HK1091831A1 - Isoxazole compounds as inhibitors of heat shock proteins - Google Patents
Isoxazole compounds as inhibitors of heat shock proteinsInfo
- Publication number
- HK1091831A1 HK1091831A1 HK06112447.8A HK06112447A HK1091831A1 HK 1091831 A1 HK1091831 A1 HK 1091831A1 HK 06112447 A HK06112447 A HK 06112447A HK 1091831 A1 HK1091831 A1 HK 1091831A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibitors
- heat shock
- shock proteins
- isoxazole compounds
- isoxazole
- Prior art date
Links
- 150000002545 isoxazoles Chemical class 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 title 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 title 1
- 101710113864 Heat shock protein 90 Proteins 0.000 abstract 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Immunology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0303105A GB0303105D0 (en) | 2003-02-11 | 2003-02-11 | Isoxazole compounds |
GBGB0306560.4A GB0306560D0 (en) | 2003-03-21 | 2003-03-21 | Isoxazole compounds |
GB0313751A GB0313751D0 (en) | 2003-06-13 | 2003-06-13 | Isoxazole compounds |
PCT/GB2004/000506 WO2004072051A1 (en) | 2003-02-11 | 2004-02-09 | Isoxazole compounds as inhibitors of heat shock proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1091831A1 true HK1091831A1 (en) | 2007-01-26 |
Family
ID=32872455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06112447.8A HK1091831A1 (en) | 2003-02-11 | 2006-11-10 | Isoxazole compounds as inhibitors of heat shock proteins |
Country Status (19)
Country | Link |
---|---|
US (6) | US7705027B2 (el) |
EP (1) | EP1611112B1 (el) |
JP (1) | JP4921162B2 (el) |
KR (1) | KR101166749B1 (el) |
CN (1) | CN1771235B (el) |
AU (1) | AU2004210779B2 (el) |
BR (1) | BRPI0407403B1 (el) |
CA (1) | CA2515726C (el) |
CY (1) | CY1113761T1 (el) |
DK (1) | DK1611112T3 (el) |
EA (1) | EA009919B1 (el) |
ES (1) | ES2393483T3 (el) |
HK (1) | HK1091831A1 (el) |
MX (1) | MXPA05008335A (el) |
NO (1) | NO335001B1 (el) |
NZ (1) | NZ541479A (el) |
PT (1) | PT1611112E (el) |
SI (1) | SI1611112T1 (el) |
WO (1) | WO2004072051A1 (el) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
JP4921162B2 (ja) * | 2003-02-11 | 2012-04-25 | ヴァーナリス(ケンブリッジ)リミテッド | 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 |
GB0315111D0 (en) * | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
EP1704856A4 (en) | 2003-12-26 | 2009-08-19 | Kyowa Hakko Kirin Co Ltd | PROTEIN INHIBITOR OF THE HSP90 FAMILY |
MXPA06013705A (es) | 2004-05-28 | 2007-02-13 | Unigen Pharmaceuticals Inc | Diarilalcanos como potentes inhibidores de enzimas binucleares. |
GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
KR101313027B1 (ko) | 2004-06-23 | 2013-10-02 | 신타 파마슈티칼스 코프. | 암 치료용 비스(티오-히드라지드 아미드) 염 |
PT1792927E (pt) | 2004-09-22 | 2013-05-15 | Nippon Kayaku Kk | Novo copolímero em bloco, preparação de micelas e agente anticancerígeno contendo o mesmo como ingrediente activo |
JPWO2006051808A1 (ja) * | 2004-11-09 | 2008-05-29 | 協和醗酵工業株式会社 | Hsp90ファミリー蛋白質阻害剤 |
RS52642B (en) | 2004-11-18 | 2013-06-28 | Synta Pharmaceuticals Corp. | TRIAZOLE COMPOUNDS MODULATING HSP90 ACTIVITY |
JP5123671B2 (ja) * | 2005-02-17 | 2013-01-23 | シンタ ファーマシューティカルズ コーポレーション | 増殖性疾患の治療のための化合物 |
DE102005007304A1 (de) * | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
FR2882361A1 (fr) * | 2005-02-22 | 2006-08-25 | Aventis Pharma Sa | Nouveaux derives de 3-aryl-1,2-benzisoxazole, compositions les contenant et leur utilisation |
JP4956737B2 (ja) * | 2005-02-23 | 2012-06-20 | 国立大学法人名古屋大学 | 抗ポリグルタミン病剤 |
US8399464B2 (en) | 2005-03-09 | 2013-03-19 | Nippon Kayaku Kabushiki Kaisha | HSP90 inhibitor |
CN1834095B (zh) * | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
JP2008137894A (ja) * | 2005-03-22 | 2008-06-19 | Nippon Kayaku Co Ltd | 新規なアセチレン誘導体 |
FR2884252B1 (fr) | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
DK1877379T3 (da) * | 2005-04-13 | 2013-04-08 | Astex Therapeutics Ltd | Hydroxybenzamidderivater og anvendelse heraf som inhibitorer af hsp90 |
JP2008536875A (ja) | 2005-04-15 | 2008-09-11 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオヒドラジド)アミド化合物による併用癌療法 |
FR2885904B1 (fr) | 2005-05-19 | 2007-07-06 | Aventis Pharma Sa | Nouveaux derives du fluorene, compositions les contenant et utilisation |
WO2006126751A1 (en) * | 2005-05-25 | 2006-11-30 | Korea Research Institute Of Bioscience And Biotechnology | New diaryl-isoxazole derivatives, and pharmaceutical compositions containing the same for the prevention and the treatment of cancers |
CA2618628C (en) | 2005-08-18 | 2014-11-18 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
GB0603880D0 (en) * | 2006-02-27 | 2006-04-05 | Novartis Ag | Organic compounds |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
JP5249016B2 (ja) | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | タキサン類の高分子結合体 |
US20070259820A1 (en) * | 2006-05-03 | 2007-11-08 | The Regents Of The University Of Michigan | Methods and reagents for activating heat shock protein 70 |
EP2019122A4 (en) | 2006-05-18 | 2009-07-01 | Nippon Kayaku Kk | POLYMER CONJUGATE OF PODOPHYL LOTOXIN |
TW201422598A (zh) | 2006-08-21 | 2014-06-16 | Synta Pharmaceuticals Corp | 用於治療增生性疾病的化合物 |
AU2007290490B2 (en) | 2006-08-31 | 2011-09-08 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
CA2662554A1 (en) * | 2006-09-14 | 2008-03-20 | Synta Pharmaceuticals Corp. | Compounds for the treatment of angiogenesis |
US20090239782A1 (en) * | 2006-10-03 | 2009-09-24 | Masaharu Nakamura | High-molecular weight conjugate of resorcinol derivatives |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
JP5410285B2 (ja) | 2006-10-12 | 2014-02-05 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
JP5528807B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
EP2080779B1 (en) | 2006-11-06 | 2016-05-18 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
WO2008056654A1 (en) | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
US7799954B2 (en) | 2006-11-17 | 2010-09-21 | Abraxis Bioscience, Llc | Dicarbonyl derivatives and methods of use |
UA101950C2 (ru) * | 2007-03-01 | 2013-05-27 | Новартис Аг | Соль присоединения с кислотами, гидрат и полиморфная форма этиламида 5-(2,4-дигидрокси-5-изопропилфенил)-4-(4-морфолин-4-илметилфенил)-изоксазол-3-карбоновой кислоты и композиция, которая содержит эти формы (варианты) |
BRPI0814532A2 (pt) | 2007-07-25 | 2015-01-27 | Hoffmann La Roche | Compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação dos receptores de h3, e uso desses compostos para a preparação de medicamentos. |
ES2748599T3 (es) | 2007-08-27 | 2020-03-17 | Dart Neuroscience Cayman Ltd | Compuestos terapéuticos de isoxazol |
WO2009026658A1 (en) * | 2007-08-29 | 2009-03-05 | The University Of Sydney | Ppar agonists |
WO2009041570A1 (ja) | 2007-09-28 | 2009-04-02 | Nippon Kayaku Kabushiki Kaisha | ステロイド類の高分子結合体 |
CA2700893A1 (en) | 2007-10-12 | 2009-04-16 | Arqule, Inc. | Substituted tetrazole compounds and uses thereof |
TW200922595A (en) * | 2007-10-12 | 2009-06-01 | Novartis Ag | Organic compounds |
CN101918389A (zh) * | 2007-11-02 | 2010-12-15 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
GB0722680D0 (en) * | 2007-11-19 | 2007-12-27 | Topotarget As | Therapeutic compounds and their use |
JP5687899B2 (ja) | 2008-03-18 | 2015-03-25 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
LT5623B (lt) * | 2008-04-30 | 2010-01-25 | Biotechnologijos Institutas, , | 5-aril-4-(5-pakeistieji 2,4-dihidroksifenil)-1,2,3-tiadiazolai kaip hsp90 šaperono slopikliai ir tarpiniai junginiai jiems gauti |
EP2284209B1 (en) | 2008-05-08 | 2016-08-31 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
CN102098918A (zh) * | 2008-05-13 | 2011-06-15 | 帕纳德制药公司 | 用于治疗癌症和神经退行性疾病的生物活性化合物 |
TWI450898B (zh) * | 2008-07-04 | 2014-09-01 | Sigma Tau Res Switzerland Sa | 具有抗腫瘤活性之芳基異唑化合物 |
KR101988329B1 (ko) | 2008-07-21 | 2019-06-12 | 유니젠, 인크. | 일련의 피부-화이트닝(라이트닝) 화합물 |
WO2010060939A2 (en) * | 2008-11-28 | 2010-06-03 | Novartis Ag | Combination of hsp90 and herceptin inhibitors |
EP2370076B1 (en) * | 2008-11-28 | 2017-01-04 | Novartis AG | Pharmaceutical combination comprising a Hsp 90 inhibitor and a mTOR inhibitor |
US8993556B2 (en) | 2009-04-21 | 2015-03-31 | Nerviano Medical Sciences S.R.L. | Resorcinol derivatives as HSP90 inhibitors |
WO2010131675A1 (ja) | 2009-05-15 | 2010-11-18 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
EP2471918A4 (en) | 2009-09-29 | 2013-06-05 | Takeda Pharmaceutical | SCREENING PROCESS |
PL2488873T3 (pl) | 2009-10-16 | 2016-01-29 | Novartis Ag | Biomarkery odpowiedzi farmakodynamicznej wobec guza |
KR101392086B1 (ko) * | 2010-02-17 | 2014-05-07 | 일동제약주식회사 | 신규 5각 헤테로 고리 유도체 및 그 제조방법 |
WO2011133520A1 (en) | 2010-04-19 | 2011-10-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
CA2816997A1 (en) | 2010-11-17 | 2012-05-24 | Nippon Kayaku Kabushiki Kaisha | Novel polymer derivative of cytidine metabolic antagonist |
KR101976642B1 (ko) | 2011-03-24 | 2019-05-09 | 유니젠, 인크. | 디아릴프로판의 제조를 위한 화합물 및 방법 |
WO2013015661A2 (en) * | 2011-07-28 | 2013-01-31 | Ildong Pharm Co.,Ltd. | Novel prodrugs of 5-(2,4-dihydroxy-5-isopropylphenyl)-n-ethyl-4-(5-methyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide |
CN102351655A (zh) * | 2011-08-18 | 2012-02-15 | 杭州澳赛诺化工有限公司 | 一种4-异丙基间苯二酚的合成方法 |
PT2754682T (pt) | 2011-09-11 | 2017-08-29 | Nippon Kayaku Kk | Método para o fabrico de copolímero de bloco |
AU2012322976B2 (en) | 2011-10-14 | 2016-05-12 | Novartis Ag | 2 - carboxamide cycloamino urea derivatives in combination with Hsp90 inhibitors for the treatment of proliferative diseases |
CN103086994A (zh) * | 2011-10-31 | 2013-05-08 | 上海壹志医药科技有限公司 | 异噁唑衍生物的盐 |
WO2013067162A1 (en) | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
CA2853806C (en) | 2011-11-02 | 2020-07-14 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with platinum-containing agents |
CA2854188A1 (en) | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
MX2015005798A (es) | 2012-11-07 | 2015-09-23 | Novartis Ag | Terapia de combinacion. |
WO2014074778A1 (en) | 2012-11-09 | 2014-05-15 | Jacobus Pharmaceutical Company, Inc. | Aryl derivatives and uses thereof |
WO2014074775A1 (en) * | 2012-11-09 | 2014-05-15 | Jacobus Pharmaceutical Company, Inc. | Heteroaryl derivatives and uses thereof |
BR112015021846A2 (pt) * | 2013-03-15 | 2017-07-18 | Novartis Ag | biomarcador |
MX2015017532A (es) * | 2013-06-26 | 2016-10-26 | Proteostasis Therapeutics Inc | Métodos para modular la actividad del regulador de transmembrana de fibrosis quística. |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
MX2016011993A (es) | 2014-03-14 | 2016-12-09 | Novartis Ag | Moleculas de anticuerpo que se unen a lag-3 y usos de las mismas. |
WO2015196071A1 (en) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
BR112017006425B8 (pt) | 2014-10-01 | 2023-05-16 | Daiichi Sankyo Co Ltd | Compostos derivados de isoxazol, seus usos, inibidores de isocitrato desidrogenase 1 mutante e da produção de d-2 hidroxiglutamato, agente antitumoral e composição farmacêutica compreendendo os mesmos |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
EP3206711B1 (en) | 2014-10-14 | 2023-05-31 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
EP3233918A1 (en) | 2014-12-19 | 2017-10-25 | Novartis AG | Combination therapies |
CN104725329B (zh) * | 2015-01-13 | 2017-01-18 | 陕西科技大学 | 一种具有抗肿瘤活性的异恶唑羧酸类化合物及其合成方法 |
RU2697703C2 (ru) * | 2015-01-22 | 2019-08-19 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | Производное резорцина в качестве ингибитора hsp90 |
KR20170129802A (ko) | 2015-03-10 | 2017-11-27 | 아두로 바이오테크, 인코포레이티드 | "인터페론 유전자의 자극인자"-의존적 신호전달을 활성화하는 조성물 및 방법 |
CN106349180B (zh) * | 2015-07-14 | 2020-05-19 | 上海翰森生物医药科技有限公司 | 4,5-二苯基异噁唑衍生物及其制备方法和应用 |
EP3316902A1 (en) | 2015-07-29 | 2018-05-09 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
EP4378957A3 (en) | 2015-07-29 | 2024-08-07 | Novartis AG | Combination therapies comprising antibody molecules to pd-1 |
DK3317301T3 (da) | 2015-07-29 | 2021-06-28 | Immutep Sas | Kombinationsterapier omfattende antistofmolekyler mod lag-3 |
AU2016348388B2 (en) | 2015-11-03 | 2023-11-30 | Janssen Biotech, Inc. | Antibodies specifically binding PD-1 and their uses |
MX2018007423A (es) | 2015-12-17 | 2018-11-09 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas. |
CN107540624B (zh) * | 2016-06-29 | 2020-06-16 | 广州市恒诺康医药科技有限公司 | 热休克蛋白抑制剂及其制备方法和应用 |
CN106146466A (zh) * | 2016-06-30 | 2016-11-23 | 珠海赛隆药业股份有限公司(长沙)医药研发中心 | 富马酸沃诺拉赞中间体、其制备方法和制备富马酸沃诺拉赞的方法 |
WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
CN109641858B (zh) * | 2016-07-21 | 2021-06-25 | 正大天晴药业集团股份有限公司 | 间苯二酚类衍生物的结晶、盐及其制备方法 |
UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
CN111217762B (zh) * | 2018-11-23 | 2021-08-20 | 华中师范大学 | 多卤代5-(2-羟基苯基)异噁唑类化合物及其制备方法和应用 |
US20220362276A1 (en) * | 2019-05-13 | 2022-11-17 | The Trustees Of Princeton University | Small Molecule Inhibitors of Viral Replication |
CN110283080A (zh) * | 2019-07-05 | 2019-09-27 | 山西大学 | 一种含氟的二苯甲酮衍生物及其制备方法和应用 |
WO2021152113A1 (en) | 2020-01-31 | 2021-08-05 | Bayer Aktiengesellschaft | Substituted 2,3-benzodiazepines derivatives |
WO2022075780A1 (ko) * | 2020-10-07 | 2022-04-14 | 광주과학기술원 | 과민성 방광의 예방 또는 치료용 약학적 조성물 |
CN115160250B (zh) * | 2021-04-02 | 2024-06-04 | 沈阳药科大学 | 4,6-联苯二酚类衍生物及其用途 |
US11324737B1 (en) * | 2021-05-25 | 2022-05-10 | Louis Habash | Modulating expression level of a gene encoding a heat shock protein by treating a human subject with a nitroxide |
US11729925B2 (en) | 2021-06-15 | 2023-08-15 | Erico International Corporation | Mounting bracket with angled mounting openings for electrical boxes |
CN114751870B (zh) * | 2022-02-28 | 2023-10-20 | 贵州医科大学 | 一种2-(异噁唑-5-基)苯基-3,4-二羟基苯甲酸酯及其衍生物及合成方法和应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0418667B1 (de) * | 1989-09-22 | 1995-08-16 | BASF Aktiengesellschaft | Carbonsäureamide |
EP0633254A1 (en) * | 1991-05-01 | 1995-01-11 | Taiho Pharmaceutical Co., Ltd. | Novel isoxazole derivative and salt thereof |
WO1994024095A1 (en) * | 1993-04-16 | 1994-10-27 | Abbott Laboratories | Immunosuppressive agents |
NZ506515A (en) * | 1996-10-15 | 2002-05-31 | G | COX-2 inhibitor (4-[5-(4-chlorophenyl)-3(difluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) for treating neoplasia |
US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
AU6645998A (en) * | 1996-12-23 | 1998-07-17 | Du Pont Pharmaceuticals Company | Oxygen or sulfur containing heteroaromatics as factor xa inhibitors |
ATE315033T1 (de) * | 1998-08-07 | 2006-02-15 | Chiron Corp | Subtituierte isoxazole derivate als estrogen rezeptor modulatore |
JP2002524463A (ja) * | 1998-09-09 | 2002-08-06 | メタバシス・セラピューティクス・インコーポレイテッド | フルクトース−1,6−ビスホスファターゼの新規な芳香族インヒビター |
CN1714866A (zh) * | 1998-12-24 | 2006-01-04 | 症变治疗公司 | 治疗糖尿病的fbp酶抑制剂与胰岛素致敏剂的组合 |
WO2001012621A1 (en) * | 1999-08-13 | 2001-02-22 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES |
SK8892002A3 (en) * | 1999-12-22 | 2003-04-01 | Metabasis Therapeutics Inc | Novel bisamidate phosphonate prodrugs, process for their preparation and use thereof |
US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
JP2002363079A (ja) * | 2001-05-31 | 2002-12-18 | National Cancer Center-Japan | モフェゾラクを有効成分とする、消化管ポリープおよび/または消化管がんの予防または治療のための薬剤 |
JP4399265B2 (ja) * | 2001-12-21 | 2010-01-13 | ヴァーナリス(ケンブリッジ)リミテッド | 3,4−ジアリールピラゾール、および癌の治療におけるそれらの使用 |
JP4921162B2 (ja) * | 2003-02-11 | 2012-04-25 | ヴァーナリス(ケンブリッジ)リミテッド | 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 |
US20110201587A1 (en) * | 2010-02-16 | 2011-08-18 | Bio Holding, Inc. | Hsp90 inhibitors and methods of use |
-
2004
- 2004-02-09 JP JP2006502254A patent/JP4921162B2/ja not_active Expired - Lifetime
- 2004-02-09 US US10/544,443 patent/US7705027B2/en active Active
- 2004-02-09 CA CA2515726A patent/CA2515726C/en not_active Expired - Lifetime
- 2004-02-09 ES ES04709273T patent/ES2393483T3/es not_active Expired - Lifetime
- 2004-02-09 CN CN2004800093392A patent/CN1771235B/zh not_active Expired - Lifetime
- 2004-02-09 AU AU2004210779A patent/AU2004210779B2/en not_active Expired
- 2004-02-09 NZ NZ541479A patent/NZ541479A/en not_active IP Right Cessation
- 2004-02-09 SI SI200431954T patent/SI1611112T1/sl unknown
- 2004-02-09 BR BRPI0407403-3A patent/BRPI0407403B1/pt active IP Right Grant
- 2004-02-09 KR KR1020057014738A patent/KR101166749B1/ko active IP Right Grant
- 2004-02-09 WO PCT/GB2004/000506 patent/WO2004072051A1/en active Search and Examination
- 2004-02-09 DK DK04709273.9T patent/DK1611112T3/da active
- 2004-02-09 PT PT04709273T patent/PT1611112E/pt unknown
- 2004-02-09 EP EP04709273A patent/EP1611112B1/en not_active Expired - Lifetime
- 2004-02-09 EA EA200501272A patent/EA009919B1/ru active IP Right Revival
- 2004-02-09 MX MXPA05008335A patent/MXPA05008335A/es active IP Right Grant
-
2005
- 2005-09-09 NO NO20054195A patent/NO335001B1/no unknown
-
2006
- 2006-11-10 HK HK06112447.8A patent/HK1091831A1/xx not_active IP Right Cessation
-
2010
- 2010-02-19 US US12/708,686 patent/US8507480B2/en active Active
-
2012
- 2012-06-18 US US13/525,409 patent/US8450310B2/en not_active Expired - Lifetime
- 2012-11-09 CY CY20121101068T patent/CY1113761T1/el unknown
-
2013
- 2013-06-27 US US13/929,098 patent/US9718793B2/en not_active Expired - Lifetime
-
2017
- 2017-06-23 US US15/631,059 patent/US10413550B2/en not_active Expired - Lifetime
-
2019
- 2019-07-31 US US16/528,278 patent/US11234987B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1091831A1 (en) | Isoxazole compounds as inhibitors of heat shock proteins | |
GB0318343D0 (en) | No title | |
DE60112974D1 (en) | Carbolinderivate | |
IL165434A0 (en) | Compounds having DPP-IV inhibitory activity | |
MXPA04002931A (es) | Heterociclos que contienen nitrogeno de 5 miembros sustituidos con fenilo para el tratamiento de la obesidad. | |
DE60317198D1 (de) | Proteinkinaseinhibitoren | |
HK1096549A1 (en) | Imidazopyridine-derivatives as inducible no-synthase inhibitors | |
MY135477A (en) | 2-(2,6-dichlorophenyl)-diarylimidazoles | |
DE60216233D1 (en) | Carbolinderivate | |
PH12009500610A1 (en) | 4-imidazolin-2-one compounds | |
WO2007062308A3 (en) | Homo- and heterocyclic compounds suitable as cetp inhibitors | |
AU2001266575A1 (en) | Chemical compounds | |
NO20044526L (no) | Hemisterlinderivater og anvendelser derav | |
BRPI0407841A (pt) | inibidores heterocìclicos de quinase | |
HK1096548A1 (en) | Imidazopyridine-derivatives as inductible no-synthase inhibitors | |
AU2001263278A1 (en) | Cyclic gmp-specific phosphodiesterase inhibitors | |
DE602004005881D1 (de) | Substituierte pyrazinonverbindungen zur behandlung von entzündungen | |
RS20060206A (en) | Aminopyridine-derivatives as inducible no-synthase inhibitors | |
GB0308201D0 (en) | Novel compounds | |
RS20060195A (en) | Imidazopyridine-derivatives as inducible no-synthase inhibitors | |
EP1476149A4 (en) | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | |
NO20001751L (no) | Nye forbindelser til bruk som neuroprotektive midler | |
MY136854A (en) | Crystalline n-formyl hydroxylamine compounds | |
AU6629000A (en) | Novel hypoxanthine and thiohypoxanthine compounds | |
SG145572A1 (en) | Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20240212 |