and uses thereof |
WO2016057306A1 (en) * | 2014-10-06 | 2016-04-14 | University Of Houston | Rho associated kinase (rock) inhibitors and their use in treating disease |
TWI779010B (zh) | 2014-12-19 | 2022-10-01 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
EP3253778A1 (de) | 2015-02-05 | 2017-12-13 | Chugai Seiyaku Kabushiki Kaisha | Antikörper mit einer ionenkonzentrationsabhängigen antigenbindenden domäne, fc-region-varianten, il-8-bindende antikörper und verwendungen davon |
CN104725514A (zh) * | 2015-02-06 | 2015-06-24 | 中国药科大学 | 新型il23拮抗剂 |
CN107660150B (zh) | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
KR101943989B1 (ko) | 2015-06-05 | 2019-01-30 | 삼성전자주식회사 | 데이터를 송수신하는 방법, 서버 및 단말기 |
EP3394098A4 (de) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin-antikörper und verfahren zur verwendung |
WO2017145166A1 (en) * | 2016-02-25 | 2017-08-31 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Composition and method for treating amyotrophic lateral sclerosis |
KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
BR112019003622A2 (pt) * | 2016-08-25 | 2019-05-21 | Jcr Pharmaceuticals Co., Ltd. | método para produção de uma proteína de fusão. |
SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
CA3093729A1 (en) | 2018-03-15 | 2019-09-19 | Chugai Seiyaku Kabushiki Kaisha | Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use |
CN110818793A (zh) * | 2018-08-14 | 2020-02-21 | 中山康方生物医药有限公司 | 抗IL-1β的抗体、其药物组合物及其用途 |
DE102018220631A1 (de) * | 2018-11-29 | 2020-06-04 | B. Braun Melsungen Ag | Wässrige Zusammensetzung, insbesondere zur Behandlung von Schleimhaut und/oder Wunden |
EP3892300A4 (de) | 2018-12-03 | 2022-12-14 | Mabprotein Co.,Ltd. | Antikörper, der ein neoepitop von aktivierten interleukin-18 proteinen erkennt, und dessen verwendung |
EP4138917A4 (de) * | 2020-06-01 | 2024-10-02 | Avalo Therapeutics Inc | Verfahren und behandlung mit antikörpern gegen il-18 |
JP2023533458A (ja) | 2020-06-24 | 2023-08-03 | プロシーナ バイオサイエンシーズ リミテッド | ソルチリンを認識する抗体 |
JPWO2023286694A1 (de) | 2021-07-13 | 2023-01-19 | ||
WO2023086336A2 (en) * | 2021-11-09 | 2023-05-19 | University Of Pittsburgh – Of The Commonwealth System Of Higher Education | Molecules that bind to prostate specific membrane antigen (psma) polypeptides |
EP4433160A1 (de) | 2021-11-17 | 2024-09-25 | Disc Medicine, Inc. | Verfahren zur behandlung von nierenkrankheitsanämie |
IL313812A (en) * | 2021-12-23 | 2024-08-01 | Prothena Biosciences Ltd | Antibodies that recognize SORTILIN |
CN117177999B (zh) * | 2022-01-14 | 2024-07-05 | 和径医药科技(上海)有限公司 | 一种靶向IL-18Rβ的抗体及其应用 |
CN117986360B (zh) * | 2024-02-01 | 2024-08-27 | 生物岛实验室 | Il18蛋白的特异性抗体及其制备方法与应用 |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US581438A (en) | 1897-04-27 | Buckle | ||
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP0542810A1 (de) | 1990-08-02 | 1993-05-26 | B.R. Centre Limited | Verfahren zur herstellung von proteinen mit einer gewünschten funktion |
US5612205A (en) | 1990-08-29 | 1997-03-18 | Genpharm International, Incorporated | Homologous recombination in mammalian cells |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
DK1279731T3 (da) | 1991-03-01 | 2007-09-24 | Dyax Corp | Fremgangsmåde til udvikling af bindende miniproteiner |
DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
CA2140638C (en) | 1992-07-24 | 2010-05-04 | Raju Kucherlapati | Generation of xenogeneic antibodies |
US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
DE69519454T2 (de) | 1994-07-14 | 2001-05-03 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen |
US5643763A (en) | 1994-11-04 | 1997-07-01 | Genpharm International, Inc. | Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating |
TW581771B (en) | 1994-11-15 | 2004-04-01 | Hayashibara Biochem Lab | Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide |
US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
WO1996033266A1 (en) | 1995-04-21 | 1996-10-24 | Cell Genesys, Inc. | Generation of large genomic dna deletions |
EP1709970A1 (de) | 1995-04-27 | 2006-10-11 | Abgenix, Inc. | Menschliche Antikörper gegen EGFR, von immunisierten transgenen Mäusen produziert |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6127977A (en) | 1996-11-08 | 2000-10-03 | Cohen; Nathan | Microstrip patch antenna with fractal structure |
AU1341797A (en) | 1995-12-29 | 1997-07-28 | Incyte Pharmaceuticals, Inc. | Nucleic acids encoding interferon gamma inducing factor-2 |
NZ512006A (en) | 1996-02-09 | 2005-05-27 | Abbott Biotech Ltd | Medical treatment with human TNF-alpha antibodies |
US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
EP1669454A3 (de) | 1996-06-27 | 2009-04-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Genomische DNS, die für ein Polypeptid kodiert, welches die Fähigkeit besitzt, die Interferon-Gamma Herstellung zu induzieren |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
CA2273194C (en) | 1996-12-03 | 2011-02-01 | Abgenix, Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
US7141393B2 (en) | 1996-12-26 | 2006-11-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18-receptor proteins |
US6087116A (en) | 1997-03-12 | 2000-07-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interleukin-18 (IL-18) receptor polypeptides and their uses |
US6054487A (en) | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
ES2146192T1 (es) | 1997-03-18 | 2000-08-01 | Basf Ag | Metodo y composiciones para modular la sensibilidad a los corticosteroides. |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
EP1030681A4 (de) | 1997-11-03 | 2001-07-04 | Wistar Inst | Verfahren und zusammensetzungen zur inhibierung von angiogenese sowie zur behandlung von krebs |
US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
NZ505499A (en) | 1998-01-23 | 2002-07-26 | Immunex Corp | Accessory protein-like DNA and polypeptides |
DK1047781T3 (da) | 1998-01-23 | 2004-12-06 | Immunex Corp | IL-18-receptorer |
CA2322749A1 (en) | 1998-03-03 | 1999-09-10 | Abgenix, Inc. | Cd147 binding molecules as therapeutics |
US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
JP2000236884A (ja) * | 1998-06-24 | 2000-09-05 | Hayashibara Biochem Lab Inc | ペプチド |
JP2002522063A (ja) | 1998-08-17 | 2002-07-23 | アブジェニックス インコーポレイテッド | 増加した血清半減期を有する改変された分子の生成 |
WO2000012555A1 (fr) | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Proteine de liaison de l'interleukine 18 |
JP3793693B2 (ja) | 1998-12-23 | 2006-07-05 | ファイザー インコーポレーテッド | Ctla−4に対するヒトモノクローナル抗体 |
AR022952A1 (es) * | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
CN101066997B (zh) | 1999-03-25 | 2013-03-27 | 艾博特股份有限两合公司 | 结合人il-12的人抗体及其生产方法 |
US6440383B1 (en) | 1999-06-24 | 2002-08-27 | Altair Nanomaterials Inc. | Processing aqueous titanium chloride solutions to ultrafine titanium dioxide |
EP1257585A2 (de) * | 2000-02-10 | 2002-11-20 | Basf Aktiengesellschaft | Antikörper die zur humane interleukin-18 binden und deren verwendung und herstellung |
EP1278778A2 (de) | 2000-05-03 | 2003-01-29 | Amgen Inc., | Modifizierte peptide, die eine fc-domäne behalten, als therapeutische agenzien |
DK1522590T3 (da) | 2000-06-28 | 2009-12-21 | Glycofi Inc | Fremgangsmåde til fremstilling af modificerede glykoproteiner |
US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
EP1345968A2 (de) * | 2000-12-28 | 2003-09-24 | Altus Biologics Inc. | Kristalle ganzer antikörper und fragmente davon und verfahren zu ihrer herstellung und verwendung |
ATE434040T1 (de) | 2001-10-01 | 2009-07-15 | Dyax Corp | Mehrkettige eukaryontische display-vektoren und deren verwendungen |
US20050100965A1 (en) * | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
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2003
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2004
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- 2004-11-12 CN CN2012101293119A patent/CN102659944A/zh active Pending
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- 2004-11-12 CA CA2805859A patent/CA2805859A1/en not_active Abandoned
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- 2004-11-12 WO PCT/US2004/037971 patent/WO2005047307A2/en active Application Filing
- 2004-11-12 CA CA002543920A patent/CA2543920A1/en not_active Abandoned
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- 2004-11-12 SI SI200431865T patent/SI1685152T1/sl unknown
- 2004-11-12 EP EP11173595A patent/EP2385070A1/de not_active Withdrawn
- 2004-11-12 KR KR1020127031335A patent/KR20130006525A/ko not_active Application Discontinuation
- 2004-11-12 PT PT04817825T patent/PT1685152E/pt unknown
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- 2004-11-12 KR KR1020127028781A patent/KR20120136416A/ko not_active Application Discontinuation
- 2004-11-12 EP EP11173631A patent/EP2460830A3/de not_active Withdrawn
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2006
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