HK1077836A1 - Method of purifying protein - Google Patents

Method of purifying protein

Info

Publication number
HK1077836A1
HK1077836A1 HK06100461.4A HK06100461A HK1077836A1 HK 1077836 A1 HK1077836 A1 HK 1077836A1 HK 06100461 A HK06100461 A HK 06100461A HK 1077836 A1 HK1077836 A1 HK 1077836A1
Authority
HK
Hong Kong
Prior art keywords
purifying protein
purifying
protein
Prior art date
Application number
HK06100461.4A
Other languages
English (en)
Inventor
Kimie Ishii
Kozo Takeda
Norimichi Ochi
Manabu Matsuhashi
Akinori Imamura
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31986593&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1077836(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of HK1077836A1 publication Critical patent/HK1077836A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK06100461.4A 2002-09-11 2006-01-11 Method of purifying protein HK1077836A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002265609 2002-09-11
PCT/JP2003/011642 WO2004024752A1 (ja) 2002-09-11 2003-09-11 タンパク質精製方法

Publications (1)

Publication Number Publication Date
HK1077836A1 true HK1077836A1 (en) 2006-02-24

Family

ID=31986593

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06100461.4A HK1077836A1 (en) 2002-09-11 2006-01-11 Method of purifying protein

Country Status (13)

Country Link
US (5) US8420789B2 (ja)
EP (3) EP1561756B1 (ja)
JP (2) JP5525118B2 (ja)
KR (1) KR101119448B1 (ja)
CN (1) CN100522989C (ja)
AU (1) AU2003262087B2 (ja)
CA (1) CA2497364C (ja)
DK (2) DK2261230T3 (ja)
ES (2) ES2626268T3 (ja)
HK (1) HK1077836A1 (ja)
HU (1) HUE027134T2 (ja)
SI (2) SI1561756T1 (ja)
WO (1) WO2004024752A1 (ja)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2382488T3 (es) 1997-03-21 2012-06-08 Chugai Seiyaku Kabushiki Kaisha Un agente preventivo o terapéutico para enfermedades mediadas por células t sensibilizadas que comprende un antagonista de il-6 como ingrediente activo
UA80091C2 (en) 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
US20050118163A1 (en) * 2002-02-14 2005-06-02 Hidefumi Mizushima Antibody-containing solution pharmaceuticals
ES2626268T3 (es) 2002-09-11 2017-07-24 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
GB2401040A (en) * 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
EP3736295A1 (en) * 2004-03-24 2020-11-11 Chugai Seiyaku Kabushiki Kaisha Subtypes of humanized antibody against interleukin-6 receptor
WO2007113188A1 (en) * 2006-03-30 2007-10-11 Novo Nordisk A/S Two-phase precipitation of proteins
CA2661872A1 (en) * 2006-08-28 2008-03-06 Ares Trading S.A. Process for the purification of fc-fusion proteins
FI2061803T4 (fi) 2006-08-28 2023-03-14 Process for the purification of fc-containing proteins
CA2660795C (en) 2006-09-18 2014-11-18 Xencor, Inc. Optimized antibodies that target hm1.24
US20080071067A1 (en) * 2006-09-20 2008-03-20 Avigenics, Inc. Methods of purifying proteins from egg white
WO2008121301A1 (en) 2007-03-29 2008-10-09 Abbott Laboratories Crystalline anti-human il-12 antibodies
KR20190140090A (ko) 2007-07-09 2019-12-18 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
AU2016213727A1 (en) * 2007-07-09 2016-08-25 Genentech, Inc. Prevention of disulfide bond reduction during recombinant production of polypeptides
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
NZ602498A (en) * 2007-11-30 2014-08-29 Abbvie Inc Protein formulations and methods of making same
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
EP3604324B1 (en) * 2008-08-14 2024-02-28 Genentech, Inc. Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
GB0818228D0 (en) * 2008-10-06 2008-11-12 Avecia Biolog Ltd Purification process
WO2010109920A1 (ja) * 2009-03-27 2010-09-30 旭化成メディカル株式会社 高濃度モノクローナル抗体溶液中のウイルス除去方法
SG177577A1 (en) * 2009-08-07 2012-03-29 Emd Millipore Corp Methods for purifying a target protein from one or more impurities in a sample
PL2493922T3 (pl) 2009-10-26 2017-07-31 F.Hoffmann-La Roche Ag Sposób wytwarzania glikozylowanych immunoglobulin
SG10201408384PA (en) 2009-12-18 2015-01-29 Novartis Ag Wash solution and method for affinity chromatography
JP5814951B2 (ja) * 2010-03-10 2015-11-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 免疫グロブリン溶液を精製するための方法
EP4029881A1 (en) 2010-11-08 2022-07-20 F. Hoffmann-La Roche AG Subcutaneously administered anti-il-6 receptor antibody
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
JP6067889B2 (ja) * 2013-02-26 2017-01-25 イー・エム・デイー・ミリポア・コーポレイシヨン 溶液条件を調整することによる活性化炭素を使用したタンパク質混合物からの１種のタンパク質の選択的除去
US10144774B2 (en) 2013-07-01 2018-12-04 Csl Behring Ag Method for purifying IgG
BR112015032960B1 (pt) 2013-07-04 2021-01-05 F. Hoffmann-La Roche Ag imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro
JP2016533172A (ja) 2013-10-03 2016-10-27 タケダ ワクチン，インコーポレイテッド 細胞株からラブドウイルスを検出および除去する方法
EP2986307A4 (en) 2014-01-03 2017-04-12 Bio-rad Laboratories, Inc. Removal of impurities from protein a eluates
JP6521351B2 (ja) 2014-10-14 2019-05-29 テックプロジェクトサービス株式会社 ウィルス不活化およびサンプリング装置
WO2016121701A1 (ja) 2015-01-26 2016-08-04 株式会社カネカ 免疫グロブリンκ鎖可変領域含有タンパク質精製用アフィニティー分離マトリックス
JP6663360B2 (ja) 2015-01-26 2020-03-11 株式会社カネカ 変異型免疫グロブリンκ鎖可変領域結合性ペプチド
EP3337818A1 (en) * 2015-08-21 2018-06-27 H. Hoffnabb-La Roche Ag Affinity chromatography purification with low conductivity wash buffer
JP7073253B2 (ja) * 2015-08-21 2022-05-23 エフ．ホフマン－ラ ロシュ アーゲー アフィニティークロマトグラフィーにおける宿主細胞タンパク質の低減方法
EP3337812B1 (en) 2015-08-21 2021-04-28 F. Hoffmann-La Roche AG Method for the reduction of host cell proteins in affinity chromatography
CN106496302B (zh) * 2015-09-08 2021-12-10 三生国健药业（上海）股份有限公司 一种用离子交换层析纯化蛋白质的方法
CN108367245A (zh) * 2015-12-09 2018-08-03 巴斯夫欧洲公司 在解吸条件下从发酵固体纯化蛋白质的方法
PL3373739T3 (pl) * 2016-02-19 2019-06-28 Coöperatie Avebe U.A. Skoagulowane białko w żywności dla ludzi
US11484591B2 (en) 2016-02-22 2022-11-01 Ohio State Innovation Foundation Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites
WO2017195638A1 (ja) 2016-05-09 2017-11-16 株式会社カネカ 抗体またはκ鎖可変領域含有抗体断片の精製方法
CN105837667A (zh) * 2016-05-18 2016-08-10 北京天坛生物制品股份有限公司 去除重组汉逊酵母乙肝表面抗原中宿主细胞残留dna的方法
US11033496B2 (en) 2017-03-17 2021-06-15 The Regents Of The University Of Michigan Nanoparticles for delivery of chemopreventive agents
EP3727629A1 (en) * 2017-12-22 2020-10-28 Regeneron Pharmaceuticals, Inc. System and method for characterizing drug product impurities
CN107937425A (zh) * 2017-12-27 2018-04-20 北京四环生物制药有限公司 长效重组人促红素的生产方法
US11603527B2 (en) * 2017-12-27 2023-03-14 Global Life Sciences Solutions Usa Llc Method and kit for viral vector isolation
CN110272491B (zh) * 2018-03-13 2023-01-24 江苏恒瑞医药股份有限公司 一种抗pd-1抗体的纯化工艺
CN111902720A (zh) 2018-03-21 2020-11-06 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
US20220177978A1 (en) 2019-04-02 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of predicting and preventing cancer in patients having premalignant lesions
WO2022155142A1 (en) * 2021-01-12 2022-07-21 Repligen Corporation Offline and inline determination of concentration of metabolites in cell culture fluid

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124576A (en) 1976-12-03 1978-11-07 Coval M L Method of producing intravenously injectable gamma globulin
JPS58201994A (ja) 1982-05-21 1983-11-25 Hideaki Hagiwara 抗原特異的ヒト免疫グロブリンの生産方法
JP2648301B2 (ja) 1983-12-27 1997-08-27 ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド 真核細胞の形質転換のための補助ｄｎａを含むベクター
FI852545L (fi) 1984-06-29 1985-12-30 Ortho Diagnostic Systems Inc Sandwichanalys av antikroppslektin.
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DE3640513A1 (de) 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
DE3641115A1 (de) 1986-12-02 1988-06-16 Lentia Gmbh Verfahren zur herstellung eines intravenoes anwendbaren und in fluessiger form stabilen immunglobulins
DE3876273T2 (de) * 1987-04-11 1993-05-27 Ciba Geigy Ag Isoelektrisches fokussierverfahren sowie einrichtung zur durchfuehrung dieses verfahrens.
ATE121418T1 (de) * 1987-10-23 1995-05-15 Schering Corp Verfahren zur proteinreinigung.
ES2063783T3 (es) 1988-06-03 1995-01-16 Chugai Pharmaceutical Co Ltd Factor de cristalino humano de estimulacion de colonias de granulocitos y procedimiento para su preparacion.
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
WO1991005867A1 (en) 1989-10-13 1991-05-02 Amgen Inc. Erythropoietin isoforms
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
GB9022547D0 (en) 1990-10-17 1990-11-28 Wellcome Found Purified immunoglobulin
US5110910A (en) 1991-03-25 1992-05-05 Miles Inc. Virucidal euglobulin precipitation
AU668349B2 (en) * 1991-04-25 1996-05-02 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
CA2124967C (en) 1991-12-17 2008-04-08 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
JPH07509137A (ja) 1992-07-24 1995-10-12 セル　ジェネシス，インク． 異種抗体の生産
DE4302163A1 (de) * 1993-01-27 1994-07-28 Thomae Gmbh Dr K Verfahren zur Reinigung von Proteinen und Peptiden
US5328989A (en) * 1993-03-05 1994-07-12 Schering-Plough Purification of human interleukin-10 from a cell culture medium
US5840297A (en) 1993-03-19 1998-11-24 Johns Hopkins University Vaccine comprising anti-idiotypic antibody to chlamydia GLXA and process
EP0754225A4 (en) 1993-04-26 2001-01-31 Genpharm Int HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
IL110669A (en) 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
JPH09506508A (ja) 1993-12-03 1997-06-30 メディカル リサーチ カウンシル 組換え結合タンパク質およびペプチド
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US8017121B2 (en) 1994-06-30 2011-09-13 Chugai Seiyaku Kabushika Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
JPH089902A (ja) 1994-07-04 1996-01-16 Shiseido Co Ltd 低アレルギー加工食品
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
JP3630453B2 (ja) 1994-09-30 2005-03-16 中外製薬株式会社 Ｉｌ−６レセプター抗体を有効成分とする未熟型骨髄腫細胞治療剤
KR20050085971A (ko) 1995-04-27 2005-08-29 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
FI952196A0 (fi) 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
DK0840624T3 (da) 1995-07-14 2007-11-05 Caf Dcf Cvba Scrl Apparat til inaktivering af viruskontaminanter i blodprodukter
JP3471195B2 (ja) 1996-06-27 2003-11-25 中外製薬株式会社 ナイトロジェンマスタード系抗癌剤と組合わせて使用するための骨髄腫治療剤
TW491855B (en) 1996-08-07 2002-06-21 Csl Ltd Purification of immunoglobulins
EP0962467A4 (en) 1996-09-26 2002-10-30 Chugai Pharmaceutical Co Ltd ANTIBODIES AGAINST HUMAN PARATHORMON RELATED PEPTIDES
UA76934C2 (en) 1996-10-04 2006-10-16 Chugai Pharmaceutical Co Ltd Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
DE69739673D1 (de) 1996-11-27 2009-12-31 Genentech Inc Affinitätsreinigung von Polypeptid-Proteinen auf einer Protein A Matrix
US5886154A (en) * 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
US6096872A (en) * 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
US5972613A (en) * 1997-12-09 1999-10-26 The Perkin-Elmer Corporation Methods of nucleic acid isolation
UA64742C2 (uk) 1997-12-24 2004-03-15 Альфа Терапевтик Корпорейшн СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ)
IL138801A0 (en) 1998-04-03 2001-10-31 Chugai Pharmaceutical Co Ltd Humanized antibody against human tissue factor and process for the preparation thereof
KR100501263B1 (ko) 1998-06-09 2005-07-18 스태튼스 세룸 인스티튜트 정맥 주사용 면역글로불린의 제조 방법 및 그 외의 면역글로불린 제품
CA2362533A1 (en) 1999-02-22 2000-08-31 Variagenics, Inc. Gene sequence variations with utility in determining the treatment of disease
JP2000319294A (ja) * 1999-05-11 2000-11-21 Asahi Chem Ind Co Ltd 生物由来高分子溶液精製方法
JP2000351799A (ja) * 1999-06-08 2000-12-19 Jcr Pharmaceuticals Co Ltd フィブロネクチン溶液の製造方法
US6355243B1 (en) 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
ES2477996T3 (es) 2000-08-11 2014-07-18 Chugai Seiyaku Kabushiki Kaisha Preparaciones estabilizadas que contienen un anticuerpo
ES2184594B1 (es) * 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
JP2002265909A (ja) 2001-03-07 2002-09-18 Nippon Synthetic Chem Ind Co Ltd:The 非水分散系感圧接着剤
EP3088412B1 (en) 2001-03-09 2021-05-05 Chugai Seiyaku Kabushiki Kaisha Protein purification method
JP4187941B2 (ja) 2001-03-14 2008-11-26 リンテック株式会社 ホウ素含有ポリオルガノシルセスキオキサン及び接着剤組成物
AU784808B2 (en) 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
ATE464068T1 (de) 2001-06-26 2010-04-15 Amgen Fremont Inc Antikörper gegen opgl
US7122641B2 (en) * 2001-12-21 2006-10-17 Immunex Corporation Methods for purifying protein
US20050118163A1 (en) 2002-02-14 2005-06-02 Hidefumi Mizushima Antibody-containing solution pharmaceuticals
ES2626268T3 (es) 2002-09-11 2017-07-24 Chugai Seiyaku Kabushiki Kaisha Método de purificación de proteínas
WO2006029385A2 (en) 2004-09-08 2006-03-16 Chelsea Therapeutics, Inc. Quinazoline derivatives as metabolically inert antifolate compounds.
JP2010524479A (ja) 2007-05-02 2010-07-22 エフ．ホフマン−ラ ロシュ アーゲー タンパク質を安定化する方法
JP5504579B2 (ja) 2008-05-12 2014-05-28 積水ハウス株式会社 住宅の床着脱構造及び住宅の改装方法
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
NZ599456A (en) 2009-10-26 2014-06-27 Nestec Sa Assays for the detection of anti-tnf drugs and autoantibodies
US8623377B2 (en) 2011-06-29 2014-01-07 University Of Maryland, Baltimore Joint-homing peptides and uses thereof
CN110074968B (zh) 2013-03-11 2021-12-21 Sio2医药产品公司 涂布包装材料
CA2922732A1 (en) 2013-09-03 2015-03-12 L. Douglas GRAHAM Treatment methods for rheumatoid arthritis

Also Published As

Publication number Publication date
AU2003262087B2 (en) 2010-11-11
KR101119448B1 (ko) 2012-03-15
ES2558303T3 (es) 2016-02-03
ES2626268T3 (es) 2017-07-24
CA2497364A1 (en) 2004-03-25
WO2004024752A1 (ja) 2004-03-25
EP1561756A4 (en) 2006-08-23
CN100522989C (zh) 2009-08-05
US10654888B2 (en) 2020-05-19
JPWO2004024752A1 (ja) 2006-01-05
CA2497364C (en) 2013-03-19
US20140323695A1 (en) 2014-10-30
US20220185843A1 (en) 2022-06-16
EP1561756B1 (en) 2015-12-23
DK1561756T3 (en) 2016-02-15
EP2261230A1 (en) 2010-12-15
SI1561756T1 (sl) 2016-02-29
US20200231624A1 (en) 2020-07-23
EP1561756A1 (en) 2005-08-10
US8420789B2 (en) 2013-04-16
US20060142549A1 (en) 2006-06-29
JP5525118B2 (ja) 2014-06-18
SI2261230T1 (sl) 2017-08-31
JP5687469B2 (ja) 2015-03-18
CN1681837A (zh) 2005-10-12
AU2003262087A1 (en) 2004-04-30
JP2011006489A (ja) 2011-01-13
US20130225796A1 (en) 2013-08-29
EP2261230B1 (en) 2017-05-10
KR20050038042A (ko) 2005-04-25
US8809509B2 (en) 2014-08-19
DK2261230T3 (en) 2017-06-12
EP3225625A1 (en) 2017-10-04
HUE027134T2 (en) 2016-10-28

Similar Documents

Publication Publication Date Title
HK1077836A1 (en) Method of purifying protein
IL262513A (en) Cleaning proteins
AU2003265235A8 (en) Non-affinity purification of proteins
EP1380589A4 (en) PROTEIN CLEANING METHOD
EP1464702A4 (en) METHOD FOR PROTEIN STABILIZATION
EP1489174A4 (en) METHOD FOR MODIFYING THE PROPERTIES OF A PROTEIN
EP1654379A4 (en) METHOD AND COMPOSITIONS FOR IMPROVED PROTEIN EXPRESSION AND CLEANING
EP1577280A4 (en) DEUTERATION PROCESS
EP1578774A4 (en) PROTEIN PURIFICATION
PL1527690T3 (pl) Sposób pozbawiania smaku i zapachu białka serwatkowego
AU2002367010A1 (en) Method of purifying brine
EP1541165A4 (en) METHOD FOR STABILIZING PROTEIN PREPARATION
EP1488046A4 (en) CONSTRUCTION METHODS
EP1686137A4 (en) PROCESS FOR STABILIZING PROTEIN SOLUTIONS
EP1549757A4 (en) PROCESS FOR CLEANING LANTIBIOTICS
EP1452597A4 (en) PROTEIN ACTIVATION METHOD
HUP0400981A3 (en) Polypeptide purification method
EP1650562A4 (en) PROCESS FOR SCREENING USEFUL PROTEIN
GB0220894D0 (en) Method of separation
GB0213198D0 (en) Method of treatment
AU2003254894A1 (en) Method of purifying lactide
AU2002237562A1 (en) Method of purifying protein
AU2003228944A8 (en) Protein complex purification
GB0207091D0 (en) Method of treatment
AU2003290331A8 (en) Protein purification means

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20230910