HK1088891A1 - 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain - Google Patents

1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain

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Publication number
HK1088891A1
HK1088891A1 HK06105728.2A HK06105728A HK1088891A1 HK 1088891 A1 HK1088891 A1 HK 1088891A1 HK 06105728 A HK06105728 A HK 06105728A HK 1088891 A1 HK1088891 A1 HK 1088891A1
Authority
HK
Hong Kong
Prior art keywords
orl1
pain
treatment
benzimidazole
dihydro
Prior art date
Application number
HK06105728.2A
Other languages
English (en)
Inventor
Qun Sun
Richard R Goehring
Donald Kyle
Zhengming Chen
Sam Victory
John Whitehead
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27501377&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1088891(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Priority to HK06105728.2A priority Critical patent/HK1088891A1/xx
Publication of HK1088891A1 publication Critical patent/HK1088891A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Finishing Walls (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK06105728.2A 2001-04-18 2004-07-13 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain HK1088891A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HK06105728.2A HK1088891A1 (en) 2001-04-18 2004-07-13 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28466801P 2001-04-18 2001-04-18
US28466901P 2001-04-18 2001-04-18
US28466601P 2001-04-18 2001-04-18
US28466701P 2001-04-18 2001-04-18
HK04105109.3A HK1063149A1 (en) 2001-04-18 2004-07-13 Nociceptin analogs
HK06105728.2A HK1088891A1 (en) 2001-04-18 2004-07-13 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain

Publications (1)

Publication Number Publication Date
HK1088891A1 true HK1088891A1 (en) 2006-11-17

Family

ID=27501377

Family Applications (4)

Application Number Title Priority Date Filing Date
HK06105728.2A HK1088891A1 (en) 2001-04-18 2004-07-13 1-(4-amino-cyclohexyl)-1,3-dihydro-2h-benzimidazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain
HK04105109.3A HK1063149A1 (en) 2001-04-18 2004-07-13 Nociceptin analogs
HK06104415.3A HK1086000A1 (en) 2001-04-18 2004-07-13 1-(4-piperidinyl)-1,3-dihydro-2h-indole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain
HK06105934.2A HK1088892A1 (en) 2001-04-18 2004-07-13 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain

Family Applications After (3)

Application Number Title Priority Date Filing Date
HK04105109.3A HK1063149A1 (en) 2001-04-18 2004-07-13 Nociceptin analogs
HK06104415.3A HK1086000A1 (en) 2001-04-18 2004-07-13 1-(4-piperidinyl)-1,3-dihydro-2h-indole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain
HK06105934.2A HK1088892A1 (en) 2001-04-18 2004-07-13 1-(4-piperidinyl)-1,3-dihydro-2h-benzoxazole-2-one derivatives and related compounds as nociceptin analogs and orl1 ligands for the treatment of pain

Country Status (26)

Country Link
US (4) US6867222B2 (de)
EP (7) EP1598339B1 (de)
JP (4) JP4364513B2 (de)
KR (2) KR100847296B1 (de)
CN (1) CN100352816C (de)
AT (4) ATE410165T1 (de)
AU (1) AU2002307416B2 (de)
BR (1) BR0209129A (de)
CA (1) CA2444198C (de)
CL (2) CL2009001278A1 (de)
CY (4) CY1108707T1 (de)
CZ (1) CZ20032850A3 (de)
DE (4) DE60231442D1 (de)
DK (4) DK1598340T3 (de)
ES (4) ES2329252T3 (de)
HK (4) HK1088891A1 (de)
HU (1) HUP0401109A3 (de)
IL (4) IL158484A0 (de)
MX (1) MXPA03009600A (de)
NO (1) NO20034661L (de)
NZ (5) NZ528977A (de)
PL (1) PL367310A1 (de)
PT (4) PT1598340E (de)
SI (4) SI1379246T1 (de)
WO (1) WO2002085357A1 (de)
YU (1) YU82303A (de)

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