CN1902229B - Il-18结合蛋白 - Google Patents
Il-18结合蛋白 Download PDFInfo
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- CN1902229B CN1902229B CN2004800399482A CN200480039948A CN1902229B CN 1902229 B CN1902229 B CN 1902229B CN 2004800399482 A CN2004800399482 A CN 2004800399482A CN 200480039948 A CN200480039948 A CN 200480039948A CN 1902229 B CN1902229 B CN 1902229B
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Abstract
Description
CDR区 | 序列标识 | 共有序列 |
CDR-H1 | SEQ IDNO.:42 | X1 X2 X3 X4 X5 X6 X7S Y W I G - -N G G H Y W TH R Y W S SR S D Y N GY C S M HV LI D |
CDR-H2 | SEQ IDNO.:43 | X1 X2 X3 X4 X5 X6 X7 X8 X9 X10 X11 X12 X13 X14 X15 X16 X17F I Y P G D S E T R Y S P T F Q -Y F S Y S G T T Y Y N P S L K S GH W S R G I N S S A D S V KS D R N I VV KH |
CDR-H3 | SEQ IDNO.:44 | X1 X2 X3 X4 X5 X6 X7 X8 X9 X10 X11 X12 X13 X14 X15 X16 X17 X18V G S G W Y P Y T - - - - - - - - -D R G S S G S F W F D I Y Y G M D VE D Y Y A S F D D D Y DS S R N G F Y P L Y F YC K T Y W V M Y H LL D T N G I E VY W N P YA V FG |
CDR-L1 | SEQ IDNO.:45 | X1 X2 X3 X4 X5 X6 X7 X8 X9 X10 X11 X12 X13 X14 X15 X16 X17R A S E S I S S N L A - - - - - -K G R I V G G G Y L A K N Y L AS Q T L L Y Y S N N T Y L C DH N F N R R D V E N T YR N S G KH D GD |
CDR-L2 | SEQ IDNO.:46 | X1 X2 X3 X4 X5 X6 X7T A S T R A TG V F I L Q SS T N EW I S FE L RY |
CDR-L3 | SEQ IDNO.:47 | X1 X2 X3 X4 X5 X6 X7 X8 X9 X10Q Q Y N N W P S - -M H N H G S L L I TY G Y I T T P TS D Y L D C SR G S I I WV Q F IL F FI E |
性质 | 量度 | NEM-huIL-18 | (4C/A)-huIL-18 |
寡聚物状态 | SEC | 单体 | 单体 |
DLS | 单体 | 单体 | |
构象 | CD(波长扫描) | 210nmCD最小 | 210nmCD最小 |
稳定性 | CD(温度扫描) | 高至40℃稳定 | 高至40℃稳定 |
生物活性 | 2ng/mL IL-18引起的IFNγ产生 | 8ng/mL IFNγ | 8ng/mL IFNγ |
表位 | 参照结合蛋白对IFNγ产生的中和 | IL-18BP-Fc,125-2H和IL-18Rα的中和 | IL-18BP-Fc,125-2H和IL-18Rα的中和 |
Biacore (KD) | IL-18BP-Fc,0.098nM125-2H:0.2nM2.5(E)mgl:0.3nM | IL-18BP-Fc,0.135nM125-2H:0.2nM2.5(E)mgl:0.2nM |
HuMAb# | KG-1 测定(IC50’M) |
NEM-rhulL-18 | |
杂交瘤 | |
2.5.1 | 3E-10; 4E-10 |
2.13.1 | 2E-10;1E-10;7E-11 |
2.3.3 | 1E-9;2E-10;7E-10 |
XENOMAX | |
215 | 1E-10;3E-10;1E-10; |
444 | 1E-10;2E-10;2E-10 |
478 | 7E-10;2E-9;3E-10 |
435 | 8E-10;7E-10;4E-10; |
413 | 1E-9;7E-10;7E-10 |
581 | 7E-10;3E-10;3E-9 |
231 | 1B-10;3E-11;2E-9 |
521 | 6E-10;3E-10;2E-9 |
336 | 7E-10 |
351 | 2E-10 |
490 | 5E-10 |
550 | TBD |
268 | 7E-9 |
抗体 | 技术a | Biacoreb(KD,nM) | RBA(IC50,nM) | KG-1b(IC50,nM) | WBA(IC50,nM) | 基因家族c序列多样性 | |
2.5(E)mgl | 杂交瘤 | 0.31 | 2.38 | 0.20 | 3 | VL-L2 | VH5-51 |
2.5(E)wtgl | 杂交瘤 | 0.40 | 2.38 | 0.30 | 3 | VL-L2 | VH5-51 |
215(E)mgld | Xenomax | 0.23 | 1.17 | 0.17 | 3 | VL-A27 | VH4-31 |
444(Q)mgld | Xenomax | 1.61 | 2.49 | 0.13 | 1 | VL-A27(7) | VH4-31(1) |
581(E)mgld | Xenomax | 2.00 | 1.28 | 1.3 | 3 | VL-A2 | VH3-30 |
2.3.1(E)wtgl | 杂交瘤 | 0.23 | 0.20 | 0.63 | 2 | VL-02 | VH4-59 |
2.13.1(E)wt8l | 杂交瘤 | 0.20 | 0.20 | 0.12 | 2 | VL、A27(8) | VH4-31(18) |
组 | huIFNg(pg/ml) | %抑制率 |
2.5(E)mgl 0.025μg/小鼠 | 70±17 | 61 |
2.5(E)mgl 0.25μg/小鼠 | 112±29 | 36 |
2.5(E)mgl 2.5μg/小鼠 | 36±10 | 80 |
2.5(E)mgl 25μg/小鼠 | 10±8 | 94 |
2.5(E)mgl 250μg/小鼠 | 3±2 | 98 |
没有处理 | 193±59 | |
HuIgG对照250μg/小鼠 | 177±33 |
组2.5(E)mgl 0.025μg/小鼠 | huIFNg(pg/ml) | %抑制率 |
156±45 | 36 | |
2.5(E)mgl 0.25μg/小鼠 | 27±9 | 89 |
2.5(E)mgl 2.5μg/小鼠 | 36±8 | 85 |
2.5(E)mgl 25μg/小鼠 | 11±6 | 96 |
2.5(E)mgl 250μg/小鼠 | 4±2 | 98 |
没有处理 | 279±26 | |
HuIgG对照250μg/小鼠 | 245±22 |
抗体浓度(μM) | 1.00E.09 | 1.00E.08 | 1.00E-07 | 1.00E-06 | 1.00E-05 | 1.00E-04 | 1.00E-03 | 1.00E-02 | 1.00E-01 |
2.5(E)wtgl | 0.50+0.00 | 0.50+0.00 | 0.63+0.12 | 0.57+0.05 | 0.60+0.00 | 1.10+0.00 | 5.80+0.05 | 29.60+0.05 | 38.76+5.19 |
23(E)mgl | 0.67+0.09 | 0.67+0.09 | 0.60+0.00 | 0.80+0.14 | 0.63+0.05 | 0.67+0.05 | 0.53+0.05 | 0.60+0.05 | 0.63+0.08 |
抗体浓度(μM) | 1.00E-06 | 1.00E-07 | 1.00E-06 | 1.00E-05 | 1.00E-04 | 1.00E-03 | 1.00E-02 | 1.00E-01 | 1.00E+00 |
2.5(E)wtgl | 0.37+0.05 | 0.37+0.05 | 0.40+0.00 | 0.43+0.05 | 0.80+0.08 | 3.43+0.21 | 19.7+0.70 | 93.33+4.90 | 134.37+12.93 |
2.5(E)mgl | 0.30+0.00 | 0.40+0.00 | 0.40+0.00 | 0.37+0.05 | 0.37+0.05 | 0.40+0.00 | 0.50+0.00 | 1.60+0.08 | 5.37+0.38 |
Clq浓度(μg/ml) | 0 | 20 | 40 | 60 | 80 | 100 | 120 |
2.5(E)wtgl | 0.09+0.00 | 0.78+0.00 | 0.98+0.00 | 1.06+0.07 | 1.14+0.06 | 1.32+0.13 | 1.24+0.06 |
2.5(E)mgl | 0.10+0.01 | 0.12+0.00 | 0.16+0.00 | 0.18+0.00 | 0.21+0.01 | 0.21+0.01 | 0.22+0.00 |
t1/2α(hr) | t1/2β(天数) | Cmax(g/mL) | CL(mL/hr) | Vss(mL) | V1(mL) | V2(mL) | MRT(天数) | AUC(hr*μg/mL) |
1.58 | 12.2 | 63.2 | 0.0162 | 6.82 | 3.15 | 3.67 | 17.5 | 12250 |
组 | muIFNg(pg/ml) | %抑制率 |
RatIgG250μg/小鼠 | 7239±365 | N/A |
MBT93-10C250μg/小鼠 | 2395±711 | 67 |
免疫后第14天平均临床评分 | |
SJL/J小鼠 IgG(BA77)PLP诱导的EAE 抗-IL-18抗体 | 42.7 |
第18天平均临床评分 | |
IL-18KO和WT大鼠中 WTMOG诱导的EAB KO | 3.62.1 |
处理 | AST | stdv | ALT | stdv |
PBS | 57 | 16 | 30 | 2 |
ConA只有 | 1138 | 416 | 1294 | 481 |
ConA+93-10C(50ug) | 183 | 70 | 153 | 88 |
ConA+93-10C(12.5ug) | 635 | 427 | 443 | 256 |
ConA+大鼠IgG1(50ug) | 3924 | 1062 | 3455 | 753 |
时间(小时) | 0 | 8 | 24 | 32 | 48 | 56 | 72 | 120 | 144 |
盐水 | 100 | 100 | 100 | 50 | 10 | 10 | 10 | 10 | 10 |
125-2H400 | 100 | 100 | 80 | 70 | 10 | 10 | 10 | 10 | 10 |
1C5400μg | 100 | 100 | 100 | 90 | 80 | 80 | 80 | 80 | 80 |
时间(小时) | 0 | 8 | 24 | 32 | 48 | 56 | 72 | 120 | 144 |
盐水 | 100 | l00 | 90 | 40 | 10 | 10 | 10 | 10 | 10 |
大鼠IgG100μg | 100 | 100 | 100 | 100 | 70 | 40 | 40 | 40 | 40 |
93-10C100μg | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Ganbank ID | 位置/功能 | 基因名称 | Unigene备注 | 0.5ng/ml | 2ng/ml | 10ng/ml | 50ng/ml | |
L29217 | 激酶 | CLK3 | CDC-样激酶3 | 9.1 | 7.4 | 8.1 | 15.0 | |
D14497 | 激酶 | MAP3K8 | 促细胞分裂剂-激活的蛋白质激酶激酶激酶8 | 6.6 | 2.9 | 5.8 | 3.9 | |
L19871 | 两个都不 | ATF3 | 激活转录因子3 | 1.0 | 1.1 | 3.3 | 2.6 | |
U15460 | 两个都不 | BATF | 碱性亮氨酸拉链转录因子,ATF-样 | 1.5 | 1.7 | 2.4 | 2.8 | |
U45878 | 两个都不 | BIRC3 | 包含杆状病毒IAP重夏3 | 7.0 | 6.2 | 10.2 | 10.0 | |
U37546 | 两个都不 | BIRC3 | 包含杆状病毒IAP重复3 | 29.4 | 26.9 | 76.6 | 63.6 | |
U72649 | 两个都不 | BTG2 | BTG家族,成员2 | 3.1 | 4.7 | 6.6 | 5.9 | |
L07765 | 两个都不 | CES1 | 羧酸酯酶1 | 1.0 | 1.3 | 2.1 | 2.1 | |
M27691 | 两个都不 | CREE1 | cDNA响应元件结合蛋白1 | 0.9 | 2.4 | 4.9 | 3.1 | |
HG3548-HT3749 | 两个都不 | CUIL1 | 切补(CCAAT替代蛋白质) | 2.5 | 2.1 | 1.3 | 0.7 | |
X59131 | 两个都不 | D13S106E | 高电荷蛋白质 | 2.1 | 0.5 | 1.5 | 2.3 | |
U53445 | 两个都不 | DOC1 | 卵巢癌1中负调节 | 2.0 | 3.3 | 3.0 | 3.8 | |
X68277 | 两个都不 | DUSP1 | 双重特异性磷酸酶1 | 2.5 | 3.1 | 4.1 | 3.3 | |
U48807 | 两个都不 | DUSP4 | 双重特异性磷酸酶4 | 2.0 | 2.3 | 2.9 | 2.0 | |
X52541 | 两个都不 | EGR1 | 早期生长响应1 | 15.5 | 12.7 | 32.4 | 20.3 | |
X63741 | 两个都不 | EGR3 | 早期生长响应3 | 5.9 | 7.3 | 15.1 | 9.0 | |
L07077 | 两个都不 | EHHADH | 烯脂酰辅酶A | 3.4 | 2.3 | 1.8 | 2.5 | |
M62831 | 两个都不 | EIR101 | 即时早期蛋白质 | 3.4 | 5.8 | 6.3 | 6.8 | |
L19314 | 两个都不 | HRY | 毛发(果蝇)同系物 | 2.3 | 2.5 | 2.3 | 2.0 | |
S81914 | 两个都不 | IER3 | 即时早期响应3 | 17.0 | 18.6 | 32.9 | 29.6 | |
X51345 | 两个都不 | JUNB | iun B原癌基因 | 7.2 | 6.1 | 10.7 | 9.6 | |
U20734 | 两个都不 | JUNB | iun B原癌基因 | 10.2 | 21.8 | 25.0 | 25.4 | |
U49957 | 两个都不 | LPP | 包含LIM结构域 | 2.2 | 1.1 | 2.0 | 1.9 | |
M58603 | 两个都不 | NFKB1 | 核因子κB(p105) | 1.6 | 2.0 | 2.9 | 2.3 | |
S76638 | 两个都不 | NFKB2 | 核因子κB | 1.7 | 2.2 | 3.5 | 4.3 | |
M69043 | 两个都不 | NFKBIA | 核因子κB | 9.6 | 10.4 | 15.5 | 15.8 | |
U91616 | 两个都不 | NFKBIE | 核因子κB | 11.6 | 14.8 | 20.7 | 21.0 | |
L13740 | 两个都不 | NR4A1 | 核受体亚家族4,族A,成员1 | 2.0 | 2.7 | 2.4 | 2.5 | |
HG4115-HT4385 | 两个都不 | OR1E3P | 嗅感受蛋白 | 4.5 | 12.0 | 4.2 | 4.1 | |
L20971 | 两个都不 | PDE4B | 磷酸二酯酶4B,cAMP-特异性 | 2.4 | 2.8 | 4.2 | 3.5 | |
U64675 | 两个都不 | RANBP2L1 | RNA结合蛋白2-样1 | 1.1 | 1.8 | 2.2 | 2.2 | |
S57153 | 两个都不 | RBBP1 | 成视网膜细胞瘤-结合蛋白1 | 2.5 | 3.4 | 5.0 | 4.1 | |
X75042 | 两个都不 | REL | v-rel | 1.6 | 2.5 | 3.9 | 3.7 | |
M83221 | 两个都不 | RELB | v-rel | 2.3 | 2.8 | 2.8 | 2.6 | |
S59049 | 两个都不 | ROS1 | G-蛋白质信号调控剂1 | 10.9 | 12.7 | 22.4 | 17.8 | |
U70426 | 两个都不 | ROS16 | G-蛋白质信号调控剂16 | 3.9 | 4.7 | 7.5 | 6.7 | |
U22377 | 两个都不 | RLF | 重排L-myc融合序列 | 2.5 | 2.0 | 2.5 | 2.6 | |
M95787 | 两个都不 | TAGLN | 转凝蛋白 | 6.6 | 4.7 | 1.0 | 1.6 | |
L47345 | 两个都不 | TCEB3 | 转录延伸因子B(110kD,延伸蛋白A) | 3.6 | 5.3 | 2.3 | 4.2 | |
M59465 | 两个都不 | NFA1F3 | 肿瘤坏死因子,α-诱导蛋白质3 | 9.9 | 12.4 | 25.4 | 20.6 | |
U19261 | 两个都不 | 7RAF1 | TNF受体结合因子1 | 2.8 | 2.8 | 4.9 | 4.1 | |
U78798 | 两个都不 | IRAF6 | TNF受体结合因子6 | 1.2 | 2.0 | 2.1 | 2.2 | |
M37435 | 分泌的 | CSF1 | 集落刺激因子1(巨噬细胞) | 2.9 | 2.9 | 2.1 | 2.6 | |
M57731 | 分泌的 | GRO2 | GRO2致癌基因 | 15.2 | 20.9 | 26.3 | 27.0 | |
X53800 | 分泌的 | GRO3 | GRO3致癌基因 | 4.1 | 5.5 | 14.8 | 9.9 | |
X04500 | 分泌的 | IL1B | 白介素1.β | 2.2 | 3.4 | 5.7 | 4.7 | |
M28130 | 分泌的 | IL8 | 白介素8 | 6.2 | 10.0 | 13.4 | 14.5 | |
Y00787 | 分泌的 | IL8 | 白介素8 | 5.8 | 7.4 | 8.3 | 8.5 | |
U89922 | 分泌的 | LTB | 淋巴毒素β(TNF超家族,成员3) | 5.0 | 5.7 | 11.0 | 12.8 |
Gcnbank ID | 位置/功能 | 基因名称 | Unigene备注 | 0.5ng/ml | 2ng/ml | 10ng/ml | 50ng/ml |
M31166 | 分泌的 | PTX3 | Pentaxin-相关基因,IL-1β快速诱导 | 3.1 | 5.2 | 10.3 | 6.4 |
M23178 | 分泌的 | SCYA3 | 小的可诱导细胞因子A3 | 1.8 | 2.0 | 5.0 | 3.8 |
M69203 | 分泌的 | SCYA4 | 小的可诱导细胞因子A4 | 0.9 | 1.9 | 7.0 | 5.6 |
J04130 | 分泌的 | SCYA4 | 小的可诱导细胞因子A4 | 1.0 | 2.6 | 5.9 | 4.5 |
M92357 | 分泌的 | TNRAIP2 | 肿瘤坏死因于,α-诱导蛋白质2 | 4.2 | 6.4 | 20.3 | 19.3 |
Z32765 | 表面 | CD36 | CD36抗原(胶原I型/TSP受体) | 1.6 | 2.0 | 1.4 | 1.2 |
Z11697 | 表面 | CD83 | CD83抗原 | 4.7 | 8.2 | 19.6 | 16.7 |
M57730 | 表面 | EFNA1 | 肝配蛋白-A1 | 9.8 | 6.0 | 9.5 | 15.2 |
A28102 | 表面 | GABRA3 | γ-氨基丁酸(GABA)受体 | 3.0 | 2.5 | 1.6 | 2.7 |
M24283 | 表面 | ICAM1 | 细胞胞间粘着分子1(CD54) | 7.5 | 11.5 | 14.5 | 13.9 |
M55024 | 表面 | ICAM1 | 细胞胞间粘着分子1(CD54) | 2.5 | 3.4 | 3.2 | 3.7 |
J03171 | 表面 | IFNAR1 | 干扰素(α,β和ε)受体1 | 3.2 | 2.5 | 2.8 | 2.6 |
X01057 | 表面 | IL2RA | 白介素2受体,α | 0.7 | 0.4 | 3.9 | 3.6 |
L10338 | 表面 | SCN1B | 钠通道肽 | 1.8 | 2.3 | 1.5 | 1.5 |
D79206 | 表面 | SDC4 | 粘结蛋白聚糖4(双栖蛋白聚糖,抗凝蛋白聚糖) | 4.0 | 4.2 | 7.2 | 6.1 |
HG961-HT961 | 表面 | SOS1 | Sos蛋白(果蝇)同系物1 | 6.3 | 6.2 | 9.1 | 9.9 |
X83490 | 表面 | TNFRSP6 | 肿瘤坏死因子受体成员6 | 1.1 | 1.3 | 3.8 | 3.3 |
U19523 | 两个都不 | GCH1 | GTP环化水解酶1 | 2.1 | |||
U37518 | 表面 | TNFSF10 | 肿瘤坏死因子受体成员10 | 1.4 | 1.4 | 2.3 | 1.6 |
Genbank ID | 基因名称 | Unigene备注 | 折叠10nng | 折叠40ng |
J00219 | IFNG | 干扰素,γ | 26.3 | 31.8 |
U17034 | PLA2R1 | 磷酸酯酶A2受体1,180kD | 29.6 | 28.7 |
M57710 | LGALS3 | 凝集素,半乳糖苷-结合,可溶性,3(半乳凝集素3) | 27.5 | 25.4 |
X97748 | PTX3 | pentaxin-相关基因,IL-1诱导的 | 15.2 | 13.6 |
M27288 | OSM | 制瘤素M | 23.1 | 12.0 |
X57809 | λ轻链可变区 | 10.9 | 10.0 | |
Y00081 | IL6 | 白介素6(干扰素,β2) | 9.2 | 9.4 |
D16583 | HDC | 组氨酸脱羧酶 | 8.0 | 9.4 |
X07730 | KLK3 | 血管舒缓素3(前列腺特异性抗原) | 5.6 | 8.8 |
HG3111-HT3287 | 未知的人克隆HH409 | 9.5 | 7.5 | |
M57732 | TCF1 | 肝核因子(HNF1) | 2.0 | 7.2 |
U77735 | PIM2 | pim-2致癌基因 | 7.1 | 7.1 |
U96094 | SLN | sarcolipin | 12.2 | 6.1 |
D50640 | PDE3B | 磷酸二酯酶3B,cGMP-抑制的 | 4.0 | 5.4 |
X14008 | LYZ | 溶菌酶(肾淀粉样变性) | 3.0 | 5.4 |
M91036 | HBG2 | 血红素,γG | 3.4 | 5.4 |
X72755 | MIG | γ干扰素诱导的单核因子 | 5.2 | 5.2 |
AC000099 | GRM8 | 谷氨酸受体,代谢型8 | 2.3 | 4.3 |
D11428 | PMP22 | 外周髓磷脂蛋白质22 | 5.0 | 4.0 |
M83667 | CEBPD | CCAAT/增强子结合蛋白 | 4.3 | 4.0 |
L19267 | DMWD | 肌强直性营养不良,WD重复基序 | 3.0 | 3.8 |
M81181 | ATP1B2 | ATP酶,Na+/K+运输 | 3.5 | 3.8 |
U79249 | 人克隆23839序列 | 3.1 | 3.7 | |
U49973 | FLJ10803 | 假定蛋白FLJ10803 | 3.2 | 3.6 |
HG870-HT670 | GOLGA3 | 高尔基体自身抗原,高尔基体亚家族a,3 | 3.5 | 3.6 |
X13589 | CYP19 | 细胞色素P450,亚家族XIX | 3.0 | 3.5 |
AB000464 | 克隆:RES4-24A | 2.9 | 3.5 | |
M96956 | TDGF1 | 畸胎瘤-产生的生长因子1 | 2.6 | 3.5 |
U31628 | IL15RA | 白介素15受体,α | 6.4 | 3.3 |
D38128 | PTGIR | 前列腺素12.(前列腺环素)受体(IP) | 8.8 | 3.3 |
J03507 | C7 | 补体成分7 | 23 | 3.1 |
M32011 | NCF2 | 嗜中性白细胞胞质因子2 | 3.5 | 3.0 |
X63131 | PML | 前髓细胞白血病 | 4.7 | 3.0 |
D82326 | SLC3A1 | 溶质载体家族3 | 4.0 | 3.0 |
L10343 | P13 | 蛋白酶抑制剂3,皮肤-产生的(SKALP) | 2.1 | 3.0 |
U89995 | FOXE1 | 叉头盒E1(甲状腺转录因子2) | 2.6 | 2.9 |
M62800 | SSA1 | (52kD,核糖核蛋白自身抗原SS-A/Ro) | 3.1 | 2.9 |
AB000584 | PLAB | 前列腺分化因子 | 2.4 | 2.8 |
U37519 | ALDH8 | 醛脱氢酶8 | 2.2 | 2.7 |
D21267 | SNAP25 | 突触体-结合蛋白,25kD | 2.2 | 2.7 |
M25667 | GAP43 | 生长相关蛋白43 | 2.5 | 2.7 |
L34357 | GATA4 | GATA-结合蛋白4 | 2.3 | 2.7 |
U43944 | ME1 | 苹果酶1,NADP(+)-依赖性,胞质 | 3.0 | 2.7 |
M16937 | HOXB7 | 同源异型框B7 | 2.9 | 2.6 |
U27326 | FUT3 | 岩藻糖转移酶3 | 2.6 | 2.6 |
Genbank ID | 基因名称 | Unigene备注 | 折叠10ng | 折叠40ng |
Z23115 | BCL2L1 | BCL2-样1 | 2.2 | 2.6 |
HG1877-HT1917 | MBP | 髓磷脂碱性蛋白 | 2.4 | 2.6 |
D10995 | HTR1B | 5-羟酪胺(血清素)受体1B | 2.5 | 2.6 |
M91463 | SLC2A4 | 溶质载体家族2葡萄糖转运蛋白 | 3.1 | 2.5 |
U19878 | TMEFF1 | 跨膜蛋白,EGF和促滤泡素抑制素样 | 2.9 | 2.4 |
U66468 | CGR11 | 带有EF-hand结构域的细胞生长调控 | 2.2 | 2.4 |
U44848 | NRF1 | 核呼吸因子1 | 3.5 | 2.4 |
U73328 | DLX4 | distal-less同源异型框4 | 3.2 | 2.4 |
HG4593-HT4998 | 电压控制钠通道(SCN1A) | 2.3 | 2.4 | |
X78710 | MTF1 | 金属调节转录因子1 | 2.7 | 2.4 |
X59727 | MAPK4 | 促细胞分裂剂-激活蛋白质激酶4 | 2.3 | 2.4 |
J03600 | ALOX5 | 花生四烯酸5-脂加氧酶 | 2.2 | 2.3 |
U87269 | E4F1 | E4F转录因于1 | 3.4 | 2.3 |
Y10375 | PTPNS1 | 酪氨酸磷酸酶,非受体作用物1 | 45 | 2.2 |
D49958 | GPM6A | 糖蛋白M6A | 3.3 | 2.2 |
U60062 | FEZ1 | 成束和伸长蛋白质ζ1(zygin) | 3.3 | 2.2 |
X14830 | CHRNB1 | 胆碱能受体,烟碱,β多肽1 | 2.4 | 2.1 |
J04076 | EGR2 | 早期生长响应2(Krox-20同系物) | 3.0 | 2.1 |
HG2981-HT3127 | CD44 | CD44抗原 | 2.2 | 2.1 |
U49187 | C6ORF32 | 染色体6开放读框32 | 3.8 | 2.1 |
X77744 | 人FLJ00032蛋白质,部分 | 2.3 | 2.1 | |
X68285 | OK | 甘油激酶 | 2.4 | 2.0 |
H33925-HT4195 | SFIPA2 | 表面活性剂,肺-相关蛋白质A2 | 3.9 | 2.0 |
M26062 | IL2RB | 白介素2受体,β | 0.2 | 0.5 |
X06182 | KIT | V-试剂盒致癌基因同系物 | 0.4 | 0.5 |
U79251 | OPCML | 阿片样物质-结合蛋白/细胞粘着分子-样 | 0.5 | 0.5 |
J03764 | SERPINE1 | 连接蛋白,纤溶酶原激活剂抑制剂1型 | 0.5 | 0.5 |
X92814 | HREV107 | 与大鼠HREV107类似物 | 0.3 | 0.5 |
L01087 | PRKCQ | 蛋白激酶C,θ | 0.2 | 0.5 |
D43772 | GRB7 | 生长因子受体-结合蛋白7 | 0.2 | 0.5 |
X15880 | COL6A1 | 胶原VI型,α1 | 0.5 | 0.5 |
HG3115-HT3291 | MBP | 髓磷脂碱性蛋白 | 0.4 | 0.5 |
X83301 | SMA3 | SMA3 | 0.5 | 0.5 |
D87469 | CELSR2 | 钙黏着蛋白,EGF LAG七跨膜区G-型受体2 | 0.4 | 05 |
M11313 | A2M | α-2-巨球蛋白 | 0.4 | 0.4 |
X64877 | HFL3 | H因子(补体)-样3 | 0.4 | 0.4 |
Z18859 | GNAT2 | 鸟嘌呤核苷酸结合蛋白(G蛋白) | 0.4 | 0.4 |
D89077 | SLA | Src-样-接头 | 0.4 | 0.4 |
L25444 | T-AF2E | TATA盒结合蛋白(TBP)-相关因子 | 0.2 | 0.4 |
M26665 | HTN3 | Histatin3 | 0.4 | 0.4 |
S69790 | WASF3 | WAS蛋白质家族,成员3 | 0.4 | 0.4 |
U79248 | 人克隆23826序列 | 0.4 | 0.4 | |
L15309 | ZNF141 | 锌指蛋白141(克隆pHZ-44) | 0.3 | 0.4 |
L41147 | HTR6 | 5-羟酪胺(血清素)受体6 | 0.4 | 0.4 |
X58431 | HOXB6 | 同源异型框B6 | 0.4 | 0.4 |
U50360 | CAMK2G | CaM激酶IIγ | 0.2 | 0.4 |
D88152 | ACATN | 乙酰辅酶A转运蛋白 | 0.4 | 0.4 |
U38480 | RXRG | 视网膜样X受体,γ | 0.3 | 0.4 |
X16866 | CYP2D7AP | 细胞色素P450,亚家族IID | 0.4 | 0.4 |
Genbank ID | 基因名称 | Unigene备注 | 折叠10ng | 折叠40ng |
X70991 | NAB2 | NGFI-A结合蛋白2(ERG1 bp2) | 0.2 | 0.4 |
M60830 | BVI2B | 嗜亲性病毒整合位点2B | 0.4 | 0.4 |
M27492 | IL1R1 | 白介素1受体,I型 | 0.4 | 0.4 |
Z35093 | SURF1 | 马荨麻疹1 | 0.4 | 0.4 |
D86425 | NID2 | 巢蛋白2 | 0.3 | 0.3 |
U59914 | MADH6 | MAD)同系物6 | 0.4 | 0.3 |
M18255 | PRKCB1 | 蛋白质激酶C,β1 | 0.4 | 0.3 |
AF000234 | P2RX4 | 嘌呤能受体P2X | 0.3 | 0.3 |
S77763 | NFE2 | 核因子(红细胞-产生的2),45kD | 0.4 | 0.3 |
U78722 | ZNF165 | 锌指蛋白165 | 0.3 | 0.3 |
L05568 | SLC6A4 | 溶质载体家族6(血清素) | 0.3 | 0.3 |
L31529 | SNTB1 | 肌养蛋白-相关蛋白A1 | 0.3 | 03 |
U47054 | ART3 | ADP-核糖基转移酶3 | 0.4 | 0.3 |
M13955 | KRT7 | 角蛋白7 | 0.4 | 0.3 |
D15049 | PIPRH | 蛋白质酪氨酸磷酸酶,受体型,H | 0.4 | 0.3 |
U03486 | GJA5 | 间隙连接蛋白,α5,40kD(连接蛋白) | 0.5 | 0.3 |
X06256 | ITOA5 | 整联蛋白,α5 | 0.4 | 0.3 |
U22314 | REST | RE1-缄默转录因子 | 0.3 | 0.3 |
U51096 | CDX2 | 尾侧型同源异形框转录因子2 | 0.2 | 0.2 |
D31762 | KIAA0057 | TRAM-样蛋白 | 0.4 | 0.2 |
M23668 | FDX1 | 铁氧化还原蛋白1 | 0.2 | 0.2 |
U53476 | WNT7A | 无翼型MMTV整合位点家族 | 0.2 | 0.2 |
X57206 | ITPKB | 肌醇1,4,5-三磷酸酶3-激酶B | 0.2 | 0.2 |
Z31695 | INPP5A | 肌醇聚磷酸酶-5-磷酸酶,40kD | 0.4 | 0.2 |
S66793 | ARR3 | 视紫红质抑制蛋白3,视网膜的(X-抑制蛋白) | 0.2 | 0.2 |
U59877 | RAB31 | RAB31,成员RAS致癌基因家族 | 0.2 | 0.2 |
U53786 | EVPL | 外被斑蛋白 | 0.2 | 0.2 |
S83362 | LIFR | 白血病抑制因子受体 | 0.3 | 0.2 |
D42038 | KIAA0087 | KIAA0087基因产物 | 0.3 | 0.2 |
HG4333-HT4603 | ZNF79 | 锌指蛋白79(pT7) | 0.1 | 0.1 |
L01406 | GHRHR | 生长激素释放激素受体 | 0.4 | 0.1 |
基因名称 | Unigene备注 | Unigene |
KLAA0001 | 假定G蛋白偶联受体,用于UDP-葡萄糖 | Hs.2465 |
LIMK2 | LIM结构域激酶2 | Hs.278027 |
KIAA0196 | KIAA0196基因产物 | Hs.8294 |
IFNG | 干扰素,γ | Hs.856 |
POLR2C | 聚合酶(RNA)II多肽 | Hs.79402 |
DAG1 | 营养不良蛋白聚糖1 | Hs.76111 |
TPSB1 | 类胰蛋白酶β1 | Hs.250700 |
CDR2 | 小脑变性-相关蛋白质(62kD) | Hs.75124 |
TCF12 | 螺旋-环-螺旋转录因子4 | Hs.21704 |
TACTILE | 晚期表达增加的T细胞激活 | Hs.142023 |
PIP5K2A | 磷脂酰肌醇-4-磷酸5-激酶 | Hs.108966 |
SF3A3 | 剪接因子3a,亚基3,60kD | Hs.77897 |
SEL1L | sel-1(lin-12的抑制剂,C.elegans)-样 | Hs.181300 |
IL15 | 白介素15 | Hs.168132 |
BAK1 | BCL2-拮抗剂/杀伤者1 | Hs.93213 |
SLAM | 信号淋巴细胞激活分子 | Hs.32970 |
SCYB11 | 小的可诱导细胞因子亚家族B(Cys-X-Cys),成员11 | Hs.103982 |
LIMK1 | LIM结构域激酶1 | Hs.36566 |
CAT56 | CAT56蛋白质 | Hs.118354 |
POLRMT | 聚合酶(RNA)线粒体(DNA指示) | Hs.153880 |
SCYA4 | 小的可诱导细胞因子A4/Mip-1b | Hs.75703 |
MIG | γ干扰素诱导的单核因子 | Hs.77367 |
SSX3 | 滑膜肉瘤,X断点3 | Hs.178749 |
TNFRSF6 | 肿瘤坏死因子受体亚家族,成员6 | Hs.82359 |
MAT1A | 蛋氨酸腺苷转移酶I,α | Hs.323715 |
KIAA0133 | KIAA0133基因产物 | Hs.57730 |
FCGBP | IgG结合蛋白的Fc片段 | Hs.111732 |
ARHD | Ras同系物基因家族,成员 | Hs.15114 |
FGFR2 | 成纤维细胞生长因子受体2 | Hs.278581 |
COL9A1 | 胶原,IX型,α1 | Hs.154850 |
HPX42B | 造血先祖同源异形框 | Hs.125231 |
TAX2 | T-细胞急性淋巴细胞白血病2 | Hs.247978 |
ESTs | Hs.196244 | |
RE | 肾素 | Hs.3210 |
FOU2F2 | POU结构域,2类,转录因子2 | Hs.1101 |
ALOX12 | 花生四烯酸12-脂氧合酶 | Hs.1200 |
ACTN2 | 辅肌动蛋白,α2 | Hs.83672 |
KLK2 | 血管舒缓素2,前列腺的 | Hs.181350 |
基因名称 | Unigene备注 | Unigene |
RCV1 | 恢复蛋白 | Hs.80539 |
B2F4 | E2F转录因子4。p107/p130-结合 | Hs.108371 |
SEMA3F | 免疫球蛋白结构域(Ig),短的碱性结构域,分泌的,脑信号蛋白)3P | Hs.32981 |
BHMT | 甜菜碱-高半胱氨酸甲基转移酶 | Hs.80756 |
EVPL | 外被斑蛋白 | Hs.25482 |
BBC3 | Bc1-2结合成分3 | Hs.87246 |
SLN | Sarcolipin | Hs.15219 |
RDBP | RD RNA-结合蛋白 | Hs.106061 |
MTlH | 金属硫蛋白 | Hs.2667 |
RAD54L | RAD54(啤酒糖酵母)-样 | Hs.66718 |
MUL3 | 骨髓/淋巴样或混合-血统白血病3 | Hs.288971 |
探针组ID | 标题 | Unigene |
202284_s_at | 细胞周期蛋白依赖性激酶抑制剂1A(p21,Cipl) | Hs.179665 |
202531_at | 干扰素调控因子1 | Hs.80645 |
204057_at | 干扰素共有序列结合蛋白1 | Hs.14453 |
205488_at | 粒酶A(粒酶1,细胞毒素T-淋巴细胞相关丝氨酸酯酶3) | Hs.90708 |
206554_x_at | SET结构域和mariner转座酶融合基因 | Hs.265855 |
206817_x_at | 包含三核苷酸重单元4 复 | Hs.26047 |
207509_s_at | 白细胞-相关Ig-样受体2 | Hs.43803 |
209546_s_at | 载脂蛋白L,1 | Hs.114309 |
214438_at | H2.0一样同源异形框1(果蝇) | Hs.74870 |
214450_at | 组织蛋白酶W(lymphopain) | Hs.87450 |
216950_s_at | FcRI b形式(AA1-344)[人],mRNA序列 | Hs.382006 |
217933_s_at | 亮氨酸氨基肽酶3 | Hs.182579 |
219386_s_at | B淋巴细胞激活剂,巨噬细胞表达的 | Hs.20450 |
219956_at | UDP-N-乙酰基-α-D-半乳糖胺:多肽N-乙酰基氨基半乳糖基转移酶6 | Hs.151678 |
219971_at | 白介素21受体 | Hs.210546 |
221223_x_at | 细胞因子可诱导SH2-包含蛋白质 | Hs.8257 |
IFN | 没有刺激的 | 刺激的 | 抗-IL182.5 | 抗-IL18 125-2H |
供体3n | 0.001 | 0.187 | 0.014 | 0.026 |
供体5n | 0.003 | 0.012 | 0.006 | 0.006 |
供体9n | 0.001 | 1.250 | 0.037 | 0.000 |
供体10n | 0.002 | 0.361 | 0.024 | 0.002 |
供体1n | 0.002 | 0.339 | 0.022 | 0.070 |
供体2n | 0.001 | 0.032 | 0.003 | 0.003 |
供体4n | 0.001 | 0.082 | 0.011 | 0.027 |
供体6n | 0.002 | 0.076 | 0.006 | 0.010 |
供体7n | 0.002 | 0.049 | 0.009 | 0.012 |
供体8n | 0.002 | 0.049 | 0.009 | 0.012 |
CXCL9 | 没有刺激的 | 刺激的 | 抗-IL182.5 | 抗-IL18 125-2H |
供体1 | 0.000 | 0.170 | 0.082 | 0.010 |
供体10 | 0.000 | 0.015 | 0.000 | 0.000 |
供体2 | 0.001 | 0.006 | 0.001 | 0.001 |
供体3 | 0.000 | 0.067 | 0.010 | 0.006 |
供体4 | 0.000 | 0.023 | 0.012 | 0.003 |
供体5 | 0.000 | 0.004 | 0.000 | 0.000 |
供体6 | 0.000 | 0.070 | 0.001 | 0.001 |
供体7 | 0.001 | 0.034 | 0.001 | 0.000 |
供体8 | 0.001 | 0.034 | 0.001 | 0.000 |
供体9 | 0.000 | 0.035 | 0.000 | 0.001 |
CCL8 | 没有刺激的 | 刺激的 | 抗-IL18 2.5 | 抗-IL18 125-2H |
供体1 | 0.036 | 8.941 | 4.054 | 1.051 |
供体10 | 0.004 | 0.987 | 0.009 | 0.025 |
供体2 | 0.036 | 1.225 | 0.105 | 0.057 |
供体3 | 0.012 | 3.923 | 0.648 | 0.663 |
供体4 | 0.021 | 2.227 | 0.994 | 0.630 |
供体5 | 0.001 | 0.005 | 0.001 | 0.001 |
供体6 | 0.000 | 0.023 | 0.002 | 0.001 |
供体7 | 0.001 | 0.009 | 0.001 | 0.001 |
供体8 | 0.001 | 0.009 | 0.001 | 0.001 |
供体9 | 0.001 | 2.438 | 0.003 | 0.059 |
可溶性重组人细胞因子,(1μM) | 捕获的2.13(E)mgl(25mg/mL) | 捕获的2.5(E)mgl(25mg/mL) |
2.13(E)mgl结合 | 2.5(E)MG1结合 | |
IFNγ | - | - |
IL-1α | - | - |
IL-1β | - | - |
其它细胞因子a | - | - |
IL-18b | + | + |
Pro-IL-18 | - | + |
2°可溶性Ab | 1°固定化Ab | ||||||||
125-2H | 2.5(E)mgl | 215 | 444 | 581 | 435 | 2.13(E)mgl | 23 | IL-18BP | |
125-2H | - | + | - | - | + | + | - | - | + |
2.5(E)mgl | + | - | + | + | - | - | + | + | + |
215 | - | + | - | - | + | + | - | - | + |
444 | - | + | - | - | + | + | - | - | + |
581 | + | - | + | + | - | - | + | + | + |
435 | + | - | + | + | - | - | + | + | + |
2.13(E)mgl | - | + | - | - | + | + | - | - | + |
2.3 | - | + | - | - | + | + | - | - | + |
IL-18BP | + | + | + | + | + | + | + | + | - |
Claims (85)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US10/706,689 US20050100965A1 (en) | 2003-11-12 | 2003-11-12 | IL-18 binding proteins |
US10/706,689 | 2003-11-12 | ||
PCT/US2004/037971 WO2005047307A2 (en) | 2003-11-12 | 2004-11-12 | Il-18 binding proteins |
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CN2010102739861A Division CN101948539B (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN201010274020XA Division CN101979412A (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN2012101293119A Division CN102659944A (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
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CN1902229B true CN1902229B (zh) | 2011-11-23 |
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CN201010274020XA Pending CN101979412A (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN2010102739861A Expired - Fee Related CN101948539B (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN2012101293119A Pending CN102659944A (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN2004800399482A Expired - Fee Related CN1902229B (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
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CN201010274020XA Pending CN101979412A (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN2010102739861A Expired - Fee Related CN101948539B (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
CN2012101293119A Pending CN102659944A (zh) | 2003-11-12 | 2004-11-12 | Il-18结合蛋白 |
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US (1) | US20050100965A1 (zh) |
EP (5) | EP2385070A1 (zh) |
JP (4) | JP5054977B2 (zh) |
KR (4) | KR20060123148A (zh) |
CN (4) | CN101979412A (zh) |
AT (1) | ATE555130T1 (zh) |
AU (1) | AU2004290073B2 (zh) |
BR (1) | BRPI0416255A (zh) |
CA (2) | CA2805859A1 (zh) |
CY (1) | CY1112893T1 (zh) |
DK (1) | DK1685152T3 (zh) |
ES (1) | ES2385484T3 (zh) |
HK (1) | HK1098762A1 (zh) |
IL (2) | IL175422A0 (zh) |
NZ (2) | NZ582097A (zh) |
PL (1) | PL1685152T3 (zh) |
PT (1) | PT1685152E (zh) |
SI (1) | SI1685152T1 (zh) |
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