SG11201701423RA - Compound targeting il-23a and tnf-alpha and uses thereof - Google Patents

Compound targeting il-23a and tnf-alpha and uses thereof

Info

Publication number
SG11201701423RA
SG11201701423RA SG11201701423RA SG11201701423RA SG11201701423RA SG 11201701423R A SG11201701423R A SG 11201701423RA SG 11201701423R A SG11201701423R A SG 11201701423RA SG 11201701423R A SG11201701423R A SG 11201701423RA SG 11201701423R A SG11201701423R A SG 11201701423RA
Authority
SG
Singapore
Prior art keywords
tnf
alpha
compound targeting
targeting
compound
Prior art date
Application number
SG11201701423RA
Inventor
Rachel Rebecca Barrett
Leslie S Johnson
Sanjaya Singh
Kathleen Last-Barney
Daw-Tsun Shih
Patricia Giblin
Scott Brodeur
Nelamangala Nagaraja
Original Assignee
Boehringer Ingelheim Int
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55401727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201701423R(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int, Macrogenics Inc filed Critical Boehringer Ingelheim Int
Publication of SG11201701423RA publication Critical patent/SG11201701423RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
SG11201701423RA 2014-09-03 2015-09-03 Compound targeting il-23a and tnf-alpha and uses thereof SG11201701423RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462045498P 2014-09-03 2014-09-03
PCT/US2015/048260 WO2016036918A1 (en) 2014-09-03 2015-09-03 Compound targeting il-23a and tnf-alpha and uses thereof

Publications (1)

Publication Number Publication Date
SG11201701423RA true SG11201701423RA (en) 2017-03-30

Family

ID=55401727

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201912591RA SG10201912591RA (en) 2014-09-03 2015-09-03 Compound targeting il-23a and tnf-alpha and uses thereof
SG11201701423RA SG11201701423RA (en) 2014-09-03 2015-09-03 Compound targeting il-23a and tnf-alpha and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201912591RA SG10201912591RA (en) 2014-09-03 2015-09-03 Compound targeting il-23a and tnf-alpha and uses thereof

Country Status (25)

Country Link
US (4) US10059763B2 (en)
EP (1) EP3189153B1 (en)
JP (2) JP6746564B2 (en)
KR (1) KR102523914B1 (en)
CN (1) CN107109456B (en)
AP (1) AP2017009776A0 (en)
AR (1) AR101753A1 (en)
AU (1) AU2015311913B2 (en)
BR (1) BR112017004169A2 (en)
CA (1) CA2959629C (en)
CL (1) CL2017000525A1 (en)
CO (1) CO2017002253A2 (en)
EA (2) EA039598B9 (en)
ES (1) ES2887549T3 (en)
IL (1) IL250717B (en)
MX (2) MX2017002765A (en)
MY (1) MY192824A (en)
PE (1) PE20171139A1 (en)
PH (1) PH12017500370A1 (en)
SG (2) SG10201912591RA (en)
TW (1) TWI711629B (en)
UA (1) UA123624C2 (en)
UY (1) UY36287A (en)
WO (1) WO2016036918A1 (en)
ZA (1) ZA201701384B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
EP3456740A1 (en) 2010-11-04 2019-03-20 Boehringer Ingelheim International GmbH Anti-il-23 antibodies
US11078265B2 (en) 2012-05-03 2021-08-03 Boehringer Ingelheim International Gmbh Anti-IL-23 antibodies
JP2017524359A (en) 2014-07-24 2017-08-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Biomarkers useful for the treatment of IL-23A related diseases
AR102417A1 (en) * 2014-11-05 2017-03-01 Lilly Co Eli ANTI-TNF- / ANTI-IL-23 BIESPECTIFIC ANTIBODIES
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
TW202016151A (en) 2018-06-09 2020-05-01 德商百靈佳殷格翰國際股份有限公司 Multi-specific binding proteins for cancer treatment
CN111273019A (en) * 2018-12-04 2020-06-12 山东博安生物技术有限公司 Duraluvian peptide ELISA detection method
CN114466864A (en) 2019-06-21 2022-05-10 索瑞索制药公司 Polypeptides
MX2021015763A (en) * 2019-06-21 2022-04-18 Sorriso Pharmaceuticals Inc Polypeptides.
EP4261222A1 (en) * 2020-12-09 2023-10-18 HK inno.N Corporation ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFalpha BISPECIFIC ANTIBODY, AND USES THEREOF
WO2024061288A1 (en) * 2022-09-21 2024-03-28 Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd. Antibodies targeting tnf alpha and il-23 and uses thereof

Family Cites Families (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
JPH0825869B2 (en) 1987-02-09 1996-03-13 株式会社ビタミン研究所 Antitumor agent-embedded liposome preparation
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
US4917951A (en) 1987-07-28 1990-04-17 Micro-Pak, Inc. Lipid vesicles formed of surfactants and steroids
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US6277969B1 (en) 1991-03-18 2001-08-21 New York University Anti-TNF antibodies and peptides of human tumor necrosis factor
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
GB9225453D0 (en) 1992-12-04 1993-01-27 Medical Res Council Binding proteins
US6090382A (en) 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
WO1997029131A1 (en) * 1996-02-09 1997-08-14 Basf Aktiengesellschaft HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a)
CA2249195A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
ES2300113T3 (en) 1996-08-02 2008-06-01 Bristol-Myers Squibb Company A PROCEDURE FOR INHIBITING TOXICITY INDUCED BY IMMUNOGLOBULINS RESULTING FROM THE USE OF IMMUNOGLOBULINS IN THERAPY AND IN VIVO DIAGNOSIS.
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
PE20000183A1 (en) 1997-07-25 2000-03-11 Schering Corp MAMMAL CYTOKINES AND RELATED REAGENTS
US6060284A (en) 1997-07-25 2000-05-09 Schering Corporation DNA encoding interleukin-B30
WO1999040195A1 (en) 1998-02-06 1999-08-12 Schering Corporation Mammalian receptor proteins; related reagents and methods
CA2323757C (en) 1998-04-02 2011-08-02 Genentech, Inc. Antibody variants and fragments thereof
ATE474849T1 (en) 1998-04-14 2010-08-15 Chugai Pharmaceutical Co Ltd NEW CYTOKINE-LIKE PROTEIN
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
JP2002521053A (en) * 1998-07-28 2002-07-16 マイクロメット アーゲー Heteromini body
US6875741B2 (en) 1998-09-02 2005-04-05 Renuka Pillutla Insulin and IGF-1 receptor agonists and antagonists
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7090847B1 (en) 1999-09-09 2006-08-15 Schering Corporation Mammalian cytokines; related reagents and methods
ES2300276T5 (en) 1999-09-09 2017-06-02 Merck Sharp & Dohme Corp. P40 of mammalian interleukin-12 and B30 interleukin. Your combinations Antibodies Uses in pharmaceutical compositions
ES2637801T3 (en) 2000-04-11 2017-10-17 Genentech, Inc. Multivalent antibodies and uses thereof
ES2307618T3 (en) 2000-05-10 2008-12-01 Schering Corporation PROTEINS SUBUNITIES OF RECEPTORS OF COTOCINAS OF MAMMALS, REAGENTS AND RELATED METHODS.
US7422743B2 (en) 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
CA2410551A1 (en) 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) Heterodimeric fusion proteins
UA81743C2 (en) 2000-08-07 2008-02-11 Центокор, Инк. HUMAN MONOCLONAL ANTIBODY WHICH SPECIFICALLY BINDS TUMOR NECROSIS FACTOR ALFA (TNFα), PHARMACEUTICAL MIXTURE CONTAINING THEREOF, AND METHOD FOR TREATING ARTHRITIS
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
EP2354149B1 (en) 2000-12-12 2017-08-30 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
JPWO2003034818A1 (en) 2001-10-24 2005-02-10 中外製薬株式会社 SGRF gene modified non-human animals
CA2466034C (en) 2001-11-08 2012-12-18 Protein Design Labs, Inc. Stable aqueous pharmaceutical formulations of daclizumab antibodies
EP1354600A1 (en) 2002-04-19 2003-10-22 Affimed Therapeutics AG Antibody combination useful for tumor therapy
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
US9701754B1 (en) 2002-10-23 2017-07-11 City Of Hope Covalent disulfide-linked diabodies and uses thereof
CA2501786C (en) 2002-10-30 2015-02-17 Genentech, Inc. Inhibition of il-17 production
ES2367302T3 (en) 2002-12-23 2011-11-02 Schering Corporation USES OF THE MAMÍFERO CYTOCHINE IL-23; RELATED REAGENTS.
WO2004071517A2 (en) 2003-02-06 2004-08-26 Schering Corporation Uses of il-23 related reagents
TWI357336B (en) 2003-03-10 2012-02-01 Schering Corp Uses of il-23 agonists and antagonists; related re
US7413894B2 (en) 2003-07-01 2008-08-19 University Of Virginia Patent Foundation TAG-1 and TAG-2 proteins and uses thereof
PL2149585T3 (en) 2003-11-04 2014-01-31 Novartis Vaccines & Diagnostics Inc Use of antagonistic anti-CD40 monoclonal antibodies
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
CN1942201B (en) 2004-02-17 2012-06-20 先灵公司 Methods of modulating cytokine activity, related reagents
US20050287593A1 (en) 2004-05-03 2005-12-29 Schering Corporation Use of cytokine expression to predict skin inflammation; methods of treatment
AU2005241020B2 (en) 2004-05-03 2008-07-10 Merck Sharp & Dohme Corp. Use of IL-17 expression to predict skin inflammation; methods of treatment
US7632924B2 (en) 2004-06-18 2009-12-15 Ambrx, Inc. Antigen-binding polypeptides and their uses
AU2005289594B2 (en) 2004-09-27 2012-02-02 Centocor, Inc. Srage mimetibody, compositions, methods and uses
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
TWI363091B (en) 2004-12-20 2012-05-01 Schering Corp Uses of mammalian cytokine; related reagents
ES2707152T3 (en) 2005-04-15 2019-04-02 Macrogenics Inc Covalent diabodies and uses thereof
US9963510B2 (en) 2005-04-15 2018-05-08 Macrogenics, Inc. Covalent diabodies and uses thereof
US9284375B2 (en) 2005-04-15 2016-03-15 Macrogenics, Inc. Covalent diabodies and uses thereof
US20090142855A1 (en) 2005-06-30 2009-06-04 Wei Tang Polynucleotides and Polypeptides of the IL-12 Family of Cytokines
HUE042561T2 (en) 2005-06-30 2019-07-29 Janssen Biotech Inc Anti-IL-23 antibodies, compositions, methods and uses
CA2619052A1 (en) 2005-08-25 2007-03-01 Eli Lily And Company Anti-il-23 antibiodies
EP3190125A1 (en) 2005-08-31 2017-07-12 Merck Sharp & Dohme Corp. Engineered anti-il-23 antibodies
ES2333260T3 (en) 2005-09-01 2010-02-18 Schering Corporation USE OF IL-23 AND IL-17 ANTAGONISTS TO TREAT AUTOIMMUNOLOGICAL EYE INFLAMMATORY DISEASE.
JP2009521933A (en) 2005-12-28 2009-06-11 セントカー・インコーポレーテツド Markers and methods for assessing and treating psoriasis and related disorders
DK3219328T3 (en) 2005-12-29 2020-07-13 Janssen Biotech Inc HUMANE ANTI-IL-23 ANTIBODIES, COMPOSITIONS, PROCEDURES AND USES
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
JP2009540018A (en) 2006-06-13 2009-11-19 ザイモジェネティクス， インコーポレイテッド IL-17 and IL-23 antagonists and methods of use thereof
CN101472611A (en) 2006-06-19 2009-07-01 惠氏公司 Methods of modulating IL-22 and IL-17
CL2008000058A1 (en) 2007-01-09 2008-05-23 Wyeth Corp FORMULATION THAT INCLUDES AN ANTI-IL13 ANTIBODY, A CRIPROTECTOR, AND A DAMPING SOLUTION; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT; METHOD TO TREAT AN IL13-RELATED DISORDER; AND PHARMACEUTICAL FORMS THAT UNDERSTAND IT.
TWI426918B (en) 2007-02-12 2014-02-21 Merck Sharp & Dohme Use of il-23 antagonists for treatment of infection
AU2008216090A1 (en) 2007-02-16 2008-08-21 Wyeth Protein formulations containing sorbitol
SG178804A1 (en) 2007-02-23 2012-03-29 Schering Corp Engineered anti-il-23p19 antibodies
EP2059534B1 (en) 2007-02-23 2012-04-25 Schering Corporation Engineered anti-il-23p19 antibodies
JP5337055B2 (en) * 2007-02-28 2013-11-06 メルク・シャープ・アンド・ドーム・コーポレーション Combination therapy for the treatment of immune disorders
EP3424951A1 (en) 2007-06-21 2019-01-09 MacroGenics, Inc. Covalent diabodies and uses thereof
EP2197903B9 (en) 2007-09-04 2015-04-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity
AR068723A1 (en) 2007-10-05 2009-12-02 Glaxo Group Ltd PROTEIN THAT JOINS ANTIGENS THAT JOINS HUMAN IL-23 AND ITS USES
EP2212442A1 (en) 2007-10-26 2010-08-04 Galderma Research & Development Non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis method thereof
CA2607771A1 (en) 2007-11-01 2009-05-01 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence Humanized anti-venezuelan equine encephalitis virus recombinant antibody
KR20190045414A (en) 2007-11-30 2019-05-02 애브비 바이오테크놀로지 리미티드 Protein formulations and methods of making same
WO2009082624A2 (en) 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonists of il-17a, il-17f, and il-23 and methods of using the same
EP3211010A1 (en) 2007-12-21 2017-08-30 Medimmune Limited Binding members for interleukin-4 receptor alpha (il-4r) - 173
KR20160116056A (en) 2008-08-14 2016-10-06 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 Anti-il-12/il-23 antibodies
MX2011002159A (en) 2008-08-27 2011-03-29 Schering Corp Lyophilized formulatons of engineered anti-il-23p19 antibodies.
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
JP5734201B2 (en) 2008-12-19 2015-06-17 マクロジェニクス，インコーポレーテッド Covalently bonded diabody and use thereof
JP2012522749A (en) 2009-04-01 2012-09-27 グラクソ グループ リミテッド Anti-IL-23 immunoglobulin
US20120027799A1 (en) 2009-04-02 2012-02-02 The Johns Hopkins University Compositions and methods for treating or preventing inflammatory bowel disease and colon cancer
WO2011011797A2 (en) 2009-07-24 2011-01-27 The Board Of Trustees Of The Leland Stanford Junior University Cytokine compositions and methods of use thereof
JO3244B1 (en) 2009-10-26 2018-03-08 Amgen Inc Human il-23 antigen binding proteins
US20120294852A1 (en) 2009-11-24 2012-11-22 Smith Jeffrey T L Antagonists of il-6 to raise albumin and/or lower crp
SI2506871T1 (en) 2009-11-30 2016-12-30 Janssen Biotech, Inc. ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS
EP3511023A1 (en) 2009-12-02 2019-07-17 Imaginab, Inc. J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use
EP2506785A4 (en) 2009-12-02 2014-10-15 Spartek Medical Inc Low profile spinal prosthesis incorporating a bone anchor having a deflectable post and a compound spinal rod
GB201013975D0 (en) 2010-08-20 2010-10-06 Imp Innovations Ltd Method of treating desease
PE20130041A1 (en) 2010-02-18 2013-01-28 Bristol Myers Squibb Co FIBRONECTIN SCAFFOLDING DOMAIN PROTEINS THAT BIND INTERLEUKIN 23 (IL-23)
AU2011217770B2 (en) * 2010-02-19 2016-02-04 Xencor, Inc. Novel CTLA4-IG immunoadhesins
RU2012139181A (en) 2010-02-26 2014-04-10 Ново Нордиск А/С STABLE COMPOSITION CONTAINING ANTIBODY
EP2542221A4 (en) 2010-03-01 2013-10-23 Cytodyn Inc Concentrated protein formulations and uses thereof
US9072668B2 (en) 2010-03-09 2015-07-07 Janssen Biotech, Inc. Non-aqueous high concentration reduced viscosity suspension formulations of antibodies
EP2583098B1 (en) 2010-06-15 2018-08-08 Celgene Corporation Biomarkers for the treatment of psoriasis
US20110311527A1 (en) 2010-06-16 2011-12-22 Allergan, Inc. IL23p19 ANTIBODY INHIBITOR FOR TREATING OCULAR AND OTHER CONDITIONS
CN103108886B (en) 2010-07-20 2016-08-24 赛法隆澳大利亚控股有限公司 Anti-il-23 heterodimer specific antibody
CN103154025B (en) * 2010-08-02 2015-07-01 宏观基因有限公司 Covalent diabodies and uses thereof
WO2012032181A2 (en) 2010-09-10 2012-03-15 Allozyne, Inc Novel antibody derivatives
BR112013010857A2 (en) 2010-11-02 2016-09-13 Abbott Laboratoires double domain variable imonoglubulines and their uses
EP3456740A1 (en) 2010-11-04 2019-03-20 Boehringer Ingelheim International GmbH Anti-il-23 antibodies
KR101941514B1 (en) 2010-12-22 2019-01-23 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 Modified antibody with improved half-life
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
TW201309330A (en) 2011-01-28 2013-03-01 Abbott Lab Compositions containing glycosylated antibodies and uses thereof
TWI671315B (en) * 2011-03-28 2019-09-11 法商賽諾菲公司 Dual variable region antibody-like binding proteins having cross-over binding region orientation
MX347818B (en) 2011-05-21 2017-05-15 Macrogenics Inc Deimmunized serum-binding domains and their use for extending serum half-life.
GB201112429D0 (en) * 2011-07-19 2011-08-31 Glaxo Group Ltd Antigen-binding proteins with increased FcRn binding
PE20141521A1 (en) * 2011-08-23 2014-10-25 Roche Glycart Ag T-CELL ACTIVATING ANTIGEN-BINDING BI-SPECIFIC MOLECULES
EP2771361A1 (en) 2011-10-24 2014-09-03 AbbVie Inc. Bispecific immunobinders directed against tnf and il-17
CN103906533A (en) * 2011-11-07 2014-07-02 米迪缪尼有限公司 Multispecific and multivalent binding proteins and uses thereof
RU2624128C2 (en) * 2012-02-15 2017-06-30 Ф. Хоффманн-Ля Рош Аг AFFINITY CHROMATOGRAPHY WITH APPLICATION OF Fc-RECEPTORS
US11078265B2 (en) * 2012-05-03 2021-08-03 Boehringer Ingelheim International Gmbh Anti-IL-23 antibodies
US9803010B2 (en) 2012-06-27 2017-10-31 Merck Sharp & Dohme Corp. Crystalline anti-human IL-23p19 antibodies
US20140213772A1 (en) * 2012-12-28 2014-07-31 Abbvie, Inc. Cross-over dual variable domain immunoglobulin constructs
CA2906384A1 (en) 2013-03-15 2014-09-18 Amgen Inc. Methods for treating crohn's disease using an anti-il23 antibody
SG10201804954UA (en) 2013-03-15 2018-07-30 Amgen Inc Methods for treating psoriasis using an anti-il-23 antibody
WO2014144299A2 (en) 2013-03-15 2014-09-18 Abbvie Inc. DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST TNFα
KR20140119396A (en) 2013-03-29 2014-10-10 삼성전자주식회사 Liquid formulation containing a protein drug
CA2972995A1 (en) 2015-02-04 2016-08-11 Boehringer Ingelheim International Gmbh Methods of treating inflammatory diseases

Also Published As

Publication number Publication date
CN107109456B (en) 2021-02-23
CA2959629C (en) 2023-10-31
US10059763B2 (en) 2018-08-28
EP3189153B1 (en) 2021-06-16
IL250717B (en) 2021-06-30
AU2015311913B2 (en) 2019-09-12
US20160060338A1 (en) 2016-03-03
US20230382988A1 (en) 2023-11-30
US10793629B2 (en) 2020-10-06
EA039598B1 (en) 2022-02-15
ES2887549T3 (en) 2021-12-23
KR20170044751A (en) 2017-04-25
CL2017000525A1 (en) 2017-11-03
AR101753A1 (en) 2017-01-11
AP2017009776A0 (en) 2017-02-28
IL250717A0 (en) 2017-04-30
EA201790505A1 (en) 2017-07-31
CA2959629A1 (en) 2016-03-10
MX2017002765A (en) 2017-10-16
EA202193002A2 (en) 2022-03-31
ZA201701384B (en) 2023-11-29
US20210054065A1 (en) 2021-02-25
UA123624C2 (en) 2021-05-05
JP2017528132A (en) 2017-09-28
BR112017004169A2 (en) 2017-12-05
EA039598B9 (en) 2022-03-10
JP7072600B2 (en) 2022-05-20
JP2020124205A (en) 2020-08-20
CN107109456A (en) 2017-08-29
WO2016036918A1 (en) 2016-03-10
UY36287A (en) 2016-04-29
US11680096B2 (en) 2023-06-20
SG10201912591RA (en) 2020-02-27
US20190016794A1 (en) 2019-01-17
TWI711629B (en) 2020-12-01
MX2021014663A (en) 2022-01-11
JP6746564B2 (en) 2020-08-26
TW201613968A (en) 2016-04-16
MY192824A (en) 2022-09-12
PH12017500370A1 (en) 2017-07-17
PE20171139A1 (en) 2017-08-09
KR102523914B1 (en) 2023-04-19
AU2015311913A1 (en) 2017-03-23
EP3189153A4 (en) 2018-02-28
CO2017002253A2 (en) 2017-07-19
EP3189153A1 (en) 2017-07-12

Similar Documents

Publication Publication Date Title
HK1243073A1 (en) Therapeutic compounds and uses thereof
GB2530831B (en) Targeted mutations
IL252216B (en) Difluoromethyl-aminopyridines and difluoromethyl-aminopyrimidines
HK1231471A1 (en) 6-heteroaryloxy- and 6-aryloxy-quinoline-2-carboxamides and uses thereof 6-- 6--2-
IL250717A0 (en) Compound targeting il-23a and tnf-alpha and uses thereof
IL251512A0 (en) Nebulizers and uses thereof
PL3110483T3 (en) Inhaler
PL3152226T3 (en) Modified cyclopentapeptides and uses thereof
ZA201701492B (en) Pyrazolothiazole compound and medicine
GB201419650D0 (en) Modified heterocyclase
AU358579S (en) Inhaler
GB201400470D0 (en) Body protection
PL2944740T3 (en) Assembly and compound body
GB201510123D0 (en) Compounds and their uses
SG10201503358UA (en) Corrector
GB201420001D0 (en) Polyamide compounds and uses thereof
PT2923578T (en) Snack-product and manufacture thereof
GB201407599D0 (en) New compounds and uses
GB201407596D0 (en) New compounds and uses
GB201414461D0 (en) Herbicidal compounds and uses
GB201414460D0 (en) Herbicidal compounds and uses
GB201414459D0 (en) Herbicidal compounds and uses
GB201414457D0 (en) Herbicidal compounds and uses
GB201414456D0 (en) Herbicidal compounds and uses
GB201414455D0 (en) Herbicidal compounds and uses